Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

B-cell receptor CD22

Gene

CD22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei120Sialic acidBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion
LigandLectin

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-5690714 CD22 mediated BCR regulation
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
B-cell receptor CD22
Alternative name(s):
B-lymphocyte cell adhesion molecule
Short name:
BL-CAM
Sialic acid-binding Ig-like lectin 2
Short name:
Siglec-2
T-cell surface antigen Leu-14
CD_antigen: CD22
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CD22
Synonyms:SIGLEC2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000012124.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1643 CD22

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
107266 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P20273

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini20 – 687ExtracellularSequence analysisAdd BLAST668
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei688 – 706HelicalSequence analysisAdd BLAST19
Topological domaini707 – 847CytoplasmicSequence analysisAdd BLAST141

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
933

Open Targets

More...
OpenTargetsi
ENSG00000012124

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26201

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3218

Drug and drug target database

More...
DrugBanki
DB04958 Epratuzumab

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2786

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CD22

Domain mapping of disease mutations (DMDM)

More...
DMDMi
6166019

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001487320 – 847B-cell receptor CD22Add BLAST828

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi39 ↔ 167PROSITE-ProRule annotation
Disulfide bondi44 ↔ 102PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi67N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi101N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi112N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi135N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi161 ↔ 219PROSITE-ProRule annotation
Glycosylationi164N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi231N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi265 ↔ 309PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki288Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Disulfide bondi353 ↔ 396PROSITE-ProRule annotation
Glycosylationi363N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi442 ↔ 484PROSITE-ProRule annotation
Glycosylationi445N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi479N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi529 ↔ 571PROSITE-ProRule annotation
Glycosylationi574N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi616 ↔ 659PROSITE-ProRule annotation
Glycosylationi634N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei725PhosphoserineBy similarity1
Modified residuei726PhosphoserineBy similarity1
Modified residuei729PhosphoserineBy similarity1
Modified residuei762PhosphotyrosineBy similarity1
Modified residuei807PhosphotyrosineBy similarity1
Modified residuei822PhosphotyrosineBy similarity1
Modified residuei842PhosphotyrosineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation of Tyr-762, Tyr-807 and Tyr-822 are involved in binding to SYK, GRB2 and SYK, respectively. Phosphorylation of Tyr-842 is involved in binding to SYK, PLCG2 and PIK3R1/PIK3R2.
Phosphorylated on tyrosine residues by LYN.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P20273

PeptideAtlas

More...
PeptideAtlasi
P20273

PRoteomics IDEntifications database

More...
PRIDEi
P20273

ProteomicsDB human proteome resource

More...
ProteomicsDBi
53740
53741 [P20273-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P20273

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P20273

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

B-lymphocytes.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000012124 Expressed in 176 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P20273 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P20273 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB002418
HPA024353

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Predominantly monomer of isoform CD22-beta. Also found as heterodimer of isoform CD22-beta and a shorter isoform. Interacts with PTPN6/SHP-1, LYN, SYK, PIK3R1/PIK3R2 and PLCG1 upon phosphorylation. Interacts with GRB2, INPP5D and SHC1 upon phosphorylation (By similarity). May form a complex with INPP5D/SHIP, GRB2 and SHC1.By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107371, 15 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
P20273

Protein interaction database and analysis system

More...
IntActi
P20273, 12 interactors

Molecular INTeraction database

More...
MINTi
P20273

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000085219

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P20273

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1847
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P20273

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P20273

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini20 – 138Ig-like V-typeAdd BLAST119
Domaini143 – 235Ig-like C2-type 1Add BLAST93
Domaini242 – 326Ig-like C2-type 2Add BLAST85
Domaini331 – 416Ig-like C2-type 3Add BLAST86
Domaini419 – 500Ig-like C2-type 4Add BLAST82
Domaini505 – 582Ig-like C2-type 5Add BLAST78
Domaini593 – 676Ig-like C2-type 6Add BLAST84

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi760 – 765ITIM motif 16
Motifi794 – 799ITIM motif 26
Motifi820 – 825ITIM motif 36
Motifi840 – 845ITIM motif 46

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IUGI Eukaryota
ENOG410YH8H LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154722

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG005272

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P20273

KEGG Orthology (KO)

