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Protein

Protachykinin-1

Gene

TAC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.

GO - Molecular functioni

  • neuromedin K receptor binding Source: UniProtKB
  • receptor ligand activity Source: UniProtKB
  • signaling receptor binding Source: GO_Central
  • substance K receptor binding Source: UniProtKB
  • substance P receptor binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionNeuropeptide, Neurotransmitter

Enzyme and pathway databases

ReactomeiR-HSA-380095 Tachykinin receptors bind tachykinins
R-HSA-416476 G alpha (q) signalling events
SIGNORiP20366

Names & Taxonomyi

Protein namesi
Recommended name:
Protachykinin-1
Alternative name(s):
PPT
Cleaved into the following 5 chains:
Neurokinin A
Short name:
NKA
Alternative name(s):
Neuromedin L
Substance K
Neuropeptide K
Short name:
NPK
Gene namesi
Name:TAC1
Synonyms:NKA, NKNA, TAC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000006128.11
HGNCiHGNC:11517 TAC1
MIMi162320 gene
neXtProtiNX_P20366

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6863
OpenTargetsiENSG00000006128
PharmGKBiPA36297

Polymorphism and mutation databases

BioMutaiTAC1
DMDMi135886

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000003352920 – 56Sequence analysisAdd BLAST37
PeptideiPRO_000003353058 – 68Substance PAdd BLAST11
PeptideiPRO_000003353172 – 107Neuropeptide KAdd BLAST36
PeptideiPRO_000003353272 – 73Neuropeptide gamma, 1st part2
PeptideiPRO_000003353389 – 107Neuropeptide gamma, 2nd partAdd BLAST19
PeptideiPRO_000003353498 – 107Neurokinin A10
PeptideiPRO_0000033535111 – 126C-terminal-flanking peptideAdd BLAST16

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei68Methionine amide1 Publication1
Modified residuei107Methionine amide2 Publications1

Post-translational modificationi

The substance P form is cleaved at Pro-59 by the prolyl endopeptidase FAP (seprase) activity (in vitro).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei59 – 60Cleavage; by FAP1 Publication2

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiP20366
PeptideAtlasiP20366
PRIDEiP20366
ProteomicsDBi53754
53755 [P20366-2]
53756 [P20366-3]
53757 [P20366-4]

PTM databases

PhosphoSitePlusiP20366

Miscellaneous databases

PMAP-CutDBiP20366

Expressioni

Gene expression databases

BgeeiENSG00000006128 Expressed in 148 organ(s), highest expression level in caudate nucleus
CleanExiHS_TAC1
GenevisibleiP20366 HS

Organism-specific databases

HPAiCAB004588
HPA014429

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112727, 6 interactors
IntActiP20366, 9 interactors
MINTiP20366
STRINGi9606.ENSP00000321106

Structurei

Secondary structure

1129
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP20366
SMRiP20366
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP20366

Family & Domainsi

Sequence similaritiesi

Belongs to the tachykinin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWZZ Eukaryota
ENOG4112BW1 LUCA
GeneTreeiENSGT00390000002457
HOVERGENiHBG000127
InParanoidiP20366
KOiK05239
OMAiMGKRSQE
OrthoDBiEOG091G0Y2V
PhylomeDBiP20366
TreeFamiTF333405

Family and domain databases

InterProiView protein in InterPro
IPR013055 Tachy_Neuro_lke_CS
IPR008215 Tachykinin_dom
IPR008216 Tachykinin_fam
PANTHERiPTHR11250 PTHR11250, 1 hit
PRINTSiPR01829 PROTACHYKNIN
SMARTiView protein in SMART
SM00203 TK, 2 hits
PROSITEiView protein in PROSITE
PS00267 TACHYKININ, 2 hits

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform Beta (identifier: P20366-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKILVALAVF FLVSTQLFAE EIGANDDLNY WSDWYDSDQI KEELPEPFEH
60 70 80 90 100
LLQRIARRPK PQQFFGLMGK RDADSSIEKQ VALLKALYGH GQISHKRHKT
110 120
DSFVGLMGKR ALNSVAYERS AMQNYERRR
Length:129
Mass (Da):15,003
Last modified:February 1, 1991 - v1
Checksum:i51412C1692368DE4
GO
Isoform Alpha (identifier: P20366-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     97-114: Missing.
     115-115: V → M

Show »
Length:111
Mass (Da):13,036
Checksum:i28E051E5ACC42C47
GO
Isoform Gamma (identifier: P20366-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     74-88: Missing.

