Neurotrophin-3

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• chemoattractant activity Source: MGI
• growth factor activity Source: MGI
• nerve growth factor binding Source: MGI
• neurotrophin p75 receptor binding Source: MGI <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "Spatiotemporal patterns of expression of neurotrophins and neurotrophin receptors in mice suggest functional roles in testicular and epididymal morphogenesis."
    Russo M.A., Giustizieri M.L., Favale A., Fantini M.C., Campagnolo L., Konda D., Germano F., Farini D., Manna C., Siracusa G.
    Biol. Reprod. 61:1123-1132(1999) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• activation of GTPase activity Source: MGI
• activation of MAPK activity Source: MGI
• activation of protein kinase B activity Source: MGI
• axon guidance Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "A chemoattractant role for NT-3 in proprioceptive axon guidance."
    Genc B., Ozdinler P.H., Mendoza A.E., Erzurumlu R.S.
    PLoS Biol. 2:e403-e403(2004) [PubMed] [Europe PMC] [Abstract]
• brain development Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Neurotrophin-3 is required for proper cerebellar development."
    Bates B., Rios M., Trumpp A., Chen C., Fan G., Bishop J.M., Jaenisch R.
    Nat. Neurosci. 2:115-117(1999) [PubMed] [Europe PMC] [Abstract]
• enteric nervous system development Source: MGIInferred from mutant phenotypeⁱ
  • "Evidence for the involvement of neurotrophins in muscle transdifferentiation and acetylcholine receptor transformation in the esophagus of Myf5(-/-):MyoD(-/-) and NT-3(-/-) embryos."
    Reddy T., Kablar B.
    Dev. Dyn. 231:683-692(2004) [PubMed] [Europe PMC] [Abstract]
• epidermis development Source: MGIInferred from mutant phenotypeⁱ
  • "A new role for neurotrophin-3: involvement in the regulation of hair follicle regression (catagen)."
    Botchkarev V.A., Welker P., Albers K.M., Botchkareva N.V., Metz M., Lewin G.R., Bulfone-Paus S., Peters E.M., Lindner G., Paus R.
    Am. J. Pathol. 153:785-799(1998) [PubMed] [Europe PMC] [Abstract]
• generation of neurons Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Genetic evidence for selective neurotrophin 3 signalling through TrkC but not TrkB in vivo."
    Stenqvist A., Agerman K., Marmigere F., Minichiello L., Ernfors P.
    EMBO Rep. 6:973-978(2005) [PubMed] [Europe PMC] [Abstract]
• glial cell fate determination Source: MGIInferred from mutant phenotypeⁱ
  • "Mice lacking NT-3, and its receptor TrkC, exhibit profound deficiencies in CNS glial cells."
    Kahn M.A., Kumar S., Liebl D., Chang R., Parada L.F., De Vellis J.
    Glia 26:153-165(1999) [PubMed] [Europe PMC] [Abstract]
• induction of positive chemotaxis Source: MGI
• mechanoreceptor differentiation Source: MGIInferred from genetic interactionⁱ
  • "Pacinian corpuscle development involves multiple Trk signaling pathways."
    Sedy J., Szeder V., Walro J.M., Ren Z.G., Nanka O., Tessarollo L., Sieber-Blum M., Grim M., Kucera J.
    Dev. Dyn. 231:551-563(2004) [PubMed] [Europe PMC] [Abstract]
• memory Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• modulation of chemical synaptic transmission Source: MGI
• myelination Source: MGI
• negative regulation of neuron apoptotic process Source: MGIInferred from mutant phenotypeⁱ
  • "Glial precursors clear sensory neuron corpses during development via Jedi-1, an engulfment receptor."
    Wu H.H., Bellmunt E., Scheib J.L., Venegas V., Burkert C., Reichardt L.F., Zhou Z., Farinas I., Carter B.D.
    Nat. Neurosci. 12:1534-1541(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of peptidyl-tyrosine phosphorylation Source: MGI
• nerve development Source: MGIInferred from mutant phenotypeⁱ
  • "Complementary roles of BDNF and NT-3 in vestibular and auditory development."
    Ernfors P., Van De Water T., Loring J., Jaenisch R.
    Neuron 14:1153-1164(1995) [PubMed] [Europe PMC] [Abstract]
• nerve growth factor signaling pathway Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• nervous system development Source: MGI
• neuromuscular synaptic transmission Source: MGIInferred from direct assayⁱ
  • "Muscle spindle-derived neurotrophin 3 regulates synaptic connectivity between muscle sensory and motor neurons."
    Chen H.H., Tourtellotte W.G., Frank E.
    J. Neurosci. 22:3512-3519(2002) [PubMed] [Europe PMC] [Abstract]
• neuron development Source: MGIInferred from mutant phenotypeⁱ
  • "Most classes of dorsal root ganglion neurons are severely depleted but not absent in mice lacking neurotrophin-3."
    Airaksinen M.S., Meyer M.
    Neuroscience 73:907-911(1996) [PubMed] [Europe PMC] [Abstract]
• neuron projection morphogenesis Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• peripheral nervous system development Source: MGIInferred from mutant phenotypeⁱ
  • "Peripheral NT3 signaling is required for ETS protein expression and central patterning of proprioceptive sensory afferents."
    Patel T.D., Kramer I., Kucera J., Niederkofler V., Jessell T.M., Arber S., Snider W.D.
    Neuron 38:403-416(2003) [PubMed] [Europe PMC] [Abstract]
  • "A local action of neurotrophin-3 prevents the death of proliferating sensory neuron precursor cells."
    ElShamy W.M., Ernfors P.
    Neuron 16:963-972(1996) [PubMed] [Europe PMC] [Abstract]
• positive regulation of actin cytoskeleton reorganization Source: MGI
• positive regulation of cell migration Source: MGI
• positive regulation of cell population proliferation Source: MGI
• positive regulation of glial cell differentiation Source: MGI
• positive regulation of peptidyl-serine phosphorylation Source: MGI
• positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
• positive regulation of receptor internalization Source: MGI
• positive regulation of transcription by RNA polymerase II Source: MGIInferred from direct assayⁱ
  • "Peripheral NT3 signaling is required for ETS protein expression and central patterning of proprioceptive sensory afferents."
    Patel T.D., Kramer I., Kucera J., Niederkofler V., Jessell T.M., Arber S., Snider W.D.
    Neuron 38:403-416(2003) [PubMed] [Europe PMC] [Abstract]
• regulation of apoptotic process Source: MGIInferred from sequence orthologyⁱ
  • "Dok5 is involved in the signaling pathway of neurotrophin-3 against TrkC-induced apoptosis."
    Pan Y., Zhang J., Liu W., Shu P., Yin B., Yuan J., Qiang B., Peng X.
    Neurosci. Lett. 553:46-51(2013) [PubMed] [Europe PMC] [Abstract]
• regulation of neuron apoptotic process Source: MGIInferred from direct assayⁱ
  • "The novel neurotrophin-regulated neuronal development-associated protein, NDAP, mediates apoptosis."
    Li H.L., Li Z., Qin L.Y., Liu S., Lau L.T., Han J.S., Yu A.C.
    FEBS Lett. 580:1723-1728(2006) [PubMed] [Europe PMC] [Abstract]
• regulation of neuron differentiation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• smooth muscle cell differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "Evidence for the involvement of neurotrophins in muscle transdifferentiation and acetylcholine receptor transformation in the esophagus of Myf5(-/-):MyoD(-/-) and NT-3(-/-) embryos."
    Reddy T., Kablar B.
    Dev. Dyn. 231:683-692(2004) [PubMed] [Europe PMC] [Abstract]
• transmembrane receptor protein tyrosine kinase signaling pathway Source: MGI

