Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Microtubule-associated protein 2

Gene

Map2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.

GO - Molecular functioni

  • actin binding Source: MGI
  • calmodulin binding Source: UniProtKB-KW
  • cytoskeletal regulatory protein binding Source: MGI
  • dystroglycan binding Source: MGI
  • microtubule binding Source: MGI
  • protein kinase binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionCalmodulin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Microtubule-associated protein 2
Short name:
MAP-2
Gene namesi
Name:Map2
Synonyms:Mtap2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:97175 Map2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000727481 – 1828Microtubule-associated protein 2Add BLAST1828

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei28PhosphoserineCombined sources1
Modified residuei136PhosphoserineCombined sources1
Modified residuei140PhosphoserineCombined sources1
Modified residuei143PhosphoserineCombined sources1
Modified residuei283PhosphoserineCombined sources1
Modified residuei333PhosphoserineCombined sources1
Modified residuei346PhosphoserineBy similarity1
Modified residuei476PhosphoserineCombined sources1
Modified residuei496PhosphoserineCombined sources1
Modified residuei520PhosphoserineBy similarity1
Modified residuei550PhosphoserineCombined sources1
Modified residuei596PhosphoserineCombined sources1
Modified residuei599PhosphoserineCombined sources1
Modified residuei603PhosphoserineCombined sources1
Modified residuei608PhosphoserineCombined sources1
Modified residuei626PhosphoserineBy similarity1
Modified residuei726PhosphoserineCombined sources1
Modified residuei730PhosphoserineCombined sources1
Modified residuei734PhosphothreonineCombined sources1
Modified residuei737PhosphoserineCombined sources1
Modified residuei739PhosphoserineCombined sources1
Modified residuei746PhosphotyrosineCombined sources1
Modified residuei823PhosphoserineCombined sources1
Modified residuei883PhosphoserineBy similarity1
Modified residuei892PhosphoserineBy similarity1
Modified residuei938PhosphoserineBy similarity1
Modified residuei1050PhosphoserineBy similarity1
Modified residuei1139PhosphoserineCombined sources1
Modified residuei1140PhosphoserineCombined sources1
Modified residuei1145PhosphoserineCombined sources1
Modified residuei1160PhosphothreonineBy similarity1
Modified residuei1161PhosphoserineCombined sources1
Modified residuei1165PhosphoserineCombined sources1
Modified residuei1352PhosphoserineCombined sources1
Modified residuei1358PhosphothreonineCombined sources1
Modified residuei1539PhosphoserineCombined sources1
Modified residuei1560PhosphoserineCombined sources1
Modified residuei1592PhosphoserineCombined sources1
Modified residuei1606PhosphothreonineCombined sources1
Modified residuei1609PhosphothreonineCombined sources1
Modified residuei1620PhosphothreonineCombined sources1
Modified residuei1623PhosphothreonineCombined sources1
Modified residuei1650PhosphothreonineCombined sources1
Modified residuei1654PhosphoserineBy similarity1
Modified residuei1680Phosphoserine; by MARK1By similarity1
Modified residuei1783PhosphoserineCombined sources1
Modified residuei1788PhosphoserineCombined sources1
Modified residuei1791PhosphoserineCombined sources1
Modified residuei1796PhosphoserineBy similarity1
Modified residuei1809PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated at serine residues in K-X-G-S motifs by causing MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), detachment from microtubules, and their disassembly (By similarity). The interaction with KNDC1 enhances MAP2 threonine phosphorylation (PubMed:17984326).By similarity1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP20357
PaxDbiP20357
PeptideAtlasiP20357
PRIDEiP20357

PTM databases

iPTMnetiP20357
PhosphoSitePlusiP20357

Expressioni

Gene expression databases

BgeeiENSMUSG00000015222 Expressed in 231 organ(s), highest expression level in olfactory bulb
CleanExiMM_MTAP2
ExpressionAtlasiP20357 baseline and differential
GenevisibleiP20357 MM

Interactioni

Subunit structurei

Interacts with KNDC1 (via KIND2); the interaction enhances MAP2 phosphorylation and localizes KNDC1 to dendrites.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Kndc1Q0KK559EBI-397863,EBI-8605532

