UniProtKB - P20126 (POLR_EPMV)
Protein
RNA replicase polyprotein
Gene
N/A
Organism
Eggplant mosaic virus
Status
Functioni
Catalytic activityi
- EC:2.7.7.48PROSITE-ProRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 776 | For protease activityPROSITE-ProRule annotation | 1 | |
Active sitei | 862 | For protease activityPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 965 – 972 | ATPBy similarity | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- cysteine-type endopeptidase activity Source: InterPro
- mRNA methyltransferase activity Source: InterPro
- RNA binding Source: InterPro
- RNA-directed 5'-3' RNA polymerase activity Source: UniProtKB-KW
GO - Biological processi
- RNA processing Source: InterPro
- transcription, DNA-templated Source: InterPro
- viral RNA genome replication Source: InterPro
Keywordsi
Molecular function | Hydrolase, Nucleotidyltransferase, Protease, RNA-directed RNA polymerase, Thiol protease, Transferase |
Biological process | Viral RNA replication |
Ligand | ATP-binding, Nucleotide-binding |
Protein family/group databases
MEROPSi | C21.001 |
Names & Taxonomyi
Protein namesi | |
Organismi | Eggplant mosaic virus |
Taxonomic identifieri | 12151 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Orthornavirae › Kitrinoviricota › Alsuviricetes › Tymovirales › Tymoviridae › Tymovirus |
Virus hosti | Solanum lycopersicum (Tomato) (Lycopersicon esculentum) [TaxID: 4081] Solanum melongena (Eggplant) (Aubergine) [TaxID: 4111] Solanum seaforthianum (Brazilian nightshade) [TaxID: 45840] |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000222934 | 1 – 1839 | RNA replicase polyproteinAdd BLAST | 1839 |
Proteomic databases
PRIDEi | P20126 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 58 – 219 | Alphavirus-like MTPROSITE-ProRule annotationAdd BLAST | 162 | |
Domaini | 723 – 877 | Peptidase C21PROSITE-ProRule annotationAdd BLAST | 155 | |
Domaini | 935 – 1092 | (+)RNA virus helicase ATP-bindingAdd BLAST | 158 | |
Domaini | 1093 – 1224 | (+)RNA virus helicase C-terminalAdd BLAST | 132 | |
Domaini | 1567 – 1673 | RdRp catalyticPROSITE-ProRule annotationAdd BLAST | 107 |
Sequence similaritiesi
Belongs to the tymovirus NS35 RNA replicase polyprotein family.Curated
Family and domain databases
Gene3Di | 3.90.70.100, 1 hit |
InterProi | View protein in InterPro IPR027351, (+)RNA_virus_helicase_core_dom IPR002588, Alphavirus-like_MT_dom IPR043502, DNA/RNA_pol_sf IPR027417, P-loop_NTPase IPR008043, Peptidase_C21 IPR007094, RNA-dir_pol_PSvirus IPR001788, Tymovirus_RNA-dep_RNA_pol IPR043181, TYMV_endopept_dom |
Pfami | View protein in Pfam PF05381, Peptidase_C21, 1 hit PF00978, RdRP_2, 1 hit PF01443, Viral_helicase1, 1 hit PF01660, Vmethyltransf, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit SSF56672, SSF56672, 1 hit |
PROSITEi | View protein in PROSITE PS51743, ALPHAVIRUS_MT, 1 hit PS51738, PEPTIDASE_C21, 1 hit PS51657, PSRV_HELICASE, 1 hit PS50507, RDRP_SSRNA_POS, 1 hit |
i Sequence
Sequence statusi: Complete.
P20126-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAFQSALEAL NSTTHRDAST NPILNSVVEP LRDSLSLYPW LLPKEAVPHL
60 70 80 90 100
LSWGIPNSGL GVTPHPHPIH KTVETFLLFN HWHALARLPS TVMFMKPSKF
110 120 130 140 150
QKLAALNPKF QELINFRLTA ADTTRYPSTS LTFPSNSICF MHDALMYFSP
160 170 180 190 200
AQIVDLFTQS PALETLYCSL IVPPESHFTD LSLFPEIYTY KISGQTLHYI
210 220 230 240 250
PENHHSGSYN QPLQAPSWLK ISSILSPSLA LSVTKLESWG PVHSILIQRG
260 270 280 290 300
LPPKPSLSAR PPVLPNQPPR ATTPNSQNQL LHQTSQLFFQ LQQPQLSLVS
310 320 330 340 350
FRIPDCVELP QATFLRQPLR HRLVPTSVYN ALFTYTRAVR TLRTSDPAGF
360 370 380 390 400
VRTQSNKPEH AWVTPNAWDN LQTLSVNAPH RPQVCYHFFS SPVARLKLHF
410 420 430 440 450
AQHWRAYLLA LTPFLTTSPL LLPLFNFNTP FPLPRLLSLF RRSVSSPRLL
460 470 480 490 500
