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Entry version 81 (23 May 2018)
Sequence version 3 (01 Oct 1993)
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Protein

Nisin biosynthesis protein NisB

Gene

nisB

Organism
Lactococcus lactis subsp. lactis (Streptococcus lactis)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the post-translational modification of the lantibiotic nisin.

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nisin biosynthesis protein NisB
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:nisB
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiLactococcus lactis subsp. lactis (Streptococcus lactis)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1360 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei838 – 851HelicalSequence analysisAdd BLAST14

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000968631 – 993Nisin biosynthesis protein NisBAdd BLAST993

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P20103

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-61450N

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1993
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P20103

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

To B.subtilis SpaB and S.epidermidis EpiB.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006827 Lant_deHydtase_N
IPR023809 Thiopep_bacteriocin_synth_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14028 Lant_dehydr_C, 1 hit
PF04738 Lant_dehydr_N, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR03891 thiopep_ocin, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P20103-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIKSSFKAQP FLVRNTILCP NDKRSFTEYT QVIETVSKNK VFLEQLLLAN
60 70 80 90 100
PKLYDVMQKY NAGLLKKKRV KKLFESIYKY YKRSYLRSTP FGLFSETSIG
110 120 130 140 150
VFSKSSQYKL MGKTTKGIRL DTQWLIRLVH KMEVDFSKKL SFTRNNANYK
160 170 180 190 200
FGDRVFQVYT INSSELEEVN IKYTNVYQII SEFCENDYQK YEDICETVTL
210 220 230 240 250
CYGDEYRELS EQYLGSLIVN HYLISNLQKD LLSDFSWNTF LTKVEAIDED
260 270 280 290 300
KKYIIPLKKV QKFIQEYSEI EIGEGIEKLK EIYQEMSQIL ENDNYIQIDL
310 320 330 340 350
ISDSEINFDV KQKQQLEHLA EFLGNTTKSV RRTYLDDYKD KFIEKYGVDQ
360 370 380 390 400
EVQITELFDS TFGIGAPYNY NHPRNDFYES EPSTLYYSEE EREKYLSMYV
410 420 430 440 450
EAVKNHNVIN LDDLESHYQK MDLEKKSELQ GLELFLNLAK EYEKDIFILG
460 470 480 490 500
DIVGNNNLGG ASGRFSALSP ELTSYHRTIV DSVERENENK EITSCEIVFL
510 520 530 540 550
PENIRHANVM HTSIMRRKVL PFFTSTSHNE VLLTNIYIGI DEKEKFYARD
560 570 580 590 600
ISTQEVLKFY ITSMYNKTLF SNELRFLYEI SLDDKFGNLP WELIYRDFDY
610 620 630 640 650
IPRLVFDEIV ISPAKWKIWG RDVNSKMTIR ELIQSKEIPK EFYIVNGDNK
660 670 680 690 700
VYLSQKNPLD MEILESAIKK SSKRKDFIEL QEYFEDENII NKGEKGRVAD
710 720 730 740 750
VVVPFIRTRA LGNEGRAFIR EKRVSVERRE KLPFNEWLYL KLYISINRQN
760 770 780 790 800
EFLLSYLPDI QKIVANLGGN LFFLRYTDPK PHIRLRIKCS DLFLAYGSIL
810 820 830 840 850
EILKRSRKNR IMSTFDISIY DQEVERYGGF DTLELSEAIF CADSKIIPNL
860 870 880 890 900
LTLIKDTNND WKVDDVSILV NYLYLKCFFQ NDNKKILNFL NLVSTKKVKE
910 920 930 940 950
NVNEKIEHYL KLLKVNNLGD QIFYDKNFKE LKHAIKNLFL KMIAQDFELQ
960 970 980 990
KVYSIIDSII HVHNNRLIGI ERDKEKLIYY TLQRLFVSEE YMK
Length:993
Mass (Da):117,502
Last modified:October 1, 1993 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0027053BEAE71E2D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti19C → S (PubMed:7689965).Curated1
Sequence conflicti19C → S (PubMed:1905517).Curated1
Sequence conflicti656K → E (PubMed:7689965).Curated1
Sequence conflicti656K → E (PubMed:1905517).Curated1
Sequence conflicti841 – 852CADSK…PNLLT → VPILKLFQICLH (PubMed:1905517).CuratedAdd BLAST12
Sequence conflicti895T → P in AAA25190 (PubMed:7689965).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X68307 Genomic DNA Translation: CAA48381.1
L16226 Genomic DNA Translation: AAA25190.1
M65089 Genomic DNA Translation: AAA73039.1
J04057 Genomic DNA Translation: AAA88607.1
D10768 Genomic DNA Translation: BAA01599.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S36735 C31915

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68307 Genomic DNA Translation: CAA48381.1
L16226 Genomic DNA Translation: AAA25190.1
M65089 Genomic DNA Translation: AAA73039.1
J04057 Genomic DNA Translation: AAA88607.1
D10768 Genomic DNA Translation: BAA01599.1
PIRiS36735 C31915

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4WD9X-ray2.90A/B1-993[»]
SMRiP20103
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-61450N

Proteomic databases

PRIDEiP20103

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR006827 Lant_deHydtase_N
IPR023809 Thiopep_bacteriocin_synth_dom
PfamiView protein in Pfam
PF14028 Lant_dehydr_C, 1 hit
PF04738 Lant_dehydr_N, 1 hit
TIGRFAMsiTIGR03891 thiopep_ocin, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNISB_LACLL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P20103
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: October 1, 1993
Last modified: May 23, 2018
This is version 81 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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