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Protein

Serine protease inhibitor Kazal-type 2

Gene

SPINK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Strong inhibitor of acrosin in male and/or female genital tract. Also inhibits trypsin.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei46 – 47Reactive bond2

GO - Molecular functioni

  • endopeptidase inhibitor activity Source: ProtInc
  • serine-type endopeptidase inhibitor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI01.012

Names & Taxonomyi

Protein namesi
Recommended name:
Serine protease inhibitor Kazal-type 2
Alternative name(s):
Acrosin-trypsin inhibitor
Epididymis tissue protein Li 172
HUSI-II
Gene namesi
Name:SPINK2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000128040.10
HGNCiHGNC:11245 SPINK2
MIMi605753 gene
neXtProtiNX_P20155

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi45P → A: No effect on inhibitory activity towards trypsin. 1 Publication1
Mutagenesisi46R → A: Loss of inhibitory activity towards trypsin. 1 Publication1
Mutagenesisi47H → A: Reduces inhibitory activity towards trypsin. 1 Publication1
Mutagenesisi48F → A: Reduces inhibitory activity towards trypsin. 1 Publication1

Organism-specific databases

DisGeNETi6691
OpenTargetsiENSG00000128040
PharmGKBiPA36075

Polymorphism and mutation databases

DMDMi123985

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 231 PublicationAdd BLAST23
ChainiPRO_000001656124 – 84Serine protease inhibitor Kazal-type 2Add BLAST61

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24Pyrrolidone carboxylic acid1 Publication1
Disulfide bondi36 ↔ 66PROSITE-ProRule annotation1 Publication
Disulfide bondi44 ↔ 63PROSITE-ProRule annotation1 Publication
Disulfide bondi52 ↔ 84PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP20155
PeptideAtlasiP20155
PRIDEiP20155
ProteomicsDBi53731

PTM databases

iPTMnetiP20155
PhosphoSitePlusiP20155

Expressioni

Tissue specificityi

Expressed in epididymis (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000128040
CleanExiHS_SPINK2
ExpressionAtlasiP20155 baseline and differential
GenevisibleiP20155 HS

Organism-specific databases

HPAiCAB020824
HPA026813

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi112569, 27 interactors
IntActiP20155, 4 interactors

Structurei

Secondary structure

184
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi27 – 32Combined sources6
Beta strandi51 – 53Combined sources3
Turni62 – 64Combined sources3
Helixi65 – 70Combined sources6
Beta strandi73 – 75Combined sources3
Beta strandi78 – 82Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JXDNMR-A23-84[»]
ProteinModelPortaliP20155
SMRiP20155
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP20155

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 84Kazal-likePROSITE-ProRule annotationAdd BLAST55

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IP08 Eukaryota
ENOG410ZF57 LUCA
GeneTreeiENSGT00530000064285
HOGENOMiHOG000090244
InParanoidiP20155
PhylomeDBiP20155

Family and domain databases

InterProiView protein in InterPro
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
PfamiView protein in Pfam
PF00050 Kazal_1, 1 hit
SMARTiView protein in SMART
SM00280 KAZAL, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
PROSITEiView protein in PROSITE
PS00282 KAZAL_1, 1 hit
PS51465 KAZAL_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20155-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSVLRLAL LLLAVTFAAS LIPQFGLFSK YRTPNCSQYR LPGCPRHFNP
60 70 80
VCGSDMSTYA NECTLCMKIR EGGHNIKIIR NGPC
Length:84
Mass (Da):9,291
Last modified:December 1, 1992 - v2
Checksum:iE1DE1792BFB1BB85
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91438 Genomic DNA Translation: AAB59431.1
X57655 mRNA Translation: CAB37834.1
M84967 Genomic DNA No translation available.
GU727622 mRNA Translation: ADU87624.1
AK312222 mRNA Translation: BAG35155.1
CR542135 mRNA Translation: CAG46932.1
CH471057 Genomic DNA Translation: EAX05513.1
BC022514 mRNA Translation: AAH22514.1
CCDSiCCDS3508.1
PIRiJU0152
RefSeqiNP_001258650.1, NM_001271721.1
NP_001258651.1, NM_001271722.1
NP_066937.1, NM_021114.3
UniGeneiHs.98243

Genome annotation databases

EnsembliENST00000248701; ENSP00000248701; ENSG00000128040
GeneIDi6691
KEGGihsa:6691
UCSCiuc003hcg.3 human

Similar proteinsi

Entry informationi

Entry nameiISK2_HUMAN
AccessioniPrimary (citable) accession number: P20155
Secondary accession number(s): Q6FGH2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: December 1, 1992
Last modified: June 20, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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