UniProtKB - P20309 (ACM3_HUMAN)
Protein
Muscarinic acetylcholine receptor M3
Gene
CHRM3
Organism
Homo sapiens (Human)
Status
Functioni
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.1 Publication
GO - Molecular functioni
- acetylcholine binding Source: UniProtKB
- G protein-coupled acetylcholine receptor activity Source: UniProtKB
- G protein-coupled serotonin receptor activity Source: GO_Central
- neurotransmitter receptor activity Source: GO_Central
- phosphatidylinositol phospholipase C activity Source: ProtInc
- signaling receptor activity Source: ProtInc
GO - Biological processi
- acetylcholine receptor signaling pathway Source: ARUK-UCL
- adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway Source: GO_Central
- calcium-mediated signaling Source: ARUK-UCL
- cellular protein modification process Source: ProtInc
- chemical synaptic transmission Source: GO_Central
- G protein-coupled acetylcholine receptor signaling pathway Source: UniProtKB
- G protein-coupled receptor signaling pathway Source: Reactome
- G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
- nervous system development Source: ProtInc
- positive regulation of smooth muscle contraction Source: InterPro
- regulation of ion transmembrane transporter activity Source: ARUK-UCL
- regulation of vascular associated smooth muscle contraction Source: GO_Central
- saliva secretion Source: InterPro
- signal transduction Source: ProtInc
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | P20309 |
Reactomei | R-HSA-390648, Muscarinic acetylcholine receptors R-HSA-399997, Acetylcholine regulates insulin secretion R-HSA-416476, G alpha (q) signalling events |
SignaLinki | P20309 |
SIGNORi | P20309 |
Names & Taxonomyi
Protein namesi | Recommended name: Muscarinic acetylcholine receptor M3 |
Gene namesi | Name:CHRM3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1952, CHRM3 |
MIMi | 118494, gene |
neXtProti | NX_P20309 |
VEuPathDBi | HostDB:ENSG00000133019.11 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein Sequence analysis
- postsynaptic cell membrane ; Multi-pass membrane protein Sequence analysis
- Basolateral cell membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Note: Colocalizes with TMEM147 in the endoplasmic reticulum (ER) membrane. TMEM147 impairs its trafficking to the cell membrane leading to its retention in the ER membrane.1 Publication
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Plasma Membrane
- basal plasma membrane Source: ARUK-UCL
- integral component of plasma membrane Source: UniProtKB
- plasma membrane Source: UniProtKB
- postsynaptic membrane Source: UniProtKB-SubCell
Other locations
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 67 | ExtracellularBy similarityAdd BLAST | 67 | |
Transmembranei | 68 – 91 | Helical; Name=1By similarityAdd BLAST | 24 | |
Topological domaini | 92 – 104 | CytoplasmicBy similarityAdd BLAST | 13 | |
Transmembranei | 105 – 130 | Helical; Name=2By similarityAdd BLAST | 26 | |
Topological domaini | 131 – 142 | ExtracellularBy similarityAdd BLAST | 12 | |
Transmembranei | 143 – 164 | Helical; Name=3By similarityAdd BLAST | 22 | |
Topological domaini | 165 – 184 | CytoplasmicBy similarityAdd BLAST | 20 | |
Transmembranei | 185 – 206 | Helical; Name=4By similarityAdd BLAST | 22 | |
Topological domaini | 207 – 229 | ExtracellularBy similarityAdd BLAST | 23 | |
Transmembranei | 230 – 252 | Helical; Name=5By similarityAdd BLAST | 23 | |
Topological domaini | 253 – 491 | CytoplasmicBy similarityAdd BLAST | 239 | |
Transmembranei | 492 – 514 | Helical; Name=6By similarityAdd BLAST | 23 | |
Topological domaini | 515 – 526 | ExtracellularBy similarityAdd BLAST | 12 | |
Transmembranei | 527 – 546 | Helical; Name=7By similarityAdd BLAST | 20 | |
Topological domaini | 547 – 590 | CytoplasmicBy similarityAdd BLAST | 44 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Endoplasmic reticulum, Membrane, Postsynaptic cell membrane, SynapsePathology & Biotechi
Involvement in diseasei
Prune belly syndrome (PBS)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA syndrome characterized by thin abdominal musculature with overlying lax skin, cryptorchism, megacystis with disorganized detrusor muscle, and urinary tract abnormalities.
