UniProtKB - P20181 (NTF3_MOUSE)
Protein
Neurotrophin-3
Gene
Ntf3
Organism
Mus musculus (Mouse)
Status
Functioni
Seems to promote the survival of visceral and proprioceptive sensory neurons.
GO - Molecular functioni
- chemoattractant activity Source: MGI
- growth factor activity Source: MGI
- nerve growth factor binding Source: MGI
- nerve growth factor receptor binding Source: GO_Central
- neurotrophin p75 receptor binding Source: MGI
GO - Biological processi
- activation of GTPase activity Source: MGI
- activation of MAPK activity Source: MGI
- activation of protein kinase B activity Source: MGI
- axon guidance Source: MGI
- brain development Source: MGI
- enteric nervous system development Source: MGI
- epidermis development Source: MGI
- generation of neurons Source: MGI
- glial cell fate determination Source: MGI
- induction of positive chemotaxis Source: MGI
- mechanoreceptor differentiation Source: MGI
- memory Source: GO_Central
- modulation of chemical synaptic transmission Source: MGI
- myelination Source: MGI
- negative regulation of neuron apoptotic process Source: MGI
- negative regulation of peptidyl-tyrosine phosphorylation Source: MGI
- nerve development Source: MGI
- nerve growth factor signaling pathway Source: GO_Central
- nervous system development Source: MGI
- neuromuscular synaptic transmission Source: MGI
- neuron development Source: MGI
- neuron projection morphogenesis Source: GO_Central
- peripheral nervous system development Source: MGI
- positive regulation of actin cytoskeleton reorganization Source: MGI
- positive regulation of cell migration Source: MGI
- positive regulation of cell population proliferation Source: MGI
- positive regulation of glial cell differentiation Source: MGI
- positive regulation of peptidyl-serine phosphorylation Source: MGI
- positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
- positive regulation of receptor internalization Source: MGI
- positive regulation of transcription by RNA polymerase II Source: MGI
- regulation of apoptotic process Source: MGI
- regulation of neuron apoptotic process Source: MGI
- regulation of neuron differentiation Source: GO_Central
- smooth muscle cell differentiation Source: MGI
- transmembrane receptor protein tyrosine kinase signaling pathway Source: MGI
Keywordsi
Molecular function | Growth factor |
Enzyme and pathway databases
Reactomei | R-MMU-9034013, NTF3 activates NTRK3 signaling R-MMU-9034793, Activated NTRK3 signals through PLCG1 R-MMU-9603381, Activated NTRK3 signals through PI3K |
Names & Taxonomyi
Protein namesi | Recommended name: Neurotrophin-3Short name: NT-3 Alternative name(s): HDNF Nerve growth factor 2 Short name: NGF-2 Neurotrophic factor |
Gene namesi | Name:Ntf3 Synonyms:Ntf-3 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:97380, Ntf3 |
Subcellular locationi
Extracellular region or secreted
Endoplasmic reticulum
- endoplasmic reticulum lumen Source: Reactome
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: GO_Central
Other locations
- axon Source: GO_Central
- cytoplasmic vesicle Source: MGI
- dendrite Source: GO_Central
- synaptic vesicle Source: GO_Central
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
PropeptideiPRO_0000019661 | 19 – 139 | 1 PublicationAdd BLAST | 121 | |
ChainiPRO_0000019662 | 140 – 258 | Neurotrophin-3Add BLAST | 119 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 131 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 153 ↔ 218 | By similarity | ||
Disulfide bondi | 196 ↔ 247 | By similarity | ||
Disulfide bondi | 206 ↔ 249 | By similarity |
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P20181 |
PRIDEi | P20181 |
PTM databases
GlyGeni | P20181, 1 site |
iPTMneti | P20181 |
PhosphoSitePlusi | P20181 |
Expressioni
Tissue specificityi
Brain and peripheral tissues.
