CHRM3

Functionⁱ

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.1 Publication

GO - Molecular functionⁱ

acetylcholine binding Source: UniProtKB
G protein-coupled acetylcholine receptor activity Source: UniProtKB
G protein-coupled receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
G protein-coupled serotonin receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
neurotransmitter receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
phosphatidylinositol phospholipase C activity
Source: ProtInc
Traceable author statementⁱ
- 1905013
signaling receptor activity
Source: ProtInc
Traceable author statementⁱ
- 10940357

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cell proliferation
Source: ProtInc
Traceable author statementⁱ
- 8063729
cellular protein modification process
Source: ProtInc
Traceable author statementⁱ
- 10051746
chemical synaptic transmission
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
G protein-coupled acetylcholine receptor signaling pathway Source: UniProtKB
G protein-coupled receptor signaling pathway Source: Reactome
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
nervous system development
Source: ProtInc
Traceable author statementⁱ
- 2739737
positive regulation of smooth muscle contraction Source: Ensembl
regulation of vascular smooth muscle contraction
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
saliva secretion Source: Ensembl
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 10940357
smooth muscle contraction Source: Ensembl
synaptic transmission, cholinergic Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer

Molecular function

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactomeⁱ	R-HSA-390648 Muscarinic acetylcholine receptors R-HSA-399997 Acetylcholine regulates insulin secretion R-HSA-416476 G alpha (q) signalling events
SignaLinkⁱ	P20309

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Muscarinic acetylcholine receptor M3
Gene namesⁱ	Name:CHRM3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000133019.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1952 CHRM3
MIMⁱ	118494 gene
neXtProtⁱ	NX_P20309

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 67	ExtracellularBy similarityAdd BLAST	67
Transmembraneⁱ	68 – 91	Helical; Name=1By similarityAdd BLAST	24
Topological domainⁱ	92 – 104	CytoplasmicBy similarityAdd BLAST	13
Transmembraneⁱ	105 – 130	Helical; Name=2By similarityAdd BLAST	26
Topological domainⁱ	131 – 142	ExtracellularBy similarityAdd BLAST	12
Transmembraneⁱ	143 – 164	Helical; Name=3By similarityAdd BLAST	22
Topological domainⁱ	165 – 184	CytoplasmicBy similarityAdd BLAST	20
Transmembraneⁱ	185 – 206	Helical; Name=4By similarityAdd BLAST	22
Topological domainⁱ	207 – 229	ExtracellularBy similarityAdd BLAST	23
Transmembraneⁱ	230 – 252	Helical; Name=5By similarityAdd BLAST	23
Topological domainⁱ	253 – 491	CytoplasmicBy similarityAdd BLAST	239
Transmembraneⁱ	492 – 514	Helical; Name=6By similarityAdd BLAST	23
Topological domainⁱ	515 – 526	ExtracellularBy similarityAdd BLAST	12
Transmembraneⁱ	527 – 546	Helical; Name=7By similarityAdd BLAST	20
Topological domainⁱ	547 – 590	CytoplasmicBy similarityAdd BLAST	44

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Prune belly syndrome (PBS)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA syndrome characterized by thin abdominal musculature with overlying lax skin, cryptorchism, megacystis with disorganized detrusor muscle, and urinary tract abnormalities.

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	276	E → A: Loss of basolateral sorting. 1 Publication	1
Mutagenesisⁱ	276	E → D: Loss of basolateral sorting. No effect on basolateral sorting; when associated with L-280 and L-281. 1 Publication	1
Mutagenesisⁱ	280	F → A: Loss of basolateral sorting. 1 Publication	1
Mutagenesisⁱ	280	F → L: No effect on basolateral sorting. 1 Publication	1
Mutagenesisⁱ	281	V → A: Loss of basolateral sorting. 1 Publication	1
Mutagenesisⁱ	281	V → L: No effect on basolateral sorting. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1131
MalaCards human disease database More...MalaCardsⁱ	CHRM3
MIMⁱ	100100 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000133019
Orphanetⁱ	2970 Prune belly syndrome
PharmGKBⁱ	PA112

