AZU1

Functionⁱ

This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Acting alone, it does not have antimicrobial activity against the Gram-negative bacteria A.actinomycetemcomitans ATCC 29532, A.actinomycetemcomitans NCTC 9709, A.actinomycetemcomitans FDC-Y4, H.aphrophilus ATCC 13252, E.corrodens ATCC 23834, C.sputigena ATCC 33123, Capnocytophaga sp ATCC 33124, Capnocytophaga sp ATCC 27872 or E.coli ML-35. Has antibacterial activity against C.sputigena ATCC 33123 when acting synergistically with either elastase or cathepsin G.3 Publications

GO - Molecular functionⁱ

heparan sulfate proteoglycan binding
Source: UniProtKB
Inferred from direct assayⁱ
- 15879141
heparin binding
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 11994286
peptidase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 21550830
serine-type endopeptidase activity Source: InterPro
toxic substance binding
Source: UniProtKB
Non-traceable author statementⁱ
- 10534120

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

antimicrobial humoral response
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 11994286
calcium-mediated signaling using intracellular calcium source
Source: UniProtKB
Inferred from genetic interactionⁱ
- 15879141
cell chemotaxis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24008408
cellular extravasation
Source: UniProtKB
Non-traceable author statementⁱ
- 11861296
defense response to Gram-negative bacterium
Source: UniProtKB
Traceable author statementⁱ
- 12465046
defense response to virus
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19274533
glial cell migration
Source: UniProtKB
Inferred from direct assayⁱ
- 12465046
induction of positive chemotaxis
Source: UniProtKB
Non-traceable author statementⁱ
- 12465046
inflammatory response
Source: UniProtKB
Non-traceable author statementⁱ
- 12678126
macrophage chemotaxis
Source: UniProtKB
Non-traceable author statementⁱ
- 1919011
microglial cell activation
Source: UniProtKB
Inferred from expression patternⁱ
- 12465046
monocyte activation
Source: UniProtKB
Traceable author statementⁱ
- 12465046
negative regulation of apoptotic process
Source: UniProtKB
Non-traceable author statementⁱ
- 10510329
neutrophil degranulation Source: Reactome
neutrophil mediated killing of bacterium
Source: UniProtKB
Inferred from direct assayⁱ
- 2312733
positive regulation of cell adhesion
Source: UniProtKB
Inferred from direct assayⁱ
- 12826073
- 15879141
positive regulation of fractalkine biosynthetic process
Source: UniProtKB
Inferred from direct assayⁱ
- 12465046
positive regulation of gene expression
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24008408
positive regulation of interleukin-1 beta biosynthetic process
Source: UniProtKB
Inferred from direct assayⁱ
- 12465046
positive regulation of MHC class II biosynthetic process
Source: UniProtKB
Inferred from expression patternⁱ
- 12465046
positive regulation of peptidyl-threonine phosphorylation
Source: UniProtKB
Inferred from direct assayⁱ
- 24008408
positive regulation of phagocytosis
Source: UniProtKB
Inferred from direct assayⁱ
- 12465046
positive regulation of protein kinase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 24008408
positive regulation of tumor necrosis factor biosynthetic process
Source: UniProtKB
Inferred from direct assayⁱ
- 12465046
protein kinase C-activating G protein-coupled receptor signaling pathway
Source: UniProtKB
Traceable author statementⁱ
- 12465046
protein kinase C signaling
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24008408
proteolysis
Source: UniProtKB
Inferred from direct assayⁱ
- 21550830
regulation of vascular permeability
Source: UniProtKB
Non-traceable author statementⁱ
- 11861296

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Antibiotic, Antimicrobial, Heparin-binding, Serine protease homolog
Biological process	Chemotaxis

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6798695 Neutrophil degranulation

Reactomeⁱ

R-HSA-6798695 Neutrophil degranulation

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	S01.971

MEROPSⁱ

S01.971

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Azurocidin1 Publication Alternative name(s): Cationic antimicrobial protein CAP371 Publication Heparin-binding protein1 Publication Short name: HBP1 Publication Short name: hHBP1 Publication
Gene namesⁱ	Name:AZU1Imported
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000172232.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:913 AZU1
MIMⁱ	162815 gene
neXtProtⁱ	NX_P20160