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• chemoattractant activity Source: MGI
• growth factor activity Source: MGI
• nerve growth factor binding Source: MGI
• neurotrophin p75 receptor binding Source: MGITraceable author statementⁱ
  • "Spatiotemporal patterns of expression of neurotrophins and neurotrophin receptors in mice suggest functional roles in testicular and epididymal morphogenesis."
    Russo M.A., Giustizieri M.L., Favale A., Fantini M.C., Campagnolo L., Konda D., Germano F., Farini D., Manna C., Siracusa G.
    Biol. Reprod. 61:1123-1132(1999) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MSILFYVIFL AYLRGIQGNS MDQRSLPEDS LNSLIIKLIQ ADILKNKLSK 
        60         70         80         90        100
QMVDVKENYQ STLPKAEAPR EPEQGEATRS EFQPMIATDT ELLRQQRRYN 
       110        120        130        140        150
SPRVLLSDST PLEPPPLYLM EDYVGNPVVA NRTSPRRKRY AEHKSHRGEY 
       160        170        180        190        200
SVCDSESLWV TDKSSAIDIR GHQVTVLGEI KTGNSPVKQY FYETRCKEAR 
       210        220        230        240        250
PVKNGCRGID DKHWNSQCKT SQTYVRALTS ENNKLVGWRW IRIDTSCVCA 

LSRKIGRT                                               

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot