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Entry version 170 (11 Dec 2019)
Sequence version 2 (27 Jul 2011)
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Protein

Microtubule-associated protein 2

Gene

Map2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Microtubule-associated protein 2
Short name:
MAP-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Map2
Synonyms:Mtap2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:97175 Map2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Microtubule

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000727481 – 1828Microtubule-associated protein 2Add BLAST1828

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei28PhosphoserineCombined sources1
Modified residuei136PhosphoserineCombined sources1
Modified residuei140PhosphoserineCombined sources1
Modified residuei143PhosphoserineCombined sources1
Modified residuei283PhosphoserineCombined sources1
Modified residuei333PhosphoserineCombined sources1
Modified residuei346PhosphoserineBy similarity1
Modified residuei476PhosphoserineCombined sources1
Modified residuei496PhosphoserineCombined sources1
Modified residuei520PhosphoserineBy similarity1
Modified residuei550PhosphoserineCombined sources1
Modified residuei596PhosphoserineCombined sources1
Modified residuei599PhosphoserineCombined sources1
Modified residuei603PhosphoserineCombined sources1
Modified residuei608PhosphoserineCombined sources1
Modified residuei626PhosphoserineBy similarity1
Modified residuei726PhosphoserineCombined sources1
Modified residuei730PhosphoserineCombined sources1
Modified residuei734PhosphothreonineCombined sources1
Modified residuei737PhosphoserineCombined sources1
Modified residuei739PhosphoserineCombined sources1
Modified residuei746PhosphotyrosineCombined sources1
Modified residuei823PhosphoserineCombined sources1
Modified residuei883PhosphoserineBy similarity1
Modified residuei892PhosphoserineBy similarity1
Modified residuei938PhosphoserineBy similarity1
Modified residuei1050PhosphoserineBy similarity1
Modified residuei1139PhosphoserineCombined sources1
Modified residuei1140PhosphoserineCombined sources1
Modified residuei1145PhosphoserineCombined sources1
Modified residuei1160PhosphothreonineBy similarity1
Modified residuei1161PhosphoserineCombined sources1
Modified residuei1165PhosphoserineCombined sources1
Modified residuei1352PhosphoserineCombined sources1
Modified residuei1358PhosphothreonineCombined sources1
Modified residuei1539PhosphoserineCombined sources1
Modified residuei1560PhosphoserineCombined sources1
Modified residuei1592PhosphoserineCombined sources1
Modified residuei1606PhosphothreonineCombined sources1
Modified residuei1609PhosphothreonineCombined sources1
Modified residuei1620PhosphothreonineCombined sources1
Modified residuei1623PhosphothreonineCombined sources1
Modified residuei1650PhosphothreonineCombined sources1
Modified residuei1654PhosphoserineBy similarity1
Modified residuei1680Phosphoserine; by MARK1By similarity1
Modified residuei1783PhosphoserineCombined sources1
Modified residuei1788PhosphoserineCombined sources1
Modified residuei1791PhosphoserineCombined sources1
Modified residuei1796PhosphoserineBy similarity1
Modified residuei1809PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated at serine residues in K-X-G-S motifs by causing MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), detachment from microtubules, and their disassembly (By similarity). The interaction with KNDC1 enhances MAP2 threonine phosphorylation (PubMed:17984326).By similarity1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P20357

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P20357

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P20357

PeptideAtlas

More...
PeptideAtlasi
P20357

PRoteomics IDEntifications database

More...
PRIDEi
P20357

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P20357

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P20357

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P20357

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000015222 Expressed in 231 organ(s), highest expression level in olfactory bulb

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P20357 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P20357 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with KNDC1 (via KIND2); the interaction enhances MAP2 phosphorylation and localizes KNDC1 to dendrites.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q0KK559EBI-397863,EBI-8605532

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
201585, 10 interactors

Protein interaction database and analysis system

More...
IntActi
P20357, 20 interactors

Molecular INTeraction database

More...
MINTi
P20357

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000076577

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P20357 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P20357

