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UniProtKB - P20340 (RAB6A_HUMAN)

Entry version 230 (02 Dec 2020)
Sequence version 3 (23 Jan 2007)
Previous versions | rss
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Protein

Ras-related protein Rab-6A

Gene

RAB6A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity. Involved in COPI-independent retrograde transport from the Golgi to the ER (PubMed:25962623).1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi20 – 28GTP3 Publications9
Nucleotide bindingi68 – 72GTP3 Publications5
Nucleotide bindingi126 – 129GTP3 Publications4
Nucleotide bindingi156 – 158GTP3 Publications3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processER-Golgi transport, Host-virus interaction, Protein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P20340

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1912420, Pre-NOTCH Processing in Golgi
R-HSA-6798695, Neutrophil degranulation
R-HSA-6811436, COPI-independent Golgi-to-ER retrograde traffic
R-HSA-6811440, Retrograde transport at the Trans-Golgi-Network
R-HSA-8854214, TBC/RABGAPs
R-HSA-8873719, RAB geranylgeranylation
R-HSA-8876198, RAB GEFs exchange GTP for GDP on RABs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ras-related protein Rab-6A
Short name:
Rab-6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RAB6A
Synonyms:RAB6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000175582.19

Human Gene Nomenclature Database

More...HGNCi		HGNC:9786, RAB6A

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		179513, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P20340

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi27T → N: Loss of APBA1-binding. No loss of RIC1- and RGP1-binding. 2 Publications1
Mutagenesisi46I → E: Loss of RAB6IP1-binding. 1 Publication1
Mutagenesisi72Q → L: Loss of GTPase activity. Interacts with APBA1. 4 Publications1

Organism-specific databases

DisGeNET

More...DisGeNETi		5870

Open Targets

More...OpenTargetsi		ENSG00000175582

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA34146

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P20340, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4105703

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RAB6A

Domain mapping of disease mutations (DMDM)

More...DMDMi		131796

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001211122 – 208Ras-related protein Rab-6AAdd BLAST207

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1 Publication1
Modified residuei82O-AMP-tyrosine; by Legionella DrrA1 Publication1
Modified residuei184PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi206S-geranylgeranyl cysteineBy similarity1
Modified residuei208Cysteine methyl esterBy similarity1
Lipidationi208S-geranylgeranyl cysteineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Prenylated.1 Publication

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P20340

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P20340

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P20340

MaxQB - The MaxQuant DataBase

More...MaxQBi		P20340

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P20340

PeptideAtlas

More...PeptideAtlasi		P20340

PRoteomics IDEntifications database

More...PRIDEi		P20340

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		27097
53752 [P20340-1]
53753 [P20340-2]
61249

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P20340-2 [P20340-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P20340

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P20340

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P20340

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P20340

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000175582, Expressed in frontal cortex and 219 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P20340, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P20340, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000175582, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with BICDL1; leads to its accumulation in the pericentrosomal region (By similarity).

Interacts with SCYL1BP1.

Interacts with VSP52 and RABGAP1.

Interacts with GCC2 (via its GRIP domain).

Interacts with RAB6IP1 (via its RUN 1 domain).

Isoform 1 interacts with RAB6KIFL. Isoform 2 does not interact with RAB6KIFL.

Isoform 1 interacts with BICD1.

Isoform 2 interacts with BICD1.

Isoform 1 interacts with BICD2.

Isoform 2 interacts with BICD2.

Interacts with TMF1. Isoform 1 (GTP-bound) interacts with DYNLRB1; the interaction is direct. Isoform 2 (GDP-bound) interacts with DYNLRB1; the interaction is direct.

Interacts with PIFO.

Interacts (GTP-bound) with APBA1/MINT1 isoform 2, also called Mint1_826, but not with isoform 1.

Interacts with RIC1 and RGP1; the interactions are direct with a preference for RAB6A-GDP.

By similarity16 Publications

(Microbial infection) Interacts with human cytomegalovirus protein UL32.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111808, 64 interactors

Database of interacting proteins

More...DIPi		DIP-39668N

Protein interaction database and analysis system

More...IntActi		P20340, 30 interactors

Molecular INTeraction database

More...MINTi		P20340

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000311449

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P20340, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1208
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P20340

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P20340

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi42 – 50Effector regionBy similarity9

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0094, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154769

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_041217_10_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P20340

Identification of Orthologs from Complete Genome Data

More...OMAi		SKAMYLE

Database for complete collections of gene phylogenies

More...PhylomeDBi		P20340

TreeFam database of animal gene trees

More...TreeFami		TF300803

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR027417, P-loop_NTPase
IPR005225, Small_GTP-bd_dom
IPR001806, Small_GTPase

