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Entry version 88 (05 Jun 2019)
Sequence version 2 (01 Feb 1996)
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Protein

RNA replicase polyprotein

Gene
N/A
Organism
Eggplant mosaic virus
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei776For protease activityPROSITE-ProRule annotation1
Active sitei862For protease activityPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi965 – 972ATPBy similarity8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Nucleotidyltransferase, Protease, RNA-directed RNA polymerase, Thiol protease, Transferase
Biological processViral RNA replication
LigandATP-binding, Nucleotide-binding

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C21.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA replicase polyprotein (EC:2.7.7.48)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEggplant mosaic virus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri12151 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaTymoviralesTymoviridaeTymovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiSolanum lycopersicum (Tomato) (Lycopersicon esculentum) [TaxID: 4081]
Solanum melongena (Eggplant) (Aubergine) [TaxID: 4111]
Solanum seaforthianum (Brazilian nightshade) [TaxID: 45840]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008664 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002229341 – 1839RNA replicase polyproteinAdd BLAST1839

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini58 – 219Alphavirus-like MTPROSITE-ProRule annotationAdd BLAST162
Domaini723 – 877Peptidase C21PROSITE-ProRule annotationAdd BLAST155
Domaini935 – 1092(+)RNA virus helicase ATP-bindingAdd BLAST158
Domaini1093 – 1224(+)RNA virus helicase C-terminalAdd BLAST132
Domaini1567 – 1673RdRp catalyticPROSITE-ProRule annotationAdd BLAST107

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
524at10239

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027351 (+)RNA_virus_helicase_core_dom
IPR002588 Alphavirus-like_MT_dom
IPR027417 P-loop_NTPase
IPR008043 Peptidase_C21
IPR007094 RNA-dir_pol_PSvirus
IPR001788 Tymovirus_RNA-dep_RNA_pol

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05381 Peptidase_C21, 1 hit
PF00978 RdRP_2, 1 hit
PF01443 Viral_helicase1, 1 hit
PF01660 Vmethyltransf, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51743 ALPHAVIRUS_MT, 1 hit
PS51738 PEPTIDASE_C21, 1 hit
PS51657 PSRV_HELICASE, 1 hit
PS50507 RDRP_SSRNA_POS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P20126-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFQSALEAL NSTTHRDAST NPILNSVVEP LRDSLSLYPW LLPKEAVPHL
60 70 80 90 100
LSWGIPNSGL GVTPHPHPIH KTVETFLLFN HWHALARLPS TVMFMKPSKF
110 120 130 140 150
QKLAALNPKF QELINFRLTA ADTTRYPSTS LTFPSNSICF MHDALMYFSP
160 170 180 190 200
AQIVDLFTQS PALETLYCSL IVPPESHFTD LSLFPEIYTY KISGQTLHYI
210 220 230 240 250
PENHHSGSYN QPLQAPSWLK ISSILSPSLA LSVTKLESWG PVHSILIQRG
260 270 280 290 300
LPPKPSLSAR PPVLPNQPPR ATTPNSQNQL LHQTSQLFFQ LQQPQLSLVS
310 320 330 340 350
FRIPDCVELP QATFLRQPLR HRLVPTSVYN ALFTYTRAVR TLRTSDPAGF
360 370 380 390 400
VRTQSNKPEH AWVTPNAWDN LQTLSVNAPH RPQVCYHFFS SPVARLKLHF
410 420 430 440 450
AQHWRAYLLA LTPFLTTSPL LLPLFNFNTP FPLPRLLSLF RRSVSSPRLL
460 470 480 490 500
HSILPSQLRG AAIPNRPLPL WVTKLHHFLD SHSLLPTPPI RPRIELQRLP
510 520 530 540 550
LMSLIPKPKI VLPLLSLLLS SPTIYIHFFQ AQTPQQLHDN YHLHLHPSRF
560 570 580 590 600
ELSWTLQSYH VTQAQSFLPL LLPAPTQAQA SNPAPRPPAF HAIPLPPQPS
610 620 630 640 650
TSSSPPLQEP TLSPHLIHPP LTREPSPLNG CACDSALLPS TAAMTSAEHP
660 670 680 690 700
TPLNPPTPSP TPDVPPPDSP GNPSLLKQVP PEANLHPIHN PDLPSSTTLP
710 720 730 740 750
SGALTLVPAK TPSIYANPTP PSSHPFTPLA DDPTAVGPCL PFHVLHPADY
760 770 780 790 800
FPLSAEFLTR TRHVPPSSLS HPKLNCLLTC FSELSGHSES DLWLSLQSIL
810 820 830 840 850
PDSQLQNPEV STLGLSTDIL TALCFIYHSS VTLHAPSGVY HYGIASSSTV
860 870 880 890 900
YVIHYQPGPP PHFSLSPRLA ASAPRCNPTN SRLVRQALRF KLNGEFLPFT
910 920 930 940 950
QAYAHESSIT HAKNLISNMK NGFDGIMSSL TDSSKGPSPR EKLTTLDSLI
960 970 980 990 1000
DVAAPREVSL IHIAGFAGCG KTHPIQKLLQ TSPFHDFRIS CPTNELRSEW
1010 1020 1030 1040 1050
KRDMQPTAEN VWRFSTWESS LLKHSEILVI DEIYKLPRGY LDLSILADPT
1060 1070 1080 1090 1100
LSLVIILGDP LQGEYHSTSP HSSNHFLPSE VHRFKSYIDC YCFWSHRIPK
1110 1120 1130 1140 1150
QIASLFGVVC HNTNEGFVRA LTSHPPNSKN LTNATNTALS LQQMGHHAIT
1160 1170 1180 1190 1200
ISARRVTFTE AHTILLDRHT NLLSPNNCLV ALTRSRTGVY FVGNLHLASN
1210 1220 1230 1240 1250
SFGTNYMFSQ ALCQGTIDLN NVFPHIMPHL PKMYEPIRSR SNRFVSGSLN
1260 1270 1280 1290 1300
FRPTTNSRLL SSLTKPTHLP PHIPTNHSLD VLVSNPVLLG ETLDPRLEVL
1310 1320 1330 1340 1350
HLPPTRLPLH LDLLPTVPSS SSFSSVDHLF PTPISPAICG YTFENLAAFF
1360 1370 1380 1390 1400
LPAHDPDLKE VLINDQKSNQ FPYLDAPFEL SCQPSSLLAP IHKPASDPTL
1410 1420 1430 1440 1450
LPGSIKKRLR FRASSSPYSI TPSDQLLGQH LFSSLCLAYG RNPNSVLPFQ
1460 1470 1480 1490 1500
PELFSECICI NDYAQLSSKT QATIVANHQR SDPDWRLTAV RIFAKAQHKV
1510 1520 1530 1540 1550
NDASIFSGWK ACQTLALMHG YIILVLGPVK KYQRIFDSKD RPPHIYYHCG
1560 1570 1580 1590 1600
KTPSQLSQWC QTHLSGSSYI ANDYTAFDQS QHGEAVVLEC LKMRRLSIPD
1610 1620 1630 1640 1650
SLIQLHSHLK CSVDTQFGPL TCMRLTGEPG TYDDNSDYNL AVIYSQYSLN
1660 1670 1680 1690 1700
GHPILISGDD SVLCGTPPPS PLWPTLKKML HLRFKIERTS HPLFCGYYVS
1710 1720 1730 1740 1750
PHGAARNPYA LFAKLMICVD DKSLHDKKLS YLSEFSTGHL AGDLVTSILP
1760 1770 1780 1790 1800
SHLLPYQSAV HDFFCRNCTP AEKILLSLDP IPESKILQLI LKVRWASQAF
1810 1820 1830
FSYLPQKARE LLVARSSLPS LYSNPKVSQL ESELLPFSQ
Length:1,839
Mass (Da):204,732
Last modified:February 1, 1996 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFD8DC1F5115E7861
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J04374 Genomic RNA Translation: AAA43039.1

Protein sequence database of the Protein Information Resource

More...
PIRi
JQ0102 RRWPEM

NCBI Reference Sequences

More...
RefSeqi
NP_040968.1, NC_001480.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1493960

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vg:1493960

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04374 Genomic RNA Translation: AAA43039.1
PIRiJQ0102 RRWPEM
RefSeqiNP_040968.1, NC_001480.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

MEROPSiC21.001

Genome annotation databases

GeneIDi1493960
KEGGivg:1493960

Phylogenomic databases

OrthoDBi524at10239

Family and domain databases

InterProiView protein in InterPro
IPR027351 (+)RNA_virus_helicase_core_dom
IPR002588 Alphavirus-like_MT_dom
IPR027417 P-loop_NTPase
IPR008043 Peptidase_C21
IPR007094 RNA-dir_pol_PSvirus
IPR001788 Tymovirus_RNA-dep_RNA_pol
PfamiView protein in Pfam
PF05381 Peptidase_C21, 1 hit
PF00978 RdRP_2, 1 hit
PF01443 Viral_helicase1, 1 hit
PF01660 Vmethyltransf, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51743 ALPHAVIRUS_MT, 1 hit
PS51738 PEPTIDASE_C21, 1 hit
PS51657 PSRV_HELICASE, 1 hit
PS50507 RDRP_SSRNA_POS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPOLR_EPMV
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P20126
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1996
Last modified: June 5, 2019
This is version 88 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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