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1662 – 1692Tau/MAP 1Add BLAST31
Repeati1693 – 1723Tau/MAP 2Add BLAST31
Repeati1724 – 1755Tau/MAP 3Add BLAST32

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni702 – 745Interaction with KNDC11 PublicationAdd BLAST44
Regioni1452 – 1472Calmodulin-bindingSequence analysisAdd BLAST21

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2418 Eukaryota
ENOG4111J07 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156597

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113477

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P20357

KEGG Orthology (KO)

More...
KOi
K10430

Identification of Orthologs from Complete Genome Data

More...
OMAi
FIEMPME

Database of Orthologous Groups

More...
OrthoDBi
716848at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR030797 MAP2
IPR027324 MAP2/MAP4/Tau
IPR013588 MAP2_projctn
IPR001084 MAP_tubulin-bd_rpt

The PANTHER Classification System

More...
PANTHERi
PTHR11501 PTHR11501, 1 hit
PTHR11501:SF15 PTHR11501:SF15, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08377 MAP2_projctn, 1 hit
PF00418 Tubulin-binding, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00229 TAU_MAP_1, 2 hits
PS51491 TAU_MAP_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.Show allAlign All

P20357-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADERKDEGK APHWTSASLT EAAAHPHSPE MKDQGGAGEG LSRNANGFPY
60 70 80 90 100
REEEEGAFGE HRSQGTYSDT KENGINGELT SADRETAEEV SARIVQVVTA
110 120 130 140 150
EAVAVLKGEQ EKEAQHKDQP AALPLAAEET ANLPPSPPPS PASEQTATVE
160 170 180 190 200
EDLLTASKME FPEQEKFPSS FAEPLDKGEM EFKMPSKPGE DFEHAALVPD
210 220 230 240 250
TSKTPQDKKD LQGMEGEKLP PVPFAQTFGT NLEDRKQSTE PSIVMPSIGL
260 270 280 290 300
SAEPPAPKEP KDWFIEMPTE SKKDEWGLAA PISPGPLTPM REKDVLEDIP
310 320 330 340 350
RWEGKQFDSP MPSPFHGGSF TLPLDTMKNE RVSEGPRPFA PVFFQSDDKV
360 370 380 390 400
SLQDPSALAT SKESSKDEEP LKDKADKVAD VSISEVTTLL GNVHSPVVEG
410 420 430 440 450
YVGENISGEV KVTTDQEKKE TSAPSVQEPT LTETEPQTKL DEKSTVSIEE
460 470 480 490 500
AVAKKEESFK LRDDKTGVIQ TSTEQSFSKE DQKGQEHTID ELKQDSFPIS
510 520 530 540 550
LEQAVTDAAM TSKTLGKVTS EPEAVSERRE IQGLFEEKTA DKNKLEGAGS
560 570 580 590 600
ATIAEVEMPF YEDKSGMSKY FETSALKEDM TRSTELGSDY YELSDSRGSA
610 620 630 640 650
QESLDTISPK NQHDEKELQA KASQPSPPAQ EAGYSTLAQS YTPDHPSELP
660 670 680 690 700
EEPSSPQERM FTIDPKVYGE KRDLHSKNKD DLTLSRSLGL GGRSAIEQRS
710 720 730 740 750
MSINLPMSCL DSIALGFNFG RGHDLSPLAS DILTNTSGSM DEGDDYLPPT
760 770 780 790 800
TPAVEKMPCF PIESKEEEDK AEQAKVTGGQ TIQVETSSES PFPAKEYYKN
810 820 830 840 850
GTVMAPDLPE MLDLAGTRSR LASVSADAEV ARRKSVPSEA MLAESSTSLP
860 870 880 890 900
PVADESPVTV KPDSQLEDMG YCVFNKYTVP LPSPVQDSEN LSGESGSFYE
910 920 930 940 950
GTDDKVRRDL ATDLSLIEVK LAAAGRVKDE FTAEKEASPP TSADKSRLSR
960 970 980 990 1000
EFDHDRKAND KLDTVLEKSE EHIDSKEHAK ESEEMGGKVE LFGLGITYDQ
1010 1020 1030 1040 1050
ASTKELITTK DTSPEKTEKG LSSVPEVAEV EPTTKADQGL DFAATKAEPS
1060 1070 1080 1090 1100
QLDIKVSDFG QMASGMNVDA GKAIELKFEV AQELTLSSEA PQEADSFMGV
1110 1120 1130 1140 1150
ESGHIKEGGK VNETEVKEKV TKPDLVHQEA VDKEESYESS GEHESLTMES
1160 1170 1180 1190 1200
LKPDEGKKET SPETSLIQDE VALKLSVEIP CPPPVSEADL STDEKGEVQM
1210 1220 1230 1240 1250
EFIQLPKEES TETPDIPAIP SDVTQPQPEA IVSEPAEVPS EEEEIEAGGE