Chemistry databases

ChEMBLⁱ	CHEMBL245
Drug and drug target database More...DrugBankⁱ	DB08897 Aclidinium DB05752 ALKS 27 DB00321 Amitriptyline DB00543 Amoxapine DB00517 Anisotropine Methylbromide DB01238 Aripiprazole DB00572 Atropine DB00767 Benzquinamide DB00835 Brompheniramine DB00185 Cevimeline DB00477 Chlorpromazine DB01239 Chlorprothixene DB00568 Cinnarizine DB00363 Clozapine DB00785 Cryptenamine DB00434 Cyproheptadine DB00496 Darifenacin DB01151 Desipramine DB09357 Dexpanthenol DB00729 Diphemanil Methylsulfate DB01231 Diphenidol DB00280 Disopyramide DB01142 Doxepin DB06702 Fesoterodine DB00986 Glycopyrronium DB00725 Homatropine Methylbromide DB00424 Hyoscyamine DB00458 Imipramine DB00332 Ipratropium bromide DB01625 Isopropamide DB04924 Itopride DB01221 Ketamine DB00408 Loxapine DB00934 Maprotiline DB04843 Mepenzolate DB06709 Methacholine DB01403 Methotrimeprazine DB00462 Methylscopolamine bromide DB00340 Metixene DB01226 Mivacurium DB00622 Nicardipine DB00540 Nortriptyline DB00334 Olanzapine DB01062 Oxybutynin DB00383 Oxyphencyclimine DB01337 Pancuronium DB00715 Paroxetine DB00454 Pethidine DB01085 Pilocarpine DB01338 Pipecuronium DB00387 Procyclidine DB00420 Promazine DB01069 Promethazine DB00777 Propiomazine DB01224 Quetiapine DB00747 Scopolamine DB01591 Solifenacin DB00202 Succinylcholine DB00342 Terfenadine DB01409 Tiotropium DB01036 Tolterodine DB00193 Tramadol DB00505 Tridihexethyl DB00376 Trihexyphenidyl DB00726 Trimipramine DB00809 Tropicamide DB09076 Umeclidinium DB00246 Ziprasidone
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	15

Polymorphism and mutation databases

BioMutaⁱ	CHRM3
DMDMⁱ	113125

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000069029	1 – 590	Muscarinic acetylcholine receptor M3Add BLAST		590

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	5	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	6	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	15	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	41	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	48	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	141 ↔ 221	PROSITE-ProRule annotation
Modified residueⁱ	385	PhosphoserineBy similarity	1
Disulfide bondⁱ	517 ↔ 520	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P20309
PaxDbⁱ	P20309
PeptideAtlas More...PeptideAtlasⁱ	P20309
PRIDEⁱ	P20309
ProteomicsDBⁱ	53745

PTM databases

iPTMnetⁱ	P20309
PhosphoSitePlusⁱ	P20309

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000133019 Expressed in 159 organ(s), highest expression level in endothelial cell
CleanExⁱ	HS_CHRM3
ExpressionAtlasⁱ	P20309 baseline and differential
Genevisibleⁱ	P20309 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA024106 HPA048036

HPAⁱ

HPA024106
HPA048036

Interactionⁱ

Subunit structureⁱ

Homodimer; the dimers can form tetramers (PubMed:23521066). Interacts with NALCN (By similarity).By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
NALCN	Q8IZF0	3	EBI-2687785,EBI-7085333

With

Entry

#Exp.

IntAct

Notes

NALCN

Q8IZF0

3

EBI-2687785,EBI-7085333

Protein-protein interaction databases

BioGridⁱ	107553, 59 interactors
Database of interacting proteins More...DIPⁱ	DIP-44291N
IntActⁱ	P20309, 4 interactors
Molecular INTeraction database More...MINTⁱ	P20309
STRINGⁱ	9606.ENSP00000255380

Chemistry databases

BindingDBⁱ

P20309

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Beta strandⁱ	280 – 283	Combined sources		4

Show more details

3D structure databases

ProteinModelPortalⁱ	P20309
SMRⁱ	P20309
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P20309

EvolutionaryTraceⁱ

P20309

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	148 – 152	Agonist bindingBy similarity		5
Regionⁱ	507 – 530	Agonist bindingBy similarityAdd BLAST		24

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	275 – 281	Basolateral sorting signal		7

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM3 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG4220 Eukaryota ENOG410YCQR LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00780000121874
HOGENOMⁱ	HOG000231484
HOVERGENⁱ	HBG105720
InParanoidⁱ	P20309
KEGG Orthology (KO) More...KOⁱ	K04131
OMAⁱ	CQCDKRK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06VI
PhylomeDBⁱ	P20309
TreeFamⁱ	TF320495

