POU3F2

Functionⁱ

Transcription factor that plays a key role in neuronal differentiation (By similarity). Binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides (By similarity). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL1, and promotes transcription of neuronal genes (By similarity).By similarity

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	354 – 413	HomeoboxPROSITE-ProRule annotationAdd BLAST		60

GO - Molecular functionⁱ

DNA-binding transcription factor activity Source: UniProtKB
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 11029584
RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl
transcription coactivator activity Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

astrocyte development Source: Ensembl
cellular response to organic substance Source: Ensembl
cerebral cortex radially oriented cell migration Source: Ensembl
epidermis development Source: Ensembl
forebrain ventricular zone progenitor cell division Source: Ensembl
hypothalamus cell differentiation Source: Ensembl
myelination in peripheral nervous system Source: Ensembl
negative regulation of gene expression Source: Ensembl
nervous system development Source: UniProtKB
neurohypophysis development Source: Ensembl
neuron development Source: UniProtKB
neuron differentiation Source: UniProtKB
neuron fate commitment Source: UniProtKB
neuron fate specification Source: UniProtKB
positive regulation of cell proliferation
Source: MGI
Inferred from direct assayⁱ
- 15024079
positive regulation of multicellular organism growth Source: Ensembl
regulation of axonogenesis Source: Ensembl
regulation of transcription by RNA polymerase II Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding
Biological process	Differentiation, Neurogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

SignaLinkⁱ	P20265
SIGNORⁱ	P20265

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: POU domain, class 3, transcription factor 2 Alternative name(s): Brain-specific homeobox/POU domain protein 2 Short name: Brain-2 Short name: Brn-2 Nervous system-specific octamer-binding transcription factor N-Oct-3 Octamer-binding protein 7 Short name: Oct-7 Octamer-binding transcription factor 7 Short name: OTF-7
Gene namesⁱ	Name:POU3F2 Synonyms:BRN2, OCT7, OTF7
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000184486.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9215 POU3F2
MIMⁱ	600494 gene
neXtProtⁱ	NX_P20265

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5454
Open Targets More...OpenTargetsⁱ	ENSG00000184486
PharmGKBⁱ	PA33539

Chemistry databases

ChEMBLⁱ	CHEMBL4189

ChEMBLⁱ

CHEMBL4189

Polymorphism and mutation databases

BioMutaⁱ	POU3F2
DMDMⁱ	78100757

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000013495	1 – 443	POU domain, class 3, transcription factor 2Add BLAST		443

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	341	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	P20265
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P20265
PaxDbⁱ	P20265
PeptideAtlas More...PeptideAtlasⁱ	P20265
PRIDEⁱ	P20265
ProteomicsDBⁱ	53737 53738 [P20265-2] 53739 [P20265-3]

PTM databases

iPTMnetⁱ	P20265
PhosphoSitePlusⁱ	P20265

Expressionⁱ

Tissue specificityⁱ

Expressed specifically in the neuroectodermal cell lineage.

Gene expression databases

Bgeeⁱ	ENSG00000184486 Expressed in 72 organ(s), highest expression level in cerebral cortex
CleanExⁱ	HS_POU3F2
Genevisibleⁱ	P20265 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA047081 HPA056261

HPAⁱ

HPA047081
HPA056261

Interactionⁱ

Subunit structureⁱ

Interacts with PQBP1 (PubMed:10332029). Interaction with ISL1 (By similarity).By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
itself		2	EBI-1167176,EBI-1167176
EP300	Q09472	3	EBI-1167176,EBI-447295
PAX3	P23760	2	EBI-1167176,EBI-1167564
SOX10	P56693	3	EBI-1167176,EBI-1167533
TBP	P20226	2	EBI-1167176,EBI-355371

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 11029584

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	111450, 8 interactors
IntActⁱ	P20265, 6 interactors
STRINGⁱ	9606.ENSP00000329170

Chemistry databases

BindingDBⁱ

P20265

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P20265
SMRⁱ	P20265
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	262 – 336	POU-specificPROSITE-ProRule annotationAdd BLAST		75

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	68 – 90	Poly-GlyAdd BLAST		23
Compositional biasⁱ	125 – 149	Poly-GlnAdd BLAST		25

