RAB6A

Functionⁱ

Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity. Involved in COPI-independent retrograde transport from the Golgi to the ER (PubMed:25962623).1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	20 – 28	GTP3 Publications	9
Nucleotide bindingⁱ	68 – 72	GTP3 Publications	5
Nucleotide bindingⁱ	126 – 129	GTP3 Publications	4
Nucleotide bindingⁱ	156 – 158	GTP3 Publications	3

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

antigen processing and presentation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19717423
early endosome to Golgi transport
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17562788
intracellular protein transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
intra-Golgi vesicle-mediated transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
minus-end-directed organelle transport along microtubule
Source: BHF-UCL
Traceable author statementⁱ
- 12447383
neutrophil degranulation Source: Reactome
peptidyl-cysteine methylation
Source: MGI
Inferred from direct assayⁱ
- 11121396
protein localization to Golgi apparatus
Source: UniProtKB
Inferred from direct assayⁱ
- 18243103
Rab protein signal transduction
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
retrograde transport, endosome to Golgi
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
retrograde vesicle-mediated transport, Golgi to ER
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 25962623
viral process Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	ER-Golgi transport, Host-virus interaction, Protein transport, Transport
Ligand	GTP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1912420 Pre-NOTCH Processing in Golgi R-HSA-6798695 Neutrophil degranulation R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network R-HSA-8854214 TBC/RABGAPs R-HSA-8873719 RAB geranylgeranylation R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Reactomeⁱ

R-HSA-1912420 Pre-NOTCH Processing in Golgi
R-HSA-6798695 Neutrophil degranulation
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network
R-HSA-8854214 TBC/RABGAPs
R-HSA-8873719 RAB geranylgeranylation
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ras-related protein Rab-6A Short name: Rab-6
Gene namesⁱ	Name:RAB6A Synonyms:RAB6
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000175582.19
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9786 RAB6A
MIMⁱ	179513 gene
neXtProtⁱ	NX_P20340

Keywords - Cellular componentⁱ

Golgi apparatus, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	27	T → N: Loss of APBA1-binding. No loss of RIC1- and RGP1-binding. 2 Publications	1
Mutagenesisⁱ	46	I → E: Loss of RAB6IP1-binding. 1 Publication	1
Mutagenesisⁱ	72	Q → L: Loss of GTPase activity. Interacts with APBA1. 4 Publications	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5870
Open Targets More...OpenTargetsⁱ	ENSG00000175582
PharmGKBⁱ	PA34146

Polymorphism and mutation databases

BioMutaⁱ	RAB6A
DMDMⁱ	131796

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources1 Publication
ChainⁱPRO_0000121112	2 – 208	Ras-related protein Rab-6AAdd BLAST		207

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylserineCombined sources1 Publication	1
Modified residueⁱ	82	O-AMP-tyrosine; by Legionella DrrA1 Publication	1
Modified residueⁱ	184	PhosphoserineBy similarity	1
Lipidationⁱ	206	S-geranylgeranyl cysteineBy similarity	1
Modified residueⁱ	208	Cysteine methyl esterBy similarity	1
Lipidationⁱ	208	S-geranylgeranyl cysteineBy similarity	1

Post-translational modificationⁱ

Prenylated.1 Publication

Keywords - PTMⁱ

Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

EPDⁱ	P20340
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P20340
PaxDbⁱ	P20340
PeptideAtlas More...PeptideAtlasⁱ	P20340
PRIDEⁱ	P20340
ProteomicsDBⁱ	53752 53753 [P20340-2]
TopDownProteomicsⁱ	P20340-2 [P20340-2]

PTM databases

iPTMnetⁱ	P20340
PhosphoSitePlusⁱ	P20340
SwissPalmⁱ	P20340

Expressionⁱ

Tissue specificityⁱ

Ubiquitous.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000175582 Expressed in 202 organ(s), highest expression level in frontal cortex
CleanExⁱ	HS_RAB6A
ExpressionAtlasⁱ	P20340 baseline and differential
Genevisibleⁱ	P20340 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB009936 HPA059131

HPAⁱ

CAB009936
HPA059131

Interactionⁱ

Subunit structureⁱ

Interacts with BICDL1; leads to its accumulation in the pericentrosomal region (By similarity). Interacts with SCYL1BP1. Interacts with VSP52 and RABGAP1. Interacts with GCC2 (via its GRIP domain). Interacts with RAB6IP1 (via its RUN 1 domain). Isoform 1 interacts with RAB6KIFL. Isoform 2 does not interact with RAB6KIFL. Isoform 1 interacts with BICD1. Isoform 2 interacts with BICD1. Isoform 1 interacts with BICD2. Isoform 2 interacts with BICD2. Interacts with TMF1. Isoform 1 (GTP-bound) interacts with DYNLRB1; the interaction is direct. Isoform 2 (GDP-bound) interacts with DYNLRB1; the interaction is direct. Interacts with PIFO. Interacts (GTP-bound) with APBA1/MINT1 isoform 2, also called Mint1_826, but not with isoform 1. Interacts with RIC1 and RGP1; the interactions are direct with a preference for RAB6A-GDP.By similarity16 Publications

(Microbial infection) Interacts with human cytomegalovirus protein UL32.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
APBA1	Q02410-2	4	EBI-8851226,EBI-9247455
Dennd5a	Q6PAL8	4	EBI-8851226,EBI-15750630	From Mus musculus.
GCC2	Q8IWJ2	4	EBI-1052826,EBI-1645320
lpg0940	Q5ZWZ3	2	EBI-8851226,EBI-6417967	From Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513).
OCRL	Q01968	12	EBI-1052826,EBI-6148898
PMM1	Q92871	4	EBI-1052826,EBI-746784

GO - Molecular functionⁱ

myosin V binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 24006491
protein domain specific binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 12447383

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	111808, 43 interactors
Database of interacting proteins More...DIPⁱ	DIP-39668N
IntActⁱ	P20340, 25 interactors
Molecular INTeraction database More...MINTⁱ	P20340
STRINGⁱ	9606.ENSP00000311449

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	15 – 21	Combined sources	7
Helixⁱ	26 – 35	Combined sources	10
Beta strandⁱ	47 – 56	Combined sources	10
Beta strandⁱ	61 – 69	Combined sources	9
Helixⁱ	73 – 78	Combined sources	6
Helixⁱ	79 – 83	Combined sources	5
Beta strandⁱ	87 – 94	Combined sources	8
Helixⁱ	98 – 102	Combined sources	5
Helixⁱ	104 – 115	Combined sources	12
Beta strandⁱ	118 – 126	Combined sources	9
Helixⁱ	128 – 130	Combined sources	3
Helixⁱ	131 – 133	Combined sources	3
Helixⁱ	138 – 147	Combined sources	10
Beta strandⁱ	151 – 154	Combined sources	4
Turnⁱ	157 – 159	Combined sources	3
Helixⁱ	163 – 173	Combined sources	11

Show more details

3D structure databases

ProteinModelPortalⁱ	P20340
SMRⁱ	P20340
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P20340

EvolutionaryTraceⁱ

P20340

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	42 – 50	Effector regionBy similarity		9

Sequence similaritiesⁱ

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0094 Eukaryota ENOG410XPBI LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144073
HOGENOMⁱ	HOG000233968
HOVERGENⁱ	HBG009351
InParanoidⁱ	P20340
KEGG Orthology (KO) More...KOⁱ	K07893
OMAⁱ	VPEASQC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0ORZ
PhylomeDBⁱ	P20340
TreeFamⁱ	TF300803

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00071 Ras, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51419 RAB, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P20340-1) [UniParc]FASTA Add to basket

Also known as: Rab-6a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSTGGDFGNP LRKFKLVFLG EQSVGKTSLI TRFMYDSFDN TYQATIGIDF 
        60         70         80         90        100
LSKTMYLEDR TVRLQLWDTA GQERFRSLIP SYIRDSTVAV VVYDITNVNS 
       110        120        130        140        150
FQQTTKWIDD VRTERGSDVI IMLVGNKTDL ADKRQVSIEE GERKAKELNV 
       160        170        180        190        200
MFIETSAKAG YNVKQLFRRV AAALPGMEST QDRSREDMID IKLEKPQEQP 

VSEGGCSC

Length:208

Mass (Da):23,593

Last modified:January 23, 2007 - v3

Checksum:ⁱC9A3C2DDBF6C3E9E

GO

Isoform 2 (identifier: P20340-2) [UniParc]FASTA Add to basket

Also known as: Rab-6a', Rab-6C, Rab6C

The sequence of this isoform differs from the canonical sequence as follows:
62-88: VRLQLWDTAGQERFRSLIPSYIRDSTV → IRLQLWDTAGQERFRSLIPSYIRDSAA

« Hide

        10         20         30         40         50
MSTGGDFGNP LRKFKLVFLG EQSVGKTSLI TRFMYDSFDN TYQATIGIDF 
        60         70         80         90        100
LSKTMYLEDR TIRLQLWDTA GQERFRSLIP SYIRDSAAAV VVYDITNVNS 
       110        120        130        140        150
FQQTTKWIDD VRTERGSDVI IMLVGNKTDL ADKRQVSIEE GERKAKELNV 
       160        170        180        190        200
MFIETSAKAG YNVKQLFRRV AAALPGMEST QDRSREDMID IKLEKPQEQP 

VSEGGCSC

Show »

Length:208

Mass (Da):23,549

Checksum:ⁱDF4B42559600F98B

GO

Isoform 3 (identifier: P20340-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
62-165: Missing.

