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Entry version 165 (07 Oct 2020)
Sequence version 1 (01 Feb 1991)
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Protein

Diacylglycerol kinase alpha

Gene

DGKA

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:8034597). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:8034597). Also plays an important role in the biosynthesis of complex lipids. Can also phosphorylate 1-alkyl-2-acylglycerol in vitro as efficiently as diacylglycerol provided it contains an arachidonoyl group. Also involved in the production of alkyl-lysophosphatidic acid, another bioactive lipid, through the phosphorylation of 1-alkyl-2-acetyl glycerol (By similarity).By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Stimulated by calcium and phosphatidylserine.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.13 mM for ATP (at pH 7.4)1 Publication
  2. KM=0.1 mM for ATP (at pH 7.4 and 30 degrees Celsius)1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: glycerolipid metabolism

    This protein is involved in the pathway glycerolipid metabolism, which is part of Lipid metabolism.1 Publication
    View all proteins of this organism that are known to be involved in the pathway glycerolipid metabolism and in Lipid metabolism.

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi122 – 1331PROSITE-ProRule annotationAdd BLAST12
    Calcium bindingi167 – 1782PROSITE-ProRule annotationAdd BLAST12
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri204 – 252Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST49
    Zinc fingeri268 – 318Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST51

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionKinase, Transferase
    Biological processLipid metabolism
    LigandATP-binding, Calcium, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    2.7.1.107, 6170

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-SSC-114508, Effects of PIP2 hydrolysis

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    P20192

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00230

    Chemistry databases

    SwissLipids knowledge resource for lipid biology

    More...
    SwissLipidsi
    SLP:000000924

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Diacylglycerol kinase alpha (EC:2.7.1.1073 Publications)
    Short name:
    DAG kinase alpha
    Alternative name(s):
    80 kDa diacylglycerol kinase
    Diglyceride kinase alpha
    Short name:
    DGK-alpha
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:DGKA
    Synonyms:DAGK, DAGK1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSus scrofa (Pig)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9823 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaSuinaSuidaeSus
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000008227 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi248K → R: No significant effect on diacylglycerol kinase activity. 1 Publication1
    Mutagenesisi383K → N: No significant effect on diacylglycerol kinase activity. 1 Publication1
    Mutagenesisi395K → N: No significant effect on diacylglycerol kinase activity. 1 Publication1
    Mutagenesisi483K → N: No significant effect on diacylglycerol kinase activity. 1 Publication1
    Mutagenesisi492K → R: No significant effect on diacylglycerol kinase activity. 1 Publication1
    Mutagenesisi554K → N: No significant effect on diacylglycerol kinase activity. 1 Publication1

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002184551 – 734Diacylglycerol kinase alphaAdd BLAST734

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei483N6-acetyllysineBy similarity1

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P20192

    PeptideAtlas

    More...
    PeptideAtlasi
    P20192

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P20192

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    P20192

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSSSCG00000000370, Expressed in testis and 34 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    P20192, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    P20192, SS

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Monomer.

    By similarity

    Protein-protein interaction databases

    STRING: functional protein association networks

    More...
    STRINGi
    9823.ENSSSCP00000000387

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini109 – 144EF-hand 1PROSITE-ProRule annotationAdd BLAST36
    Domaini154 – 189EF-hand 2PROSITE-ProRule annotationAdd BLAST36
    Domaini371 – 505DAGKcPROSITE-ProRule annotationAdd BLAST135

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni358 – 505Necessary and sufficient for the diacylglycerol kinase activity1 PublicationAdd BLAST148

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Zinc finger

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Zinc fingeri204 – 252Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST49
    Zinc fingeri268 – 318Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST51

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1169, Eukaryota

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_003770_1_1_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P20192

    KEGG Orthology (KO)

    More...
    KOi
    K00901

    Database of Orthologous Groups

    More...
    OrthoDBi
    633642at2759

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF313104

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd00029, C1, 1 hit
    cd00051, EFh, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    1.10.238.110, 1 hit
    3.40.50.10330, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR017438, ATP-NAD_kinase_N
    IPR029477, DAG_kinase_typeI_N
    IPR037607, DGK
    IPR038199, DGK_typeI_N_sf
    IPR000756, Diacylglycerol_kin_accessory
    IPR001206, Diacylglycerol_kinase_cat_dom
    IPR011992, EF-hand-dom_pair
    IPR018247, EF_Hand_1_Ca_BS
    IPR002048, EF_hand_dom
    IPR016064, NAD/diacylglycerol_kinase_sf
    IPR002219, PE/DAG-bd

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR11255, PTHR11255, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00130, C1_1, 2 hits
    PF14513, DAG_kinase_N, 1 hit
    PF00609, DAGK_acc, 1 hit
    PF00781, DAGK_cat, 1 hit
    PF13499, EF-hand_7, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00109, C1, 2 hits
    SM00045, DAGKa, 1 hit
    SM00046, DAGKc, 1 hit
    SM00054, EFh, 2 hits

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF111331, SSF111331, 1 hit
    SSF47473, SSF47473, 2 hits

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS50146, DAGK, 1 hit
    PS00018, EF_HAND_1, 2 hits
    PS50222, EF_HAND_2, 2 hits
    PS00479, ZF_DAG_PE_1, 2 hits
    PS50081, ZF_DAG_PE_2, 2 hits

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    P20192-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MSKERGLISP SDFAQLQKYM EYSTKKVSDV LKLFEDGEMA EYLQGDAIGY
    60 70 80 90 100
    EGFQQFLKIY LEVDSVPSHL SLALFQSFQT SYCSEETVKR DVVCLSDVSC
    110 120 130 140 150
    YFSLLEGGRP EDKLEFTFKL YDTDRNGILD SSEVDRIIIQ MMRMAEYLDW
    160 170 180 190 200
    DVSELRPILQ EMMKEIDYDG SGSVSLAEWL RAGATTVPLL VLLGLEMTLK
    210 220 230 240 250
    DNGQHMWRPK RFPRPVYCNL CESSIGLGKQ GLSCNLCKYT VHDQCAMKAL
    260 270 280 290 300
    PCEVSTYAKS RKDIGVQTHV WVRGGCESGR CDRCQKKIRI YHSLVGLHCV
    310 320 330 340 350
    WCHLEIHDDC LPAMGHECDC GLLRDHILPP SSIYPSVLAS GQERKVSKTS
    360 370 380 390 400
    QKTTDDLNLS TSEALRIDPV SNTHPLLVFV NPKSGGKQGE RVLWKFQYLL
    410 420 430 440 450
    NPRQVFNLLK DGPEPGLRFF REVPDYRILV CGGDGTVGWI LETIDKANLP
    460 470 480 490 500
    FVPPVAVLPL GTGNDLARCL RWGGGYEGQN LGKILKDLEA SKVVHMDRWS
    510 520 530 540 550
    VEVIPQQTEE KSDPVPFQII NNYFSIGVDA SIAHRFHIMR EKYPEKFNSR
    560 570 580 590 600
    MKNKLWYFEF ATSESIFSTC KKLEESLTVE ICGKPLDLSN LSLEGIAVLN
    610 620 630 640 650
    IPSTHGGSNL WGDTKRPHGD IHGINQALGA MAKVITDPDI LKTCVPDLSD
    660 670 680 690 700
    KRLEVVGLEG AIEMGQIYTK LKNAGHRLAK CSEITFHTTK TLPMQIDGEP
    710 720 730
    WMQTPCTIKI THRNQMPMLV GPPPRSSNFF GFLC
    Length:734
    Mass (Da):82,606
    Last modified:February 1, 1991 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i711C2E66FB4B4E80
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    X53256 mRNA Translation: CAA37347.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    S09156

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_999197.1, NM_214032.2
    XP_005663934.1, XM_005663877.2

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENSSSCT00005020961; ENSSSCP00005012568; ENSSSCG00005012782
    ENSSSCT00015071712; ENSSSCP00015028738; ENSSSCG00015053448
    ENSSSCT00015071920; ENSSSCP00015028848; ENSSSCG00015053448
    ENSSSCT00040003422; ENSSSCP00040001033; ENSSSCG00040002738
    ENSSSCT00040003461; ENSSSCP00040001053; ENSSSCG00040002738
    ENSSSCT00045059915; ENSSSCP00045042055; ENSSSCG00045034839
    ENSSSCT00045060222; ENSSSCP00045042289; ENSSSCG00045034839
    ENSSSCT00055021361; ENSSSCP00055016919; ENSSSCG00055010666
    ENSSSCT00055021423; ENSSSCP00055016971; ENSSSCG00055010666
    ENSSSCT00060098048; ENSSSCP00060042504; ENSSSCG00060071679
    ENSSSCT00060098153; ENSSSCP00060042553; ENSSSCG00060071679
    ENSSSCT00065064046; ENSSSCP00065027748; ENSSSCG00065046800
    ENSSSCT00065064056; ENSSSCP00065027755; ENSSSCG00065046800

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    397097

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    ssc:397097

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    X53256 mRNA Translation: CAA37347.1
    PIRiS09156
    RefSeqiNP_999197.1, NM_214032.2
    XP_005663934.1, XM_005663877.2

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Protein-protein interaction databases

    STRINGi9823.ENSSSCP00000000387

    Chemistry databases

    SwissLipidsiSLP:000000924

    PTM databases

    iPTMnetiP20192

    Proteomic databases

    PaxDbiP20192
    PeptideAtlasiP20192
    PRIDEiP20192

    Genome annotation databases

    EnsembliENSSSCT00005020961; ENSSSCP00005012568; ENSSSCG00005012782
    ENSSSCT00015071712; ENSSSCP00015028738; ENSSSCG00015053448
    ENSSSCT00015071920; ENSSSCP00015028848; ENSSSCG00015053448
    ENSSSCT00040003422; ENSSSCP00040001033; ENSSSCG00040002738
    ENSSSCT00040003461; ENSSSCP00040001053; ENSSSCG00040002738
    ENSSSCT00045059915; ENSSSCP00045042055; ENSSSCG00045034839
    ENSSSCT00045060222; ENSSSCP00045042289; ENSSSCG00045034839
    ENSSSCT00055021361; ENSSSCP00055016919; ENSSSCG00055010666
    ENSSSCT00055021423; ENSSSCP00055016971; ENSSSCG00055010666
    ENSSSCT00060098048; ENSSSCP00060042504; ENSSSCG00060071679
    ENSSSCT00060098153; ENSSSCP00060042553; ENSSSCG00060071679
    ENSSSCT00065064046; ENSSSCP00065027748; ENSSSCG00065046800
    ENSSSCT00065064056; ENSSSCP00065027755; ENSSSCG00065046800
    GeneIDi397097
    KEGGissc:397097

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    1606

    Phylogenomic databases

    eggNOGiKOG1169, Eukaryota
    HOGENOMiCLU_003770_1_1_1
    InParanoidiP20192
    KOiK00901
    OrthoDBi633642at2759
    TreeFamiTF313104

    Enzyme and pathway databases

    UniPathwayiUPA00230
    BRENDAi2.7.1.107, 6170
    ReactomeiR-SSC-114508, Effects of PIP2 hydrolysis
    SABIO-RKiP20192

    Gene expression databases

    BgeeiENSSSCG00000000370, Expressed in testis and 34 other tissues
    ExpressionAtlasiP20192, baseline and differential
    GenevisibleiP20192, SS

    Family and domain databases

    CDDicd00029, C1, 1 hit
    cd00051, EFh, 1 hit
    Gene3Di1.10.238.110, 1 hit
    3.40.50.10330, 1 hit
    InterProiView protein in InterPro
    IPR017438, ATP-NAD_kinase_N
    IPR029477, DAG_kinase_typeI_N
    IPR037607, DGK
    IPR038199, DGK_typeI_N_sf
    IPR000756, Diacylglycerol_kin_accessory
    IPR001206, Diacylglycerol_kinase_cat_dom
    IPR011992, EF-hand-dom_pair
    IPR018247, EF_Hand_1_Ca_BS
    IPR002048, EF_hand_dom
    IPR016064, NAD/diacylglycerol_kinase_sf
    IPR002219, PE/DAG-bd
    PANTHERiPTHR11255, PTHR11255, 1 hit
    PfamiView protein in Pfam
    PF00130, C1_1, 2 hits
    PF14513, DAG_kinase_N, 1 hit
    PF00609, DAGK_acc, 1 hit
    PF00781, DAGK_cat, 1 hit
    PF13499, EF-hand_7, 1 hit
    SMARTiView protein in SMART
    SM00109, C1, 2 hits
    SM00045, DAGKa, 1 hit
    SM00046, DAGKc, 1 hit
    SM00054, EFh, 2 hits
    SUPFAMiSSF111331, SSF111331, 1 hit
    SSF47473, SSF47473, 2 hits
    PROSITEiView protein in PROSITE
    PS50146, DAGK, 1 hit
    PS00018, EF_HAND_1, 2 hits
    PS50222, EF_HAND_2, 2 hits
    PS00479, ZF_DAG_PE_1, 2 hits
    PS50081, ZF_DAG_PE_2, 2 hits

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
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    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDGKA_PIG
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P20192
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: February 1, 1991
    Last modified: October 7, 2020
    This is version 165 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
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