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	52	C → S: Loss of antibiotic activity. 1 Publication		1
Mutagenesisⁱ	68	C → S: Loss of antibiotic activity. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	566
Open Targets More...OpenTargetsⁱ	ENSG00000172232
PharmGKBⁱ	PA25206

Polymorphism and mutation databases

BioMutaⁱ	AZU1
DMDMⁱ	416746

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 19	1 PublicationAdd BLAST	19
PropeptideⁱPRO_0000435372	20 – 26	Removed in mature form10 Publications	7
PropeptideⁱPRO_0000435373	25 – 26	Dipeptide found in non-mature form1 Publication	2
ChainⁱPRO_0000027705	27 – 248	Azurocidin2 PublicationsAdd BLAST	222
PropeptideⁱPRO_0000027706	249 – 251	Removed in mature form2 Publications	3

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	52 ↔ 68	2 Publications
Glycosylationⁱ	126	N-linked (GlcNAc...) asparagine; partial2 Publications	1
Glycosylationⁱ	140	N-linked (GlcNAc...) asparagine2 Publications	1
Disulfide bondⁱ	149 ↔ 207	2 Publications
Glycosylationⁱ	171	N-linked (GlcNAc...) asparagine; partial2 Publications	1
Disulfide bondⁱ	180 ↔ 186	2 Publications
Disulfide bondⁱ	197 ↔ 222	2 Publications

Post-translational modificationⁱ

Cleavage of the N-terminal propeptide which is composed of 7 amino acids occurs in two steps. The initial cleavage of 5 amino acids is followed by the cleavage of a dipeptide to produce the mature form.1 Publication

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

EPDⁱ	P20160
PaxDbⁱ	P20160
PeptideAtlas More...PeptideAtlasⁱ	P20160
PRIDEⁱ	P20160
ProteomicsDBⁱ	53732

PTM databases

GlyConnectⁱ	1023
iPTMnetⁱ	P20160

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000172232 Expressed in 80 organ(s), highest expression level in trabecular bone tissue
CleanExⁱ	HS_AZU1
ExpressionAtlasⁱ	P20160 baseline and differential
Genevisibleⁱ	P20160 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA055851

HPAⁱ

HPA055851

Interactionⁱ

GO - Molecular functionⁱ

heparan sulfate proteoglycan binding
Source: UniProtKB
Inferred from direct assayⁱ
- 15879141

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	107043, 14 interactors
IntActⁱ	P20160, 2 interactors
Molecular INTeraction database More...MINTⁱ	P20160
STRINGⁱ	9606.ENSP00000233997

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	41 – 46	Combined sources	6
Beta strandⁱ	49 – 58	Combined sources	10
Beta strandⁱ	61 – 64	Combined sources	4
Helixⁱ	66 – 68	Combined sources	3
Beta strandⁱ	76 – 82	Combined sources	7
Turnⁱ	91 – 93	Combined sources	3
Beta strandⁱ	95 – 103	Combined sources	9
Turnⁱ	109 – 112	Combined sources	4
Beta strandⁱ	117 – 123	Combined sources	7
Beta strandⁱ	148 – 154	Combined sources	7
Beta strandⁱ	157 – 160	Combined sources	4
Beta strandⁱ	168 – 174	Combined sources	7
Helixⁱ	177 – 179	Combined sources	3
Beta strandⁱ	184 – 188	Combined sources	5
Beta strandⁱ	190 – 193	Combined sources	4
Beta strandⁱ	204 – 207	Combined sources	4
Beta strandⁱ	210 – 218	Combined sources	9
Beta strandⁱ	227 – 231	Combined sources	5
Helixⁱ	232 – 235	Combined sources	4
Helixⁱ	236 – 244	Combined sources	9

Show more details

3D structure databases

ProteinModelPortalⁱ	P20160
SMRⁱ	P20160
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P20160

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	27 – 244	Peptidase S1PROSITE-ProRule annotationAdd BLAST		218

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	46 – 70	Possesses antibiotic activity1 PublicationAdd BLAST		25

Sequence similaritiesⁱ

Belongs to the peptidase S1 family. Elastase subfamily.PROSITE-ProRule annotation

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	KOG3627 Eukaryota COG5640 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144219
HOGENOMⁱ	HOG000251820
HOVERGENⁱ	HBG013304
InParanoidⁱ	P20160
OMAⁱ	ALFRNWI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0DF7
PhylomeDBⁱ	P20160
TreeFamⁱ	TF335284

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00190 Tryp_SPc, 1 hit
InterProⁱ	View protein in InterPro IPR009003 Peptidase_S1_PA IPR001314 Peptidase_S1A IPR001254 Trypsin_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00089 Trypsin, 1 hit
PRINTSⁱ	PR00722 CHYMOTRYPSIN
SMARTⁱ	View protein in SMART SM00020 Tryp_SPc, 1 hit
SUPFAMⁱ	SSF50494 SSF50494, 1 hit
PROSITEⁱ	View protein in PROSITE PS50240 TRYPSIN_DOM, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P20160-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTRLTVLALL AGLLASSRAG SSPLLDIVGG RKARPRQFPF LASIQNQGRH 
        60         70         80         90        100
FCGGALIHAR FVMTAASCFQ SQNPGVSTVV LGAYDLRRRE RQSRQTFSIS 
       110        120        130        140        150
SMSENGYDPQ QNLNDLMLLQ LDREANLTSS VTILPLPLQN ATVEAGTRCQ 
       160        170        180        190        200
VAGWGSQRSG GRLSRFPRFV NVTVTPEDQC RPNNVCTGVL TRRGGICNGD 
       210        220        230        240        250
GGTPLVCEGL AHGVASFSLG PCGRGPDFFT RVALFRDWID GVLNNPGPGP 

A

Length:251

Mass (Da):26,886

Last modified:October 1, 1993 - v3

Checksum:ⁱ22F80D9EBE87DE60

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A087WXP0	A0A087WXP0_HUMAN		Azurocidin Azurocidin	AZU1	150	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	36	R → H AA sequence (PubMed:2404977).Curated		1
Sequence conflictⁱ	130	S → N AA sequence (PubMed:2026172).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M96326 Genomic DNA Translation: AAB59353.1 AC004799 Genomic DNA No translation available. BC069495 mRNA Translation: AAH69495.1 BC093931 mRNA Translation: AAH93931.1 BC093933 mRNA Translation: AAH93933.1 X58794 mRNA Translation: CAA41601.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12044.1
PIRⁱ	A46268 TRHUAZ
NCBI Reference Sequences More...RefSeqⁱ	NP_001691.1, NM_001700.4
UniGeneⁱ	Hs.72885

Genome annotation databases

Ensemblⁱ	ENST00000233997; ENSP00000233997; ENSG00000172232 ENST00000620695; ENSP00000479183; ENSG00000278624
GeneIDⁱ	566
KEGGⁱ	hsa:566
UCSC genome browser More...UCSCⁱ	uc002lpz.2 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P20160	AZU1 isoform 1		PANTR		253	UniRef90_P20160
Uncharacterized protein		PANPA		253
AZU1 isoform 1		PONAB		251
Azurocidin 1		GORGO		251
UPI00001104B6		HUMAN		225
+3

Protein	Similar proteins		Species	Score	Length	Source
P20160	AZU1 isoform 1		PANTR		253	UniRef50_P20160
Uncharacterized protein		PANPA		253
AZU1 isoform 1		PONAB		251
Azurocidin 1		GORGO		251
azurocidin		Florida manatee		253
+38

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M96326 Genomic DNA Translation: AAB59353.1 AC004799 Genomic DNA No translation available. BC069495 mRNA Translation: AAH69495.1 BC093931 mRNA Translation: AAH93931.1 BC093933 mRNA Translation: AAH93933.1 X58794 mRNA Translation: CAA41601.1
CCDSⁱ	CCDS12044.1
PIRⁱ	A46268 TRHUAZ
RefSeqⁱ	NP_001691.1, NM_001700.4
UniGeneⁱ	Hs.72885

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1A7S	X-ray	1.12	A	27-251	[»]
	1AE5	X-ray	2.30	A	27-251	[»]
	1FY1	X-ray	2.50	A	27-251	[»]
	1FY3	X-ray	1.89	A	27-251	[»]
ProteinModelPortalⁱ	P20160
SMRⁱ	P20160
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107043, 14 interactors
IntActⁱ	P20160, 2 interactors
MINTⁱ	P20160
STRINGⁱ	9606.ENSP00000233997

Protein family/group databases

MEROPSⁱ	S01.971

MEROPSⁱ

S01.971

PTM databases

GlyConnectⁱ	1023
iPTMnetⁱ	P20160

Polymorphism and mutation databases

BioMutaⁱ	AZU1
DMDMⁱ	416746

Proteomic databases

EPDⁱ	P20160
PaxDbⁱ	P20160
PeptideAtlasⁱ	P20160
PRIDEⁱ	P20160
ProteomicsDBⁱ	53732

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	566
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000233997; ENSP00000233997; ENSG00000172232 ENST00000620695; ENSP00000479183; ENSG00000278624
GeneIDⁱ	566
KEGGⁱ	hsa:566
UCSCⁱ	uc002lpz.2 human

Organism-specific databases

CTDⁱ	566
DisGeNETⁱ	566
EuPathDBⁱ	HostDB:ENSG00000172232.9
GeneCardsⁱ	AZU1
HGNCⁱ	HGNC:913 AZU1
HPAⁱ	HPA055851
MIMⁱ	162815 gene
neXtProtⁱ	NX_P20160
OpenTargetsⁱ	ENSG00000172232
PharmGKBⁱ	PA25206
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3627 Eukaryota COG5640 LUCA
GeneTreeⁱ	ENSGT00910000144219
HOGENOMⁱ	HOG000251820
HOVERGENⁱ	HBG013304
InParanoidⁱ	P20160
OMAⁱ	ALFRNWI
OrthoDBⁱ	EOG091G0DF7
PhylomeDBⁱ	P20160
TreeFamⁱ	TF335284

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6798695 Neutrophil degranulation

Reactomeⁱ

R-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

EvolutionaryTraceⁱ	P20160
GeneWikiⁱ	Azurocidin_1
GenomeRNAiⁱ	566
Protein Ontology More...PROⁱ	PR:P20160
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000172232 Expressed in 80 organ(s), highest expression level in trabecular bone tissue
CleanExⁱ	HS_AZU1
ExpressionAtlasⁱ	P20160 baseline and differential
Genevisibleⁱ	P20160 HS

Family and domain databases

CDDⁱ	cd00190 Tryp_SPc, 1 hit
InterProⁱ	View protein in InterPro IPR009003 Peptidase_S1_PA IPR001314 Peptidase_S1A IPR001254 Trypsin_dom
Pfamⁱ	View protein in Pfam PF00089 Trypsin, 1 hit
PRINTSⁱ	PR00722 CHYMOTRYPSIN
SMARTⁱ	View protein in SMART SM00020 Tryp_SPc, 1 hit
SUPFAMⁱ	SSF50494 SSF50494, 1 hit
PROSITEⁱ	View protein in PROSITE PS50240 TRYPSIN_DOM, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CAP7_HUMAN
Accessionⁱ	P20160Primary (citable) accession number: P20160 Secondary accession number(s): P80014 , Q52LG4, Q9UCM1, Q9UCT5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
	Last sequence update:	October 1, 1993
	Last modified:	November 7, 2018
	This is version 185 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Peptidase families
Classification of peptidase families and list of entries
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P20160 (CAP7_HUMAN)

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Azurocidin

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Extracellular region or secreted

Lysosome

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