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd15299 7tmA_mAChR_M3, 1 hit
InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR001183 Musac_Ach_M3_rcpt IPR000995 Musac_Ach_rcpt
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR00243 MUSCARINICR PR00540 MUSCRINICM3R
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P20309-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTLHNNSTTS PLFPNISSSW IHSPSDAGLP PGTVTHFGSY NVSRAAGNFS 
        60         70         80         90        100
SPDGTTDDPL GGHTVWQVVF IAFLTGILAL VTIIGNILVI VSFKVNKQLK 
       110        120        130        140        150
TVNNYFLLSL ACADLIIGVI SMNLFTTYII MNRWALGNLA CDLWLAIDYV 
       160        170        180        190        200
ASNASVMNLL VISFDRYFSI TRPLTYRAKR TTKRAGVMIG LAWVISFVLW 
       210        220        230        240        250
APAILFWQYF VGKRTVPPGE CFIQFLSEPT ITFGTAIAAF YMPVTIMTIL 
       260        270        280        290        300
YWRIYKETEK RTKELAGLQA SGTEAETENF VHPTGSSRSC SSYELQQQSM 
       310        320        330        340        350
KRSNRRKYGR CHFWFTTKSW KPSSEQMDQD HSSSDSWNNN DAAASLENSA 
       360        370        380        390        400
SSDEEDIGSE TRAIYSIVLK LPGHSTILNS TKLPSSDNLQ VPEEELGMVD 
       410        420        430        440        450
LERKADKLQA QKSVDDGGSF PKSFSKLPIQ LESAVDTAKT SDVNSSVGKS 
       460        470        480        490        500
TATLPLSFKE ATLAKRFALK TRSQITKRKR MSLVKEKKAA QTLSAILLAF 
       510        520        530        540        550
IITWTPYNIM VLVNTFCDSC IPKTFWNLGY WLCYINSTVN PVCYALCNKT 
       560        570        580        590
FRTTFKMLLL CQCDKKKRRK QQYQQRQSVI FHKRAPEQAL

Length:590

Mass (Da):66,128

Last modified:February 1, 1991 - v1

Checksum:ⁱ5CB473C57B9526E9

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	B1AN12	B1AN12_HUMAN		Muscarinic acetylcholine receptor M... Muscarinic acetylcholine receptor M3	CHRM3	109	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	382 – 384	KLP → RLS in AAG30036 (PubMed:11238933).Curated		3

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_033461	65	V → I. Corresponds to variant dbSNP:rs2067481Ensembl.		1
Natural variantⁱVAR_049368	431	L → P. Corresponds to variant dbSNP:rs16839102Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X15266 Genomic DNA Translation: CAA33337.1 U29589 Genomic DNA Translation: AAA70337.1 AB041395 Genomic DNA Translation: BAA94480.1 AF498917 mRNA Translation: AAM18940.1 AL356361 Genomic DNA No translation available. BC096844 mRNA Translation: AAH96844.1 BC121026 mRNA Translation: AAI21027.1 AF279779 mRNA Translation: AAG30036.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1616.1
PIRⁱ	S10128
NCBI Reference Sequences More...RefSeqⁱ	NP_000731.1, NM_000740.3 NP_001334645.1, NM_001347716.1 XP_005273089.1, XM_005273032.3 XP_011542343.1, XM_011544041.2 XP_011542345.1, XM_011544043.2 XP_011542346.1, XM_011544044.2 XP_011542348.1, XM_011544046.2 XP_011542349.1, XM_011544047.2 XP_016855641.1, XM_017000152.1 XP_016855642.1, XM_017000153.1 XP_016855643.1, XM_017000154.1 XP_016855644.1, XM_017000155.1 XP_016855645.1, XM_017000156.1 XP_016855646.1, XM_017000157.1 XP_016855647.1, XM_017000158.1 XP_016855648.1, XM_017000159.1 XP_016855649.1, XM_017000160.1 XP_016855650.1, XM_017000161.1 XP_016855651.1, XM_017000162.1 XP_016855652.1, XM_017000163.1
UniGeneⁱ	Hs.155736 Hs.7138