Sequence similaritiesⁱ

Belongs to the POU transcription factor family. Class-3 subfamily.Curated

Keywords - Domainⁱ

Homeobox

Phylogenomic databases

eggNOGⁱ	KOG3802 Eukaryota ENOG410XQ7X LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118935
HOGENOMⁱ	HOG000116303
HOVERGENⁱ	HBG053120
InParanoidⁱ	P20265
KEGG Orthology (KO) More...KOⁱ	K09365
OMAⁱ	SFTVNGM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0U0S
PhylomeDBⁱ	P20265
TreeFamⁱ	TF316413

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR010982 Lambda_DNA-bd_dom_sf IPR013847 POU IPR000327 POU_dom IPR016362 TF_POU_3
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit PF00157 Pou, 1 hit
PIRSFⁱ	PIRSF002629 Transcription_factor_POU, 1 hit
PRINTSⁱ	PR00028 POUDOMAIN
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit SM00352 POU, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit SSF47413 SSF47413, 1 hit
PROSITEⁱ	View protein in PROSITE PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit PS00035 POU_1, 1 hit PS00465 POU_2, 1 hit PS51179 POU_3, 1 hit

Sequences (3)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative initiation. Align Add to basket

Isoform N-OCT 3 (identifier: P20265-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATAASNHYS LLTSSASIVH AEPPGGMQQG AGGYREAQSL VQGDYGALQS 
        60         70         80         90        100
NGHPLSHAHQ WITALSHGGG GGGGGGGGGG GGGGGGGGDG SPWSTSPLGQ 
       110        120        130        140        150
PDIKPSVVVQ QGGRGDELHG PGALQQQHQQ QQQQQQQQQQ QQQQQQQQQR 
       160        170        180        190        200
PPHLVHHAAN HHPGPGAWRS AAAAAHLPPS MGASNGGLLY SQPSFTVNGM 
       210        220        230        240        250
LGAGGQPAGL HHHGLRDAHD EPHHADHHPH PHSHPHQQPP PPPPPQGPPG 
       260        270        280        290        300
HPGAHHDPHS DEDTPTSDDL EQFAKQFKQR RIKLGFTQAD VGLALGTLYG 
       310        320        330        340        350
NVFSQTTICR FEALQLSFKN MCKLKPLLNK WLEEADSSSG SPTSIDKIAA 
       360        370        380        390        400
QGRKRKKRTS IEVSVKGALE SHFLKCPKPS AQEITSLADS LQLEKEVVRV 
       410        420        430        440 
WFCNRRQKEK RMTPPGGTLP GAEDVYGGSR DTPPHHGVQT PVQ

Length:443

Mass (Da):46,893

Last modified:September 13, 2005 - v4

Checksum:ⁱD470360894D788C6

GO

Isoform N-OCT 5A (identifier: P20265-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-180: Missing.

« Hide

        10         20         30         40         50
MGASNGGLLY SQPSFTVNGM LGAGGQPAGL HHHGLRDAHD EPHHADHHPH 
        60         70         80         90        100
PHSHPHQQPP PPPPPQGPPG HPGAHHDPHS DEDTPTSDDL EQFAKQFKQR 
       110        120        130        140        150
RIKLGFTQAD VGLALGTLYG NVFSQTTICR FEALQLSFKN MCKLKPLLNK 
       160        170        180        190        200
WLEEADSSSG SPTSIDKIAA QGRKRKKRTS IEVSVKGALE SHFLKCPKPS 
       210        220        230        240        250
AQEITSLADS LQLEKEVVRV WFCNRRQKEK RMTPPGGTLP GAEDVYGGSR 
       260 
DTPPHHGVQT PVQ

Show »

Length:263

Mass (Da):28,723

Checksum:ⁱ8E6F82E65137A377

GO

Isoform N-OCT 5B (identifier: P20265-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-199: Missing.