More...
KOi
K06467

Identification of Orthologs from Complete Genome Data

More...
OMAi
PPTNYTW

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0FT0

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P20273

TreeFam database of animal gene trees

More...
TreeFami
TF334827

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 7 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013162 CD80_C2-set
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08205 C2-set_2, 1 hit
PF13895 Ig_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409 IG, 7 hits
SM00408 IGc2, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 7 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 5 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform CD22-beta (identifier: P20273-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MHLLGPWLLL LVLEYLAFSD SSKWVFEHPE TLYAWEGACV WIPCTYRALD
60 70 80 90 100
GDLESFILFH NPEYNKNTSK FDGTRLYEST KDGKVPSEQK RVQFLGDKNK
110 120 130 140 150
NCTLSIHPVH LNDSGQLGLR MESKTEKWME RIHLNVSERP FPPHIQLPPE
160 170 180 190 200
IQESQEVTLT CLLNFSCYGY PIQLQWLLEG VPMRQAAVTS TSLTIKSVFT
210 220 230 240 250
RSELKFSPQW SHHGKIVTCQ LQDADGKFLS NDTVQLNVKH TPKLEIKVTP
260 270 280 290 300
SDAIVREGDS VTMTCEVSSS NPEYTTVSWL KDGTSLKKQN TFTLNLREVT
310 320 330 340 350
KDQSGKYCCQ VSNDVGPGRS EEVFLQVQYA PEPSTVQILH SPAVEGSQVE
360 370 380 390 400
FLCMSLANPL PTNYTWYHNG KEMQGRTEEK VHIPKILPWH AGTYSCVAEN
410 420 430 440 450
ILGTGQRGPG AELDVQYPPK KVTTVIQNPM PIREGDTVTL SCNYNSSNPS
460 470 480 490 500
VTRYEWKPHG AWEEPSLGVL KIQNVGWDNT TIACAACNSW CSWASPVALN
510 520 530 540 550
VQYAPRDVRV RKIKPLSEIH SGNSVSLQCD FSSSHPKEVQ FFWEKNGRLL
560 570 580 590 600
GKESQLNFDS ISPEDAGSYS CWVNNSIGQT ASKAWTLEVL YAPRRLRVSM
610 620 630 640 650
SPGDQVMEGK SATLTCESDA NPPVSHYTWF DWNNQSLPYH SQKLRLEPVK
660 670 680 690 700
VQHSGAYWCQ GTNSVGKGRS PLSTLTVYYS PETIGRRVAV GLGSCLAILI
710 720 730 740 750
LAICGLKLQR RWKRTQSQQG LQENSSGQSF FVRNKKVRRA PLSEGPHSLG
760 770 780 790 800
CYNPMMEDGI SYTTLRFPEM NIPRTGDAES SEMQRPPPDC DDTVTYSALH
810 820 830 840
KRQVGDYENV IPDFPEDEGI HYSELIQFGV GERPQAQENV DYVILKH
Length:847
Mass (Da):95,348
Last modified:July 15, 1999 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i38EB0BE4220ACA2D
GO
Isoform CD22-alpha (identifier: P20273-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     241-417: Missing.

Show »
Length:670
Mass (Da):75,799
Checksum:i04F241A74FF61471
GO
Isoform 3 (identifier: P20273-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     330-417: Missing.

Note: No experimental confirmation available.
Show »
Length:759
Mass (Da):85,675
Checksum:i18C7BFA0D4C94AE5
GO
Isoform 4 (identifier: P20273-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     737-751: VRRAPLSEGPHSLGC → RCRVLRDAETSPGLR
     752-847: Missing.

Note: Gene prediction based on EST data.
Show »
Length:751
Mass (Da):84,480
Checksum:i1DA8314C562A6D00
GO
Isoform 5 (identifier: P20273-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-3: MHL → MSL
     4-175: Missing.

