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Protein

Ras-related protein Rab-4A

Gene

RAB4A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein transport. Probably involved in vesicular traffic (By similarity).By similarity

Caution

It is uncertain whether Met-1 or Met-6 is the initiator.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi20 – 28GTP1 Publication9
Nucleotide bindingi68 – 72GTP1 Publication5
Nucleotide bindingi126 – 129GTP1 Publication4
Nucleotide bindingi156 – 158GTP1 Publication3

GO - Molecular functioni

GO - Biological processi

  • antigen processing and presentation Source: UniProtKB
  • intracellular protein transport Source: GO_Central
  • phosphatidylinositol biosynthetic process Source: Reactome
  • Rab protein signal transduction Source: GO_Central
  • regulation of endocytosis Source: GO_Central

Keywordsi

Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-1660499 Synthesis of PIPs at the plasma membrane
R-HSA-8854214 TBC/RABGAPs
R-HSA-8873719 RAB geranylgeranylation
R-HSA-8875656 MET receptor recycling
SignaLinkiP20338
SIGNORiP20338

Protein family/group databases

MoonDBiP20338 Predicted

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-4A
Gene namesi
Name:RAB4A
Synonyms:RAB4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000168118.11
HGNCiHGNC:9781 RAB4A
MIMi179511 gene
neXtProtiNX_P20338

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi51G → A: 10-fold decrease in ZFYVE20 binding affinity. 1 Publication1
Mutagenesisi51G → L: 10-fold decrease in ZFYVE20 binding affinity. 1 Publication1

Organism-specific databases

DisGeNETi5867
OpenTargetsiENSG00000168118
PharmGKBiPA34141

Polymorphism and mutation databases

DMDMi460018296

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001210931 – 218Ras-related protein Rab-4AAdd BLAST218

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei190PhosphoserineCombined sources1
Modified residuei204Phosphoserine; by CDK11 Publication1
Lipidationi216S-geranylgeranyl cysteineBy similarity1
Modified residuei218Cysteine methyl esterBy similarity1
Lipidationi218S-geranylgeranyl cysteineBy similarity1

Post-translational modificationi

Phosphorylated by CDK1 kinase during mitosis.2 Publications

Keywords - PTMi

Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

EPDiP20338
MaxQBiP20338
PaxDbiP20338
PeptideAtlasiP20338
PRIDEiP20338
ProteomicsDBi53750

PTM databases

iPTMnetiP20338
PhosphoSitePlusiP20338

Expressioni

Gene expression databases

BgeeiENSG00000168118 Expressed in 241 organ(s), highest expression level in vagina
CleanExiHS_RAB4A
ExpressionAtlasiP20338 baseline and differential
GenevisibleiP20338 HS

Interactioni

Subunit structurei

Interacts with SGSM1, SGSM2 and SGSM3 (By similarity). Interacts with RAB11FIP1, RABEP1, ZFYVE20 and RUFY1 (PubMed:10698684, PubMed:11786538, PubMed:11788822, PubMed:14617813, PubMed:15280022, PubMed:16034420). Interacts (membrane-bound form) with NDRG1; the interaction involves NDRG1 in vesicular recycling of E-cadherin (PubMed:17786215). Interacts (in GTP-bound form) with GRIPAP1 (via N-terminus) (PubMed:20098723). Interacts with RABEP1 and RBSN (PubMed:20098723). Does not interact with HPS4 (By similarity).By similarity9 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111805, 43 interactors
DIPiDIP-372N
IntActiP20338, 21 interactors
MINTiP20338
STRINGi9606.ENSP00000355651

Structurei

Secondary structure

1218
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP20338
SMRiP20338
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP20338

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 50Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0086 Eukaryota
ENOG410XQ9X LUCA
GeneTreeiENSGT00760000118841
HOVERGENiHBG009351
InParanoidiP20338
KOiK07879
OMAiGTQECGC
OrthoDBiEOG091G0QOB
PhylomeDBiP20338
TreeFamiTF300032

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P20338-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQTAMSETY DFLFKFLVIG NAGTGKSCLL HQFIEKKFKD DSNHTIGVEF
60 70 80 90 100
GSKIINVGGK YVKLQIWDTA GQERFRSVTR SYYRGAAGAL LVYDITSRET
110 120 130 140 150
YNALTNWLTD ARMLASQNIV IILCGNKKDL DADREVTFLE ASRFAQENEL
160 170 180 190 200
MFLETSALTG ENVEEAFVQC ARKILNKIES GELDPERMGS GIQYGDAALR
210
QLRSPRRAQA PNAQECGC
Length:218
Mass (Da):24,390
Last modified:March 6, 2013 - v3
Checksum:i983D65E1162741B0
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WYT5A0A087WYT5_HUMAN
Ras-related protein Rab-4A
RAB4A
113Annotation score:

Sequence cautioni

The sequence AAA60244 differs from that shown. Reason: Frameshift at position 6.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti162N → D in AAA60244 (PubMed:2501306).Curated1
Sequence conflicti208A → T in AAA60244 (PubMed:2501306).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28211 mRNA Translation: AAA60244.1 Frameshift.
AY585832 mRNA Translation: AAT91347.1
AF498934 mRNA Translation: AAM21082.1
AK313807 mRNA Translation: BAG36543.1
AL162595 Genomic DNA No translation available.
AL117350 Genomic DNA No translation available.
CH471098 Genomic DNA Translation: EAW69890.1
BC002438 mRNA Translation: AAH02438.1
BC004309 mRNA Translation: AAH04309.1
CCDSiCCDS31050.1
PIRiE34323
RefSeqiNP_001258927.1, NM_001271998.1
NP_004569.2, NM_004578.3
UniGeneiHs.296169

Genome annotation databases

EnsembliENST00000366690; ENSP00000355651; ENSG00000168118
GeneIDi5867
KEGGihsa:5867
UCSCiuc001hth.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28211 mRNA Translation: AAA60244.1 Frameshift.
AY585832 mRNA Translation: AAT91347.1
AF498934 mRNA Translation: AAM21082.1
AK313807 mRNA Translation: BAG36543.1
AL162595 Genomic DNA No translation available.
AL117350 Genomic DNA No translation available.
CH471098 Genomic DNA Translation: EAW69890.1
BC002438 mRNA Translation: AAH02438.1
BC004309 mRNA Translation: AAH04309.1
CCDSiCCDS31050.1
PIRiE34323
RefSeqiNP_001258927.1, NM_001271998.1
NP_004569.2, NM_004578.3
UniGeneiHs.296169

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YU9X-ray2.07A7-177[»]
1Z0KX-ray1.92A/C7-177[»]
2BMDX-ray1.80A6-189[»]
2BMEX-ray1.57A/B/C/D6-189[»]
ProteinModelPortaliP20338
SMRiP20338
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111805, 43 interactors
DIPiDIP-372N
IntActiP20338, 21 interactors
MINTiP20338
STRINGi9606.ENSP00000355651

Protein family/group databases

MoonDBiP20338 Predicted

PTM databases

iPTMnetiP20338
PhosphoSitePlusiP20338

Polymorphism and mutation databases

DMDMi460018296

Proteomic databases

EPDiP20338
MaxQBiP20338
PaxDbiP20338
PeptideAtlasiP20338
PRIDEiP20338
ProteomicsDBi53750

Protocols and materials databases

DNASUi5867
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366690; ENSP00000355651; ENSG00000168118
GeneIDi5867
KEGGihsa:5867
UCSCiuc001hth.5 human

Organism-specific databases

CTDi5867
DisGeNETi5867
EuPathDBiHostDB:ENSG00000168118.11
GeneCardsiRAB4A
HGNCiHGNC:9781 RAB4A
MIMi179511 gene
neXtProtiNX_P20338
OpenTargetsiENSG00000168118
PharmGKBiPA34141
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0086 Eukaryota
ENOG410XQ9X LUCA
GeneTreeiENSGT00760000118841
HOVERGENiHBG009351
InParanoidiP20338
KOiK07879
OMAiGTQECGC
OrthoDBiEOG091G0QOB
PhylomeDBiP20338
TreeFamiTF300032

Enzyme and pathway databases

ReactomeiR-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-1660499 Synthesis of PIPs at the plasma membrane
R-HSA-8854214 TBC/RABGAPs
R-HSA-8873719 RAB geranylgeranylation
R-HSA-8875656 MET receptor recycling
SignaLinkiP20338
SIGNORiP20338

Miscellaneous databases

ChiTaRSiRAB4A human
EvolutionaryTraceiP20338
GeneWikiiRAB4A
GenomeRNAii5867
PROiPR:P20338
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168118 Expressed in 241 organ(s), highest expression level in vagina
CleanExiHS_RAB4A
ExpressionAtlasiP20338 baseline and differential
GenevisibleiP20338 HS

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRAB4A_HUMAN
AccessioniPrimary (citable) accession number: P20338
Secondary accession number(s): Q5T7P7, Q9BQ44
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: March 6, 2013
Last modified: November 7, 2018
This is version 201 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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