« Hide

        10         20         30         40         50
MLGAGGQPAG LHHHGLRDAH DEPHHADHHP HPHSHPHQQP PPPPPPQGPP 
        60         70         80         90        100
GHPGAHHDPH SDEDTPTSDD LEQFAKQFKQ RRIKLGFTQA DVGLALGTLY 
       110        120        130        140        150
GNVFSQTTIC RFEALQLSFK NMCKLKPLLN KWLEEADSSS GSPTSIDKIA 
       160        170        180        190        200
AQGRKRKKRT SIEVSVKGAL ESHFLKCPKP SAQEITSLAD SLQLEKEVVR 
       210        220        230        240 
VWFCNRRQKE KRMTPPGGTL PGAEDVYGGS RDTPPHHGVQ TPVQ

Show »

Length:244

Mass (Da):26,841

Checksum:ⁱD185AA0BBD6C33C7

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	26	G → A in CAA77990 (PubMed:8441633).Curated	1
Sequence conflictⁱ	170	S → T (PubMed:8441633).Curated	1
Sequence conflictⁱ	170	S → T (PubMed:7651733).Curated	1
Sequence conflictⁱ	207	P → S in AAH51699 (PubMed:15489334).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_018750	1 – 199	Missing in isoform N-OCT 5B. CuratedAdd BLAST		199
Alternative sequenceⁱVSP_018749	1 – 180	Missing in isoform N-OCT 5A. CuratedAdd BLAST		180

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z11933 mRNA Translation: CAA77990.1 L37868 Genomic DNA Translation: AAB59611.1 AL022395 Genomic DNA No translation available. BC051699 mRNA Translation: AAH51699.2
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5040.1 [P20265-1]
PIRⁱ	S29334
NCBI Reference Sequences More...RefSeqⁱ	NP_005595.2, NM_005604.3 [P20265-1]
UniGeneⁱ	Hs.182505

Genome annotation databases

Ensemblⁱ	ENST00000328345; ENSP00000329170; ENSG00000184486 [P20265-1]
GeneIDⁱ	5454
KEGGⁱ	hsa:5454
UCSC genome browser More...UCSCⁱ	uc003ppe.4 human [P20265-1]

Keywords - Coding sequence diversityⁱ

Alternative initiation

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P20265	POU domain protein		PANTR		443	UniRef100_P20265
POU domain protein		PONAB		443
POU domain protein		PONPY		443
POU domain protein		western gorilla		443
P20265-2	Isoform N-OCT 5B of POU domain, class 3, transcription factor 2		HUMAN		244	UniRef100_P20265-2
UPI0006C9C30E		PANPA		568
P20265-3	Isoform N-OCT 5A of POU domain, class 3, transcription factor 2		HUMAN		263	UniRef100_P20265-2
UPI0006C9C30E		PANPA		568

Protein	Similar proteins		Species	Score	Length	Source
P20265	POU domain, class 3, transcription factor 2		MOUSE		445	UniRef90_P31360
POU domain, class 3, transcription factor 2		RAT		445
POU domain, class 3, transcription factor 2 (Fragment)		MACMU		77
POU domain protein		MESAU		445
POU domain protein		MONDO		444
+33
P20265-2	Isoform N-OCT 5B of POU domain, class 3, transcription factor 2		HUMAN		244	UniRef90_P20265-2
UPI0006C9C30E		PANPA		568
P20265-3	Isoform N-OCT 5A of POU domain, class 3, transcription factor 2		HUMAN		263	UniRef90_P20265-2
UPI0006C9C30E		PANPA		568

Protein	Similar proteins		Species	Score	Length	Source
P20265	POU domain, class 3, transcription factor 2		MOUSE		445	UniRef50_P31360
POU domain, class 3, transcription factor 2		RAT		445
POU domain, class 3, transcription factor 2-B		XENLA		385
POU domain, class 3, transcription factor 4		MESAU		361
POU domain, class 3, transcription factor 4		HUMAN		361
+206
P20265-2	Isoform N-OCT 5B of POU domain, class 3, transcription factor 2		HUMAN		244	UniRef50_P20265-2
POU domain, class 3, transcription factor 2		MYOBR		123
POU domain protein (Fragment)		HETGA		233
POU class 3 homeobox 2 (Fragment)		NEOVI		83
POU domain, class 3, transcription factor 2		TARSY		123
+16
P20265-3	Isoform N-OCT 5A of POU domain, class 3, transcription factor 2		HUMAN		263	UniRef50_P20265-2
POU domain, class 3, transcription factor 2		MYOBR		123
POU domain protein (Fragment)		HETGA		233
POU class 3 homeobox 2 (Fragment)		NEOVI		83
POU domain, class 3, transcription factor 2		TARSY		123
+16

