UniProtKB - P20109 (IL13_MOUSE)
Protein
Interleukin-13
Gene
Il13
Organism
Mus musculus (Mouse)
Status
Functioni
Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses (By similarity). Positively regulates IL31RA expression in macrophages (PubMed:25847241).By similarity1 Publication
GO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
- interleukin-13 receptor binding Source: MGI
GO - Biological processi
- cellular response to cytokine stimulus Source: MGI
- immune response Source: InterPro
- inflammatory response Source: MGI
- macrophage activation Source: MGI
- microglial cell activation Source: MGI
- negative regulation of complement-dependent cytotoxicity Source: MGI
- negative regulation of endothelial cell apoptotic process Source: MGI
- negative regulation of inflammatory response Source: MGI
- negative regulation of NAD(P)H oxidase activity Source: MGI
- negative regulation of neuron death Source: MGI
- negative regulation of transforming growth factor beta production Source: MGI
- positive regulation of B cell proliferation Source: MGI
- positive regulation of cold-induced thermogenesis Source: YuBioLab
- positive regulation of connective tissue growth factor production Source: MGI
- positive regulation of gene expression Source: MGI
- positive regulation of immunoglobulin production Source: MGI
- positive regulation of interleukin-10 production Source: MGI
- positive regulation of ion transport Source: MGI
- positive regulation of macrophage activation Source: BHF-UCL
- positive regulation of mast cell degranulation Source: MGI
- positive regulation of pancreatic stellate cell proliferation Source: MGI
- positive regulation of protein secretion Source: MGI
- positive regulation of release of sequestered calcium ion into cytosol Source: MGI
- positive regulation of smooth muscle cell proliferation Source: MGI
- positive regulation of tyrosine phosphorylation of STAT protein Source: MGI
- regulation of proton transport Source: MGI
- response to nicotine Source: MGI
Keywordsi
Molecular function | Cytokine |
Names & Taxonomyi
Protein namesi | Recommended name: Interleukin-13Short name: IL-13 Alternative name(s): T-cell activation protein P600 |
Gene namesi | Name:Il13 Synonyms:Il-13 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:96541, Il13 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: MGI
- extracellular space Source: MGI
Plasma Membrane
- external side of plasma membrane Source: MGI
Other locations
- cytoplasm Source: MGI
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
ChainiPRO_0000015550 | 19 – 131 | Interleukin-13Add BLAST | 113 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 42 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 51 ↔ 79 | By similarity | ||
Glycosylationi | 52 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 67 ↔ 93 | By similarity | ||
Glycosylationi | 75 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P20109 |
PRIDEi | P20109 |
ProteomicsDBi | 267315 |
PTM databases
GlyGeni | P20109, 3 sites |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000020383, Expressed in hindlimb zeugopod muscle and 62 other tissues |
Genevisiblei | P20109, MM |
Interactioni
Subunit structurei
Interacts with IL13RA2.
By similarityBinary interactionsi
P20109
With | #Exp. | IntAct |
---|---|---|
Il13ra2 [O88786] | 4 | EBI-20559598,EBI-20260800 |
GO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
- interleukin-13 receptor binding Source: MGI
Protein-protein interaction databases
IntActi | P20109, 2 interactors |
STRINGi | 10090.ENSMUSP00000020650 |
Miscellaneous databases
RNActi | P20109, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the IL-4/IL-13 family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502SZKX, Eukaryota |
GeneTreei | ENSGT00390000003225 |
HOGENOMi | CLU_158063_0_0_1 |
InParanoidi | P20109 |
OMAi | QKTPLCN |
OrthoDBi | 1578920at2759 |
PhylomeDBi | P20109 |
TreeFami | TF336383 |
Family and domain databases
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR020470, IL-13 IPR001325, IL-4/IL-13 IPR018096, IL-4/IL-13_CS |
Pfami | View protein in Pfam PF03487, IL13, 1 hit |
PRINTSi | PR01929, INTRLEUKIN13 |
SMARTi | View protein in SMART SM00190, IL4_13, 1 hit |
SUPFAMi | SSF47266, SSF47266, 1 hit |
PROSITEi | View protein in PROSITE PS00838, INTERLEUKIN_4_13, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P20109-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALWVTAVLA LACLGGLAAP GPVPRSVSLP LTLKELIEEL SNITQDQTPL
60 70 80 90 100
CNGSMVWSVD LAAGGFCVAL DSLTNISNCN AIYRTQRILH GLCNRKAPTT
110 120 130
VSSLPDTKIE VAHFITKLLS YTKQLFRHGP F
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M23504 mRNA Translation: AAA40149.1 |
CCDSi | CCDS24683.1 |
PIRi | E30552 |
RefSeqi | NP_032381.1, NM_008355.3 |
Genome annotation databases
Ensembli | ENSMUST00000020650; ENSMUSP00000020650; ENSMUSG00000020383 |
GeneIDi | 16163 |
KEGGi | mmu:16163 |
UCSCi | uc007iwr.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M23504 mRNA Translation: AAA40149.1 |
CCDSi | CCDS24683.1 |
PIRi | E30552 |
RefSeqi | NP_032381.1, NM_008355.3 |
3D structure databases
SMRi | P20109 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | P20109, 2 interactors |
STRINGi | 10090.ENSMUSP00000020650 |
PTM databases
GlyGeni | P20109, 3 sites |
Proteomic databases
PaxDbi | P20109 |
PRIDEi | P20109 |
ProteomicsDBi | 267315 |
Protocols and materials databases
ABCDi | P20109, 1 sequenced antibody |
Antibodypediai | 14499, 1146 antibodies |
DNASUi | 16163 |
Genome annotation databases
Ensembli | ENSMUST00000020650; ENSMUSP00000020650; ENSMUSG00000020383 |
GeneIDi | 16163 |
KEGGi | mmu:16163 |
UCSCi | uc007iwr.2, mouse |
Organism-specific databases
CTDi | 3596 |
MGIi | MGI:96541, Il13 |
Phylogenomic databases
eggNOGi | ENOG502SZKX, Eukaryota |
GeneTreei | ENSGT00390000003225 |
HOGENOMi | CLU_158063_0_0_1 |
InParanoidi | P20109 |
OMAi | QKTPLCN |
OrthoDBi | 1578920at2759 |
PhylomeDBi | P20109 |
TreeFami | TF336383 |
Miscellaneous databases
BioGRID-ORCSi | 16163, 0 hits in 54 CRISPR screens |
PROi | PR:P20109 |
RNActi | P20109, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000020383, Expressed in hindlimb zeugopod muscle and 62 other tissues |
Genevisiblei | P20109, MM |
Family and domain databases
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR020470, IL-13 IPR001325, IL-4/IL-13 IPR018096, IL-4/IL-13_CS |
Pfami | View protein in Pfam PF03487, IL13, 1 hit |
PRINTSi | PR01929, INTRLEUKIN13 |
SMARTi | View protein in SMART SM00190, IL4_13, 1 hit |
SUPFAMi | SSF47266, SSF47266, 1 hit |
PROSITEi | View protein in PROSITE PS00838, INTERLEUKIN_4_13, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IL13_MOUSE | |
Accessioni | P20109Primary (citable) accession number: P20109 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1991 |
Last sequence update: | February 1, 1991 | |
Last modified: | April 7, 2021 | |
This is version 154 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families