Related information in OMIMMutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 276 | E → A: Loss of basolateral sorting. 1 Publication | 1 | |
Mutagenesisi | 276 | E → D: Loss of basolateral sorting. No effect on basolateral sorting; when associated with L-280 and L-281. 1 Publication | 1 | |
Mutagenesisi | 280 | F → A: Loss of basolateral sorting. 1 Publication | 1 | |
Mutagenesisi | 280 | F → L: No effect on basolateral sorting. 1 Publication | 1 | |
Mutagenesisi | 281 | V → A: Loss of basolateral sorting. 1 Publication | 1 | |
Mutagenesisi | 281 | V → L: No effect on basolateral sorting. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 1131 |
MalaCardsi | CHRM3 |
MIMi | 100100, phenotype |
OpenTargetsi | ENSG00000133019 |
Orphaneti | 2970, Prune belly syndrome |
PharmGKBi | PA112 |
Miscellaneous databases
Pharosi | P20309, Tclin |
Chemistry databases
ChEMBLi | CHEMBL245 |
DrugBanki | DB03128, Acetylcholine DB08897, Aclidinium DB05752, ALKS 27 DB00321, Amitriptyline DB00543, Amoxapine DB00517, Anisotropine methylbromide DB04365, Arecoline DB01238, Aripiprazole DB14185, Aripiprazole lauroxil DB00572, Atropine DB00767, Benzquinamide DB01019, Bethanechol DB00835, Brompheniramine DB09300, Butylscopolamine DB00411, Carbamoylcholine DB00185, Cevimeline DB00477, Chlorpromazine DB01239, Chlorprothixene DB00568, Cinnarizine DB00363, Clozapine DB00434, Cyproheptadine DB00496, Darifenacin DB01151, Desipramine DB13720, Diphemanil DB01231, Diphenidol DB00280, Disopyramide DB09167, Dosulepin DB01142, Doxepin DB00366, Doxylamine DB09194, Etoperidone DB06702, Fesoterodine DB00986, Glycopyrronium DB00502, Haloperidol DB06787, Hexocyclium DB11181, Homatropine DB00725, Homatropine methylbromide DB00424, Hyoscyamine DB09262, Imidafenacin DB00458, Imipramine DB00332, Ipratropium DB01625, Isopropamide DB01221, Ketamine DB00408, Loxapine DB00934, Maprotiline DB04843, Mepenzolate DB00454, Meperidine DB06709, Methacholine DB00940, Methantheline DB01403, Methotrimeprazine DB00462, Methscopolamine bromide DB00340, Metixene DB01226, Mivacurium DB00622, Nicardipine DB00540, Nortriptyline DB00334, Olanzapine DB01062, Oxybutynin DB00383, Oxyphencyclimine DB01337, Pancuronium DB00715, Paroxetine DB01085, Pilocarpine DB01338, Pipecuronium DB06153, Pizotifen DB00387, Procyclidine DB01069, Promethazine DB00777, Propiomazine DB12278, Propiverine DB01224, Quetiapine DB11855, Revefenacin DB13581, Rociverine DB00747, Scopolamine DB01591, Solifenacin DB00202, Succinylcholine DB00342, Terfenadine DB00599, Thiopental DB11235, Thonzylamine DB01409, Tiotropium DB01036, Tolterodine DB00193, Tramadol DB00505, Tridihexethyl DB00376, Trihexyphenidyl DB09089, Trimebutine DB00726, Trimipramine DB00809, Tropicamide DB00209, Trospium DB09076, Umeclidinium DB00246, Ziprasidone |
DrugCentrali | P20309 |
GuidetoPHARMACOLOGYi | 15 |
Genetic variation databases
BioMutai | CHRM3 |
DMDMi | 113125 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069029 | 1 – 590 | Muscarinic acetylcholine receptor M3Add BLAST | 590 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 5 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 6 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 15 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 41 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 48 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 141 ↔ 221 | PROSITE-ProRule annotation | ||
Modified residuei | 385 | PhosphoserineBy similarity | 1 | |
Disulfide bondi | 517 ↔ 520 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
jPOSTi | P20309 |
MassIVEi | P20309 |
MaxQBi | P20309 |
PaxDbi | P20309 |
PeptideAtlasi | P20309 |
PRIDEi | P20309 |
ProteomicsDBi | 53745 |
PTM databases
GlyGeni | P20309, 5 sites |
iPTMneti | P20309 |
PhosphoSitePlusi | P20309 |
Expressioni
Gene expression databases
Bgeei | ENSG00000133019, Expressed in endothelial cell and 179 other tissues |
ExpressionAtlasi | P20309, baseline and differential |
Genevisiblei | P20309, HS |
Organism-specific databases
HPAi | ENSG00000133019, Tissue enhanced (retina) |