Show »
Length:114
Mass (Da):13,343
Checksum:i499EECB627AECDE6
GO
Isoform Delta (identifier: P20366-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     74-88: Missing.
     97-114: Missing.
     115-115: V → M

Show »
Length:96
Mass (Da):11,376
Checksum:iAE50A94DF2437361
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32S → P in BAD96677 (Ref. 4) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00637574 – 88Missing in isoform Gamma and isoform Delta. 2 PublicationsAdd BLAST15
Alternative sequenceiVSP_00637697 – 114Missing in isoform Alpha and isoform Delta. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_006377115V → M in isoform Alpha and isoform Delta. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54469 mRNA Translation: CAA38351.1
U37529 mRNA Translation: AAA79195.1
CR407602 mRNA Translation: CAG28529.1
CR541730 mRNA Translation: CAG46531.1
AK222957 mRNA Translation: BAD96677.1
AC004140 Genomic DNA Translation: AAQ96888.1
AC004140 Genomic DNA Translation: AAQ96889.1
AC004140 Genomic DNA Translation: AAQ96890.1
AC004140 Genomic DNA Translation: AAQ96891.1
CH236949 Genomic DNA Translation: EAL24116.1
CH236949 Genomic DNA Translation: EAL24117.1
CH236949 Genomic DNA Translation: EAL24118.1
CH236949 Genomic DNA Translation: EAL24119.1
CH471091 Genomic DNA Translation: EAW76734.1
CH471091 Genomic DNA Translation: EAW76735.1
CH471091 Genomic DNA Translation: EAW76736.1
CH471091 Genomic DNA Translation: EAW76737.1
BC018047 mRNA Translation: AAH18047.1
M68906 mRNA Translation: AAA60159.1
M68907 mRNA Translation: AAA60160.1
AF050655 mRNA Translation: AAC15701.1
AF050656 mRNA Translation: AAC15702.1
AF050658 mRNA Translation: AAC15704.1
CCDSiCCDS5649.1 [P20366-1]
CCDS5650.1 [P20366-2]
CCDS5651.1 [P20366-3]
PIRiA24805 SPHUB
RefSeqiNP_003173.1, NM_003182.2 [P20366-1]
NP_054702.1, NM_013996.2 [P20366-2]
NP_054703.1, NM_013997.2 [P20366-3]
NP_054704.1, NM_013998.2 [P20366-4]
UniGeneiHs.2563

Genome annotation databases

EnsembliENST00000319273; ENSP00000321106; ENSG00000006128 [P20366-1]
ENST00000346867; ENSP00000289574; ENSG00000006128 [P20366-3]
ENST00000350485; ENSP00000289576; ENSG00000006128 [P20366-2]
GeneIDi6863
KEGGihsa:6863
UCSCiuc003uop.5 human [P20366-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