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00071, Ras, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00231, small_GTP, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51419, RAB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P20340-1) [UniParc]FASTAAdd to basket
Also known as: Rab-6a

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSTGGDFGNP LRKFKLVFLG EQSVGKTSLI TRFMYDSFDN TYQATIGIDF 
        60         70         80         90        100
LSKTMYLEDR TVRLQLWDTA GQERFRSLIP SYIRDSTVAV VVYDITNVNS 
       110        120        130        140        150
FQQTTKWIDD VRTERGSDVI IMLVGNKTDL ADKRQVSIEE GERKAKELNV 
       160        170        180        190        200
MFIETSAKAG YNVKQLFRRV AAALPGMEST QDRSREDMID IKLEKPQEQP 

VSEGGCSC
Length:208
Mass (Da):23,593
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC9A3C2DDBF6C3E9E
GO
Isoform 2 (identifier: P20340-2) [UniParc]FASTAAdd to basket
Also known as: Rab-6a', Rab-6C, Rab6C

The sequence of this isoform differs from the canonical sequence as follows:
     62-88: VRLQLWDTAGQERFRSLIPSYIRDSTV → IRLQLWDTAGQERFRSLIPSYIRDSAA

Show »
Length:208
Mass (Da):23,549
Checksum:iDF4B42559600F98B
GO
Isoform 3 (identifier: P20340-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     62-165: Missing.

Show »
Length:104
Mass (Da):11,715
Checksum:i47907D182528BE16
GO
Isoform 4 (identifier: P20340-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: Missing.
     62-88: VRLQLWDTAGQERFRSLIPSYIRDSTV → IRLQLWDTAGQERFRSLIPSYIRDSAA

Show »
Length:175
Mass (Da):19,935
Checksum:i1667A3BFAE94F873
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H3K7F5H3K7_HUMAN
Ras-related protein Rab-6A
RAB6A
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GX61F5GX61_HUMAN
Ras-related protein Rab-6A
RAB6A
87Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti189I → T in BAH13508 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0469671 – 33Missing in isoform 4. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_04530262 – 165Missing in isoform 3. 1 PublicationAdd BLAST104
Alternative sequenceiVSP_00552762 – 88VRLQL…RDSTV → IRLQLWDTAGQERFRSLIPS YIRDSAA in isoform 2 and isoform 4. 6 PublicationsAdd BLAST27

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M28212 mRNA Translation: AAA60246.1
AF130986 mRNA Translation: AAD25535.1
AF119836 mRNA Translation: AAF23593.1
AF198616 mRNA Translation: AAF73841.1
AF130122 mRNA Translation: AAD27707.1
DQ437503 mRNA Translation: ABD93919.1
AK057157 mRNA Translation: BAB71371.1
AK289748 mRNA Translation: BAF82437.1
AK290132 mRNA Translation: BAF82821.1
AK301534 mRNA Translation: BAH13508.1
AF498939 mRNA Translation: AAM21087.1
AF498941 mRNA Translation: AAM21089.1
BT019698 mRNA Translation: AAV38504.1
AP002770 Genomic DNA No translation available.
AP002993 Genomic DNA No translation available.
BC003617 mRNA Translation: AAH03617.1
BC068486 mRNA Translation: AAH68486.1
BC096818 mRNA Translation: AAH96818.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS58155.1 [P20340-4]
CCDS58156.1 [P20340-3]
CCDS8223.1 [P20340-2]
CCDS8224.1 [P20340-1]

Protein sequence database of the Protein Information Resource

More...PIRi		G34323

NCBI Reference Sequences

More...RefSeqi		NP_001230647.1, NM_001243718.1 [P20340-3]
NP_001230648.1, NM_001243719.1 [P20340-4]
NP_002860.2, NM_002869.4 [P20340-2]
NP_942599.1, NM_198896.1 [P20340-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000310653; ENSP00000311449; ENSG00000175582 [P20340-2]
ENST00000336083; ENSP00000336850; ENSG00000175582 [P20340-1]
ENST00000541588; ENSP00000445350; ENSG00000175582 [P20340-3]
ENST00000541973; ENSP00000443782; ENSG00000175582 [P20340-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5870