Interactioni
Subunit structurei
Binary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 107553, 76 interactors |
DIPi | DIP-44291N |
IntActi | P20309, 65 interactors |
MINTi | P20309 |
STRINGi | 9606.ENSP00000255380 |
Chemistry databases
BindingDBi | P20309 |
Miscellaneous databases
RNActi | P20309, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P20309 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P20309 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 148 – 152 | Agonist bindingBy similarity | 5 | |
Regioni | 507 – 530 | Agonist bindingBy similarityAdd BLAST | 24 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 275 – 281 | Basolateral sorting signal | 7 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM3 sub-subfamily.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4220, Eukaryota |
GeneTreei | ENSGT00940000160084 |
HOGENOMi | CLU_009579_11_2_1 |
InParanoidi | P20309 |
OMAi | VIFHKRI |
OrthoDBi | 1245472at2759 |
PhylomeDBi | P20309 |
TreeFami | TF320495 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR001183, Musac_Ach_M3_rcpt IPR000995, Musac_Ach_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00243, MUSCARINICR PR00540, MUSCRINICM3R |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
P20309-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTLHNNSTTS PLFPNISSSW IHSPSDAGLP PGTVTHFGSY NVSRAAGNFS
60 70 80 90 100
SPDGTTDDPL GGHTVWQVVF IAFLTGILAL VTIIGNILVI VSFKVNKQLK
110 120 130 140 150
TVNNYFLLSL ACADLIIGVI SMNLFTTYII MNRWALGNLA CDLWLAIDYV
160 170 180 190 200
ASNASVMNLL VISFDRYFSI TRPLTYRAKR TTKRAGVMIG LAWVISFVLW
210 220 230 240 250
APAILFWQYF VGKRTVPPGE CFIQFLSEPT ITFGTAIAAF YMPVTIMTIL
260 270 280 290 300
YWRIYKETEK RTKELAGLQA SGTEAETENF VHPTGSSRSC SSYELQQQSM
310 320 330 340 350
KRSNRRKYGR CHFWFTTKSW KPSSEQMDQD HSSSDSWNNN DAAASLENSA
360 370 380 390 400
SSDEEDIGSE TRAIYSIVLK LPGHSTILNS TKLPSSDNLQ VPEEELGMVD
410 420 430 440 450
LERKADKLQA QKSVDDGGSF PKSFSKLPIQ LESAVDTAKT SDVNSSVGKS
460 470 480 490 500
TATLPLSFKE ATLAKRFALK TRSQITKRKR MSLVKEKKAA QTLSAILLAF
510 520 530 540 550
IITWTPYNIM VLVNTFCDSC IPKTFWNLGY WLCYINSTVN PVCYALCNKT
560 570 580 590
FRTTFKMLLL CQCDKKKRRK QQYQQRQSVI FHKRAPEQAL
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB1AN12 | B1AN12_HUMAN | Muscarinic acetylcholine receptor M... | CHRM3 | 109 | Annotation score: | ||
A0A6Q8PG67 | A0A6Q8PG67_HUMAN | Muscarinic acetylcholine receptor M... | CHRM3 | 166 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 382 – 384 | KLP → RLS in AAG30036 (PubMed:11238933).Curated | 3 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_033461 | 65 | V → I. Corresponds to variant dbSNP:rs2067481Ensembl. | 1 | |
Natural variantiVAR_049368 | 431 | L → P. Corresponds to variant dbSNP:rs16839102EnsemblClinVar. | 1 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000255380; ENSP00000255380; ENSG00000133019 ENST00000615928; ENSP00000482377; ENSG00000133019 ENST00000675184; ENSP00000502349; ENSG00000133019 ENST00000676153; ENSP00000502667; ENSG00000133019 ENST00000676433; ENSP00000502013; ENSG00000133019 |
GeneIDi | 1131 |
KEGGi | hsa:1131 |
UCSCi | uc001hyp.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2CSA | NMR | - | A | 271-289 | [»] | |
SMRi | P20309 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107553, 76 interactors |
DIPi | DIP-44291N |
IntActi | P20309, 65 interactors |
MINTi | P20309 |
STRINGi | 9606.ENSP00000255380 |
Chemistry databases
BindingDBi | P20309 |
ChEMBLi | CHEMBL245 |
