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UniProtKB - P20337 (RAB3B_HUMAN)
Protein
Ras-related protein Rab-3B
Gene
RAB3B
Organism
Homo sapiens (Human)
Status
Functioni
Protein transport. Probably involved in vesicular traffic (By similarity).
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 29 – 37 | GTPCombined sources | 9 | |
Nucleotide bindingi | 48 – 54 | GTPBy similarity | 7 | |
Nucleotide bindingi | 77 – 81 | GTPBy similarity | 5 | |
Nucleotide bindingi | 135 – 138 | GTPCombined sources | 4 | |
Nucleotide bindingi | 165 – 167 | GTPCombined sources | 3 |
GO - Molecular functioni
- GDP binding Source: UniProtKB
- GTPase activity Source: UniProtKB
- GTP binding Source: UniProtKB-KW
- myosin V binding Source: UniProtKB
GO - Biological processi
- antigen processing and presentation Source: UniProtKB
- positive regulation of dopamine uptake involved in synaptic transmission Source: UniProtKB
- protein localization to plasma membrane Source: GO_Central
- protein secretion Source: GO_Central
- regulation of exocytosis Source: GO_Central
- regulation of synaptic vesicle cycle Source: SynGO
- regulation of vesicle size Source: UniProtKB
- vesicle docking involved in exocytosis Source: GO_Central
Keywordsi
Biological process | Protein transport, Transport |
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | P20337 |
Reactomei | R-HSA-8873719, RAB geranylgeranylation |
SignaLinki | P20337 |
Names & Taxonomyi
Protein namesi | Recommended name: Ras-related protein Rab-3B |
Gene namesi | Name:RAB3B |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9778, RAB3B |
MIMi | 179510, gene |
neXtProti | NX_P20337 |
VEuPathDBi | HostDB:ENSG00000169213 |
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated
Golgi apparatus
- Golgi apparatus By similarity
Note: Colocalizes with GAS8/DRC4 in the Golgi apparatus.By similarity
Cytosol
- cytosol Source: Ensembl
Endosome
- endosome Source: GO_Central
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Golgi apparatus
- Golgi apparatus Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- anchored component of synaptic vesicle membrane Source: SynGO
- cytoplasm Source: UniProtKB
- dopaminergic synapse Source: SynGO
- perinuclear region of cytoplasm Source: UniProtKB
- synaptic vesicle Source: GO_Central
- vesicle Source: UniProtKB
Keywords - Cellular componenti
Cell membrane, Golgi apparatus, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 86 | T → A: Loss of phosphorylation. No effect on GDI2, CHM and CHML binding. 1 Publication | 1 | |
Mutagenesisi | 86 | T → E: Phosphomimetic mutant. Loss of GDI2, CHM and CHML binding. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 5865 |
OpenTargetsi | ENSG00000169213 |
PharmGKBi | PA34133 |
Miscellaneous databases
Pharosi | P20337, Tbio |
Genetic variation databases
BioMutai | RAB3B |
DMDMi | 38258903 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000121081 | 2 – 219 | Ras-related protein Rab-3BAdd BLAST | 218 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Modified residuei | 86 | Phosphothreonine; by LRRK21 Publication | 1 | |
Modified residuei | 188 | PhosphoserineBy similarity | 1 | |
Modified residuei | 190 | PhosphoserineCombined sources | 1 | |
Lipidationi | 217 | S-geranylgeranyl cysteineBy similarity | 1 | |
Modified residuei | 219 | Cysteine methyl esterBy similarity | 1 | |
Lipidationi | 219 | S-geranylgeranyl cysteineBy similarity | 1 |
Post-translational modificationi
Phosphorylation of Thr-86 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitor GDI2.1 Publication
Keywords - PTMi
Acetylation, Lipoprotein, Methylation, Phosphoprotein, PrenylationProteomic databases
EPDi | P20337 |
jPOSTi | P20337 |
MassIVEi | P20337 |
MaxQBi | P20337 |
PaxDbi | P20337 |
PeptideAtlasi | P20337 |
PRIDEi | P20337 |
ProteomicsDBi | 53749 |
PTM databases
iPTMneti | P20337 |
MetOSitei | P20337 |
PhosphoSitePlusi | P20337 |
SwissPalmi | P20337 |
Expressioni
Gene expression databases
Bgeei | ENSG00000169213, Expressed in islet of Langerhans and 130 other tissues |
Genevisiblei | P20337, HS |
Organism-specific databases
HPAi | ENSG00000169213, Group enriched (brain, pituitary gland, prostate) |
Interactioni
Subunit structurei
Interacts with RIMS1, RIMS2, RPH3A and RPH3AL. The GTP-bound form interacts with GAS8/DRC4 (via coiled-coil domains) (By similarity).
Interacts with GDI2, CHM and CHML; phosphorylation at Thr-86 disrupts these interactions (PubMed:29125462).
Interacts with MADD (via uDENN domain); the GTP-bound form is preferred for interaction (By similarity).
