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UniProtKB - P20241 (NRG_DROME)

Entry version 214 (07 Oct 2020)
Sequence version 2 (01 Jun 2001)
Previous versions | rss
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Protein

Neuroglian

Gene

Nrg

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The long isoform may play a role in neural and glial cell adhesion in the developing embryo. The short isoform may be a more general cell adhesion molecule involved in other tissues and imaginal disk morphogenesis. Vital for embryonic development. Essential for septate junctions. Septate junctions, which are the equivalent of vertebrates tight junctions, are characterized by regular arrays of transverse structures that span the intermembrane space and form a physical barrier to diffusion. Required for the blood-brain barrier formation.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium ion binding Source: FlyBase
  • cell adhesion molecule binding Source: FlyBase
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processCell adhesion

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neuroglian
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nrg
ORF Names:CG1634
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0264975, Nrg

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini24 – 1138ExtracellularSequence analysisAdd BLAST1115
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1139 – 1154HelicalSequence analysisAdd BLAST16
Topological domaini1155 – 1302CytoplasmicSequence analysisAdd BLAST148

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 231 PublicationAdd BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001505524 – 1302NeuroglianAdd BLAST1279

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi59 ↔ 111PROSITE-ProRule annotation
Disulfide bondi155 ↔ 212By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi182N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi198N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi268 ↔ 317By similarity
Disulfide bondi360 ↔ 410By similarity
Glycosylationi411N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi448N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi625 ↔ 706PROSITE-ProRule annotation1 Publication
Glycosylationi652N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi683N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi821N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1125N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P20241

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P20241

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Long isoform is restricted to surface of neurons and glia in the developing nervous system and the short isoform to other non-neuronal tissues.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0264975, Expressed in oviduct (Drosophila) and 50 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P20241, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P20241, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a complex with Nrx and Cont.

1 Publication

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		58251, 24 interactors

Database of interacting proteins

More...DIPi		DIP-22412N

Protein interaction database and analysis system

More...IntActi		P20241, 79 interactors

STRING: functional protein association networks

More...STRINGi		7227.FBpp0297081

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11302
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P20241

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P20241

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini29 – 133Ig-like C2-type 1Add BLAST105
Domaini134 – 225Ig-like C2-type 2Add BLAST92
Domaini245 – 330Ig-like C2-type 3Add BLAST86
Domaini339 – 426Ig-like C2-type 4Add BLAST88
Domaini432 – 524Ig-like C2-type 5Add BLAST93
Domaini521 – 610Ig-like C2-type 6Add BLAST90
Domaini614 – 711Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST98
Domaini716 – 813Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST98
Domaini818 – 915Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST98
Domaini916 – 1017Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST102
Domaini1021 – 1119Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST99

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3513, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P20241

KEGG Orthology (KO)

More...KOi		K06756

Identification of Orthologs from Complete Genome Data

More...OMAi		WEPQGDN

Database for complete collections of gene phylogenies

More...PhylomeDBi		P20241

Family and domain databases

Conserved Domains Database

More...CDDi		cd00063, FN3, 5 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 11 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR013151, Immunoglobulin
IPR026966, Neurofascin/L1/NrCAM_C

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13882, Bravo_FIGEY, 1 hit
PF00041, fn3, 3 hits
PF07679, I-set, 2 hits
PF00047, ig, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00060, FN3, 5 hits
SM00409, IG, 6 hits
SM00408, IGc2, 6 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48726, SSF48726, 6 hits
SSF49265, SSF49265, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50853, FN3, 5 hits
PS50835, IG_LIKE, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform B (identifier: P20241-1) [UniParc]FASTAAdd to basket
Also known as: 180 kDa form

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWRQSTILAA LLVALLCAGS AESKGNRPPR ITKQPAPGEL LFKVAQQNKE 
        60         70         80         90        100
SDNPFIIECE ADGQPEPEYS WIKNGKKFDW QAYDNRMLRQ PGRGTLVITI 
       110        120        130        140        150
PKDEDRGHYQ CFASNEFGTA TSNSVYVRKA ELNAFKDEAA KTLEAVEGEP 
       160        170        180        190        200
FMLKCAAPDG FPSPTVNWMI QESIDGSIKS INNSRMTLDP EGNLWFSNVT 
       210        220        230        240        250
REDASSDFYY ACSATSVFRS EYKIGNKVLL DVKQMGVSAS QNKHPPVRQY 
       260        270        280        290        300
VSRRQSLALR GKRMELFCIY GGTPLPQTVW SKDGQRIQWS DRITQGHYGK 
       310        320        330        340        350
SLVIRQTNFD DAGTYTCDVS NGVGNAQSFS IILNVNSVPY FTKEPEIATA 
       360        370        380        390        400
AEDEEVVFEC RAAGVPEPKI SWIHNGKPIE QSTPNPRRTV TDNTIRIINL 
       410        420        430        440        450
VKGDTGNYGC NATNSLGYVY KDVYLNVQAE PPTISEAPAA VSTVDGRNVT 
       460        470        480        490        500
IKCRVNGSPK PLVKWLRASN WLTGGRYNVQ ANGDLEIQDV TFSDAGKYTC 
       510        520        530        540        550
YAQNKFGEIQ ADGSLVVKEH TRITQEPQNY EVAAGQSATF RCNEAHDDTL 
       560        570        580        590        600
EIEIDWWKDG QSIDFEAQPR FVKTNDNSLT IAKTMELDSG EYTCVARTRL 
       610        620        630        640        650
DEATARANLI VQDVPNAPKL TGITCQADKA EIHWEQQGDN RSPILHYTIQ 
       660        670        680        690        700
FNTSFTPASW DAAYEKVPNT DSSFVVQMSP WANYTFRVIA FNKIGASPPS 
       710        720        730        740        750
AHSDSCTTQP DVPFKNPDNV VGQGTEPNNL VISWTPMPEI EHNAPNFHYY 
       760        770        780        790        800
VSWKRDIPAA AWENNNIFDW RQNNIVIADQ PTFVKYLIKV VAINDRGESN 
       810        820        830        840        850
VAAEEVVGYS GEDRPLDAPT NFTMRQITSS TSGYMAWTPV SEESVRGHFK 
       860        870        880        890        900
GYKIQTWTEN EGEEGLREIH VKGDTHNALV TQFKPDSKNY ARILAYNGRF 
       910        920        930        940        950
NGPPSAVIDF DTPEGVPSPV QGLDAYPLGS SAFMLHWKKP LYPNGKLTGY 
       960        970        980        990       1000
KIYYEEVKES YVGERREYDP HITDPRVTRM KMAGLKPNSK YRISITATTK 
      1010       1020       1030       1040       1050
MGEGSEHYIE KTTLKDAVNV APATPSFSWE QLPSDNGLAK FRINWLPSTE 
      1060       1070       1080       1090       1100
GHPGTHFFTM HRIKGETQWI RENEEKNSDY QEVGGLDPET AYEFRVVSVD 
      1110       1120       1130       1140       1150
GHFNTESATQ EIDTNTVEGP IMVANETVAN AGWFIGMMLA LAFIIILFII 
      1160       1170       1180       1190       1200
ICIIRRNRGG KYDVHDRELA NGRRDYPEEG GFHEYSQPLD NKSAGRQSVS 
      1210       1220       1230       1240       1250
SANKPGVESD TDSMAEYGDG DTGQFTEDGS FIGQYVPGKL QPPVSPQPLN 
      1260       1270       1280       1290       1300
NSAAAHQAAP TAGGSGAAGS AAAAGASGGA SSAGGAAASN GGAAAGAVAT 

YV
Length:1,302
Mass (Da):143,618
Last modified:June 1, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i59BD9DF286756F1A
GO
Isoform A (identifier: P20241-2) [UniParc]FASTAAdd to basket
Also known as: C, 167 kDa form

The sequence of this isoform differs from the canonical sequence as follows:
     1224-1239: QFTEDGSFIGQYVPGK → MNEDGSFIGQYGRKGL
     1240-1302: Missing.

Show »
Length:1,239
Mass (Da):138,362
Checksum:i49E12282D0D7F27D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E1JJF8E1JJF8_DROME
Neuroglian, isoform E
Nrg ceb, CT4318, Dmel\CG1634, fs(1)M72, ibx
1,302Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E1JJF9E1JJF9_DROME
Neuroglian, isoform D
Nrg ceb, CT4318, Dmel\CG1634, fs(1)M72, ibx
1,239Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9NEZ5M9NEZ5_DROME
Neuroglian, isoform G
Nrg ceb, CT4318, Dmel\CG1634, fs(1)M72, ibx
1,309Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti85 – 86NR → KP in AAC28613 (PubMed:9666073).Curated2
Sequence conflicti85 – 86NR → KP in AAC28614 (PubMed:9666073).Curated2
Sequence conflicti1232Missing in ABE01201 (Ref. 7) Curated1
Sequence conflicti1282Missing in CAA53823 (PubMed:1693086).Curated1
Sequence conflicti1299A → V in ABE01201 (Ref. 7) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0026011224 – 1239QFTED…YVPGK → MNEDGSFIGQYGRKGL in isoform A. 3 PublicationsAdd BLAST16
Alternative sequenceiVSP_0026021240 – 1302Missing in isoform A. 3 PublicationsAdd BLAST63

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M28231 mRNA Translation: AAA28728.2
AF050085, AF050084 Genomic DNA Translation: AAC28613.2
AF050085, AF050084 Genomic DNA Translation: AAC28614.2
AE014298 Genomic DNA Translation: AAF46387.1
AE014298 Genomic DNA Translation: AAN09236.1
AE014298 Genomic DNA Translation: AAS65287.1
AY058284 mRNA Translation: AAL13513.1
BT024971 mRNA Translation: ABE01201.1
X76243 mRNA Translation: CAA53822.1
X76244 mRNA Translation: CAA53823.1

Protein sequence database of the Protein Information Resource

More...PIRi		A32579

NCBI Reference Sequences

More...RefSeqi		NP_001162704.1, NM_001169233.2 [P20241-2]
NP_001162705.1, NM_001169234.3 [P20241-1]
NP_001162706.1, NM_001169235.1 [P20241-2]
NP_001259336.1, NM_001272407.2 [P20241-2]
NP_001259337.1, NM_001272408.1 [P20241-1]
NP_511090.1, NM_078535.3 [P20241-2]
NP_727274.1, NM_167160.2 [P20241-1]
NP_996380.1, NM_206657.4 [P20241-2]

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0071207; FBpp0071154; FBgn0264975 [P20241-2]
FBtr0071208; FBpp0071155; FBgn0264975 [P20241-1]
FBtr0071209; FBpp0089326; FBgn0264975 [P20241-2]
FBtr0301762; FBpp0290976; FBgn0264975 [P20241-2]
FBtr0301763; FBpp0290977; FBgn0264975 [P20241-1]
FBtr0301764; FBpp0290978; FBgn0264975 [P20241-2]
FBtr0333522; FBpp0305702; FBgn0264975 [P20241-2]
FBtr0333523; FBpp0305703; FBgn0264975 [P20241-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		31792

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG1634

UCSC genome browser

More...UCSCi		CG1634-RC, d. melanogaster

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28231 mRNA Translation: AAA28728.2
AF050085, AF050084 Genomic DNA Translation: AAC28613.2
AF050085, AF050084 Genomic DNA Translation: AAC28614.2
AE014298 Genomic DNA Translation: AAF46387.1
AE014298 Genomic DNA Translation: AAN09236.1
AE014298 Genomic DNA Translation: AAS65287.1
AY058284 mRNA Translation: AAL13513.1
BT024971 mRNA Translation: ABE01201.1
X76243 mRNA Translation: CAA53822.1
X76244 mRNA Translation: CAA53823.1
PIRiA32579
RefSeqiNP_001162704.1, NM_001169233.2 [P20241-2]
NP_001162705.1, NM_001169234.3 [P20241-1]
NP_001162706.1, NM_001169235.1 [P20241-2]
NP_001259336.1, NM_001272407.2 [P20241-2]
NP_001259337.1, NM_001272408.1 [P20241-1]
NP_511090.1, NM_078535.3 [P20241-2]
NP_727274.1, NM_167160.2 [P20241-1]
NP_996380.1, NM_206657.4 [P20241-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CFBX-ray2.00A610-814[»]
SMRiP20241
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi58251, 24 interactors
DIPiDIP-22412N
IntActiP20241, 79 interactors
STRINGi7227.FBpp0297081

PTM databases

iPTMnetiP20241

Proteomic databases

PaxDbiP20241

Genome annotation databases

EnsemblMetazoaiFBtr0071207; FBpp0071154; FBgn0264975 [P20241-2]
FBtr0071208; FBpp0071155; FBgn0264975 [P20241-1]
FBtr0071209; FBpp0089326; FBgn0264975 [P20241-2]
FBtr0301762; FBpp0290976; FBgn0264975 [P20241-2]
FBtr0301763; FBpp0290977; FBgn0264975 [P20241-1]
FBtr0301764; FBpp0290978; FBgn0264975 [P20241-2]
FBtr0333522; FBpp0305702; FBgn0264975 [P20241-2]
FBtr0333523; FBpp0305703; FBgn0264975 [P20241-1]
GeneIDi31792
KEGGidme:Dmel_CG1634
UCSCiCG1634-RC, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		31792
FlyBaseiFBgn0264975, Nrg

Phylogenomic databases

eggNOGiKOG3513, Eukaryota
InParanoidiP20241
KOiK06756
OMAiWEPQGDN
PhylomeDBiP20241

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		31792, 0 hits in 5 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Nrg, fly
EvolutionaryTraceiP20241

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		31792

Protein Ontology

More...PROi		PR:P20241

Gene expression databases

BgeeiFBgn0264975, Expressed in oviduct (Drosophila) and 50 other tissues
ExpressionAtlasiP20241, baseline and differential
GenevisibleiP20241, DM

Family and domain databases

CDDicd00063, FN3, 5 hits
Gene3Di2.60.40.10, 11 hits
InterProiView protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR013151, Immunoglobulin
IPR026966, Neurofascin/L1/NrCAM_C
PfamiView protein in Pfam
PF13882, Bravo_FIGEY, 1 hit
PF00041, fn3, 3 hits
PF07679, I-set, 2 hits
PF00047, ig, 2 hits
SMARTiView protein in SMART
SM00060, FN3, 5 hits
SM00409, IG, 6 hits
SM00408, IGc2, 6 hits
SUPFAMiSSF48726, SSF48726, 6 hits
SSF49265, SSF49265, 3 hits
PROSITEiView protein in PROSITE
PS50853, FN3, 5 hits
PS50835, IG_LIKE, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNRG_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P20241
Secondary accession number(s): A4V452
, O61541, O61542, Q1WWD5, Q24414, Q24415, Q95U64, Q9V3X0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: June 1, 2001
Last modified: October 7, 2020
This is version 214 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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