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201585, 9 interactors
IntActiP20357, 20 interactors
MINTiP20357
STRINGi10090.ENSMUSP00000109650

Structurei

3D structure databases

ProteinModelPortaliP20357
SMRiP20357
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati1662 – 1692Tau/MAP 1Add BLAST31
Repeati1693 – 1723Tau/MAP 2Add BLAST31
Repeati1724 – 1755Tau/MAP 3Add BLAST32

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni702 – 745Interaction with KNDC11 PublicationAdd BLAST44
Regioni1452 – 1472Calmodulin-bindingSequence analysisAdd BLAST21

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2418 Eukaryota
ENOG4111J07 LUCA
GeneTreeiENSGT00530000063491
HOGENOMiHOG000113477
HOVERGENiHBG006322
InParanoidiP20357
KOiK10430
OMAiKTETYDD
OrthoDBiEOG091G00IT

Family and domain databases

InterProiView protein in InterPro
IPR030797 MAP2
IPR013588 MAP2_projctn
IPR001084 MAP_tubulin-bd_rpt
PANTHERiPTHR11501:SF15 PTHR11501:SF15, 1 hit
PfamiView protein in Pfam
PF08377 MAP2_projctn, 1 hit
PF00418 Tubulin-binding, 3 hits
PROSITEiView protein in PROSITE
PS00229 TAU_MAP_1, 2 hits
PS51491 TAU_MAP_2, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.Show allAlign All

P20357-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADERKDEGK APHWTSASLT EAAAHPHSPE MKDQGGAGEG LSRNANGFPY
60 70 80 90 100
REEEEGAFGE HRSQGTYSDT KENGINGELT SADRETAEEV SARIVQVVTA
110 120 130 140 150
EAVAVLKGEQ EKEAQHKDQP AALPLAAEET ANLPPSPPPS PASEQTATVE
160 170 180 190 200
EDLLTASKME FPEQEKFPSS FAEPLDKGEM EFKMPSKPGE DFEHAALVPD
210 220 230 240 250
TSKTPQDKKD LQGMEGEKLP PVPFAQTFGT NLEDRKQSTE PSIVMPSIGL
260 270 280 290 300
SAEPPAPKEP KDWFIEMPTE SKKDEWGLAA PISPGPLTPM REKDVLEDIP
310 320 330 340 350
RWEGKQFDSP MPSPFHGGSF TLPLDTMKNE RVSEGPRPFA PVFFQSDDKV
360 370 380 390 400
SLQDPSALAT SKESSKDEEP LKDKADKVAD VSISEVTTLL GNVHSPVVEG
410 420 430 440 450
YVGENISGEV KVTTDQEKKE TSAPSVQEPT LTETEPQTKL DEKSTVSIEE
460 470 480 490 500
AVAKKEESFK LRDDKTGVIQ TSTEQSFSKE DQKGQEHTID ELKQDSFPIS
510 520 530 540 550
LEQAVTDAAM TSKTLGKVTS EPEAVSERRE IQGLFEEKTA DKNKLEGAGS
560 570 580 590 600
ATIAEVEMPF YEDKSGMSKY FETSALKEDM TRSTELGSDY YELSDSRGSA
610 620 630 640 650
QESLDTISPK NQHDEKELQA KASQPSPPAQ EAGYSTLAQS YTPDHPSELP
660 670 680 690 700
EEPSSPQERM FTIDPKVYGE KRDLHSKNKD DLTLSRSLGL GGRSAIEQRS
710 720 730 740 750
MSINLPMSCL DSIALGFNFG RGHDLSPLAS DILTNTSGSM DEGDDYLPPT
760 770 780 790 800
TPAVEKMPCF PIESKEEEDK AEQAKVTGGQ TIQVETSSES PFPAKEYYKN
810 820 830 840 850
GTVMAPDLPE MLDLAGTRSR LASVSADAEV ARRKSVPSEA MLAESSTSLP
860 870 880 890 900
PVADESPVTV KPDSQLEDMG YCVFNKYTVP LPSPVQDSEN LSGESGSFYE
910 920 930 940 950
GTDDKVRRDL ATDLSLIEVK LAAAGRVKDE FTAEKEASPP TSADKSRLSR
960 970 980 990 1000
EFDHDRKAND KLDTVLEKSE EHIDSKEHAK ESEEMGGKVE LFGLGITYDQ
1010 1020 1030 1040 1050
ASTKELITTK DTSPEKTEKG LSSVPEVAEV EPTTKADQGL DFAATKAEPS
1060 1070 1080 1090 1100
QLDIKVSDFG QMASGMNVDA GKAIELKFEV AQELTLSSEA PQEADSFMGV
1110 1120 1130 1140 1150
ESGHIKEGGK VNETEVKEKV TKPDLVHQEA VDKEESYESS GEHESLTMES
1160 1170 1180 1190 1200
LKPDEGKKET SPETSLIQDE VALKLSVEIP CPPPVSEADL STDEKGEVQM
1210 1220 1230 1240 1250
EFIQLPKEES TETPDIPAIP SDVTQPQPEA IVSEPAEVPS EEEEIEAGGE
1260 1270 1280 1290 1300
YDKLLFRSDT LQISDLLVSE SREEFVETCP GELKGVVESV VTIEDDFITV
1310 1320 1330 1340 1350
VQTTTDEGES GSHSVRFAAP AQPEEERRPR PHDEELEIEM AAEAQAEPKD
1360 1370 1380 1390 1400
GSPDAPATPE KEEVAFSEYK TETYDDYKDE TTIDDSIMDA DSLWVDTQDD
1410 1420 1430 1440 1450
DRSILTEQLE TIPKEERAEK DARRPSLEKH RKEKPFKTGR GRISTPERKV
1460 1470 1480 1490 1500
AKKEPSTVSR DEVRRKKAVY KKAELAKKSE VQAHSPSRKL ILKPAIKYTR
1510 1520 1530 1540 1550
PTHLSCVKRK TTAASGDLAQ APGAFKQAKD KVTDGISKSP EKRSSLPRPS
1560 1570 1580 1590 1600
SILPPRRGVS GDREENSFSL NSSISSARRT TRSEPIRRAG KSGTSTPTTP
1610 1620 1630 1640 1650
GSTAITPGTP PSYSSRTPGT PGTPSYPRTP GTPKSGILVP SEKKVAIIRT
1660 1670 1680 1690 1700
PPKSPATPKQ LRLINQPLPD LKNVKSKIGS TDNIKYQPKG GQVQIVTKKI
1710 1720 1730 1740 1750
DLSHVTSKCG SLKNIRHRPG GGRVKIESVK LDFKEKAQAK VGSLDNAHHV
1760 1770 1780 1790 1800
PGGGNVKIDS QKLNFREHAK ARVDHGAEII TQSPSRSSVA SPRRLSNVSS
1810 1820
SGSINLLESP QLATLAEDVT AALAKQGL
Length:1,828
Mass (Da):199,132
Last modified:July 27, 2011 - v2
Checksum:iE8FA7621C45D5A0D
GO

Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q80ZL4Q80ZL4_MOUSE
Microtubule-associated protein
Map2 Mtap2
467Annotation score:
Q3TLQ0Q3TLQ0_MOUSE
Microtubule-associated protein
Map2 Mtap2
498Annotation score:
G3UZV6G3UZV6_MOUSE
Microtubule-associated protein
Map2 Mtap2
381Annotation score:
G3UWW1G3UWW1_MOUSE
Microtubule-associated protein
Map2 Mtap2
336Annotation score:
G3UZJ2G3UZJ2_MOUSE
Microtubule-associated protein
Map2 Mtap2
240Annotation score:
Q80X35Q80X35_MOUSE
Microtubule-associated protein
Map2 Mtap2
466Annotation score:
E9Q8Y2E9Q8Y2_MOUSE
Microtubule-associated protein 2
Map2 Mtap2
139Annotation score:
G3UZE9G3UZE9_MOUSE
Microtubule-associated protein 2
Map2 Mtap2
565Annotation score:
G3UZK9G3UZK9_MOUSE
Microtubule-associated protein 2
Map2 Mtap2
608Annotation score:
F7ALC8F7ALC8_MOUSE
Microtubule-associated protein 2
Map2 Mtap2
262Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti116H → Y no nucleotide entry (PubMed:3205744).Curated1
Sequence conflicti116H → Y in AAA39490 (PubMed:3142041).Curated1
Sequence conflicti455K → E no nucleotide entry (PubMed:3205744).Curated1
Sequence conflicti455K → E in AAA39490 (PubMed:3142041).Curated1
Sequence conflicti459F → L no nucleotide entry (PubMed:3205744).Curated1
Sequence conflicti459F → L in AAA39490 (PubMed:3142041).Curated1
Sequence conflicti644D → G no nucleotide entry (PubMed:3205744).Curated1
Sequence conflicti644D → G in AAA39490 (PubMed:3142041).Curated1
Sequence conflicti938S → T no nucleotide entry (PubMed:3205744).Curated1
Sequence conflicti938S → T in AAA39490 (PubMed:3142041).Curated1
Sequence conflicti947R → G no nucleotide entry (PubMed:3205744).Curated1
Sequence conflicti947R → G in AAA39490 (PubMed:3142041).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21041 mRNA Translation: AAA39490.1
AC091465 Genomic DNA No translation available.
CCDSiCCDS83550.1
PIRiA40115
RefSeqiNP_001297563.1, NM_001310634.1
XP_006495817.1, XM_006495754.2
UniGeneiMm.256966
Mm.436793

Genome annotation databases

EnsembliENSMUST00000114013; ENSMUSP00000109646; ENSMUSG00000015222
GeneIDi17756
KEGGimmu:17756
UCSCiuc007bhz.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21041 mRNA Translation: AAA39490.1
AC091465 Genomic DNA No translation available.
CCDSiCCDS83550.1
PIRiA40115
RefSeqiNP_001297563.1, NM_001310634.1
XP_006495817.1, XM_006495754.2
UniGeneiMm.256966
Mm.436793

3D structure databases

ProteinModelPortaliP20357
SMRiP20357
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201585, 9 interactors
IntActiP20357, 20 interactors
MINTiP20357
STRINGi10090.ENSMUSP00000109650

PTM databases

iPTMnetiP20357
PhosphoSitePlusiP20357

Proteomic databases

MaxQBiP20357
PaxDbiP20357
PeptideAtlasiP20357
PRIDEiP20357

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000114013; ENSMUSP00000109646; ENSMUSG00000015222
GeneIDi17756
KEGGimmu:17756
UCSCiuc007bhz.1 mouse

Organism-specific databases

CTDi4133
MGIiMGI:97175 Map2

Phylogenomic databases

eggNOGiKOG2418 Eukaryota
ENOG4111J07 LUCA
GeneTreeiENSGT00530000063491
HOGENOMiHOG000113477
HOVERGENiHBG006322
InParanoidiP20357
KOiK10430
OMAiKTETYDD
OrthoDBiEOG091G00IT

Miscellaneous databases

ChiTaRSiMap2 mouse
PROiPR:P20357
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000015222 Expressed in 231 organ(s), highest expression level in olfactory bulb
CleanExiMM_MTAP2
ExpressionAtlasiP20357 baseline and differential
GenevisibleiP20357 MM

Family and domain databases

InterProiView protein in InterPro
IPR030797 MAP2
IPR013588 MAP2_projctn
IPR001084 MAP_tubulin-bd_rpt
PANTHERiPTHR11501:SF15 PTHR11501:SF15, 1 hit
PfamiView protein in Pfam
PF08377 MAP2_projctn, 1 hit
PF00418 Tubulin-binding, 3 hits
PROSITEiView protein in PROSITE
PS00229 TAU_MAP_1, 2 hits
PS51491 TAU_MAP_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMTAP2_MOUSE
AccessioniPrimary (citable) accession number: P20357
Secondary accession number(s): E9QLE1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again