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Entry version 186 (08 May 2019)
Sequence version 1 (01 Feb 1991)
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Protein

Protachykinin-1

Gene

TAC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNeuropeptide, Neurotransmitter

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-380095 Tachykinin receptors bind tachykinins
R-HSA-416476 G alpha (q) signalling events

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P20366

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protachykinin-1
Alternative name(s):
PPT
Cleaved into the following 5 chains:
Neurokinin A
Short name:
NKA
Alternative name(s):
Neuromedin L
Substance K
Neuropeptide K
Short name:
NPK
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TAC1
Synonyms:NKA, NKNA, TAC2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11517 TAC1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
162320 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P20366

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6863

Open Targets

More...
OpenTargetsi
ENSG00000006128

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36297

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TAC1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
135886

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000003352920 – 56Sequence analysisAdd BLAST37
<p>This subsection of the ‘PTM / Processing’ section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_000003353058 – 68Substance PAdd BLAST11
PeptideiPRO_000003353172 – 107Neuropeptide KAdd BLAST36
PeptideiPRO_000003353272 – 73Neuropeptide gamma, 1st part2
PeptideiPRO_000003353389 – 107Neuropeptide gamma, 2nd partAdd BLAST19
PeptideiPRO_000003353498 – 107Neurokinin A10
PeptideiPRO_0000033535111 – 126C-terminal-flanking peptideAdd BLAST16

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei68Methionine amide1 Publication1
Modified residuei107Methionine amide2 Publications1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The substance P form is cleaved at Pro-59 by the prolyl endopeptidase FAP (seprase) activity (in vitro).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei59 – 60Cleavage; by FAP1 Publication2

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P20366

PeptideAtlas

More...
PeptideAtlasi
P20366

PRoteomics IDEntifications database

More...
PRIDEi
P20366

ProteomicsDB human proteome resource

More...
ProteomicsDBi
53754
53755 [P20366-2]
53756 [P20366-3]
53757 [P20366-4]

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P20366

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P20366

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000006128 Expressed in 148 organ(s), highest expression level in caudate nucleus

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P20366 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB004588
HPA014429

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112727, 6 interactors

Protein interaction database and analysis system

More...
IntActi
P20366, 10 interactors

Molecular INTeraction database

More...
MINTi
P20366

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000321106

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1129
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P20366

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P20366

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tachykinin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IWZZ Eukaryota
ENOG4112BW1 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000002457

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P20366

KEGG Orthology (KO)

More...
KOi
K05239

Identification of Orthologs from Complete Genome Data

More...
OMAi
MGKRSQE

Database of Orthologous Groups

More...
OrthoDBi
1504814at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P20366

TreeFam database of animal gene trees

More...
TreeFami
TF333405

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013055 Tachy_Neuro_lke_CS
IPR008215 Tachykinin_dom
IPR008216 Tachykinin_fam

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01829 PROTACHYKNIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00203 TK, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00267 TACHYKININ, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform Beta (identifier: P20366-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKILVALAVF FLVSTQLFAE EIGANDDLNY WSDWYDSDQI KEELPEPFEH
60 70 80 90 100
LLQRIARRPK PQQFFGLMGK RDADSSIEKQ VALLKALYGH GQISHKRHKT
110 120
DSFVGLMGKR ALNSVAYERS AMQNYERRR
Length:129
Mass (Da):15,003
Last modified:February 1, 1991 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i51412C1692368DE4
GO
Isoform Alpha (identifier: P20366-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     97-114: Missing.
     115-115: V → M

Show »
Length:111
Mass (Da):13,036
Checksum:i28E051E5ACC42C47
GO
Isoform Gamma (identifier: P20366-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     74-88: Missing.

Show »
Length:114
Mass (Da):13,343
Checksum:i499EECB627AECDE6
GO
Isoform Delta (identifier: P20366-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     74-88: Missing.
     97-114: Missing.
     115-115: V → M

Show »
Length:96
Mass (Da):11,376
Checksum:iAE50A94DF2437361
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti32S → P in BAD96677 (Ref. 4) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00637574 – 88Missing in isoform Gamma and isoform Delta. 2 PublicationsAdd BLAST15
Alternative sequenceiVSP_00637697 – 114Missing in isoform Alpha and isoform Delta. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_006377115V → M in isoform Alpha and isoform Delta. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X54469 mRNA Translation: CAA38351.1
U37529 mRNA Translation: AAA79195.1
CR407602 mRNA Translation: CAG28529.1
CR541730 mRNA Translation: CAG46531.1
AK222957 mRNA Translation: BAD96677.1
AC004140 Genomic DNA Translation: AAQ96888.1
AC004140 Genomic DNA Translation: AAQ96889.1
AC004140 Genomic DNA Translation: AAQ96890.1
AC004140 Genomic DNA Translation: AAQ96891.1
CH236949 Genomic DNA Translation: EAL24116.1
CH236949 Genomic DNA Translation: EAL24117.1
CH236949 Genomic DNA Translation: EAL24118.1
CH236949 Genomic DNA Translation: EAL24119.1
CH471091 Genomic DNA Translation: EAW76734.1
CH471091 Genomic DNA Translation: EAW76735.1
CH471091 Genomic DNA Translation: EAW76736.1
CH471091 Genomic DNA Translation: EAW76737.1
BC018047 mRNA Translation: AAH18047.1
M68906 mRNA Translation: AAA60159.1
M68907 mRNA Translation: AAA60160.1
AF050655 mRNA Translation: AAC15701.1
AF050656 mRNA Translation: AAC15702.1
AF050658 mRNA Translation: AAC15704.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5649.1 [P20366-1]
CCDS5650.1 [P20366-2]
CCDS5651.1 [P20366-3]