Note: No experimental confirmation available.
Show »
Length:675
Mass (Da):75,354
Checksum:iE0969BC34AC17057
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R1M2M0R1M2_HUMAN
B-cell receptor CD22
CD22
225Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QZ01M0QZ01_HUMAN
B-cell receptor CD22
CD22
191Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R2R8M0R2R8_HUMAN
B-cell receptor CD22
CD22
137Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R0R6M0R0R6_HUMAN
B-cell receptor CD22
CD22
158Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QY05M0QY05_HUMAN
B-cell receptor CD22
CD22
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QY14M0QY14_HUMAN
B-cell receptor CD22
CD22
164Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R2M0M0R2M0_HUMAN
B-cell receptor CD22
CD22
133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QYP4M0QYP4_HUMAN
B-cell receptor CD22
CD22
106Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QZP5M0QZP5_HUMAN
B-cell receptor CD22
CD22
38Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R3H1M0R3H1_HUMAN
B-cell receptor CD22
CD22
145Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA36988 differs from that shown. Reason: Frameshift at position 806.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti486A → R in CAA42006 (PubMed:1691828).Curated1
Sequence conflicti788 – 789PD → RT in CAA42006 (PubMed:1691828).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01413334A → T1 PublicationCorresponds to variant dbSNP:rs201453271Ensembl.1
Natural variantiVAR_003913152Q → E Observed with a marginally higher frequency in patients with systemic lupus erythematosus. 1 PublicationCorresponds to variant dbSNP:rs554866571Ensembl.1
Natural variantiVAR_014134203E → K1 PublicationCorresponds to variant dbSNP:rs752024645Ensembl.1
Natural variantiVAR_049903551G → R. Corresponds to variant dbSNP:rs35715143Ensembl.1
Natural variantiVAR_014135639Y → H1 PublicationCorresponds to variant dbSNP:rs1058407Ensembl.1
Natural variantiVAR_003914664S → G1 PublicationCorresponds to variant dbSNP:rs17719289Ensembl.1
Natural variantiVAR_003915669R → C1 PublicationCorresponds to variant dbSNP:rs749980313Ensembl.1
Natural variantiVAR_003916745G → D1 PublicationCorresponds to variant dbSNP:rs10406069Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0546191 – 3MHL → MSL in isoform 5. 1 Publication3
Alternative sequenceiVSP_0546204 – 175Missing in isoform 5. 1 PublicationAdd BLAST172
Alternative sequenceiVSP_002531241 – 417Missing in isoform CD22-alpha. CuratedAdd BLAST177
Alternative sequenceiVSP_045363330 – 417Missing in isoform 3. 1 PublicationAdd BLAST88
Alternative sequenceiVSP_047223737 – 751VRRAP…HSLGC → RCRVLRDAETSPGLR in isoform 4. CuratedAdd BLAST15
Alternative sequenceiVSP_047224752 – 847Missing in isoform 4. CuratedAdd BLAST96

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U62631 Genomic DNA Translation: AAB06448.1
U62631 Genomic DNA Translation: AAB06449.1
X59350 mRNA Translation: CAA42006.1
X52785 mRNA Translation: CAA36988.1 Frameshift.
AK225625 mRNA No translation available.
AC002132 Genomic DNA No translation available.
BC109306 mRNA Translation: AAI09307.1
AB012995 Genomic DNA Translation: BAA36564.1
AB012996 Genomic DNA Translation: BAA36565.1
AB012997 Genomic DNA Translation: BAA36566.1
AB012998 Genomic DNA Translation: BAA36567.1
AB012999 Genomic DNA Translation: BAA36568.1
AB013000 Genomic DNA Translation: BAA36569.1
AB013002 Genomic DNA Translation: BAA36571.1
AB013003 Genomic DNA Translation: BAA36572.1
AB013004 Genomic DNA Translation: BAA36573.1
AB013006 Genomic DNA Translation: BAA36575.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12457.1 [P20273-1]
CCDS54247.1 [P20273-4]
CCDS54248.1 [P20273-3]
CCDS54249.1 [P20273-2]
CCDS62634.1 [P20273-5]

Protein sequence database of the Protein Information Resource

More...
PIRi
A35648

NCBI Reference Sequences

More...
RefSeqi
NP_001172028.1, NM_001185099.1 [P20273-3]
NP_001172029.1, NM_001185100.1 [P20273-4]
NP_001172030.1, NM_001185101.1 [P20273-2]
NP_001265346.1, NM_001278417.1 [P20273-5]
NP_001762.2, NM_001771.3 [P20273-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.579691

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000085219; ENSP00000085219; ENSG00000012124 [P20273-1]
ENST00000341773; ENSP00000339349; ENSG00000012124 [P20273-2]
ENST00000419549; ENSP00000403822; ENSG00000012124 [P20273-5]
ENST00000536635; ENSP00000442279; ENSG00000012124 [P20273-3]
ENST00000544992; ENSP00000441237; ENSG00000012124 [P20273-4]
ENST00000594250; ENSP00000469984; ENSG00000012124 [P20273-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
933

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:933

UCSC genome browser

More...
UCSCi
uc002nzb.6 human [P20273-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Siglec-2 [3 Fc Domains]

