Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tissue factor

Gene

F3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processBlood coagulation, Hemostasis

Names & Taxonomyi

Protein namesi
Recommended name:
Tissue factor
Short name:
TF
Alternative name(s):
Coagulation factor III
CD_antigen: CD142
Gene namesi
Name:F3
Synonyms:Cf-3, Cf3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:88381 F3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 251ExtracellularSequence analysisAdd BLAST223
Transmembranei252 – 274HelicalSequence analysisAdd BLAST23
Topological domaini275 – 294CytoplasmicSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5787

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Add BLAST28
ChainiPRO_000003363929 – 294Tissue factorAdd BLAST266

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi37N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi57N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi75 ↔ 83By similarity
Glycosylationi169N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi200N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi218 ↔ 241By similarity
Lipidationi275S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

MaxQBiP20352
PaxDbiP20352
PeptideAtlasiP20352
PRIDEiP20352

PTM databases

iPTMnetiP20352
PhosphoSitePlusiP20352
SwissPalmiP20352

Expressioni

Inductioni

Expression in the liver oscillates in a circadian manner.1 Publication

Gene expression databases

CleanExiMM_F3

Interactioni

Subunit structurei

Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII.By similarity

GO - Molecular functioni

Protein-protein interaction databases

ComplexPortaliCPX-279 Factor VII - TF complex
IntActiP20352, 1 interactor
MINTiP20352
STRINGi10090.ENSMUSP00000029771

Structurei

3D structure databases

ProteinModelPortaliP20352
SMRiP20352
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi245 – 247WKS motif3

Sequence similaritiesi

Belongs to the tissue factor family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IYA1 Eukaryota
ENOG4111MW4 LUCA
HOGENOMiHOG000043076
HOVERGENiHBG005051
InParanoidiP20352
KOiK03901
PhylomeDBiP20352
TreeFamiTF352627

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR015373 Interferon/interleukin_rcp_dom
IPR001187 Tissue_factor
IPR030472 Tissue_Factor_CS
PANTHERiPTHR20859:SF22 PTHR20859:SF22, 1 hit
PfamiView protein in Pfam
PF09294 Interfer-bind, 1 hit
PF01108 Tissue_fac, 1 hit
PIRSFiPIRSF002498 Tissue_factor_3, 1 hit
PRINTSiPR00346 TISSUEFACTOR
SUPFAMiSSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS00621 TISSUE_FACTOR, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

P20352-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAILVRPRLL AALAPTFLGC LLLQVIAGAG IPEKAFNLTW ISTDFKTILE
60 70 80 90 100
WQPKPTNYTY TVQISDRSRN WKNKCFSTTD TECDLTDEIV KDVTWAYEAK
110 120 130 140 150
VLSVPRRNSV HGDGDQLVIH GEEPPFTNAP KFLPYRDTNL GQPVIQQFEQ
160 170 180 190 200
DGRKLNVVVK DSLTLVRKNG TFLTLRQVFG KDLGYIITYR KGSSTGKKTN
210 220 230 240 250
ITNTNEFSID VEEGVSYCFF VQAMIFSRKT NQNSPGSSTV CTEQWKSFLG
260 270 280 290
ETLIIVGAVV LLATIFIILL SISLCKRRKN RAGQKGKNTP SRLA
Length:294
Mass (Da):32,935
Last modified:August 1, 1991 - v2
Checksum:iA306101293C31FA0
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J088A0A0R4J088_MOUSE
Tissue factor
F3 mCG_4679
294Annotation score:
A0A0G2JGS5A0A0G2JGS5_MOUSE
Tissue factor
F3
157Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26I → T in AAA40414 (PubMed:2761539).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57896 mRNA Translation: AAA63400.1
M26071 mRNA Translation: AAA40414.1
BC016397 mRNA Translation: AAH16397.1
CCDSiCCDS17805.1
PIRiA32318 KFMS3
RefSeqiNP_034301.3, NM_010171.3
UniGeneiMm.273188

Genome annotation databases

GeneIDi14066
KEGGimmu:14066
UCSCiuc008ree.2 mouse

Similar proteinsi

Entry informationi

Entry nameiTF_MOUSE
AccessioniPrimary (citable) accession number: P20352
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: August 1, 1991
Last modified: September 12, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again