DrugBanki | DB03128, Acetylcholine DB08897, Aclidinium DB05752, ALKS 27 DB00321, Amitriptyline DB00543, Amoxapine DB00517, Anisotropine methylbromide DB04365, Arecoline DB01238, Aripiprazole DB14185, Aripiprazole lauroxil DB00572, Atropine DB00767, Benzquinamide DB01019, Bethanechol DB00835, Brompheniramine DB09300, Butylscopolamine DB00411, Carbamoylcholine DB00185, Cevimeline DB00477, Chlorpromazine DB01239, Chlorprothixene DB00568, Cinnarizine DB00363, Clozapine DB00434, Cyproheptadine DB00496, Darifenacin DB01151, Desipramine DB13720, Diphemanil DB01231, Diphenidol DB00280, Disopyramide DB09167, Dosulepin DB01142, Doxepin DB00366, Doxylamine DB09194, Etoperidone DB06702, Fesoterodine DB00986, Glycopyrronium DB00502, Haloperidol DB06787, Hexocyclium DB11181, Homatropine DB00725, Homatropine methylbromide DB00424, Hyoscyamine DB09262, Imidafenacin DB00458, Imipramine DB00332, Ipratropium DB01625, Isopropamide DB01221, Ketamine DB00408, Loxapine DB00934, Maprotiline DB04843, Mepenzolate DB00454, Meperidine DB06709, Methacholine DB00940, Methantheline DB01403, Methotrimeprazine DB00462, Methscopolamine bromide DB00340, Metixene DB01226, Mivacurium DB00622, Nicardipine DB00540, Nortriptyline DB00334, Olanzapine DB01062, Oxybutynin DB00383, Oxyphencyclimine DB01337, Pancuronium DB00715, Paroxetine DB01085, Pilocarpine DB01338, Pipecuronium DB06153, Pizotifen DB00387, Procyclidine DB01069, Promethazine DB00777, Propiomazine DB12278, Propiverine DB01224, Quetiapine DB11855, Revefenacin DB13581, Rociverine DB00747, Scopolamine DB01591, Solifenacin DB00202, Succinylcholine DB00342, Terfenadine DB00599, Thiopental DB11235, Thonzylamine DB01409, Tiotropium DB01036, Tolterodine DB00193, Tramadol DB00505, Tridihexethyl DB00376, Trihexyphenidyl DB09089, Trimebutine DB00726, Trimipramine DB00809, Tropicamide DB00209, Trospium DB09076, Umeclidinium DB00246, Ziprasidone |
DrugCentrali | P20309 |
GuidetoPHARMACOLOGYi | 15 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P20309, 5 sites |
iPTMneti | P20309 |
PhosphoSitePlusi | P20309 |
Genetic variation databases
BioMutai | CHRM3 |
DMDMi | 113125 |
Proteomic databases
jPOSTi | P20309 |
MassIVEi | P20309 |
MaxQBi | P20309 |
PaxDbi | P20309 |
PeptideAtlasi | P20309 |
PRIDEi | P20309 |
ProteomicsDBi | 53745 |
Protocols and materials databases
Antibodypediai | 4169, 366 antibodies |
DNASUi | 1131 |
Genome annotation databases
Ensembli | ENST00000255380; ENSP00000255380; ENSG00000133019 ENST00000615928; ENSP00000482377; ENSG00000133019 ENST00000675184; ENSP00000502349; ENSG00000133019 ENST00000676153; ENSP00000502667; ENSG00000133019 ENST00000676433; ENSP00000502013; ENSG00000133019 |
GeneIDi | 1131 |
KEGGi | hsa:1131 |
UCSCi | uc001hyp.4, human |
Organism-specific databases
CTDi | 1131 |
DisGeNETi | 1131 |
GeneCardsi | CHRM3 |
HGNCi | HGNC:1952, CHRM3 |
HPAi | ENSG00000133019, Tissue enhanced (retina) |
MalaCardsi | CHRM3 |
MIMi | 100100, phenotype 118494, gene |
neXtProti | NX_P20309 |
OpenTargetsi | ENSG00000133019 |
Orphaneti | 2970, Prune belly syndrome |
PharmGKBi | PA112 |
VEuPathDBi | HostDB:ENSG00000133019.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4220, Eukaryota |
GeneTreei | ENSGT00940000160084 |
HOGENOMi | CLU_009579_11_2_1 |
InParanoidi | P20309 |
OMAi | VIFHKRI |
OrthoDBi | 1245472at2759 |
PhylomeDBi | P20309 |
TreeFami | TF320495 |
Enzyme and pathway databases
PathwayCommonsi | P20309 |
Reactomei | R-HSA-390648, Muscarinic acetylcholine receptors R-HSA-399997, Acetylcholine regulates insulin secretion R-HSA-416476, G alpha (q) signalling events |
SignaLinki | P20309 |
SIGNORi | P20309 |
Miscellaneous databases
BioGRID-ORCSi | 1131, 5 hits in 991 CRISPR screens |
ChiTaRSi | CHRM3, human |
EvolutionaryTracei | P20309 |
GeneWikii | Muscarinic_acetylcholine_receptor_M3 |
GenomeRNAii | 1131 |
Pharosi | P20309, Tclin |
PROi | PR:P20309 |
RNActi | P20309, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000133019, Expressed in endothelial cell and 179 other tissues |
ExpressionAtlasi | P20309, baseline and differential |
Genevisiblei | P20309, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR001183, Musac_Ach_M3_rcpt IPR000995, Musac_Ach_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00243, MUSCARINICR PR00540, MUSCRINICM3R |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ACM3_HUMAN | |
Accessioni | P20309Primary (citable) accession number: P20309 Secondary accession number(s): Q0VAJ8 Q9HB60 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1991 |
Last sequence update: | February 1, 1991 | |
Last modified: | April 7, 2021 | |
This is version 204 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families