Gene expression databases
Bgeei | ENSMUSG00000049107, Expressed in retina and 240 other tissues |
ExpressionAtlasi | P20181, baseline and differential |
Genevisiblei | P20181, MM |
Interactioni
GO - Molecular functioni
- chemoattractant activity Source: MGI
- growth factor activity Source: MGI
- nerve growth factor binding Source: MGI
- nerve growth factor receptor binding Source: GO_Central
- neurotrophin p75 receptor binding Source: MGI
Protein-protein interaction databases
DIPi | DIP-5721N |
STRINGi | 10090.ENSMUSP00000107863 |
Miscellaneous databases
RNActi | P20181, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the NGF-beta family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502R4FK, Eukaryota |
GeneTreei | ENSGT00390000007725 |
HOGENOMi | CLU_059942_1_1_1 |
InParanoidi | P20181 |
OMAi | KQMVDIK |
OrthoDBi | 1156054at2759 |
PhylomeDBi | P20181 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR020408, Nerve_growth_factor-like IPR002072, Nerve_growth_factor-rel IPR019846, Nerve_growth_factor_CS IPR015578, Neurotrophin-3 |
PANTHERi | PTHR11589, PTHR11589, 1 hit PTHR11589:SF4, PTHR11589:SF4, 1 hit |
Pfami | View protein in Pfam PF00243, NGF, 1 hit |
PIRSFi | PIRSF001789, NGF, 1 hit |
PRINTSi | PR01914, NEUROTROPHN3 PR00268, NGF |
SMARTi | View protein in SMART SM00140, NGF, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00248, NGF_1, 1 hit PS50270, NGF_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P20181-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSILFYVIFL AYLRGIQGNS MDQRSLPEDS LNSLIIKLIQ ADILKNKLSK
60 70 80 90 100
QMVDVKENYQ STLPKAEAPR EPEQGEATRS EFQPMIATDT ELLRQQRRYN
110 120 130 140 150
SPRVLLSDST PLEPPPLYLM EDYVGNPVVA NRTSPRRKRY AEHKSHRGEY
160 170 180 190 200
SVCDSESLWV TDKSSAIDIR GHQVTVLGEI KTGNSPVKQY FYETRCKEAR
210 220 230 240 250
PVKNGCRGID DKHWNSQCKT SQTYVRALTS ENNKLVGWRW IRIDTSCVCA
LSRKIGRT
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ3V1A4 | Q3V1A4_MOUSE | Neurotrophin-3 | Ntf3 | 271 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X53257 Genomic DNA Translation: CAA37348.1 BC065785 mRNA Translation: AAH65785.1 |
CCDSi | CCDS20553.1 |
PIRi | S09155 |
RefSeqi | NP_001157506.1, NM_001164034.1 NP_001157507.1, NM_001164035.1 NP_032768.1, NM_008742.3 XP_006505779.1, XM_006505716.2 |
Genome annotation databases
Ensembli | ENSMUST00000050484; ENSMUSP00000052302; ENSMUSG00000049107 |
GeneIDi | 18205 |
KEGGi | mmu:18205 |
UCSCi | uc012esy.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X53257 Genomic DNA Translation: CAA37348.1 BC065785 mRNA Translation: AAH65785.1 |
CCDSi | CCDS20553.1 |
PIRi | S09155 |
RefSeqi | NP_001157506.1, NM_001164034.1 NP_001157507.1, NM_001164035.1 NP_032768.1, NM_008742.3 XP_006505779.1, XM_006505716.2 |
3D structure databases
SMRi | P20181 |
ModBasei | Search... |
Protein-protein interaction databases
DIPi | DIP-5721N |
STRINGi | 10090.ENSMUSP00000107863 |
PTM databases
GlyGeni | P20181, 1 site |
iPTMneti | P20181 |
PhosphoSitePlusi | P20181 |
Proteomic databases
PaxDbi | P20181 |
PRIDEi | P20181 |
Protocols and materials databases
Antibodypediai | 22321, 632 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000050484; ENSMUSP00000052302; ENSMUSG00000049107 |
GeneIDi | 18205 |
KEGGi | mmu:18205 |
UCSCi | uc012esy.1, mouse |
Organism-specific databases
CTDi | 4908 |
MGIi | MGI:97380, Ntf3 |
Phylogenomic databases
eggNOGi | ENOG502R4FK, Eukaryota |
GeneTreei | ENSGT00390000007725 |
HOGENOMi | CLU_059942_1_1_1 |
InParanoidi | P20181 |
OMAi | KQMVDIK |
OrthoDBi | 1156054at2759 |
PhylomeDBi | P20181 |
Enzyme and pathway databases
Reactomei | R-MMU-9034013, NTF3 activates NTRK3 signaling R-MMU-9034793, Activated NTRK3 signals through PLCG1 R-MMU-9603381, Activated NTRK3 signals through PI3K |
Miscellaneous databases
BioGRID-ORCSi | 18205, 0 hits in 17 CRISPR screens |
ChiTaRSi | Nutf2, mouse |
PROi | PR:P20181 |
RNActi | P20181, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000049107, Expressed in retina and 240 other tissues |
ExpressionAtlasi | P20181, baseline and differential |
Genevisiblei | P20181, MM |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR020408, Nerve_growth_factor-like IPR002072, Nerve_growth_factor-rel IPR019846, Nerve_growth_factor_CS IPR015578, Neurotrophin-3 |
PANTHERi | PTHR11589, PTHR11589, 1 hit PTHR11589:SF4, PTHR11589:SF4, 1 hit |
Pfami | View protein in Pfam PF00243, NGF, 1 hit |
PIRSFi | PIRSF001789, NGF, 1 hit |
PRINTSi | PR01914, NEUROTROPHN3 PR00268, NGF |
SMARTi | View protein in SMART SM00140, NGF, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00248, NGF_1, 1 hit PS50270, NGF_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NTF3_MOUSE | |
Accessioni | P20181Primary (citable) accession number: P20181 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1991 |
Last sequence update: | February 1, 1991 | |
Last modified: | December 2, 2020 | |
This is version 167 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families