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Protein

Flocculation suppression protein

Gene

SFL1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in cell surface assembly and regulation of the gene related to flocculation (asexual cell aggregation). Mutations in SFL1 causes constitutive cell aggregation.

Miscellaneous

Present with 1040 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi64 – 186By similarityAdd BLAST123

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-33661-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Flocculation suppression protein
Alternative name(s):
Protein SFL1
Gene namesi
Name:SFL1
Ordered Locus Names:YOR140W
ORF Names:YOR3339W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR140W
SGDiS000005666 SFL1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001245951 – 766Flocculation suppression proteinAdd BLAST766

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei220PhosphoserineCombined sources1
Modified residuei556PhosphoserineCombined sources1
Modified residuei733PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP20134
PaxDbiP20134
PRIDEiP20134

PTM databases

iPTMnetiP20134

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi34534, 353 interactors
DIPiDIP-5501N
IntActiP20134, 2 interactors
MINTiP20134
STRINGi4932.YOR140W

Structurei

3D structure databases

ProteinModelPortaliP20134
SMRiP20134
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

In the N-terminal section; belongs to the HSF family.Curated

Phylogenomic databases

GeneTreeiENSGT00550000075934
InParanoidiP20134
OMAiVASKNSH
OrthoDBiEOG092C2G9O

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000232 HSF_DNA-bd
IPR027725 HSF_fam
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR10015 PTHR10015, 1 hit
PfamiView protein in Pfam
PF00447 HSF_DNA-bind, 1 hit
PRINTSiPR00056 HSFDOMAIN
SMARTiView protein in SMART
SM00415 HSF, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00434 HSF_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

P20134-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEEETVSAP APASTPAPAG TDVGSGGAAA GIANAGAEGG DGAEDVKKHG
60 70 80 90 100
SKMLVGPRPP QNAIFIHKLY QILEDESLHD LIWWTPSGLS FMIKPVERFS
110 120 130 140 150
KALATYFKHT NITSFVRQLN IYGFHKVSHD HSSNDANSGD DANTNDDSNT
160 170 180 190 200
HDDNSGNKNS SGDENTGGGV QEKEKSNPTK IWEFKHSSGI FKKGDIEGLK
210 220 230 240 250
HIKRRASSRN NSSINSRKNS SNQNYDIDSG ARVRPSSIQD PSTSSNSFGN
260 270 280 290 300
FVPQIPGANN SIPEYFNNSH VTYENANHAP LESNNPEMQE QNRPPNFQDE
310 320 330 340 350
TLKHLKEINF DMVKIIESMQ HFISLQHSFC SQSFTFKNVS KKKSENIVKD
360 370 380 390 400
HQKQLQAFES DMLTFKQHVM SRAHRTIDSL CAVNAAATAA SVAPAPAPTS
410 420 430 440 450
TSAYAPKSQY EMMVPPGNQY VPQKSSSTTN IPSRFNTASV PPSQLFVQYQ
460 470 480 490 500
PQSQQHVTYA KQPAHVPNFI NQPIPIQQLP PQYADTFSTP QMMHNPFASK
510 520 530 540 550
NNNKPGNTKR TNSVLMDPLT PAASVGVQGP LNYPIMNINP SVRDYNKPVP
560 570 580 590 600
QNMAPSPIYP INEPTTRLYS QPKMRSLGST SSLPNDRRNS PLKLTPRSSL
610 620 630 640 650
NEDSLYPKPR NSLKSSISGT SLSSSFTLVA NNPAPIRYSQ QGLLRSLNKA
660 670 680 690 700
ANCAPDSVTP LDSSVLTGPP PKNMDNLPAV SSNLINSPMN VEHSSSLSQA
710 720 730 740 750
EPAPQIELPQ PSLPTTSTTK NTGEADNSKR KGSGVYSLLN QEDSSTSSAD
760
PKTEDKAAPA LKKVKM
Length:766
Mass (Da):83,345
Last modified:September 21, 2011 - v3
Checksum:i85D2594DFF42F938
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti446 – 454FVQYQPQSQ → LYNTNRSRN in CAA64057 (PubMed:9200815).Curated9
Sequence conflicti446 – 454FVQYQPQSQ → LYNTNRSRN in CAA99338 (PubMed:9169874).Curated9
Sequence conflicti461 – 462KQ → SE in CAA64057 (PubMed:9200815).Curated2
Sequence conflicti461 – 462KQ → SE in CAA99338 (PubMed:9169874).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94335 Genomic DNA Translation: CAA64057.1
Z75047 Genomic DNA Translation: CAA99338.1
BK006948 Genomic DNA Translation: DAA10912.2
PIRiS61694
RefSeqiNP_014783.4, NM_001183559.4

Genome annotation databases

EnsemblFungiiYOR140W; YOR140W; YOR140W
GeneIDi854307
KEGGisce:YOR140W

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94335 Genomic DNA Translation: CAA64057.1
Z75047 Genomic DNA Translation: CAA99338.1
BK006948 Genomic DNA Translation: DAA10912.2
PIRiS61694
RefSeqiNP_014783.4, NM_001183559.4

3D structure databases

ProteinModelPortaliP20134
SMRiP20134
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34534, 353 interactors
DIPiDIP-5501N
IntActiP20134, 2 interactors
MINTiP20134
STRINGi4932.YOR140W

PTM databases

iPTMnetiP20134

Proteomic databases

MaxQBiP20134
PaxDbiP20134
PRIDEiP20134

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOR140W; YOR140W; YOR140W
GeneIDi854307
KEGGisce:YOR140W

Organism-specific databases

EuPathDBiFungiDB:YOR140W
SGDiS000005666 SFL1

Phylogenomic databases

GeneTreeiENSGT00550000075934
InParanoidiP20134
OMAiVASKNSH
OrthoDBiEOG092C2G9O

Enzyme and pathway databases

BioCyciYEAST:G3O-33661-MONOMER

Miscellaneous databases

PROiPR:P20134

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000232 HSF_DNA-bd
IPR027725 HSF_fam
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR10015 PTHR10015, 1 hit
PfamiView protein in Pfam
PF00447 HSF_DNA-bind, 1 hit
PRINTSiPR00056 HSFDOMAIN
SMARTiView protein in SMART
SM00415 HSF, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00434 HSF_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSFL1_YEAST
AccessioniPrimary (citable) accession number: P20134
Secondary accession number(s): D6W2J6, Q99194
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: September 21, 2011
Last modified: September 12, 2018
This is version 169 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
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Main funding by: National Institutes of Health

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