Functional Glycomics Gateway - Glycan Binding

Siglec-2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62631 Genomic DNA Translation: AAB06448.1
U62631 Genomic DNA Translation: AAB06449.1
X59350 mRNA Translation: CAA42006.1
X52785 mRNA Translation: CAA36988.1 Frameshift.
AK225625 mRNA No translation available.
AC002132 Genomic DNA No translation available.
BC109306 mRNA Translation: AAI09307.1
AB012995 Genomic DNA Translation: BAA36564.1
AB012996 Genomic DNA Translation: BAA36565.1
AB012997 Genomic DNA Translation: BAA36566.1
AB012998 Genomic DNA Translation: BAA36567.1
AB012999 Genomic DNA Translation: BAA36568.1
AB013000 Genomic DNA Translation: BAA36569.1
AB013002 Genomic DNA Translation: BAA36571.1
AB013003 Genomic DNA Translation: BAA36572.1
AB013004 Genomic DNA Translation: BAA36573.1
AB013006 Genomic DNA Translation: BAA36575.1
CCDSiCCDS12457.1 [P20273-1]
CCDS54247.1 [P20273-4]
CCDS54248.1 [P20273-3]
CCDS54249.1 [P20273-2]
CCDS62634.1 [P20273-5]
PIRiA35648
RefSeqiNP_001172028.1, NM_001185099.1 [P20273-3]
NP_001172029.1, NM_001185100.1 [P20273-4]
NP_001172030.1, NM_001185101.1 [P20273-2]
NP_001265346.1, NM_001278417.1 [P20273-5]
NP_001762.2, NM_001771.3 [P20273-1]
UniGeneiHs.579691

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5VKJX-ray2.12A20-330[»]
5VKMX-ray2.20A20-330[»]
5VL3X-ray3.10Q/R/S/T22-330[»]
ProteinModelPortaliP20273
SMRiP20273
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107371, 15 interactors
ELMiP20273
IntActiP20273, 12 interactors
MINTiP20273
STRINGi9606.ENSP00000085219

Chemistry databases

BindingDBiP20273
ChEMBLiCHEMBL3218
DrugBankiDB04958 Epratuzumab
GuidetoPHARMACOLOGYi2786

PTM databases

iPTMnetiP20273
PhosphoSitePlusiP20273

Polymorphism and mutation databases

BioMutaiCD22
DMDMi6166019

Proteomic databases

PaxDbiP20273
PeptideAtlasiP20273
PRIDEiP20273
ProteomicsDBi53740
53741 [P20273-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000085219; ENSP00000085219; ENSG00000012124 [P20273-1]
ENST00000341773; ENSP00000339349; ENSG00000012124 [P20273-2]
ENST00000419549; ENSP00000403822; ENSG00000012124 [P20273-5]
ENST00000536635; ENSP00000442279; ENSG00000012124 [P20273-3]
ENST00000544992; ENSP00000441237; ENSG00000012124 [P20273-4]
ENST00000594250; ENSP00000469984; ENSG00000012124 [P20273-2]
GeneIDi933
KEGGihsa:933
UCSCiuc002nzb.6 human [P20273-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
933
DisGeNETi933
EuPathDBiHostDB:ENSG00000012124.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CD22
HGNCiHGNC:1643 CD22
HPAiCAB002418
HPA024353
MIMi107266 gene
neXtProtiNX_P20273
OpenTargetsiENSG00000012124
PharmGKBiPA26201

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IUGI Eukaryota
ENOG410YH8H LUCA
GeneTreeiENSGT00940000154722
HOVERGENiHBG005272
InParanoidiP20273
KOiK06467
OMAiPPTNYTW
OrthoDBiEOG091G0FT0
PhylomeDBiP20273
TreeFamiTF334827

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-5690714 CD22 mediated BCR regulation
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CD22 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CD22

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
933

Protein Ontology

More...
PROi
PR:P20273

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000012124 Expressed in 176 organ(s), highest expression level in corpus callosum
ExpressionAtlasiP20273 baseline and differential
GenevisibleiP20273 HS

Family and domain databases

Gene3Di2.60.40.10, 7 hits
InterProiView protein in InterPro
IPR013162 CD80_C2-set
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF08205 C2-set_2, 1 hit
PF13895 Ig_2, 1 hit
SMARTiView protein in SMART
SM00409 IG, 7 hits
SM00408 IGc2, 4 hits
SUPFAMiSSF48726 SSF48726, 7 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCD22_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P20273
Secondary accession number(s): F5GYU4
, F5H7U3, O95699, O95701, O95702, O95703, Q01665, Q32M46, Q92872, Q92873, Q9UQA6, Q9UQA7, Q9UQA8, Q9UQA9, Q9UQB0, Q9Y2A6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: July 15, 1999
Last modified: December 5, 2018
This is version 204 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again