« Hide

        10         20         30         40         50
MSTGGDFGNP LRKFKLVFLG EQSVGKTSLI TRFMYDSFDN TYQATIGIDF 
        60         70         80         90        100
LSKTMYLEDR TLFRRVAAAL PGMESTQDRS REDMIDIKLE KPQEQPVSEG 

GCSC

Show »

Length:104

Mass (Da):11,715

Checksum:ⁱ47907D182528BE16

GO

Isoform 4 (identifier: P20340-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-33: Missing.
62-88: VRLQLWDTAGQERFRSLIPSYIRDSTV → IRLQLWDTAGQERFRSLIPSYIRDSAA

« Hide

        10         20         30         40         50
MYDSFDNTYQ ATIGIDFLSK TMYLEDRTIR LQLWDTAGQE RFRSLIPSYI 
        60         70         80         90        100
RDSAAAVVVY DITNVNSFQQ TTKWIDDVRT ERGSDVIIML VGNKTDLADK 
       110        120        130        140        150
RQVSIEEGER KAKELNVMFI ETSAKAGYNV KQLFRRVAAA LPGMESTQDR 
       160        170 
SREDMIDIKL EKPQEQPVSE GGCSC

Show »

Length:175

Mass (Da):19,935

Checksum:ⁱ1667A3BFAE94F873

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F5GX61	F5GX61_HUMAN	Ras-related protein Rab-6A Ras-related protein Rab-6A	RAB6A	87	Annotation score:
F5H3K7	F5H3K7_HUMAN	Ras-related protein Rab-6A Ras-related protein Rab-6A	RAB6A	71	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	189	I → T in BAH13508 (PubMed:14702039).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_046967	1 – 33	Missing in isoform 4. 1 PublicationAdd BLAST	33
Alternative sequenceⁱVSP_045302	62 – 165	Missing in isoform 3. 1 PublicationAdd BLAST	104
Alternative sequenceⁱVSP_005527	62 – 88	VRLQL…RDSTV → IRLQLWDTAGQERFRSLIPS YIRDSAA in isoform 2 and isoform 4. 6 PublicationsAdd BLAST	27

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M28212 mRNA Translation: AAA60246.1 AF130986 mRNA Translation: AAD25535.1 AF119836 mRNA Translation: AAF23593.1 AF198616 mRNA Translation: AAF73841.1 AF130122 mRNA Translation: AAD27707.1 DQ437503 mRNA Translation: ABD93919.1 AK057157 mRNA Translation: BAB71371.1 AK289748 mRNA Translation: BAF82437.1 AK290132 mRNA Translation: BAF82821.1 AK301534 mRNA Translation: BAH13508.1 AF498939 mRNA Translation: AAM21087.1 AF498941 mRNA Translation: AAM21089.1 BT019698 mRNA Translation: AAV38504.1 AP002770 Genomic DNA No translation available. AP002993 Genomic DNA No translation available. BC003617 mRNA Translation: AAH03617.1 BC068486 mRNA Translation: AAH68486.1 BC096818 mRNA Translation: AAH96818.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS58155.1 [P20340-4] CCDS58156.1 [P20340-3] CCDS8223.1 [P20340-2] CCDS8224.1 [P20340-1]
PIRⁱ	G34323
NCBI Reference Sequences More...RefSeqⁱ	NP_001230647.1, NM_001243718.1 [P20340-3] NP_001230648.1, NM_001243719.1 [P20340-4] NP_002860.2, NM_002869.4 [P20340-2] NP_942599.1, NM_198896.1 [P20340-1]
UniGeneⁱ	Hs.503222 Hs.591552

Genome annotation databases

Ensemblⁱ	ENST00000310653; ENSP00000311449; ENSG00000175582 [P20340-2] ENST00000336083; ENSP00000336850; ENSG00000175582 [P20340-1] ENST00000541588; ENSP00000445350; ENSG00000175582 [P20340-3] ENST00000541973; ENSP00000443782; ENSG00000175582 [P20340-4]
GeneIDⁱ	5870
KEGGⁱ	hsa:5870
UCSC genome browser More...UCSCⁱ	uc001oue.4 human [P20340-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P20340	Ras-related protein Rab-6A		PONAB		208	UniRef100_P20340
H.sapiens ras-related Hrab6 protein		HUMAN		208
RAB6A isoform 3		PANTR		208
Uncharacterized protein		PANPA		208
Uncharacterized protein		GORGO		208
+5
P20340-2	RAB6A, member RAS oncogene family, isoform CRA_b		HUMAN		208	UniRef100_A0A024R5H8
RAB6A isoform 1		PANTR		208
Uncharacterized protein		PONAB		208
Uncharacterized protein		PANPA		208
Uncharacterized protein		GORGO		208
P20340-3	RAB6A isoform 5		PANTR		104	UniRef100_A0A2I3SEK0
Uncharacterized protein		PANPA		104
Uncharacterized protein		GORGO		104
P20340-4	Ras-related protein Rab-6A isoform a		CALJA		208	UniRef100_U3FBI9
Uncharacterized protein		PROCO		208
Ras-related protein Rab-6A isoform a		MACMU		208
Uncharacterized protein		COLAP		208
ras-related protein Rab-6A isoform X2		ODORO		208
+29

Protein	Similar proteins		Species	Score	Length	Source
P20340	Ras-related protein Rab-6A		PONAB		208	UniRef90_P20340
Ras-related protein Rab-6A		MOUSE		208
Ras-related protein Rab-6A		RAT		208
H.sapiens ras-related Hrab6 protein		HUMAN		208
RAB6A isoform 3		PANTR		208
+69
P20340-2	Ras-related protein Rab-6A		CHICK		208	UniRef90_Q1KME6
Ras-related protein Rab-6A isoform A		ALLMI		208
Uncharacterized protein		LATCH		210
Uncharacterized protein		CALSU		209
Uncharacterized protein		FICAL		208
+161
P20340-3	RAB6A isoform 5		PANTR		104	UniRef90_A0A2I3SEK0
Uncharacterized protein		PANPA		104
Uncharacterized protein		GORGO		104
Uncharacterized protein		SAIBB		104
Uncharacterized protein		CALJA		104
+25
P20340-4	Uncharacterized protein		AILME		255	UniRef90_G1MFX4
LOW QUALITY PROTEIN: ras-related protein Rab-6C-like		BALAS		258
Ras-related protein Rab-6A isoform a		CALJA		208
Uncharacterized protein		PROCO		208
Ras-related protein Rab-6A isoform a		MACMU		208
+47

Protein	Similar proteins		Species	Score	Length	Source
P20340	Ras-related protein Rab-6A		PONAB		208	UniRef50_P20340
Ras-related protein Rab-6A		MOUSE		208
Ras-related protein Rab-6A		RAT		208
GTP-binding protein YPT6		YEAST		215
Ras-related protein Rab-6A		CHICK		208
+576
P20340-3	Ras-related protein Rab-6A		HUMAN		87	UniRef50_F5GX61
RAB6A isoform 4		PANTR		87
Uncharacterized protein		PANPA		87
Uncharacterized protein		GORGO		87
Uncharacterized protein		MACMU		87
+55
P20340-4	Uncharacterized protein		AILME		255	UniRef50_G1MFX4
LOW QUALITY PROTEIN: ras-related protein Rab-6C-like		BALAS		258
Ras-related protein Rab-6A isoform a		CALJA		208
Uncharacterized protein		PROCO		208
Ras-related protein Rab-6A isoform a		MACMU		208
+51

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M28212 mRNA Translation: AAA60246.1 AF130986 mRNA Translation: AAD25535.1 AF119836 mRNA Translation: AAF23593.1 AF198616 mRNA Translation: AAF73841.1 AF130122 mRNA Translation: AAD27707.1 DQ437503 mRNA Translation: ABD93919.1 AK057157 mRNA Translation: BAB71371.1 AK289748 mRNA Translation: BAF82437.1 AK290132 mRNA Translation: BAF82821.1 AK301534 mRNA Translation: BAH13508.1 AF498939 mRNA Translation: AAM21087.1 AF498941 mRNA Translation: AAM21089.1 BT019698 mRNA Translation: AAV38504.1 AP002770 Genomic DNA No translation available. AP002993 Genomic DNA No translation available. BC003617 mRNA Translation: AAH03617.1 BC068486 mRNA Translation: AAH68486.1 BC096818 mRNA Translation: AAH96818.1
CCDSⁱ	CCDS58155.1 [P20340-4] CCDS58156.1 [P20340-3] CCDS8223.1 [P20340-2] CCDS8224.1 [P20340-1]
PIRⁱ	G34323
RefSeqⁱ	NP_001230647.1, NM_001243718.1 [P20340-3] NP_001230648.1, NM_001243719.1 [P20340-4] NP_002860.2, NM_002869.4 [P20340-2] NP_942599.1, NM_198896.1 [P20340-1]
UniGeneⁱ	Hs.503222 Hs.591552

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1YZQ	X-ray	1.78	A	10-177	[»]
	2GIL	X-ray	1.82	A/B/C/D	13-174	[»]
	3BBP	X-ray	3.00	A/B/C	1-206	[»]
	3CWZ	X-ray	3.20	A	8-195	[»]
	4DKX	X-ray	1.90	A/B	1-208	[»]
	5LEF	X-ray	2.09	A/B	8-195	[»]
ProteinModelPortalⁱ	P20340
SMRⁱ	P20340
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111808, 43 interactors
DIPⁱ	DIP-39668N
IntActⁱ	P20340, 25 interactors
MINTⁱ	P20340
STRINGⁱ	9606.ENSP00000311449

PTM databases

iPTMnetⁱ	P20340
PhosphoSitePlusⁱ	P20340
SwissPalmⁱ	P20340

Polymorphism and mutation databases

BioMutaⁱ	RAB6A
DMDMⁱ	131796

Proteomic databases

EPDⁱ	P20340
MaxQBⁱ	P20340
PaxDbⁱ	P20340
PeptideAtlasⁱ	P20340
PRIDEⁱ	P20340
ProteomicsDBⁱ	53752 53753 [P20340-2]
TopDownProteomicsⁱ	P20340-2 [P20340-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5870
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000310653; ENSP00000311449; ENSG00000175582 [P20340-2] ENST00000336083; ENSP00000336850; ENSG00000175582 [P20340-1] ENST00000541588; ENSP00000445350; ENSG00000175582 [P20340-3] ENST00000541973; ENSP00000443782; ENSG00000175582 [P20340-4]
GeneIDⁱ	5870
KEGGⁱ	hsa:5870
UCSCⁱ	uc001oue.4 human [P20340-1]

Organism-specific databases

CTDⁱ	5870
DisGeNETⁱ	5870
EuPathDBⁱ	HostDB:ENSG00000175582.19
GeneCardsⁱ	RAB6A
HGNCⁱ	HGNC:9786 RAB6A
HPAⁱ	CAB009936 HPA059131
MIMⁱ	179513 gene
neXtProtⁱ	NX_P20340
OpenTargetsⁱ	ENSG00000175582
PharmGKBⁱ	PA34146
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0094 Eukaryota ENOG410XPBI LUCA
GeneTreeⁱ	ENSGT00910000144073
HOGENOMⁱ	HOG000233968
HOVERGENⁱ	HBG009351
InParanoidⁱ	P20340
KOⁱ	K07893
OMAⁱ	VPEASQC
OrthoDBⁱ	EOG091G0ORZ
PhylomeDBⁱ	P20340
TreeFamⁱ	TF300803

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1912420 Pre-NOTCH Processing in Golgi R-HSA-6798695 Neutrophil degranulation R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network R-HSA-8854214 TBC/RABGAPs R-HSA-8873719 RAB geranylgeranylation R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Reactomeⁱ

R-HSA-1912420 Pre-NOTCH Processing in Golgi
R-HSA-6798695 Neutrophil degranulation
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network
R-HSA-8854214 TBC/RABGAPs
R-HSA-8873719 RAB geranylgeranylation
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

ChiTaRSⁱ	RAB6A human
EvolutionaryTraceⁱ	P20340
GeneWikiⁱ	RAB6A
GenomeRNAiⁱ	5870
Protein Ontology More...PROⁱ	PR:P20340
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000175582 Expressed in 202 organ(s), highest expression level in frontal cortex
CleanExⁱ	HS_RAB6A
ExpressionAtlasⁱ	P20340 baseline and differential
Genevisibleⁱ	P20340 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase
Pfamⁱ	View protein in Pfam PF00071 Ras, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51419 RAB, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RAB6A_HUMAN
Accessionⁱ	P20340Primary (citable) accession number: P20340 Secondary accession number(s): A8K133 , B7Z772, F5H668, Q1W5D8, Q5U0A8, Q9UBE4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
	Last sequence update:	January 23, 2007
	Last modified:	November 7, 2018
	This is version 213 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM

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UniProtKB - P20340 (RAB6A_HUMAN)

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Ras-related protein Rab-6A

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GO - Molecular functionⁱ

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Keywords - PTMⁱ

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