1260 1270 1280 1290 1300
YDKLLFRSDT LQISDLLVSE SREEFVETCP GELKGVVESV VTIEDDFITV
1310 1320 1330 1340 1350
VQTTTDEGES GSHSVRFAAP AQPEEERRPR PHDEELEIEM AAEAQAEPKD
1360 1370 1380 1390 1400
GSPDAPATPE KEEVAFSEYK TETYDDYKDE TTIDDSIMDA DSLWVDTQDD
1410 1420 1430 1440 1450
DRSILTEQLE TIPKEERAEK DARRPSLEKH RKEKPFKTGR GRISTPERKV
1460 1470 1480 1490 1500
AKKEPSTVSR DEVRRKKAVY KKAELAKKSE VQAHSPSRKL ILKPAIKYTR
1510 1520 1530 1540 1550
PTHLSCVKRK TTAASGDLAQ APGAFKQAKD KVTDGISKSP EKRSSLPRPS
1560 1570 1580 1590 1600
SILPPRRGVS GDREENSFSL NSSISSARRT TRSEPIRRAG KSGTSTPTTP
1610 1620 1630 1640 1650
GSTAITPGTP PSYSSRTPGT PGTPSYPRTP GTPKSGILVP SEKKVAIIRT
1660 1670 1680 1690 1700
PPKSPATPKQ LRLINQPLPD LKNVKSKIGS TDNIKYQPKG GQVQIVTKKI
1710 1720 1730 1740 1750
DLSHVTSKCG SLKNIRHRPG GGRVKIESVK LDFKEKAQAK VGSLDNAHHV
1760 1770 1780 1790 1800
PGGGNVKIDS QKLNFREHAK ARVDHGAEII TQSPSRSSVA SPRRLSNVSS
1810 1820
SGSINLLESP QLATLAEDVT AALAKQGL
Length:1,828
Mass (Da):199,132
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE8FA7621C45D5A0D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q80ZL4Q80ZL4_MOUSE
Microtubule-associated protein
Map2 Mtap2
467Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UWW1G3UWW1_MOUSE
Microtubule-associated protein
Map2 Mtap2
336Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UZV6G3UZV6_MOUSE
Microtubule-associated protein
Map2 Mtap2
381Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q3TLQ0Q3TLQ0_MOUSE
Microtubule-associated protein
Map2 Mtap2
498Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UZJ2G3UZJ2_MOUSE
Microtubule-associated protein
Map2 Mtap2
240Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q80X35Q80X35_MOUSE
Microtubule-associated protein
Map2 Mtap2
466Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7ALC8F7ALC8_MOUSE
Microtubule-associated protein 2
Map2 Mtap2
262Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UZE9G3UZE9_MOUSE
Microtubule-associated protein 2
Map2 Mtap2
565Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UZK9G3UZK9_MOUSE
Microtubule-associated protein 2
Map2 Mtap2
608Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q8Y2E9Q8Y2_MOUSE
Microtubule-associated protein 2
Map2 Mtap2
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti116H → Y no nucleotide entry (PubMed:3205744).Curated1
Sequence conflicti116H → Y in AAA39490 (PubMed:3142041).Curated1
Sequence conflicti455K → E no nucleotide entry (PubMed:3205744).Curated1
Sequence conflicti455K → E in AAA39490 (PubMed:3142041).Curated1
Sequence conflicti459F → L no nucleotide entry (PubMed:3205744).Curated1
Sequence conflicti459F → L in AAA39490 (PubMed:3142041).Curated1
Sequence conflicti644D → G no nucleotide entry (PubMed:3205744).Curated1
Sequence conflicti644D → G in AAA39490 (PubMed:3142041).Curated1
Sequence conflicti938S → T no nucleotide entry (PubMed:3205744).Curated1
Sequence conflicti938S → T in AAA39490 (PubMed:3142041).Curated1
Sequence conflicti947R → G no nucleotide entry (PubMed:3205744).Curated1
Sequence conflicti947R → G in AAA39490 (PubMed:3142041).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M21041 mRNA Translation: AAA39490.1
AC091465 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS83550.1