HSILPSQLRG AAIPNRPLPL WVTKLHHFLD SHSLLPTPPI RPRIELQRLP
510 520 530 540 550
LMSLIPKPKI VLPLLSLLLS SPTIYIHFFQ AQTPQQLHDN YHLHLHPSRF
560 570 580 590 600
ELSWTLQSYH VTQAQSFLPL LLPAPTQAQA SNPAPRPPAF HAIPLPPQPS
610 620 630 640 650
TSSSPPLQEP TLSPHLIHPP LTREPSPLNG CACDSALLPS TAAMTSAEHP
660 670 680 690 700
TPLNPPTPSP TPDVPPPDSP GNPSLLKQVP PEANLHPIHN PDLPSSTTLP
710 720 730 740 750
SGALTLVPAK TPSIYANPTP PSSHPFTPLA DDPTAVGPCL PFHVLHPADY
760 770 780 790 800
FPLSAEFLTR TRHVPPSSLS HPKLNCLLTC FSELSGHSES DLWLSLQSIL
810 820 830 840 850
PDSQLQNPEV STLGLSTDIL TALCFIYHSS VTLHAPSGVY HYGIASSSTV
860 870 880 890 900
YVIHYQPGPP PHFSLSPRLA ASAPRCNPTN SRLVRQALRF KLNGEFLPFT
910 920 930 940 950
QAYAHESSIT HAKNLISNMK NGFDGIMSSL TDSSKGPSPR EKLTTLDSLI
960 970 980 990 1000
DVAAPREVSL IHIAGFAGCG KTHPIQKLLQ TSPFHDFRIS CPTNELRSEW
1010 1020 1030 1040 1050
KRDMQPTAEN VWRFSTWESS LLKHSEILVI DEIYKLPRGY LDLSILADPT
1060 1070 1080 1090 1100
LSLVIILGDP LQGEYHSTSP HSSNHFLPSE VHRFKSYIDC YCFWSHRIPK
1110 1120 1130 1140 1150
QIASLFGVVC HNTNEGFVRA LTSHPPNSKN LTNATNTALS LQQMGHHAIT
1160 1170 1180 1190 1200
ISARRVTFTE AHTILLDRHT NLLSPNNCLV ALTRSRTGVY FVGNLHLASN
1210 1220 1230 1240 1250
SFGTNYMFSQ ALCQGTIDLN NVFPHIMPHL PKMYEPIRSR SNRFVSGSLN
1260 1270 1280 1290 1300
FRPTTNSRLL SSLTKPTHLP PHIPTNHSLD VLVSNPVLLG ETLDPRLEVL
1310 1320 1330 1340 1350
HLPPTRLPLH LDLLPTVPSS SSFSSVDHLF PTPISPAICG YTFENLAAFF
1360 1370 1380 1390 1400
LPAHDPDLKE VLINDQKSNQ FPYLDAPFEL SCQPSSLLAP IHKPASDPTL
1410 1420 1430 1440 1450
LPGSIKKRLR FRASSSPYSI TPSDQLLGQH LFSSLCLAYG RNPNSVLPFQ
1460 1470 1480 1490 1500
PELFSECICI NDYAQLSSKT QATIVANHQR SDPDWRLTAV RIFAKAQHKV
1510 1520 1530 1540 1550
NDASIFSGWK ACQTLALMHG YIILVLGPVK KYQRIFDSKD RPPHIYYHCG
1560 1570 1580 1590 1600
KTPSQLSQWC QTHLSGSSYI ANDYTAFDQS QHGEAVVLEC LKMRRLSIPD
1610 1620 1630 1640 1650
SLIQLHSHLK CSVDTQFGPL TCMRLTGEPG TYDDNSDYNL AVIYSQYSLN
1660 1670 1680 1690 1700
GHPILISGDD SVLCGTPPPS PLWPTLKKML HLRFKIERTS HPLFCGYYVS
1710 1720 1730 1740 1750
PHGAARNPYA LFAKLMICVD DKSLHDKKLS YLSEFSTGHL AGDLVTSILP
1760 1770 1780 1790 1800
SHLLPYQSAV HDFFCRNCTP AEKILLSLDP IPESKILQLI LKVRWASQAF
1810 1820 1830
FSYLPQKARE LLVARSSLPS LYSNPKVSQL ESELLPFSQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J04374 Genomic RNA Translation: AAA43039.1 |
PIRi | JQ0102, RRWPEM |
RefSeqi | NP_040968.1, NC_001480.1 |
Genome annotation databases
GeneIDi | 1493960 |
KEGGi | vg:1493960 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J04374 Genomic RNA Translation: AAA43039.1 |
PIRi | JQ0102, RRWPEM |
RefSeqi | NP_040968.1, NC_001480.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein family/group databases
MEROPSi | C21.001 |
Proteomic databases
PRIDEi | P20126 |
Genome annotation databases
GeneIDi | 1493960 |
KEGGi | vg:1493960 |
Family and domain databases
Gene3Di | 3.90.70.100, 1 hit |
InterProi | View protein in InterPro IPR027351, (+)RNA_virus_helicase_core_dom IPR002588, Alphavirus-like_MT_dom IPR043502, DNA/RNA_pol_sf IPR027417, P-loop_NTPase IPR008043, Peptidase_C21 IPR007094, RNA-dir_pol_PSvirus IPR001788, Tymovirus_RNA-dep_RNA_pol IPR043181, TYMV_endopept_dom |
Pfami | View protein in Pfam PF05381, Peptidase_C21, 1 hit PF00978, RdRP_2, 1 hit PF01443, Viral_helicase1, 1 hit PF01660, Vmethyltransf, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit SSF56672, SSF56672, 1 hit |
PROSITEi | View protein in PROSITE PS51743, ALPHAVIRUS_MT, 1 hit PS51738, PEPTIDASE_C21, 1 hit PS51657, PSRV_HELICASE, 1 hit PS50507, RDRP_SSRNA_POS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | POLR_EPMV | |
Accessioni | P20126Primary (citable) accession number: P20126 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1991 |
Last sequence update: | February 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 94 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |