UniProtKB - P20136 (GSTM2_CHICK)
Protein
Glutathione S-transferase 2
Gene
GSTM2
Organism
Gallus gallus (Chicken)
Status
Functioni
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (By similarity) (PubMed:10903867). Participates in the formation of novel hepoxilin regioisomers (By similarity).By similarity1 Publication
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 50 | GlutathioneBy similarity | 1 | |
Binding sitei | 116 | SubstrateBy similarity | 1 |
GO - Molecular functioni
- enzyme binding Source: Ensembl
- glutathione binding Source: Ensembl
- glutathione transferase activity Source: GO_Central
- leukotriene-C4 synthase activity Source: Ensembl
- protein homodimerization activity Source: Ensembl
GO - Biological processi
- glutathione metabolic process Source: GO_Central
- long-chain fatty acid biosynthetic process Source: Ensembl
- nitrobenzene metabolic process Source: Ensembl
- xenobiotic catabolic process Source: Ensembl
Keywordsi
Molecular function | Transferase |
Names & Taxonomyi
Protein namesi | Recommended name: Glutathione S-transferase 2Curated (EC:2.5.1.181 Publication)Alternative name(s): GST class-mu GST-CL2 GSTM1-1 |
Gene namesi | Name:GSTM2 |
Organismi | Gallus gallus (Chicken) |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Proteomesi |
|
Subcellular locationi
Other locations
Cytosol
- cytosol Source: Ensembl
Extracellular region or secreted
- intercellular bridge Source: Ensembl
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 108 | R → E: Reduced affinity for glutathione. 1 Publication | 1 | |
Mutagenesisi | 108 | R → L: Reduced catalytic activity. 1 Publication | 1 | |
Mutagenesisi | 210 | W → F: Reduced affinity for glutathione. 1 Publication | 1 | |
Mutagenesisi | 210 | W → H, I or P: Reduced catalytic activity. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000185838 | 2 – 220 | Glutathione S-transferase 2Add BLAST | 219 |
Interactioni
Subunit structurei
Homodimer.
2 PublicationsGO - Molecular functioni
- enzyme binding Source: Ensembl
- protein homodimerization activity Source: Ensembl
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P20136 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P20136 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 88 | GST N-terminalAdd BLAST | 87 | |
Domaini | 90 – 208 | GST C-terminalAdd BLAST | 119 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 7 – 8 | Glutathione binding2 Publications | 2 | |
Regioni | 43 – 46 | Glutathione binding2 Publications | 4 | |
Regioni | 59 – 60 | Glutathione binding2 Publications | 2 | |
Regioni | 72 – 73 | Glutathione binding2 Publications | 2 |
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00940000154679 |
InParanoidi | P20136 |
OrthoDBi | 1162336at2759 |
PhylomeDBi | P20136 |
Family and domain databases
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR010987, Glutathione-S-Trfase_C-like IPR036282, Glutathione-S-Trfase_C_sf IPR040079, Glutathione_S-Trfase IPR004045, Glutathione_S-Trfase_N IPR004046, GST_C IPR003081, GST_mu IPR036249, Thioredoxin-like_sf |
Pfami | View protein in Pfam PF00043, GST_C, 1 hit PF02798, GST_N, 1 hit |
PRINTSi | PR01267, GSTRNSFRASEM |
SFLDi | SFLDS00019, Glutathione_Transferase_(cytos, 1 hit |
SUPFAMi | SSF47616, SSF47616, 1 hit SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS50405, GST_CTER, 1 hit PS50404, GST_NTER, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P20136-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVVTLGYWDI RGLAHAIRLL LEYTETPYQE RRYKAGPAPD FDPSDWTNEK
60 70 80 90 100
EKLGLDFPNL PYLIDGDVKL TQSNAILRYI ARKHNMCGET EVEKQRVDVL
110 120 130 140 150
ENHLMDLRMA FARLCYSPDF EKLKPAYLEQ LPGKLRQLSR FLGSRSWFVG
160 170 180 190 200
DKLTFVDFLA YDVLDQQRMF VPDCPELQGN LSQFLQRFEA LEKISAYMRS
210 220
GRFMKAPIFW YTALWNNKKE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X58248 mRNA Translation: CAA41202.1 |
PIRi | S18464 |
RefSeqi | NP_990421.1, NM_205090.1 |
Genome annotation databases
Ensembli | ENSGALT00000077418; ENSGALP00000048878; ENSGALG00000032922 |
GeneIDi | 395976 |
KEGGi | gga:395976 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X58248 mRNA Translation: CAA41202.1 |
PIRi | S18464 |
RefSeqi | NP_990421.1, NM_205090.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1C72 | X-ray | 2.80 | A/B/C/D | 2-220 | [»] | |
1GSU | X-ray | 1.94 | A/B | 2-220 | [»] | |
SMRi | P20136 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Genome annotation databases
Ensembli | ENSGALT00000077418; ENSGALP00000048878; ENSGALG00000032922 |
GeneIDi | 395976 |
KEGGi | gga:395976 |
Organism-specific databases
CTDi | 2946 |
Phylogenomic databases
GeneTreei | ENSGT00940000154679 |
InParanoidi | P20136 |
OrthoDBi | 1162336at2759 |
PhylomeDBi | P20136 |
Miscellaneous databases
EvolutionaryTracei | P20136 |
PROi | PR:P20136 |
Gene expression databases
ExpressionAtlasi | P20136, baseline and differential |
Family and domain databases
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR010987, Glutathione-S-Trfase_C-like IPR036282, Glutathione-S-Trfase_C_sf IPR040079, Glutathione_S-Trfase IPR004045, Glutathione_S-Trfase_N IPR004046, GST_C IPR003081, GST_mu IPR036249, Thioredoxin-like_sf |
Pfami | View protein in Pfam PF00043, GST_C, 1 hit PF02798, GST_N, 1 hit |
PRINTSi | PR01267, GSTRNSFRASEM |
SFLDi | SFLDS00019, Glutathione_Transferase_(cytos, 1 hit |
SUPFAMi | SSF47616, SSF47616, 1 hit SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS50405, GST_CTER, 1 hit PS50404, GST_NTER, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GSTM2_CHICK | |
Accessioni | P20136Primary (citable) accession number: P20136 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1991 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 134 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families