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Protein

Gastricsin

Gene

PGC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Hydrolyzes a variety of proteins.

Catalytic activityi

More restricted specificity than pepsin A, but shows preferential cleavage at Tyr-|-Xaa bonds. High activity on hemoglobin.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei911
Active sitei2761

GO - Molecular functioni

  • aspartic-type endopeptidase activity Source: UniProtKB

GO - Biological processi

  • digestion Source: ProtInc
  • positive regulation of antibacterial peptide production Source: UniProtKB
  • protein catabolic process Source: GO_Central
  • proteolysis Source: GO_Central

Keywordsi

Molecular functionAspartyl protease, Hydrolase, Protease
Biological processDigestion

Enzyme and pathway databases

BRENDAi3.4.23.3 2681

Protein family/group databases

MEROPSiA01.003
TCDBi8.A.32.1.4 the Beta-amyloid cleaving enzyme (bace1) family

Names & Taxonomyi

Protein namesi
Recommended name:
Gastricsin (EC:3.4.23.3)
Alternative name(s):
Pepsinogen C
Gene namesi
Name:PGC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000096088.16
HGNCiHGNC:8890 PGC
MIMi169740 gene
neXtProtiNX_P20142

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi5225
OpenTargetsiENSG00000096088
PharmGKBiPA33228

Chemistry databases

ChEMBLiCHEMBL2136
GuidetoPHARMACOLOGYi2391

Polymorphism and mutation databases

BioMutaiPGC
DMDMi129796

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 162 PublicationsAdd BLAST16
PropeptideiPRO_000002605617 – 59Activation peptideAdd BLAST43
ChainiPRO_000002605760 – 388GastricsinAdd BLAST329

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi104 ↔ 109
Disulfide bondi267 ↔ 271
Disulfide bondi310 ↔ 343

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

MaxQBiP20142
PaxDbiP20142
PeptideAtlasiP20142
PRIDEiP20142
ProteomicsDBi53726
53727 [P20142-2]

PTM databases

iPTMnetiP20142
PhosphoSitePlusiP20142

Miscellaneous databases

PMAP-CutDBiP20142

Expressioni

Gene expression databases

BgeeiENSG00000096088 Expressed in 94 organ(s), highest expression level in stomach
CleanExiHS_PGC
ExpressionAtlasiP20142 baseline and differential
GenevisibleiP20142 HS

Organism-specific databases

HPAiHPA031717
HPA031718

Interactioni

Protein-protein interaction databases

BioGridi111246, 4 interactors
STRINGi9606.ENSP00000362116

Chemistry databases

BindingDBiP20142

Structurei

Secondary structure

1388
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP20142
SMRiP20142
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP20142

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini73 – 385Peptidase A1PROSITE-ProRule annotationAdd BLAST313

Sequence similaritiesi

Belongs to the peptidase A1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1339 Eukaryota
ENOG410XNV7 LUCA
GeneTreeiENSGT00760000118929
HOGENOMiHOG000197681
HOVERGENiHBG000482
InParanoidiP20142
KOiK01377
OMAiFGYQPVD
OrthoDBiEOG091G0JP7
PhylomeDBiP20142
TreeFamiTF314990

