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Protein

Interleukin-13

Gene

Il13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses (By similarity). Positively regulates IL31RA expression in macrophages (PubMed:25847241).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

ReactomeiR-MMU-6785807 Interleukin-4 and Interleukin-13 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-13
Short name:
IL-13
Alternative name(s):
T-cell activation protein P600
Gene namesi
Name:Il13
Synonyms:Il-13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:96541 Il13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000001555022 – 131Interleukin-13Add BLAST110

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi42N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi51 ↔ 79By similarity
Glycosylationi52N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi67 ↔ 93By similarity
Glycosylationi75N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP20109
PRIDEiP20109

Expressioni

Gene expression databases

BgeeiENSMUSG00000020383 Expressed in 41 organ(s), highest expression level in embryo
CleanExiMM_IL13
GenevisibleiP20109 MM

Interactioni

Subunit structurei

Interacts with IL13RA2.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Il13ra2O887862EBI-20559598,EBI-20260800

GO - Molecular functioni

Protein-protein interaction databases

IntActiP20109, 1 interactor
STRINGi10090.ENSMUSP00000020650

Structurei

3D structure databases

ProteinModelPortaliP20109
SMRiP20109
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-4/IL-13 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JCI3 Eukaryota
ENOG4111BX2 LUCA
GeneTreeiENSGT00390000003225
HOGENOMiHOG000113028
HOVERGENiHBG006140
InParanoidiP20109
KOiK05435
OMAiVYCAALE
OrthoDBiEOG091G10SR
PhylomeDBiP20109
TreeFamiTF336383

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR020470 IL-13
IPR001325 IL-4/IL-13
IPR018096 IL-4/IL-13_CS
PANTHERiPTHR45413 PTHR45413, 1 hit
PfamiView protein in Pfam
PF03487 IL13, 1 hit
PRINTSiPR01929 INTRLEUKIN13
SMARTiView protein in SMART
SM00190 IL4_13, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00838 INTERLEUKIN_4_13, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20109-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALWVTAVLA LACLGGLAAP GPVPRSVSLP LTLKELIEEL SNITQDQTPL
60 70 80 90 100
CNGSMVWSVD LAAGGFCVAL DSLTNISNCN AIYRTQRILH GLCNRKAPTT
110 120 130
VSSLPDTKIE VAHFITKLLS YTKQLFRHGP F
Length:131
Mass (Da):14,108
Last modified:February 1, 1991 - v1
Checksum:i954F93F105713FED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23504 mRNA Translation: AAA40149.1
CCDSiCCDS24683.1
PIRiE30552
RefSeqiNP_032381.1, NM_008355.3
UniGeneiMm.1284

Genome annotation databases

EnsembliENSMUST00000020650; ENSMUSP00000020650; ENSMUSG00000020383
GeneIDi16163
KEGGimmu:16163
UCSCiuc007iwr.2 mouse

Similar proteinsi

Entry informationi

Entry nameiIL13_MOUSE
AccessioniPrimary (citable) accession number: P20109
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: September 12, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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