Protein sequence database of the Protein Information Resource

More...
PIRi
A24805 SPHUB

NCBI Reference Sequences

More...
RefSeqi
NP_003173.1, NM_003182.2 [P20366-1]
NP_054702.1, NM_013996.2 [P20366-2]
NP_054703.1, NM_013997.2 [P20366-3]
NP_054704.1, NM_013998.2 [P20366-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000319273; ENSP00000321106; ENSG00000006128 [P20366-1]
ENST00000346867; ENSP00000289574; ENSG00000006128 [P20366-3]
ENST00000350485; ENSP00000289576; ENSG00000006128 [P20366-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6863

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6863

UCSC genome browser

More...
UCSCi
uc003uop.5 human [P20366-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Neurokinin-1 entry

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54469 mRNA Translation: CAA38351.1
U37529 mRNA Translation: AAA79195.1
CR407602 mRNA Translation: CAG28529.1
CR541730 mRNA Translation: CAG46531.1
AK222957 mRNA Translation: BAD96677.1
AC004140 Genomic DNA Translation: AAQ96888.1
AC004140 Genomic DNA Translation: AAQ96889.1
AC004140 Genomic DNA Translation: AAQ96890.1
AC004140 Genomic DNA Translation: AAQ96891.1
CH236949 Genomic DNA Translation: EAL24116.1
CH236949 Genomic DNA Translation: EAL24117.1
CH236949 Genomic DNA Translation: EAL24118.1
CH236949 Genomic DNA Translation: EAL24119.1
CH471091 Genomic DNA Translation: EAW76734.1
CH471091 Genomic DNA Translation: EAW76735.1
CH471091 Genomic DNA Translation: EAW76736.1
CH471091 Genomic DNA Translation: EAW76737.1
BC018047 mRNA Translation: AAH18047.1
M68906 mRNA Translation: AAA60159.1
M68907 mRNA Translation: AAA60160.1
AF050655 mRNA Translation: AAC15701.1
AF050656 mRNA Translation: AAC15702.1
AF050658 mRNA Translation: AAC15704.1
CCDSiCCDS5649.1 [P20366-1]
CCDS5650.1 [P20366-2]
CCDS5651.1 [P20366-3]
PIRiA24805 SPHUB
RefSeqiNP_003173.1, NM_003182.2 [P20366-1]
NP_054702.1, NM_013996.2 [P20366-2]
NP_054703.1, NM_013997.2 [P20366-3]
NP_054704.1, NM_013998.2 [P20366-4]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B19NMR-A72-107[»]
2KS9NMR-B58-68[»]
2KSANMR-B58-68[»]
2KSBNMR-B58-68[»]
4HOMX-ray1.90B58-68[»]
SMRiP20366
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112727, 6 interactors
IntActiP20366, 10 interactors
MINTiP20366
STRINGi9606.ENSP00000321106

PTM databases

PhosphoSitePlusiP20366

Polymorphism and mutation databases

BioMutaiTAC1
DMDMi135886

Proteomic databases

PaxDbiP20366
PeptideAtlasiP20366
PRIDEiP20366
ProteomicsDBi53754
53755 [P20366-2]
53756 [P20366-3]
53757 [P20366-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
6863
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319273; ENSP00000321106; ENSG00000006128 [P20366-1]
ENST00000346867; ENSP00000289574; ENSG00000006128 [P20366-3]
ENST00000350485; ENSP00000289576; ENSG00000006128 [P20366-2]
GeneIDi6863
KEGGihsa:6863
UCSCiuc003uop.5 human [P20366-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6863
DisGeNETi6863

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TAC1
HGNCiHGNC:11517 TAC1
HPAiCAB004588
HPA014429
MIMi162320 gene
neXtProtiNX_P20366
OpenTargetsiENSG00000006128
PharmGKBiPA36297

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IWZZ Eukaryota
ENOG4112BW1 LUCA
GeneTreeiENSGT00390000002457
InParanoidiP20366
KOiK05239
OMAiMGKRSQE
OrthoDBi1504814at2759
PhylomeDBiP20366
TreeFamiTF333405

Enzyme and pathway databases

ReactomeiR-HSA-380095 Tachykinin receptors bind tachykinins
R-HSA-416476 G alpha (q) signalling events
SIGNORiP20366

Miscellaneous databases

EvolutionaryTraceiP20366

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TAC1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6863
PMAP-CutDBiP20366

Protein Ontology

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PROi
PR:P20366

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000006128 Expressed in 148 organ(s), highest expression level in caudate nucleus
GenevisibleiP20366 HS

Family and domain databases

InterProiView protein in InterPro
IPR013055 Tachy_Neuro_lke_CS
IPR008215 Tachykinin_dom
IPR008216 Tachykinin_fam
PRINTSiPR01829 PROTACHYKNIN
SMARTiView protein in SMART
SM00203 TK, 2 hits
PROSITEiView protein in PROSITE
PS00267 TACHYKININ, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTKN1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P20366
Secondary accession number(s): O60600
, O60601, Q00072, Q53GH4, Q549V0, Q549V1, Q549V2, Q6FHM1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: May 8, 2019
This is version 186 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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