Family and domain databases

Gene3Di2.40.70.10, 2 hits
InterProiView protein in InterPro
IPR001461 Aspartic_peptidase_A1
IPR001969 Aspartic_peptidase_AS
IPR012848 Aspartic_peptidase_N
IPR033735 Gastricsin
IPR033121 PEPTIDASE_A1
IPR021109 Peptidase_aspartic_dom_sf
PANTHERiPTHR13683 PTHR13683, 1 hit
PTHR13683:SF292 PTHR13683:SF292, 1 hit
PfamiView protein in Pfam
PF07966 A1_Propeptide, 1 hit
PF00026 Asp, 1 hit
PRINTSiPR00792 PEPSIN
SUPFAMiSSF50630 SSF50630, 1 hit
PROSITEiView protein in PROSITE
PS00141 ASP_PROTEASE, 2 hits
PS51767 PEPTIDASE_A1, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P20142-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKWMVVVLVC LQLLEAAVVK VPLKKFKSIR ETMKEKGLLG EFLRTHKYDP
60 70 80 90 100
AWKYRFGDLS VTYEPMAYMD AAYFGEISIG TPPQNFLVLF DTGSSNLWVP
110 120 130 140 150
SVYCQSQACT SHSRFNPSES STYSTNGQTF SLQYGSGSLT GFFGYDTLTV
160 170 180 190 200
QSIQVPNQEF GLSENEPGTN FVYAQFDGIM GLAYPALSVD EATTAMQGMV
210 220 230 240 250
QEGALTSPVF SVYLSNQQGS SGGAVVFGGV DSSLYTGQIY WAPVTQELYW
260 270 280 290 300
QIGIEEFLIG GQASGWCSEG CQAIVDTGTS LLTVPQQYMS ALLQATGAQE
310 320 330 340 350
DEYGQFLVNC NSIQNLPSLT FIINGVEFPL PPSSYILSNN GYCTVGVEPT
360 370 380
YLSSQNGQPL WILGDVFLRS YYSVYDLGNN RVGFATAA
Length:388
Mass (Da):42,426
Last modified:February 1, 1991 - v1
Checksum:iF862DFDC1438BB92
GO
Isoform 2 (identifier: P20142-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     217-388: QQGSSGGAVV...NNRVGFATAA → LVLESSGLGP...PPRSQHHSGA

Show »
Length:315
Mass (Da):34,208
Checksum:i79BD7C79ABDF8879
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q4VXA6Q4VXA6_HUMAN
Gastricsin
PGC
139Annotation score:
A2A3L9A2A3L9_HUMAN
Gastricsin
PGC
86Annotation score:

Sequence cautioni

The sequence AAA60062 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti40 – 41GE → ED AA sequence (PubMed:6816595).Curated2
Sequence conflicti52W → S AA sequence (PubMed:6816595).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042312217 – 388QQGSS…FATAA → LVLESSGLGPLLTPSRAAPP SSTLQLPEKPLEQTWNILTP FTKTLPVSNLSRKVTSWAGV GIPVTCLPEAGSGGERRAEC GLGVPTTRGPPRSQHHSGA in isoform 2. 1 PublicationAdd BLAST172

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18667
, M18659, M18660, M18661, M18662, M18663, M18664, M18665, M18666 Genomic DNA Translation: AAA60062.1 Different initiation.
J04443 mRNA Translation: AAA60074.1
M23077
, M23069, M23070, M23071, M23072, M23073, M23074, M23075 Genomic DNA Translation: AAA60063.1
U75272 mRNA Translation: AAB18273.1
AK301298 mRNA Translation: BAG62855.1
AL365205 Genomic DNA No translation available.
BC073740 mRNA Translation: AAH73740.1
CCDSiCCDS4859.1 [P20142-1]
CCDS55000.1 [P20142-2]
PIRiA29937
RefSeqiNP_001159896.1, NM_001166424.1 [P20142-2]
NP_002621.1, NM_002630.3 [P20142-1]
UniGeneiHs.1867

Genome annotation databases

EnsembliENST00000373025; ENSP00000362116; ENSG00000096088 [P20142-1]
ENST00000425343; ENSP00000405094; ENSG00000096088 [P20142-2]
GeneIDi5225
KEGGihsa:5225
UCSCiuc003ora.3 human [P20142-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18667
, M18659, M18660, M18661, M18662, M18663, M18664, M18665, M18666 Genomic DNA Translation: AAA60062.1 Different initiation.
J04443 mRNA Translation: AAA60074.1
M23077
, M23069, M23070, M23071, M23072, M23073, M23074, M23075 Genomic DNA Translation: AAA60063.1
U75272 mRNA Translation: AAB18273.1
AK301298 mRNA Translation: BAG62855.1
AL365205 Genomic DNA No translation available.
BC073740 mRNA Translation: AAH73740.1
CCDSiCCDS4859.1 [P20142-1]
CCDS55000.1 [P20142-2]
PIRiA29937
RefSeqiNP_001159896.1, NM_001166424.1 [P20142-2]
NP_002621.1, NM_002630.3 [P20142-1]
UniGeneiHs.1867

