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Protein

Ras-related protein Rab-3B

Gene

RAB3B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein transport. Probably involved in vesicular traffic (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi29 – 37GTPCombined sources9
Nucleotide bindingi48 – 54GTPBy similarity7
Nucleotide bindingi77 – 81GTPBy similarity5
Nucleotide bindingi135 – 138GTPCombined sources4
Nucleotide bindingi165 – 167GTPCombined sources3

GO - Molecular functioni

  • GDP binding Source: UniProtKB
  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB-KW
  • GTP-dependent protein binding Source: Ensembl
  • myosin V binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-8873719 RAB geranylgeranylation

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-3B
Gene namesi
Name:RAB3B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000169213.6
HGNCiHGNC:9778 RAB3B
MIMi179510 gene
neXtProtiNX_P20337

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5865
OpenTargetsiENSG00000169213
PharmGKBiPA34133

Polymorphism and mutation databases

BioMutaiRAB3B
DMDMi38258903

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001210812 – 219Ras-related protein Rab-3BAdd BLAST218

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei188PhosphoserineBy similarity1
Modified residuei190PhosphoserineCombined sources1
Lipidationi217S-geranylgeranyl cysteineBy similarity1
Modified residuei219Cysteine methyl esterBy similarity1
Lipidationi219S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

EPDiP20337
MaxQBiP20337
PaxDbiP20337
PeptideAtlasiP20337
PRIDEiP20337
ProteomicsDBi53749

PTM databases

iPTMnetiP20337
PhosphoSitePlusiP20337
SwissPalmiP20337

Expressioni

Gene expression databases

BgeeiENSG00000169213 Expressed in 109 organ(s), highest expression level in islet of Langerhans
CleanExiHS_RAB3B
GenevisibleiP20337 HS

Organism-specific databases

HPAiCAB023293
HPA003159

Interactioni

Subunit structurei

Interacts with RIMS1, RIMS2, RPH3A and RPH3AL. The GTP-bound form interacts with GAS8/DRC4 (via coiled-coil domains).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111803, 28 interactors
IntActiP20337, 2 interactors
STRINGi9606.ENSP00000360718

Structurei

Secondary structure

1219
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP20337
SMRiP20337
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP20337

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi51 – 59Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0093 Eukaryota
ENOG410ZZXQ LUCA
GeneTreeiENSGT00890000139330
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiP20337
KOiK06108
OMAiPSQQNCS
OrthoDBiEOG091G0J64
PhylomeDBiP20337
TreeFamiTF313199

Family and domain databases

CDDicd01865 Rab3, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR037872 Rab3
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20337-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASVTDGKTG VKDASDQNFD YMFKLLIIGN SSVGKTSFLF RYADDTFTPA
60 70 80 90 100
FVSTVGIDFK VKTVYRHEKR VKLQIWDTAG QERYRTITTA YYRGAMGFIL
110 120 130 140 150
MYDITNEESF NAVQDWATQI KTYSWDNAQV ILVGNKCDME EERVVPTEKG
160 170 180 190 200
QLLAEQLGFD FFEASAKENI SVRQAFERLV DAICDKMSDS LDTDPSMLGS
210
SKNTRLSDTP PLLQQNCSC
Length:219
Mass (Da):24,758
Last modified:October 31, 2003 - v2
Checksum:iB73A014B4295A60D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9T → H in AAA60243 (PubMed:2501306).Curated1
Sequence conflicti40F → L in AAA60243 (PubMed:2501306).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28214 mRNA Translation: AAA60243.1
AF498932 mRNA Translation: AAM21080.1
AL589663 Genomic DNA No translation available.
AL445685 Genomic DNA No translation available.
BC005035 mRNA Translation: AAH05035.1
CCDSiCCDS560.1
PIRiD34323
RefSeqiNP_002858.2, NM_002867.3
XP_016857447.1, XM_017001958.1
UniGeneiHs.123072

Genome annotation databases

EnsembliENST00000371655; ENSP00000360718; ENSG00000169213
GeneIDi5865
KEGGihsa:5865
UCSCiuc001cth.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28214 mRNA Translation: AAA60243.1
AF498932 mRNA Translation: AAM21080.1
AL589663 Genomic DNA No translation available.
AL445685 Genomic DNA No translation available.
BC005035 mRNA Translation: AAH05035.1
CCDSiCCDS560.1
PIRiD34323
RefSeqiNP_002858.2, NM_002867.3
XP_016857447.1, XM_017001958.1
UniGeneiHs.123072

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DZ8X-ray1.90A18-190[»]
ProteinModelPortaliP20337
SMRiP20337
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111803, 28 interactors
IntActiP20337, 2 interactors
STRINGi9606.ENSP00000360718

PTM databases

iPTMnetiP20337
PhosphoSitePlusiP20337
SwissPalmiP20337

Polymorphism and mutation databases

BioMutaiRAB3B
DMDMi38258903

Proteomic databases

EPDiP20337
MaxQBiP20337
PaxDbiP20337
PeptideAtlasiP20337
PRIDEiP20337
ProteomicsDBi53749

Protocols and materials databases

DNASUi5865
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371655; ENSP00000360718; ENSG00000169213
GeneIDi5865
KEGGihsa:5865
UCSCiuc001cth.3 human

Organism-specific databases

CTDi5865
DisGeNETi5865
EuPathDBiHostDB:ENSG00000169213.6
GeneCardsiRAB3B
HGNCiHGNC:9778 RAB3B
HPAiCAB023293
HPA003159
MIMi179510 gene
neXtProtiNX_P20337
OpenTargetsiENSG00000169213
PharmGKBiPA34133
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0093 Eukaryota
ENOG410ZZXQ LUCA
GeneTreeiENSGT00890000139330
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiP20337
KOiK06108
OMAiPSQQNCS
OrthoDBiEOG091G0J64
PhylomeDBiP20337
TreeFamiTF313199

Enzyme and pathway databases

ReactomeiR-HSA-8873719 RAB geranylgeranylation

Miscellaneous databases

ChiTaRSiRAB3B human
EvolutionaryTraceiP20337
GeneWikiiRAB3B
GenomeRNAii5865
PROiPR:P20337
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169213 Expressed in 109 organ(s), highest expression level in islet of Langerhans
CleanExiHS_RAB3B
GenevisibleiP20337 HS

Family and domain databases

CDDicd01865 Rab3, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR037872 Rab3
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRAB3B_HUMAN
AccessioniPrimary (citable) accession number: P20337
Secondary accession number(s): Q5VUL2, Q9BSI1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: October 31, 2003
Last modified: October 10, 2018
This is version 180 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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