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z11933 mRNA Translation: CAA77990.1 L37868 Genomic DNA Translation: AAB59611.1 AL022395 Genomic DNA No translation available. BC051699 mRNA Translation: AAH51699.2
CCDSⁱ	CCDS5040.1 [P20265-1]
PIRⁱ	S29334
RefSeqⁱ	NP_005595.2, NM_005604.3 [P20265-1]
UniGeneⁱ	Hs.182505

3D structure databases

ProteinModelPortalⁱ	P20265
SMRⁱ	P20265
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111450, 8 interactors
IntActⁱ	P20265, 6 interactors
STRINGⁱ	9606.ENSP00000329170

Chemistry databases

BindingDBⁱ	P20265
ChEMBLⁱ	CHEMBL4189

PTM databases

iPTMnetⁱ	P20265
PhosphoSitePlusⁱ	P20265

Polymorphism and mutation databases

BioMutaⁱ	POU3F2
DMDMⁱ	78100757

Proteomic databases

EPDⁱ	P20265
MaxQBⁱ	P20265
PaxDbⁱ	P20265
PeptideAtlasⁱ	P20265
PRIDEⁱ	P20265
ProteomicsDBⁱ	53737 53738 [P20265-2] 53739 [P20265-3]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000328345; ENSP00000329170; ENSG00000184486 [P20265-1]
GeneIDⁱ	5454
KEGGⁱ	hsa:5454
UCSCⁱ	uc003ppe.4 human [P20265-1]

Organism-specific databases

CTDⁱ	5454
DisGeNETⁱ	5454
EuPathDBⁱ	HostDB:ENSG00000184486.8
GeneCardsⁱ	POU3F2
HGNCⁱ	HGNC:9215 POU3F2
HPAⁱ	HPA047081 HPA056261
MIMⁱ	600494 gene
neXtProtⁱ	NX_P20265
OpenTargetsⁱ	ENSG00000184486
PharmGKBⁱ	PA33539
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3802 Eukaryota ENOG410XQ7X LUCA
GeneTreeⁱ	ENSGT00760000118935
HOGENOMⁱ	HOG000116303
HOVERGENⁱ	HBG053120
InParanoidⁱ	P20265
KOⁱ	K09365
OMAⁱ	SFTVNGM
OrthoDBⁱ	EOG091G0U0S
PhylomeDBⁱ	P20265
TreeFamⁱ	TF316413

Enzyme and pathway databases

SignaLinkⁱ	P20265
SIGNORⁱ	P20265

Miscellaneous databases

ChiTaRSⁱ	POU3F2 human
GeneWikiⁱ	POU3F2
GenomeRNAiⁱ	5454
Protein Ontology More...PROⁱ	PR:P20265
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000184486 Expressed in 72 organ(s), highest expression level in cerebral cortex
CleanExⁱ	HS_POU3F2
Genevisibleⁱ	P20265 HS

Family and domain databases

CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR010982 Lambda_DNA-bd_dom_sf IPR013847 POU IPR000327 POU_dom IPR016362 TF_POU_3
Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit PF00157 Pou, 1 hit
PIRSFⁱ	PIRSF002629 Transcription_factor_POU, 1 hit
PRINTSⁱ	PR00028 POUDOMAIN
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit SM00352 POU, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit SSF47413 SSF47413, 1 hit
PROSITEⁱ	View protein in PROSITE PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit PS00035 POU_1, 1 hit PS00465 POU_2, 1 hit PS51179 POU_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PO3F2_HUMAN
Accessionⁱ	P20265Primary (citable) accession number: P20265 Secondary accession number(s): Q14960, Q86V54, Q9UJL0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
	Last sequence update:	September 13, 2005
	Last modified:	September 12, 2018
	This is version 191 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM
SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

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UniRef

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Supporting data

UniProtKB - P20265 (PO3F2_HUMAN)

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POU domain, class 3, transcription factor 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