Protein sequence database of the Protein Information Resource

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PIRi
A40115

NCBI Reference Sequences

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RefSeqi
NP_001297563.1, NM_001310634.1
XP_006495817.1, XM_006495754.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000114013; ENSMUSP00000109646; ENSMUSG00000015222

Database of genes from NCBI RefSeq genomes

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GeneIDi
17756

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:17756

UCSC genome browser

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UCSCi
uc007bhz.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21041 mRNA Translation: AAA39490.1
AC091465 Genomic DNA No translation available.
CCDSiCCDS83550.1
PIRiA40115
RefSeqiNP_001297563.1, NM_001310634.1
XP_006495817.1, XM_006495754.2

3D structure databases

SMRiP20357
ModBaseiSearch...

Protein-protein interaction databases

BioGridi201585, 10 interactors
IntActiP20357, 20 interactors
MINTiP20357
STRINGi10090.ENSMUSP00000076577

PTM databases

iPTMnetiP20357
PhosphoSitePlusiP20357
SwissPalmiP20357

Proteomic databases

jPOSTiP20357
MaxQBiP20357
PaxDbiP20357
PeptideAtlasiP20357
PRIDEiP20357

Protocols and materials databases

ABCD curated depository of sequenced antibodies

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ABCDi
P20357

Genome annotation databases

EnsembliENSMUST00000114013; ENSMUSP00000109646; ENSMUSG00000015222
GeneIDi17756
KEGGimmu:17756
UCSCiuc007bhz.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
4133
MGIiMGI:97175 Map2

Phylogenomic databases

eggNOGiKOG2418 Eukaryota
ENOG4111J07 LUCA
GeneTreeiENSGT00940000156597
HOGENOMiHOG000113477
InParanoidiP20357
KOiK10430
OMAiFIEMPME
OrthoDBi716848at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Map2 mouse

Protein Ontology

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PROi
PR:P20357
RNActiP20357 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000015222 Expressed in 231 organ(s), highest expression level in olfactory bulb
ExpressionAtlasiP20357 baseline and differential
GenevisibleiP20357 MM

Family and domain databases

InterProiView protein in InterPro
IPR030797 MAP2
IPR027324 MAP2/MAP4/Tau
IPR013588 MAP2_projctn
IPR001084 MAP_tubulin-bd_rpt
PANTHERiPTHR11501 PTHR11501, 1 hit
PTHR11501:SF15 PTHR11501:SF15, 1 hit
PfamiView protein in Pfam
PF08377 MAP2_projctn, 1 hit
PF00418 Tubulin-binding, 3 hits
PROSITEiView protein in PROSITE
PS00229 TAU_MAP_1, 2 hits
PS51491 TAU_MAP_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMTAP2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P20357
Secondary accession number(s): E9QLE1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: July 27, 2011
Last modified: December 11, 2019
This is version 170 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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