By similarity1 PublicationBinary interactionsi
GO - Molecular functioni
- myosin V binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 111803, 293 interactors |
IntActi | P20337, 18 interactors |
MINTi | P20337 |
STRINGi | 9606.ENSP00000360718 |
Miscellaneous databases
RNActi | P20337, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P20337 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P20337 |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 51 – 59 | Effector regionBy similarity | 9 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0093, Eukaryota |
GeneTreei | ENSGT00940000159943 |
HOGENOMi | CLU_041217_10_1_1 |
InParanoidi | P20337 |
OMAi | AICEKMS |
OrthoDBi | 1426655at2759 |
PhylomeDBi | P20337 |
TreeFami | TF313199 |
Family and domain databases
CDDi | cd01865, Rab3, 1 hit |
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR037872, Rab3 IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SMARTi | View protein in SMART SM00174, RHO, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51419, RAB, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P20337-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASVTDGKTG VKDASDQNFD YMFKLLIIGN SSVGKTSFLF RYADDTFTPA
60 70 80 90 100
FVSTVGIDFK VKTVYRHEKR VKLQIWDTAG QERYRTITTA YYRGAMGFIL
110 120 130 140 150
MYDITNEESF NAVQDWATQI KTYSWDNAQV ILVGNKCDME EERVVPTEKG
160 170 180 190 200
QLLAEQLGFD FFEASAKENI SVRQAFERLV DAICDKMSDS LDTDPSMLGS
210
SKNTRLSDTP PLLQQNCSC
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 9 | T → H in AAA60243 (PubMed:2501306).Curated | 1 | |
Sequence conflicti | 40 | F → L in AAA60243 (PubMed:2501306).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M28214 mRNA Translation: AAA60243.1 AF498932 mRNA Translation: AAM21080.1 AL589663 Genomic DNA No translation available. AL445685 Genomic DNA No translation available. BC005035 mRNA Translation: AAH05035.1 |
CCDSi | CCDS560.1 |
PIRi | D34323 |
RefSeqi | NP_002858.2, NM_002867.3 XP_016857447.1, XM_017001958.1 |
Genome annotation databases
Ensembli | ENST00000371655; ENSP00000360718; ENSG00000169213 |
GeneIDi | 5865 |
KEGGi | hsa:5865 |
MANE-Selecti | ENST00000371655.4; ENSP00000360718.3; NM_002867.4; NP_002858.2 |
UCSCi | uc001cth.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M28214 mRNA Translation: AAA60243.1 AF498932 mRNA Translation: AAM21080.1 AL589663 Genomic DNA No translation available. AL445685 Genomic DNA No translation available. BC005035 mRNA Translation: AAH05035.1 |
CCDSi | CCDS560.1 |
PIRi | D34323 |
RefSeqi | NP_002858.2, NM_002867.3 XP_016857447.1, XM_017001958.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3DZ8 | X-ray | 1.90 | A | 18-190 | [»] | |
SMRi | P20337 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111803, 293 interactors |
IntActi | P20337, 18 interactors |
MINTi | P20337 |
STRINGi | 9606.ENSP00000360718 |
PTM databases
iPTMneti | P20337 |
MetOSitei | P20337 |
PhosphoSitePlusi | P20337 |
SwissPalmi | P20337 |
Genetic variation databases
BioMutai | RAB3B |
DMDMi | 38258903 |
Proteomic databases
EPDi | P20337 |
jPOSTi | P20337 |
MassIVEi | P20337 |
MaxQBi | P20337 |
PaxDbi | P20337 |
PeptideAtlasi | P20337 |
PRIDEi | P20337 |
ProteomicsDBi | 53749 |
Protocols and materials databases
Antibodypediai | 19062, 175 antibodies from 26 providers |
DNASUi | 5865 |
Genome annotation databases
Ensembli | ENST00000371655; ENSP00000360718; ENSG00000169213 |
GeneIDi | 5865 |
KEGGi | hsa:5865 |
MANE-Selecti | ENST00000371655.4; ENSP00000360718.3; NM_002867.4; NP_002858.2 |
UCSCi | uc001cth.3, human |
Organism-specific databases
CTDi | 5865 |
DisGeNETi | 5865 |
GeneCardsi | RAB3B |
HGNCi | HGNC:9778, RAB3B |
HPAi | ENSG00000169213, Group enriched (brain, pituitary gland, prostate) |
MIMi | 179510, gene |
neXtProti | NX_P20337 |
OpenTargetsi | ENSG00000169213 |
PharmGKBi | PA34133 |
VEuPathDBi | HostDB:ENSG00000169213 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0093, Eukaryota |
GeneTreei | ENSGT00940000159943 |
HOGENOMi | CLU_041217_10_1_1 |
InParanoidi | P20337 |
OMAi | AICEKMS |
OrthoDBi | 1426655at2759 |
PhylomeDBi | P20337 |
TreeFami | TF313199 |
Enzyme and pathway databases
PathwayCommonsi | P20337 |
Reactomei | R-HSA-8873719, RAB geranylgeranylation |
SignaLinki | P20337 |
Miscellaneous databases
BioGRID-ORCSi | 5865, 3 hits in 1042 CRISPR screens |
ChiTaRSi | RAB3B, human |
EvolutionaryTracei | P20337 |
GeneWikii | RAB3B |
GenomeRNAii | 5865 |
Pharosi | P20337, Tbio |
PROi | PR:P20337 |
RNActi | P20337, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000169213, Expressed in islet of Langerhans and 130 other tissues |
Genevisiblei | P20337, HS |
Family and domain databases
CDDi | cd01865, Rab3, 1 hit |
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR037872, Rab3 IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SMARTi | View protein in SMART SM00174, RHO, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51419, RAB, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RAB3B_HUMAN | |
Accessioni | P20337Primary (citable) accession number: P20337 Secondary accession number(s): Q5VUL2, Q9BSI1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1991 |
Last sequence update: | October 31, 2003 | |
Last modified: | February 23, 2022 | |
This is version 201 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families