Genome annotation databases

Ensemblⁱ	ENST00000255380; ENSP00000255380; ENSG00000133019 ENST00000615928; ENSP00000482377; ENSG00000133019
GeneIDⁱ	1131
KEGGⁱ	hsa:1131
UCSC genome browser More...UCSCⁱ	uc001hyp.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P20309	Muscarinic acetylcholine receptor		HUMAN		590	UniRef100_P20309
CHRM3 (Fragment)		MACMU		122
Muscarinic acetylcholine receptor M3 (Fragment)		HUMAN		109

Protein	Similar proteins		Species	Score	Length	Source
P20309	Muscarinic acetylcholine receptor M3	)	RAT		589	UniRef90_P08483
Muscarinic acetylcholine receptor M3		BOVIN		590
Muscarinic acetylcholine receptor M3		PONPY		590
Muscarinic acetylcholine receptor M3		PIG		590
Muscarinic acetylcholine receptor M3		PANTR		590
+126

Protein	Similar proteins		Species	Score	Length	Source
P20309	Muscarinic acetylcholine receptor M3	)	RAT		589	UniRef50_P08483
Muscarinic acetylcholine receptor M3		PIG		590
Muscarinic acetylcholine receptor M3		BOVIN		590
Muscarinic acetylcholine receptor M3		GORGO		590
Muscarinic acetylcholine receptor M3		PONPY		590
+350

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X15266 Genomic DNA Translation: CAA33337.1 U29589 Genomic DNA Translation: AAA70337.1 AB041395 Genomic DNA Translation: BAA94480.1 AF498917 mRNA Translation: AAM18940.1 AL356361 Genomic DNA No translation available. BC096844 mRNA Translation: AAH96844.1 BC121026 mRNA Translation: AAI21027.1 AF279779 mRNA Translation: AAG30036.1
CCDSⁱ	CCDS1616.1
PIRⁱ	S10128
RefSeqⁱ	NP_000731.1, NM_000740.3 NP_001334645.1, NM_001347716.1 XP_005273089.1, XM_005273032.3 XP_011542343.1, XM_011544041.2 XP_011542345.1, XM_011544043.2 XP_011542346.1, XM_011544044.2 XP_011542348.1, XM_011544046.2 XP_011542349.1, XM_011544047.2 XP_016855641.1, XM_017000152.1 XP_016855642.1, XM_017000153.1 XP_016855643.1, XM_017000154.1 XP_016855644.1, XM_017000155.1 XP_016855645.1, XM_017000156.1 XP_016855646.1, XM_017000157.1 XP_016855647.1, XM_017000158.1 XP_016855648.1, XM_017000159.1 XP_016855649.1, XM_017000160.1 XP_016855650.1, XM_017000161.1 XP_016855651.1, XM_017000162.1 XP_016855652.1, XM_017000163.1
UniGeneⁱ	Hs.155736 Hs.7138

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2CSA	NMR	-	A	271-289	[»]
ProteinModelPortalⁱ	P20309
SMRⁱ	P20309
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107553, 59 interactors
DIPⁱ	DIP-44291N
IntActⁱ	P20309, 4 interactors
MINTⁱ	P20309
STRINGⁱ	9606.ENSP00000255380