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AVFX-ray2.36A/J60-388[»]
P/Q17-42[»]
1HTRX-ray1.62B60-388[»]
P17-59[»]
ProteinModelPortaliP20142
SMRiP20142
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111246, 4 interactors
STRINGi9606.ENSP00000362116

Chemistry databases

BindingDBiP20142
ChEMBLiCHEMBL2136
GuidetoPHARMACOLOGYi2391

Protein family/group databases

MEROPSiA01.003
TCDBi8.A.32.1.4 the Beta-amyloid cleaving enzyme (bace1) family

PTM databases

iPTMnetiP20142
PhosphoSitePlusiP20142

Polymorphism and mutation databases

BioMutaiPGC
DMDMi129796

Proteomic databases

MaxQBiP20142
PaxDbiP20142
PeptideAtlasiP20142
PRIDEiP20142
ProteomicsDBi53726
53727 [P20142-2]

Protocols and materials databases

DNASUi5225
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373025; ENSP00000362116; ENSG00000096088 [P20142-1]
ENST00000425343; ENSP00000405094; ENSG00000096088 [P20142-2]
GeneIDi5225
KEGGihsa:5225
UCSCiuc003ora.3 human [P20142-1]

Organism-specific databases

CTDi5225
DisGeNETi5225
EuPathDBiHostDB:ENSG00000096088.16
GeneCardsiPGC
HGNCiHGNC:8890 PGC
HPAiHPA031717
HPA031718
MIMi169740 gene
neXtProtiNX_P20142
OpenTargetsiENSG00000096088
PharmGKBiPA33228
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1339 Eukaryota
ENOG410XNV7 LUCA
GeneTreeiENSGT00760000118929
HOGENOMiHOG000197681
HOVERGENiHBG000482
InParanoidiP20142
KOiK01377
OMAiFGYQPVD
OrthoDBiEOG091G0JP7
PhylomeDBiP20142
TreeFamiTF314990

Enzyme and pathway databases

BRENDAi3.4.23.3 2681

Miscellaneous databases

ChiTaRSiPGC human
EvolutionaryTraceiP20142
GeneWikiiGastricsin
GenomeRNAii5225
PMAP-CutDBiP20142
PROiPR:P20142
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000096088 Expressed in 94 organ(s), highest expression level in stomach
CleanExiHS_PGC
ExpressionAtlasiP20142 baseline and differential
GenevisibleiP20142 HS

Family and domain databases

Gene3Di2.40.70.10, 2 hits
InterProiView protein in InterPro
IPR001461 Aspartic_peptidase_A1
IPR001969 Aspartic_peptidase_AS
IPR012848 Aspartic_peptidase_N
IPR033735 Gastricsin
IPR033121 PEPTIDASE_A1
IPR021109 Peptidase_aspartic_dom_sf
PANTHERiPTHR13683 PTHR13683, 1 hit
PTHR13683:SF292 PTHR13683:SF292, 1 hit
PfamiView protein in Pfam
PF07966 A1_Propeptide, 1 hit
PF00026 Asp, 1 hit
PRINTSiPR00792 PEPSIN
SUPFAMiSSF50630 SSF50630, 1 hit
PROSITEiView protein in PROSITE
PS00141 ASP_PROTEASE, 2 hits
PS51767 PEPTIDASE_A1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPEPC_HUMAN
AccessioniPrimary (citable) accession number: P20142
Secondary accession number(s): B4DVZ3, Q5T3D7, Q5T3D8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: November 7, 2018
This is version 179 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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