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5870

UCSC genome browser

More...UCSCi		uc001oue.4, human [P20340-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28212 mRNA Translation: AAA60246.1
AF130986 mRNA Translation: AAD25535.1
AF119836 mRNA Translation: AAF23593.1
AF198616 mRNA Translation: AAF73841.1
AF130122 mRNA Translation: AAD27707.1
DQ437503 mRNA Translation: ABD93919.1
AK057157 mRNA Translation: BAB71371.1
AK289748 mRNA Translation: BAF82437.1
AK290132 mRNA Translation: BAF82821.1
AK301534 mRNA Translation: BAH13508.1
AF498939 mRNA Translation: AAM21087.1
AF498941 mRNA Translation: AAM21089.1
BT019698 mRNA Translation: AAV38504.1
AP002770 Genomic DNA No translation available.
AP002993 Genomic DNA No translation available.
BC003617 mRNA Translation: AAH03617.1
BC068486 mRNA Translation: AAH68486.1
BC096818 mRNA Translation: AAH96818.1
CCDSiCCDS58155.1 [P20340-4]
CCDS58156.1 [P20340-3]
CCDS8223.1 [P20340-2]
CCDS8224.1 [P20340-1]
PIRiG34323
RefSeqiNP_001230647.1, NM_001243718.1 [P20340-3]
NP_001230648.1, NM_001243719.1 [P20340-4]
NP_002860.2, NM_002869.4 [P20340-2]
NP_942599.1, NM_198896.1 [P20340-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YZQX-ray1.78A10-177[»]
2GILX-ray1.82A/B/C/D13-174[»]
3BBPX-ray3.00A/B/C1-206[»]
3CWZX-ray3.20A8-195[»]
4DKXX-ray1.90A/B1-208[»]
5LEFX-ray2.09A/B8-195[»]
SMRiP20340
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi111808, 64 interactors
DIPiDIP-39668N
IntActiP20340, 30 interactors
MINTiP20340
STRINGi9606.ENSP00000311449

Chemistry databases

ChEMBLiCHEMBL4105703

PTM databases

iPTMnetiP20340
MetOSiteiP20340
PhosphoSitePlusiP20340
SwissPalmiP20340

Polymorphism and mutation databases

BioMutaiRAB6A
DMDMi131796

Proteomic databases

EPDiP20340
jPOSTiP20340
MassIVEiP20340
MaxQBiP20340
PaxDbiP20340
PeptideAtlasiP20340
PRIDEiP20340
ProteomicsDBi27097
53752 [P20340-1]
53753 [P20340-2]
61249
TopDownProteomicsiP20340-2 [P20340-2]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P20340, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

More...Antibodypediai		4093, 281 antibodies

The DNASU plasmid repository

More...DNASUi		5870

Genome annotation databases

EnsembliENST00000310653; ENSP00000311449; ENSG00000175582 [P20340-2]
ENST00000336083; ENSP00000336850; ENSG00000175582 [P20340-1]
ENST00000541588; ENSP00000445350; ENSG00000175582 [P20340-3]
ENST00000541973; ENSP00000443782; ENSG00000175582 [P20340-4]
GeneIDi5870
KEGGihsa:5870
UCSCiuc001oue.4, human [P20340-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5870
DisGeNETi5870
EuPathDBiHostDB:ENSG00000175582.19

GeneCards: human genes, protein and diseases

More...GeneCardsi		RAB6A
HGNCiHGNC:9786, RAB6A
HPAiENSG00000175582, Low tissue specificity
MIMi179513, gene
neXtProtiNX_P20340
OpenTargetsiENSG00000175582
PharmGKBiPA34146

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0094, Eukaryota
GeneTreeiENSGT00940000154769
HOGENOMiCLU_041217_10_2_1
InParanoidiP20340
OMAiSKAMYLE
PhylomeDBiP20340
TreeFamiTF300803

Enzyme and pathway databases

PathwayCommonsiP20340
ReactomeiR-HSA-1912420, Pre-NOTCH Processing in Golgi
R-HSA-6798695, Neutrophil degranulation
R-HSA-6811436, COPI-independent Golgi-to-ER retrograde traffic
R-HSA-6811440, Retrograde transport at the Trans-Golgi-Network
R-HSA-8854214, TBC/RABGAPs
R-HSA-8873719, RAB geranylgeranylation
R-HSA-8876198, RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		5870, 300 hits in 826 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		RAB6A, human
EvolutionaryTraceiP20340

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		RAB6A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5870
PharosiP20340, Tbio

Protein Ontology

More...PROi		PR:P20340
RNActiP20340, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000175582, Expressed in frontal cortex and 219 other tissues
ExpressionAtlasiP20340, baseline and differential
GenevisibleiP20340, HS

Family and domain databases

InterProiView protein in InterPro
IPR027417, P-loop_NTPase
IPR005225, Small_GTP-bd_dom
IPR001806, Small_GTPase
PfamiView protein in Pfam
PF00071, Ras, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
TIGRFAMsiTIGR00231, small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419, RAB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRAB6A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P20340
Secondary accession number(s): A8K133
, B7Z772, F5H668, Q1W5D8, Q5U0A8, Q9UBE4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: January 23, 2007
Last modified: December 2, 2020
This is version 230 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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