Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
The new UniProt website is here! Take me to UniProt BETA

UniProtKB - P20338 (RAB4A_HUMAN)

Entry version 221 (25 May 2022)
Sequence version 3 (06 Mar 2013)
Previous versions | rss
Add a publicationFeedback
Protein

Ras-related protein Rab-4A

Gene

RAB4A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state (PubMed:15907487, PubMed:16034420).

Involved in protein transport (PubMed:29425100).

Plays a role in vesicular traffic. Mediates VEGFR2 endosomal trafficking to enhance VEGFR2 signaling (PubMed:29425100).

Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (By similarity).

By similarity3 Publications

Caution

It is uncertain whether Met-1 or Met-6 is the initiator.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi20 – 28GTP1 Publication9
Nucleotide bindingi68 – 72GTP1 Publication5
Nucleotide bindingi126 – 129GTP1 Publication4
Nucleotide bindingi156 – 158GTP1 Publication3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P20338

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1445148, Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-1660499, Synthesis of PIPs at the plasma membrane
R-HSA-8854214, TBC/RABGAPs
R-HSA-8873719, RAB geranylgeranylation
R-HSA-8875656, MET receptor recycling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P20338

SIGNOR Signaling Network Open Resource

More...SIGNORi		P20338

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...MoonDBi		P20338, Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ras-related protein Rab-4A (EC:3.6.5.22 Publications)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RAB4A
Synonyms:RAB4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:9781, RAB4A

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		179511, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P20338

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000168118

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi51G → A: 10-fold decrease in ZFYVE20 binding affinity. 1 Publication1
Mutagenesisi51G → L: 10-fold decrease in ZFYVE20 binding affinity. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		5867

Open Targets

More...OpenTargetsi		ENSG00000168118

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA34141

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P20338, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RAB4A

Domain mapping of disease mutations (DMDM)

More...DMDMi		460018296

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001210931 – 218Ras-related protein Rab-4AAdd BLAST218

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei725-glutamyl serotoninBy similarity1
Modified residuei190PhosphoserineCombined sources1
Modified residuei204Phosphoserine; by CDK11 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi216S-geranylgeranyl cysteineBy similarity1
Modified residuei218Cysteine methyl esterBy similarity1
Lipidationi218S-geranylgeranyl cysteineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by CDK1 kinase during mitosis.2 Publications
Serotonylation of Gln-72 by TGM2 during activation and aggregation of platelets leads to constitutive activation of GTPase activity.By similarity

Keywords - PTMi

Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P20338

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P20338

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P20338

MaxQB - The MaxQuant DataBase

More...MaxQBi		P20338

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P20338

PeptideAtlas

More...PeptideAtlasi		P20338

PRoteomics IDEntifications database

More...PRIDEi		P20338

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		53750

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P20338

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P20338

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000168118, Expressed in vagina and 251 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P20338, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P20338, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000168118, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SGSM1, SGSM2 and SGSM3 (By similarity).

Interacts with RAB11FIP1, RABEP1, ZFYVE20 and RUFY1 (PubMed:10698684, PubMed:11786538, PubMed:11788822, PubMed:14617813, PubMed:15280022, PubMed:16034420).

Interacts (membrane-bound form) with NDRG1; the interaction involves NDRG1 in vesicular recycling of E-cadherin (PubMed:17786215).

Interacts (in GTP-bound form) with GRIPAP1 (via N-terminus) (PubMed:20098723).

Interacts with RABEP1 and RBSN (PubMed:20098723). Does not interact with HPS4 (By similarity).

Interacts with RABEP2; this interaction may mediate VEGFR2 cell surface expression (PubMed:29425100).

By similarity10 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111805, 382 interactors

Database of interacting proteins

More...DIPi		DIP-372N

Protein interaction database and analysis system

More...IntActi		P20338, 31 interactors

Molecular INTeraction database

More...MINTi		P20338

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000355651

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P20338, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1218
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P20338

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P20338

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P20338

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi42 – 50Effector regionBy similarity9

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0086, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157464

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_041217_23_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P20338

Identification of Orthologs from Complete Genome Data

More...OMAi		STQECGC

Database of Orthologous Groups

More...OrthoDBi		1146851at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P20338

TreeFam database of animal gene trees

More...TreeFami		TF300032

Family and domain databases

Conserved Domains Database

More...CDDi		cd04113, Rab4, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.300, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR027417, P-loop_NTPase
IPR041819, Rab4
IPR005225, Small_GTP-bd_dom
IPR001806, Small_GTPase

