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UniProtKB - P20126 (POLR_EPMV)

Entry version 88 (05 Jun 2019)
Sequence version 2 (01 Feb 1996)
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Protein

RNA replicase polyprotein

Gene
N/A
Organism
Eggplant mosaic virus
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei776For protease activityPROSITE-ProRule annotation1
Active sitei862For protease activityPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi965 – 972ATPBy similarity8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Nucleotidyltransferase, Protease, RNA-directed RNA polymerase, Thiol protease, Transferase
Biological processViral RNA replication
LigandATP-binding, Nucleotide-binding

Protein family/group databases

MEROPS protease database

More...MEROPSi		C21.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA replicase polyprotein (EC:2.7.7.48)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEggplant mosaic virus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri12151 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiViruses › Riboviria › Tymovirales › Tymoviridae › Tymovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiSolanum lycopersicum (Tomato) (Lycopersicon esculentum) [TaxID: 4081]
Solanum melongena (Eggplant) (Aubergine) [TaxID: 4111]
Solanum seaforthianum (Brazilian nightshade) [TaxID: 45840]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008664 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002229341 – 1839RNA replicase polyproteinAdd BLAST1839

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini58 – 219Alphavirus-like MTPROSITE-ProRule annotationAdd BLAST162
Domaini723 – 877Peptidase C21PROSITE-ProRule annotationAdd BLAST155
Domaini935 – 1092(+)RNA virus helicase ATP-bindingAdd BLAST158
Domaini1093 – 1224(+)RNA virus helicase C-terminalAdd BLAST132
Domaini1567 – 1673RdRp catalyticPROSITE-ProRule annotationAdd BLAST107

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tymovirus NS35 RNA replicase polyprotein family.Curated

Phylogenomic databases

Database of Orthologous Groups

More...OrthoDBi		524at10239

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR027351 (+)RNA_virus_helicase_core_dom
IPR002588 Alphavirus-like_MT_dom
IPR027417 P-loop_NTPase
IPR008043 Peptidase_C21
IPR007094 RNA-dir_pol_PSvirus
IPR001788 Tymovirus_RNA-dep_RNA_pol

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05381 Peptidase_C21, 1 hit
PF00978 RdRP_2, 1 hit
PF01443 Viral_helicase1, 1 hit
PF01660 Vmethyltransf, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51743 ALPHAVIRUS_MT, 1 hit
PS51738 PEPTIDASE_C21, 1 hit
PS51657 PSRV_HELICASE, 1 hit
PS50507 RDRP_SSRNA_POS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P20126-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFQSALEAL NSTTHRDAST NPILNSVVEP LRDSLSLYPW LLPKEAVPHL 
        60         70         80         90        100
LSWGIPNSGL GVTPHPHPIH KTVETFLLFN HWHALARLPS TVMFMKPSKF 
       110        120        130        140        150
QKLAALNPKF QELINFRLTA ADTTRYPSTS LTFPSNSICF MHDALMYFSP 
       160        170        180        190        200
AQIVDLFTQS PALETLYCSL IVPPESHFTD LSLFPEIYTY KISGQTLHYI 
       210        220        230        240        250
PENHHSGSYN QPLQAPSWLK ISSILSPSLA LSVTKLESWG PVHSILIQRG 
       260        270        280        290        300
LPPKPSLSAR PPVLPNQPPR ATTPNSQNQL LHQTSQLFFQ LQQPQLSLVS 
       310        320        330        340        350
FRIPDCVELP QATFLRQPLR HRLVPTSVYN ALFTYTRAVR TLRTSDPAGF 
       360        370        380        390        400
VRTQSNKPEH AWVTPNAWDN LQTLSVNAPH RPQVCYHFFS SPVARLKLHF 
       410        420        430        440        450
AQHWRAYLLA LTPFLTTSPL LLPLFNFNTP FPLPRLLSLF RRSVSSPRLL 
       460        470        480        490        500
HSILPSQLRG AAIPNRPLPL WVTKLHHFLD SHSLLPTPPI RPRIELQRLP 
       510        520        530        540        550
LMSLIPKPKI VLPLLSLLLS SPTIYIHFFQ AQTPQQLHDN YHLHLHPSRF 
       560        570        580        590        600
ELSWTLQSYH VTQAQSFLPL LLPAPTQAQA SNPAPRPPAF HAIPLPPQPS 
       610        620        630        640        650
TSSSPPLQEP TLSPHLIHPP LTREPSPLNG CACDSALLPS TAAMTSAEHP 
       660        670        680        690        700
TPLNPPTPSP TPDVPPPDSP GNPSLLKQVP PEANLHPIHN PDLPSSTTLP 
       710        720        730        740        750
SGALTLVPAK TPSIYANPTP PSSHPFTPLA DDPTAVGPCL PFHVLHPADY 
       760        770        780        790        800
FPLSAEFLTR TRHVPPSSLS HPKLNCLLTC FSELSGHSES DLWLSLQSIL 
       810        820        830        840        850
PDSQLQNPEV STLGLSTDIL TALCFIYHSS VTLHAPSGVY HYGIASSSTV 
       860        870        880        890        900
YVIHYQPGPP PHFSLSPRLA ASAPRCNPTN SRLVRQALRF KLNGEFLPFT 
       910        920        930        940        950
QAYAHESSIT HAKNLISNMK NGFDGIMSSL TDSSKGPSPR EKLTTLDSLI 
       960        970        980        990       1000
DVAAPREVSL IHIAGFAGCG KTHPIQKLLQ TSPFHDFRIS CPTNELRSEW 
      1010       1020       1030       1040       1050
KRDMQPTAEN VWRFSTWESS LLKHSEILVI DEIYKLPRGY LDLSILADPT 
      1060       1070       1080       1090       1100
LSLVIILGDP LQGEYHSTSP HSSNHFLPSE VHRFKSYIDC YCFWSHRIPK 
      1110       1120       1130       1140       1150
QIASLFGVVC HNTNEGFVRA LTSHPPNSKN LTNATNTALS LQQMGHHAIT 
      1160       1170       1180       1190       1200
ISARRVTFTE AHTILLDRHT NLLSPNNCLV ALTRSRTGVY FVGNLHLASN 
      1210       1220       1230       1240       1250
SFGTNYMFSQ ALCQGTIDLN NVFPHIMPHL PKMYEPIRSR SNRFVSGSLN 
      1260       1270       1280       1290       1300
FRPTTNSRLL SSLTKPTHLP PHIPTNHSLD VLVSNPVLLG ETLDPRLEVL 
      1310       1320       1330       1340       1350
HLPPTRLPLH LDLLPTVPSS SSFSSVDHLF PTPISPAICG YTFENLAAFF 
      1360       1370       1380       1390       1400
LPAHDPDLKE VLINDQKSNQ FPYLDAPFEL SCQPSSLLAP IHKPASDPTL 
      1410       1420       1430       1440       1450
LPGSIKKRLR FRASSSPYSI TPSDQLLGQH LFSSLCLAYG RNPNSVLPFQ 
      1460       1470       1480       1490       1500
PELFSECICI NDYAQLSSKT QATIVANHQR SDPDWRLTAV RIFAKAQHKV 
      1510       1520       1530       1540       1550
NDASIFSGWK ACQTLALMHG YIILVLGPVK KYQRIFDSKD RPPHIYYHCG 
      1560       1570       1580       1590       1600
KTPSQLSQWC QTHLSGSSYI ANDYTAFDQS QHGEAVVLEC LKMRRLSIPD 
      1610       1620       1630       1640       1650
SLIQLHSHLK CSVDTQFGPL TCMRLTGEPG TYDDNSDYNL AVIYSQYSLN 
      1660       1670       1680       1690       1700
GHPILISGDD SVLCGTPPPS PLWPTLKKML HLRFKIERTS HPLFCGYYVS 
      1710       1720       1730       1740       1750
PHGAARNPYA LFAKLMICVD DKSLHDKKLS YLSEFSTGHL AGDLVTSILP 
      1760       1770       1780       1790       1800
SHLLPYQSAV HDFFCRNCTP AEKILLSLDP IPESKILQLI LKVRWASQAF 
      1810       1820       1830 
FSYLPQKARE LLVARSSLPS LYSNPKVSQL ESELLPFSQ
Length:1,839
Mass (Da):204,732
Last modified:February 1, 1996 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFD8DC1F5115E7861
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
J04374 Genomic RNA Translation: AAA43039.1

Protein sequence database of the Protein Information Resource

More...PIRi		JQ0102 RRWPEM

NCBI Reference Sequences

More...RefSeqi		NP_040968.1, NC_001480.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1493960

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		vg:1493960

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04374 Genomic RNA Translation: AAA43039.1
PIRiJQ0102 RRWPEM
RefSeqiNP_040968.1, NC_001480.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein family/group databases

MEROPSiC21.001

Genome annotation databases

GeneIDi1493960
KEGGivg:1493960

Phylogenomic databases

OrthoDBi524at10239

Family and domain databases

InterProiView protein in InterPro
IPR027351 (+)RNA_virus_helicase_core_dom
IPR002588 Alphavirus-like_MT_dom
IPR027417 P-loop_NTPase
IPR008043 Peptidase_C21
IPR007094 RNA-dir_pol_PSvirus
IPR001788 Tymovirus_RNA-dep_RNA_pol
PfamiView protein in Pfam
PF05381 Peptidase_C21, 1 hit
PF00978 RdRP_2, 1 hit
PF01443 Viral_helicase1, 1 hit
PF01660 Vmethyltransf, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51743 ALPHAVIRUS_MT, 1 hit
PS51738 PEPTIDASE_C21, 1 hit
PS51657 PSRV_HELICASE, 1 hit
PS50507 RDRP_SSRNA_POS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPOLR_EPMV
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P20126
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1996
Last modified: June 5, 2019
This is version 88 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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