Neurokinin-1 entry

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54469 mRNA Translation: CAA38351.1
U37529 mRNA Translation: AAA79195.1
CR407602 mRNA Translation: CAG28529.1
CR541730 mRNA Translation: CAG46531.1
AK222957 mRNA Translation: BAD96677.1
AC004140 Genomic DNA Translation: AAQ96888.1
AC004140 Genomic DNA Translation: AAQ96889.1
AC004140 Genomic DNA Translation: AAQ96890.1
AC004140 Genomic DNA Translation: AAQ96891.1
CH236949 Genomic DNA Translation: EAL24116.1
CH236949 Genomic DNA Translation: EAL24117.1
CH236949 Genomic DNA Translation: EAL24118.1
CH236949 Genomic DNA Translation: EAL24119.1
CH471091 Genomic DNA Translation: EAW76734.1
CH471091 Genomic DNA Translation: EAW76735.1
CH471091 Genomic DNA Translation: EAW76736.1
CH471091 Genomic DNA Translation: EAW76737.1
BC018047 mRNA Translation: AAH18047.1
M68906 mRNA Translation: AAA60159.1
M68907 mRNA Translation: AAA60160.1
AF050655 mRNA Translation: AAC15701.1
AF050656 mRNA Translation: AAC15702.1
AF050658 mRNA Translation: AAC15704.1
CCDSiCCDS5649.1 [P20366-1]
CCDS5650.1 [P20366-2]
CCDS5651.1 [P20366-3]
PIRiA24805 SPHUB
RefSeqiNP_003173.1, NM_003182.2 [P20366-1]
NP_054702.1, NM_013996.2 [P20366-2]
NP_054703.1, NM_013997.2 [P20366-3]
NP_054704.1, NM_013998.2 [P20366-4]
UniGeneiHs.2563

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B19NMR-A72-107[»]
2KS9NMR-B58-68[»]
2KSANMR-B58-68[»]
2KSBNMR-B58-68[»]
4HOMX-ray1.90B58-68[»]
ProteinModelPortaliP20366
SMRiP20366
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112727, 6 interactors
IntActiP20366, 9 interactors
MINTiP20366
STRINGi9606.ENSP00000321106

PTM databases

PhosphoSitePlusiP20366

Polymorphism and mutation databases

BioMutaiTAC1
DMDMi135886

Proteomic databases

PaxDbiP20366
PeptideAtlasiP20366
PRIDEiP20366
ProteomicsDBi53754
53755 [P20366-2]
53756 [P20366-3]
53757 [P20366-4]

Protocols and materials databases

DNASUi6863
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319273; ENSP00000321106; ENSG00000006128 [P20366-1]
ENST00000346867; ENSP00000289574; ENSG00000006128 [P20366-3]
ENST00000350485; ENSP00000289576; ENSG00000006128 [P20366-2]
GeneIDi6863
KEGGihsa:6863
UCSCiuc003uop.5 human [P20366-1]

Organism-specific databases

CTDi6863
DisGeNETi6863
EuPathDBiHostDB:ENSG00000006128.11
GeneCardsiTAC1
HGNCiHGNC:11517 TAC1
HPAiCAB004588
HPA014429
MIMi162320 gene
neXtProtiNX_P20366
OpenTargetsiENSG00000006128
PharmGKBiPA36297
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWZZ Eukaryota
ENOG4112BW1 LUCA
GeneTreeiENSGT00390000002457
HOVERGENiHBG000127
InParanoidiP20366
KOiK05239
OMAiMGKRSQE
OrthoDBiEOG091G0Y2V
PhylomeDBiP20366
TreeFamiTF333405

Enzyme and pathway databases

ReactomeiR-HSA-380095 Tachykinin receptors bind tachykinins
R-HSA-416476 G alpha (q) signalling events
SIGNORiP20366

Miscellaneous databases

EvolutionaryTraceiP20366
GeneWikiiTAC1
GenomeRNAii6863
PMAP-CutDBiP20366
PROiPR:P20366
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000006128 Expressed in 148 organ(s), highest expression level in caudate nucleus
CleanExiHS_TAC1
GenevisibleiP20366 HS

Family and domain databases

InterProiView protein in InterPro
IPR013055 Tachy_Neuro_lke_CS
IPR008215 Tachykinin_dom
IPR008216 Tachykinin_fam
PANTHERiPTHR11250 PTHR11250, 1 hit
PRINTSiPR01829 PROTACHYKNIN
SMARTiView protein in SMART
SM00203 TK, 2 hits
PROSITEiView protein in PROSITE
PS00267 TACHYKININ, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTKN1_HUMAN
AccessioniPrimary (citable) accession number: P20366
Secondary accession number(s): O60600
, O60601, Q00072, Q53GH4, Q549V0, Q549V1, Q549V2, Q6FHM1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: November 7, 2018
This is version 183 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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