Chemistry databases

BindingDBⁱ	P20309
ChEMBLⁱ	CHEMBL245
DrugBankⁱ	DB08897 Aclidinium DB05752 ALKS 27 DB00321 Amitriptyline DB00543 Amoxapine DB00517 Anisotropine Methylbromide DB01238 Aripiprazole DB00572 Atropine DB00767 Benzquinamide DB00835 Brompheniramine DB00185 Cevimeline DB00477 Chlorpromazine DB01239 Chlorprothixene DB00568 Cinnarizine DB00363 Clozapine DB00785 Cryptenamine DB00434 Cyproheptadine DB00496 Darifenacin DB01151 Desipramine DB09357 Dexpanthenol DB00729 Diphemanil Methylsulfate DB01231 Diphenidol DB00280 Disopyramide DB01142 Doxepin DB06702 Fesoterodine DB00986 Glycopyrronium DB00725 Homatropine Methylbromide DB00424 Hyoscyamine DB00458 Imipramine DB00332 Ipratropium bromide DB01625 Isopropamide DB04924 Itopride DB01221 Ketamine DB00408 Loxapine DB00934 Maprotiline DB04843 Mepenzolate DB06709 Methacholine DB01403 Methotrimeprazine DB00462 Methylscopolamine bromide DB00340 Metixene DB01226 Mivacurium DB00622 Nicardipine DB00540 Nortriptyline DB00334 Olanzapine DB01062 Oxybutynin DB00383 Oxyphencyclimine DB01337 Pancuronium DB00715 Paroxetine DB00454 Pethidine DB01085 Pilocarpine DB01338 Pipecuronium DB00387 Procyclidine DB00420 Promazine DB01069 Promethazine DB00777 Propiomazine DB01224 Quetiapine DB00747 Scopolamine DB01591 Solifenacin DB00202 Succinylcholine DB00342 Terfenadine DB01409 Tiotropium DB01036 Tolterodine DB00193 Tramadol DB00505 Tridihexethyl DB00376 Trihexyphenidyl DB00726 Trimipramine DB00809 Tropicamide DB09076 Umeclidinium DB00246 Ziprasidone
GuidetoPHARMACOLOGYⁱ	15

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

iPTMnetⁱ	P20309
PhosphoSitePlusⁱ	P20309

Polymorphism and mutation databases

BioMutaⁱ	CHRM3
DMDMⁱ	113125

Proteomic databases

MaxQBⁱ	P20309
PaxDbⁱ	P20309
PeptideAtlasⁱ	P20309
PRIDEⁱ	P20309
ProteomicsDBⁱ	53745

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1131
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000255380; ENSP00000255380; ENSG00000133019 ENST00000615928; ENSP00000482377; ENSG00000133019
GeneIDⁱ	1131
KEGGⁱ	hsa:1131
UCSCⁱ	uc001hyp.4 human

Organism-specific databases

CTDⁱ	1131
DisGeNETⁱ	1131
EuPathDBⁱ	HostDB:ENSG00000133019.11
GeneCardsⁱ	CHRM3
HGNCⁱ	HGNC:1952 CHRM3
HPAⁱ	HPA024106 HPA048036
MalaCardsⁱ	CHRM3
MIMⁱ	100100 phenotype 118494 gene
neXtProtⁱ	NX_P20309
OpenTargetsⁱ	ENSG00000133019
Orphanetⁱ	2970 Prune belly syndrome
PharmGKBⁱ	PA112
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4220 Eukaryota ENOG410YCQR LUCA
GeneTreeⁱ	ENSGT00780000121874
HOGENOMⁱ	HOG000231484
HOVERGENⁱ	HBG105720
InParanoidⁱ	P20309
KOⁱ	K04131
OMAⁱ	CQCDKRK
OrthoDBⁱ	EOG091G06VI
PhylomeDBⁱ	P20309
TreeFamⁱ	TF320495

Enzyme and pathway databases

Reactomeⁱ	R-HSA-390648 Muscarinic acetylcholine receptors R-HSA-399997 Acetylcholine regulates insulin secretion R-HSA-416476 G alpha (q) signalling events
SignaLinkⁱ	P20309

Miscellaneous databases

ChiTaRSⁱ	CHRM3 human
EvolutionaryTraceⁱ	P20309
GeneWikiⁱ	Muscarinic_acetylcholine_receptor_M3
GenomeRNAiⁱ	1131
Protein Ontology More...PROⁱ	PR:P20309
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000133019 Expressed in 159 organ(s), highest expression level in endothelial cell
CleanExⁱ	HS_CHRM3
ExpressionAtlasⁱ	P20309 baseline and differential
Genevisibleⁱ	P20309 HS

Family and domain databases

CDDⁱ	cd15299 7tmA_mAChR_M3, 1 hit
InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR001183 Musac_Ach_M3_rcpt IPR000995 Musac_Ach_rcpt
Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR00243 MUSCARINICR PR00540 MUSCRINICM3R
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ACM3_HUMAN
Accessionⁱ	P20309Primary (citable) accession number: P20309 Secondary accession number(s): Q0VAJ8 , Q4QRI3, Q5VXY2, Q9HB60
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
	Last sequence update:	February 1, 1991
	Last modified:	November 7, 2018
	This is version 186 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries

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Supporting data

UniProtKB - P20309 (ACM3_HUMAN)

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Muscarinic acetylcholine receptor M3

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