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Protein

Ras-related protein Rab-3A

Gene

RAB3A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi29 – 37GTPBy similarity9
Nucleotide bindingi48 – 54GTPBy similarity7
Nucleotide bindingi77 – 81GTPBy similarity5
Nucleotide bindingi135 – 138GTPBy similarity4
Nucleotide bindingi165 – 167GTPBy similarity3

GO - Molecular functioni

  • ATPase activator activity Source: Ensembl
  • ATPase binding Source: Ensembl
  • GDP-dissociation inhibitor binding Source: Ensembl
  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB-KW
  • GTP-dependent protein binding Source: Ensembl
  • myosin V binding Source: UniProtKB
  • protein C-terminus binding Source: Ensembl

GO - Biological processi

Keywordsi

Biological processExocytosis, Protein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-181429 Serotonin Neurotransmitter Release Cycle
R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle
R-HSA-210500 Glutamate Neurotransmitter Release Cycle
R-HSA-212676 Dopamine Neurotransmitter Release Cycle
R-HSA-264642 Acetylcholine Neurotransmitter Release Cycle
R-HSA-6798695 Neutrophil degranulation
R-HSA-8873719 RAB geranylgeranylation
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs
R-HSA-888590 GABA synthesis, release, reuptake and degradation
SIGNORiP20336

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-3A
Gene namesi
Name:RAB3A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105649.9
HGNCiHGNC:9777 RAB3A
MIMi179490 gene
neXtProtiNX_P20336

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5864
OpenTargetsiENSG00000105649
PharmGKBiPA34132

Polymorphism and mutation databases

BioMutaiRAB3A
DMDMi131801

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001210761 – 220Ras-related protein Rab-3AAdd BLAST220

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei188PhosphoserineBy similarity1
Modified residuei190PhosphoserineBy similarity1
Lipidationi218S-geranylgeranyl cysteine2 Publications1
Modified residuei220Cysteine methyl ester1 Publication1
Lipidationi220S-geranylgeranyl cysteine2 Publications1

Keywords - PTMi

Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

EPDiP20336
MaxQBiP20336
PaxDbiP20336
PeptideAtlasiP20336
PRIDEiP20336
ProteomicsDBi53748

PTM databases

iPTMnetiP20336
PhosphoSitePlusiP20336
SwissPalmiP20336

Expressioni

Tissue specificityi

Specifically expressed in brain.

Gene expression databases

BgeeiENSG00000105649 Expressed in 205 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_RAB3A
ExpressionAtlasiP20336 baseline and differential
GenevisibleiP20336 HS

Organism-specific databases

HPAiCAB009949
CAB078998
HPA003160

Interactioni

Subunit structurei

Heterodimer with RIMS2. Part of a ternary complex involving PCLO and EPAC2. Interacts with RPH3A and RPH3AL. Interacts with the exocyst complex through SEC15. Binds SYTL4 and RIMS1. Interacts with RAB3IP. Interacts with SGSM1 and SGSM3 (By similarity).By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111802, 39 interactors
IntActiP20336, 12 interactors
MINTiP20336
STRINGi9606.ENSP00000222256

Structurei

3D structure databases

ProteinModelPortaliP20336
SMRiP20336
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi51 – 59Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0093 Eukaryota
ENOG410ZZXQ LUCA
GeneTreeiENSGT00890000139330
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiP20336
KOiK07882
OMAiQLTEQPA
OrthoDBiEOG091G0J64
PhylomeDBiP20336
TreeFamiTF313199

Family and domain databases

CDDicd01865 Rab3, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR037872 Rab3
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P20336-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASATDSRYG QKESSDQNFD YMFKILIIGN SSVGKTSFLF RYADDSFTPA
60 70 80 90 100
FVSTVGIDFK VKTIYRNDKR IKLQIWDTAG QERYRTITTA YYRGAMGFIL
110 120 130 140 150
MYDITNEESF NAVQDWSTQI KTYSWDNAQV LLVGNKCDME DERVVSSERG
160 170 180 190 200
RQLADHLGFE FFEASAKDNI NVKQTFERLV DVICEKMSES LDTADPAVTG
210 220
AKQGPQLSDQ QVPPHQDCAC
Length:220
Mass (Da):24,984
Last modified:February 1, 1991 - v1
Checksum:i08B59F8C9BD2EB40
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R257M0R257_HUMAN
Ras-related protein Rab-3A
RAB3A
115Annotation score:
S4R3Q3S4R3Q3_HUMAN
Ras-related protein Rab-3A
RAB3A
125Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti70R → K in AAF67748 (PubMed:10574328).Curated1
Sequence conflicti180V → E in AAF67748 (PubMed:10574328).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28210 mRNA Translation: AAA60242.1
AF157809
, AF157806, AF157807, AF157808 Genomic DNA Translation: AAD46811.1
AF254795 mRNA Translation: AAF67748.1
AF498931 mRNA Translation: AAM21079.1
AK289559 mRNA Translation: BAF82248.1
AC068499 Genomic DNA Translation: AAF67385.1
CH471106 Genomic DNA Translation: EAW84672.1
BC011782 mRNA Translation: AAH11782.1
CCDSiCCDS12372.1
PIRiC34323
RefSeqiNP_002857.1, NM_002866.4
XP_011526466.1, XM_011528164.1
UniGeneiHs.27744

Genome annotation databases

EnsembliENST00000222256; ENSP00000222256; ENSG00000105649
GeneIDi5864
KEGGihsa:5864
UCSCiuc002nie.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28210 mRNA Translation: AAA60242.1
AF157809
, AF157806, AF157807, AF157808 Genomic DNA Translation: AAD46811.1
AF254795 mRNA Translation: AAF67748.1
AF498931 mRNA Translation: AAM21079.1
AK289559 mRNA Translation: BAF82248.1
AC068499 Genomic DNA Translation: AAF67385.1
CH471106 Genomic DNA Translation: EAW84672.1
BC011782 mRNA Translation: AAH11782.1
CCDSiCCDS12372.1
PIRiC34323
RefSeqiNP_002857.1, NM_002866.4
XP_011526466.1, XM_011528164.1
UniGeneiHs.27744

3D structure databases

ProteinModelPortaliP20336
SMRiP20336
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111802, 39 interactors
IntActiP20336, 12 interactors
MINTiP20336
STRINGi9606.ENSP00000222256

PTM databases

iPTMnetiP20336
PhosphoSitePlusiP20336
SwissPalmiP20336

Polymorphism and mutation databases

BioMutaiRAB3A
DMDMi131801

Proteomic databases

EPDiP20336
MaxQBiP20336
PaxDbiP20336
PeptideAtlasiP20336
PRIDEiP20336
ProteomicsDBi53748

Protocols and materials databases

DNASUi5864
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000222256; ENSP00000222256; ENSG00000105649
GeneIDi5864
KEGGihsa:5864
UCSCiuc002nie.3 human

Organism-specific databases

CTDi5864
DisGeNETi5864
EuPathDBiHostDB:ENSG00000105649.9
GeneCardsiRAB3A
HGNCiHGNC:9777 RAB3A
HPAiCAB009949
CAB078998
HPA003160
MIMi179490 gene
neXtProtiNX_P20336
OpenTargetsiENSG00000105649
PharmGKBiPA34132
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0093 Eukaryota
ENOG410ZZXQ LUCA
GeneTreeiENSGT00890000139330
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiP20336
KOiK07882
OMAiQLTEQPA
OrthoDBiEOG091G0J64
PhylomeDBiP20336
TreeFamiTF313199

Enzyme and pathway databases

ReactomeiR-HSA-181429 Serotonin Neurotransmitter Release Cycle
R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle
R-HSA-210500 Glutamate Neurotransmitter Release Cycle
R-HSA-212676 Dopamine Neurotransmitter Release Cycle
R-HSA-264642 Acetylcholine Neurotransmitter Release Cycle
R-HSA-6798695 Neutrophil degranulation
R-HSA-8873719 RAB geranylgeranylation
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs
R-HSA-888590 GABA synthesis, release, reuptake and degradation
SIGNORiP20336

Miscellaneous databases

GeneWikiiRAB3A
GenomeRNAii5864
PROiPR:P20336
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105649 Expressed in 205 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_RAB3A
ExpressionAtlasiP20336 baseline and differential
GenevisibleiP20336 HS

Family and domain databases

CDDicd01865 Rab3, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR037872 Rab3
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRAB3A_HUMAN
AccessioniPrimary (citable) accession number: P20336
Secondary accession number(s): A8K0J4, Q9NYE1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: November 7, 2018
This is version 200 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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