Protein ultraspiracle

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• core promoter sequence-specific DNA binding Source: CAFA <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "The composite nature of the interaction between nuclear receptors EcR and DHR38."
    Zoglowek A., Orlowski M., Pakula S., Dutko-Gwozdz J., Pajdzik D., Gwozdz T., Rymarczyk G., Wieczorek E., Dobrucki J., Dobryszycki P., Ozyhar A.
    Biol Chem 393:457-471(2012) [PubMed] [Europe PMC] [Abstract]
• DNA binding Source: FlyBase <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Ecdysone- and NO-mediated gene regulation by competing EcR/Usp and E75A nuclear receptors during Drosophila development."
    Johnston D.M., Sedkov Y., Petruk S., Riley K.M., Fujioka M., Jaynes J.B., Mazo A.
    Mol Cell 44:51-61(2011) [PubMed] [Europe PMC] [Abstract]
• hormone binding Source: FlyBaseInferred from direct assayⁱ
  • "Ligand binding pocket function of Drosophila USP is necessary for metamorphosis."
    Jones G., Teal P., Henrich V.C., Krzywonos A., Sapa A., Wozniak M., Smolka J., Jones D.
    Gen Comp Endocrinol 182:73-82(2013) [PubMed] [Europe PMC] [Abstract]
• lipid binding Source: FlyBaseInferred from direct assayⁱ
  • "The structure of the ultraspiracle ligand-binding domain reveals a nuclear receptor locked in an inactive conformation."
    Clayton G.M., Peak-Chew S.Y., Evans R.M., Schwabe J.W.
    Proc Natl Acad Sci U S A 98:1549-1554(2001) [PubMed] [Europe PMC] [Abstract]
• nuclear receptor activity Source: FlyBaseInferred from direct assayⁱ
  • "DNA binding and heteromerization of the Drosophila transcription factor chorion factor 1/ultraspiracle."
    Christianson A.M., King D.L., Hatzivassiliou E., Casas J.E., Hallenbeck P.L., Nikodem V.M., Mitsialis S.A., Kafatos F.C.
    Proc Natl Acad Sci U S A 89:11503-11507(1992) [PubMed] [Europe PMC] [Abstract]
• protein heterodimerization activity Source: CAFAInferred from mutant phenotypeⁱ
  • "The composite nature of the interaction between nuclear receptors EcR and DHR38."
    Zoglowek A., Orlowski M., Pakula S., Dutko-Gwozdz J., Pajdzik D., Gwozdz T., Rymarczyk G., Wieczorek E., Dobrucki J., Dobryszycki P., Ozyhar A.
    Biol Chem 393:457-471(2012) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• signaling receptor binding Source: CAFA <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "The composite nature of the interaction between nuclear receptors EcR and DHR38."
    Zoglowek A., Orlowski M., Pakula S., Dutko-Gwozdz J., Pajdzik D., Gwozdz T., Rymarczyk G., Wieczorek E., Dobrucki J., Dobryszycki P., Ozyhar A.
    Biol Chem 393:457-471(2012) [PubMed] [Europe PMC] [Abstract]
• steroid hormone receptor activity Source: InterPro
• transcription cis-regulatory region binding Source: FlyBaseInferred from direct assayⁱ
  • "Ecdysone regulation of the Drosophila Sgs-4 gene is mediated by the synergistic action of ecdysone receptor and SEBP 3."
    Lehmann M., Korge G.
    EMBO J 14:716-726(1995) [PubMed] [Europe PMC] [Abstract]
• zinc ion binding Source: InterPro