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00071, Ras, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00174, RHO, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00231, small_GTP, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51419, RAB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P20338-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQTAMSETY DFLFKFLVIG NAGTGKSCLL HQFIEKKFKD DSNHTIGVEF 
        60         70         80         90        100
GSKIINVGGK YVKLQIWDTA GQERFRSVTR SYYRGAAGAL LVYDITSRET 
       110        120        130        140        150
YNALTNWLTD ARMLASQNIV IILCGNKKDL DADREVTFLE ASRFAQENEL 
       160        170        180        190        200
MFLETSALTG ENVEEAFVQC ARKILNKIES GELDPERMGS GIQYGDAALR 
       210 
QLRSPRRAQA PNAQECGC
Length:218
Mass (Da):24,390
Last modified:March 6, 2013 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i983D65E1162741B0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WYT5A0A087WYT5_HUMAN
Ras-related protein Rab-4A
RAB4A
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA60244 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti162N → D in AAA60244 (PubMed:2501306).Curated1
Sequence conflicti208A → T in AAA60244 (PubMed:2501306).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M28211 mRNA Translation: AAA60244.1 Frameshift.
AY585832 mRNA Translation: AAT91347.1
AF498934 mRNA Translation: AAM21082.1
AK313807 mRNA Translation: BAG36543.1
AL162595 Genomic DNA No translation available.
AL117350 Genomic DNA No translation available.
CH471098 Genomic DNA Translation: EAW69890.1
BC002438 mRNA Translation: AAH02438.1
BC004309 mRNA Translation: AAH04309.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS31050.1

Protein sequence database of the Protein Information Resource

More...PIRi		E34323

NCBI Reference Sequences

More...RefSeqi		NP_001258927.1, NM_001271998.1
NP_004569.2, NM_004578.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000366690.5; ENSP00000355651.4; ENSG00000168118.12

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5867

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5867

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000366690.5; ENSP00000355651.4; NM_004578.4; NP_004569.2

UCSC genome browser

More...UCSCi		uc001hth.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28211 mRNA Translation: AAA60244.1 Frameshift.
AY585832 mRNA Translation: AAT91347.1
AF498934 mRNA Translation: AAM21082.1
AK313807 mRNA Translation: BAG36543.1
AL162595 Genomic DNA No translation available.
AL117350 Genomic DNA No translation available.
CH471098 Genomic DNA Translation: EAW69890.1
BC002438 mRNA Translation: AAH02438.1
BC004309 mRNA Translation: AAH04309.1
CCDSiCCDS31050.1
PIRiE34323
RefSeqiNP_001258927.1, NM_001271998.1
NP_004569.2, NM_004578.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YU9X-ray2.07A7-177[»]
1Z0KX-ray1.92A/C7-177[»]
2BMDX-ray1.80A6-189[»]
2BMEX-ray1.57A/B/C/D6-189[»]
AlphaFoldDBiP20338
SMRiP20338
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi111805, 382 interactors
DIPiDIP-372N
IntActiP20338, 31 interactors
MINTiP20338
STRINGi9606.ENSP00000355651

Protein family/group databases

MoonDBiP20338, Predicted

PTM databases

iPTMnetiP20338
PhosphoSitePlusiP20338

Genetic variation databases

BioMutaiRAB4A
DMDMi460018296

Proteomic databases

EPDiP20338
jPOSTiP20338
MassIVEiP20338
MaxQBiP20338
PaxDbiP20338
PeptideAtlasiP20338
PRIDEiP20338
ProteomicsDBi53750

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		34673, 341 antibodies from 35 providers

The DNASU plasmid repository

More...DNASUi		5867

Genome annotation databases

EnsembliENST00000366690.5; ENSP00000355651.4; ENSG00000168118.12
GeneIDi5867
KEGGihsa:5867
MANE-SelectiENST00000366690.5; ENSP00000355651.4; NM_004578.4; NP_004569.2
UCSCiuc001hth.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5867
DisGeNETi5867

GeneCards: human genes, protein and diseases

More...GeneCardsi		RAB4A
HGNCiHGNC:9781, RAB4A
HPAiENSG00000168118, Low tissue specificity
MIMi179511, gene
neXtProtiNX_P20338
OpenTargetsiENSG00000168118
PharmGKBiPA34141
VEuPathDBiHostDB:ENSG00000168118

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0086, Eukaryota
GeneTreeiENSGT00940000157464
HOGENOMiCLU_041217_23_1_1
InParanoidiP20338
OMAiSTQECGC
OrthoDBi1146851at2759
PhylomeDBiP20338
TreeFamiTF300032

Enzyme and pathway databases

PathwayCommonsiP20338
ReactomeiR-HSA-1445148, Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-1660499, Synthesis of PIPs at the plasma membrane
R-HSA-8854214, TBC/RABGAPs
R-HSA-8873719, RAB geranylgeranylation
R-HSA-8875656, MET receptor recycling
SignaLinkiP20338
SIGNORiP20338

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		5867, 48 hits in 1081 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		RAB4A, human
EvolutionaryTraceiP20338

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		RAB4A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5867
PharosiP20338, Tbio

Protein Ontology

More...PROi		PR:P20338
RNActiP20338, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000168118, Expressed in vagina and 251 other tissues
ExpressionAtlasiP20338, baseline and differential
GenevisibleiP20338, HS

Family and domain databases

CDDicd04113, Rab4, 1 hit
Gene3Di3.40.50.300, 1 hit
InterProiView protein in InterPro
IPR027417, P-loop_NTPase
IPR041819, Rab4
IPR005225, Small_GTP-bd_dom
IPR001806, Small_GTPase
PfamiView protein in Pfam
PF00071, Ras, 1 hit
SMARTiView protein in SMART
SM00174, RHO, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
TIGRFAMsiTIGR00231, small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419, RAB, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRAB4A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P20338
Secondary accession number(s): Q5T7P7, Q9BQ44
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: March 6, 2013
Last modified: May 25, 2022
This is version 221 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again