GO - Biological processⁱ

• anatomical structure development Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• border follicle cell migration Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Regulation of invasive cell behavior by taiman, a Drosophila protein related to AIB1, a steroid receptor coactivator amplified in breast cancer."
    Bai J., Uehara Y., Montell D.J.
    Cell 103:1047-1058(2000) [PubMed] [Europe PMC] [Abstract]
• cell differentiation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cellular response to ecdysone Source: FlyBaseInferred from direct assayⁱ
  • "The ligand-binding domains of the three RXR-USP nuclear receptor types support distinct tissue and ligand specific hormonal responses in transgenic Drosophila."
    Beck Y., Delaporte C., Moras D., Richards G., Billas I.M.
    Dev Biol 330:1-11(2009) [PubMed] [Europe PMC] [Abstract]
• dendrite morphogenesis Source: FlyBase <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • "Dendritic development: lessons from Drosophila and related branches."
    Grueber W.B., Jan Y.N.
    Curr Opin Neurobiol 14:74-82(2004) [PubMed] [Europe PMC] [Abstract]
• ecdysone biosynthetic process Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Nutritional control of body size through FoxO-Ultraspiracle mediated ecdysone biosynthesis."
    Koyama T., Rodrigues M.A., Athanasiadis A., Shingleton A.W., Mirth C.K.
    Elife 3:0-0(2014) [PubMed] [Europe PMC] [Abstract]
• germ cell development Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Ecdysteroids affect Drosophila ovarian stem cell niche formation and early germline differentiation."
    Konig A., Yatsenko A.S., Weiss M., Shcherbata H.R.
    EMBO J 30:1549-1562(2011) [PubMed] [Europe PMC] [Abstract]
• metamorphosis Source: CACAOInferred from mutant phenotypeⁱ
  • "Ligand binding pocket function of Drosophila USP is necessary for metamorphosis."
    Jones G., Teal P., Henrich V.C., Krzywonos A., Sapa A., Wozniak M., Smolka J., Jones D.
    Gen Comp Endocrinol 182:73-82(2013) [PubMed] [Europe PMC] [Abstract]
• mushroom body development Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Nuclear receptor unfulfilled regulates axonal guidance and cell identity of Drosophila mushroom body neurons."
    Lin S., Huang Y., Lee T.
    PLoS One 4:e8392-e8392(2009) [PubMed] [Europe PMC] [Abstract]
  • "Steroid-induced microRNA let-7 acts as a spatio-temporal code for neuronal cell fate in the developing Drosophila brain."
    Kucherenko M.M., Barth J., Fiala A., Shcherbata H.R.
    EMBO J 31:4511-4523(2012) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell differentiation Source: FlyBase <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "Steroid regulation of postembryonic development and reproduction in Drosophila."
    Kozlova T., Thummel C.S.
    Trends Endocrinol Metab 11:276-280(2000) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription, DNA-templated Source: FlyBaseTraceable author statementⁱ
  • "Steroid regulation of postembryonic development and reproduction in Drosophila."
    Kozlova T., Thummel C.S.
    Trends Endocrinol Metab 11:276-280(2000) [PubMed] [Europe PMC] [Abstract]
• neuron remodeling Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Cell-autonomous requirement of the USP/EcR-B ecdysone receptor for mushroom body neuronal remodeling in Drosophila."
    Lee T., Marticke S., Sung C., Robinow S., Luo L.
    Neuron 28:807-818(2000) [PubMed] [Europe PMC] [Abstract]
  • "Engulfing action of glial cells is required for programmed axon pruning during Drosophila metamorphosis."
    Awasaki T., Ito K.
    Curr Biol 14:668-677(2004) [PubMed] [Europe PMC] [Abstract]
  • "Nuclear receptor unfulfilled regulates axonal guidance and cell identity of Drosophila mushroom body neurons."
    Lin S., Huang Y., Lee T.
    PLoS One 4:e8392-e8392(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription, DNA-templated Source: FlyBaseInferred from mutant phenotypeⁱ
  • "EcR-B1 and Usp nuclear hormone receptors regulate expression of the VM32E eggshell gene during Drosophila oogenesis."
    Bernardi F., Romani P., Tzertzinis G., Gargiulo G., Cavaliere V.
    Dev Biol 328:541-551(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• pupariation Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Ligand binding pocket function of Drosophila USP is necessary for metamorphosis."
    Jones G., Teal P., Henrich V.C., Krzywonos A., Sapa A., Wozniak M., Smolka J., Jones D.
    Gen Comp Endocrinol 182:73-82(2013) [PubMed] [Europe PMC] [Abstract]
• regulation of development, heterochronic Source: FlyBaseTraceable author statementⁱ
  • "Molecular mechanisms of developmental timing in C. elegans and Drosophila."
    Thummel C.S.
    Dev Cell 1:453-465(2001) [PubMed] [Europe PMC] [Abstract]
• regulation of organ growth Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Nutritional control of body size through FoxO-Ultraspiracle mediated ecdysone biosynthesis."
    Koyama T., Rodrigues M.A., Athanasiadis A., Shingleton A.W., Mirth C.K.
    Elife 3:0-0(2014) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• response to ecdysone Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Ecdysone- and NO-mediated gene regulation by competing EcR/Usp and E75A nuclear receptors during Drosophila development."
    Johnston D.M., Sedkov Y., Petruk S., Riley K.M., Fujioka M., Jaynes J.B., Mazo A.
    Mol Cell 44:51-61(2011) [PubMed] [Europe PMC] [Abstract]
• response to starvation Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Nutritional control of body size through FoxO-Ultraspiracle mediated ecdysone biosynthesis."
    Koyama T., Rodrigues M.A., Athanasiadis A., Shingleton A.W., Mirth C.K.
    Elife 3:0-0(2014) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• protein heterodimerization activity Source: CAFAInferred from mutant phenotypeⁱ
  • "The composite nature of the interaction between nuclear receptors EcR and DHR38."
    Zoglowek A., Orlowski M., Pakula S., Dutko-Gwozdz J., Pajdzik D., Gwozdz T., Rymarczyk G., Wieczorek E., Dobrucki J., Dobryszycki P., Ozyhar A.
    Biol Chem 393:457-471(2012) [PubMed] [Europe PMC] [Abstract]
• signaling receptor binding Source: CAFAInferred from physical interactionⁱ
  • "The composite nature of the interaction between nuclear receptors EcR and DHR38."
    Zoglowek A., Orlowski M., Pakula S., Dutko-Gwozdz J., Pajdzik D., Gwozdz T., Rymarczyk G., Wieczorek E., Dobrucki J., Dobryszycki P., Ozyhar A.
    Biol Chem 393:457-471(2012) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Zinc finger

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MDNCDQDASF RLSHIKEEVK PDISQLNDSN NSSFSPKAES PVPFMQAMSM 
        60         70         80         90        100
VHVLPGSNSA SSNNNSAGDA QMAQAPNSAG GSAAAAVQQQ YPPNHPLSGS 
       110        120        130        140        150
KHLCSICGDR ASGKHYGVYS CEGCKGFFKR TVRKDLTYAC RENRNCIIDK 
       160        170        180        190        200
RQRNRCQYCR YQKCLTCGMK REAVQEERQR GARNAAGRLS ASGGGSSGPG 
       210        220        230        240        250
SVGGSSSQGG GGGGGVSGGM GSGNGSDDFM TNSVSRDFSI ERIIEAEQRA 
       260        270        280        290        300
ETQCGDRALT FLRVGPYSTV QPDYKGAVSA LCQVVNKQLF QMVEYARMMP 
       310        320        330        340        350
HFAQVPLDDQ VILLKAAWIE LLIANVAWCS IVSLDDGGAG GGGGGLGHDG 
       360        370        380        390        400
SFERRSPGLQ PQQLFLNQSF SYHRNSAIKA GVSAIFDRIL SELSVKMKRL 
       410        420        430        440        450
NLDRRELSCL KAIILYNPDI RGIKSRAEIE MCREKVYACL DEHCRLEHPG 
       460        470        480        490        500
DDGRFAQLLL RLPALRSISL KCQDHLFLFR ITSDRPLEEL FLEQLEAPPP 

PGLAMKLE                                               

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Drosophila
   Drosophila: entries, gene names and cross-references to FlyBase
2. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
3. SIMILARITY comments
   Index of protein domains and families