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Protein

FK506-binding protein 1

Gene

FPR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Miscellaneous

Binds to the immunosuppressant drug FK506 and also mediates the sensitivity to rapamycin. Rapamycin disrupts interaction with FAP1.
Present with 43300 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

  • FK506 binding Source: GO_Central
  • macrolide binding Source: SGD
  • peptidyl-prolyl cis-trans isomerase activity Source: SGD

GO - Biological processi

  • chaperone-mediated protein folding Source: GO_Central
  • chromatin organization Source: SGD
  • protein folding Source: SGD
  • regulation of homoserine biosynthetic process Source: SGD

Keywordsi

Molecular functionIsomerase, Rotamase

Enzyme and pathway databases

BioCyciYEAST:YNL135C-MONOMER
ReactomeiR-SCE-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-SCE-3371568 Attenuation phase
R-SCE-8939211 ESR-mediated signaling

Names & Taxonomyi

Protein namesi
Recommended name:
FK506-binding protein 1
Short name:
FKBP
Alternative name(s):
Peptidyl-prolyl cis-trans isomerase (EC:5.2.1.8)
Short name:
PPIase
Rapamycin-binding protein
Gene namesi
Name:FPR1
Synonyms:FKB1, RBP1
Ordered Locus Names:YNL135C
ORF Names:N1213, N1845
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL135C
SGDiS000005079 FPR1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi43F → Y: Reduces interaction with FAP1. 1 Publication1
Mutagenesisi44D → V: Abrogates interaction with FAP1. 1 Publication1
Mutagenesisi48D → V: Abrogates interaction with FAP1. 1 Publication1
Mutagenesisi49R → I: Abrogates interaction with FAP1. 1 Publication1
Mutagenesisi94F → V: Abrogates interaction with FAP1. 1 Publication1
Mutagenesisi106F → Y: Reduces interaction with FAP1. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000753052 – 114FK506-binding protein 1Add BLAST113

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei51PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP20081
PaxDbiP20081
PRIDEiP20081
TopDownProteomicsiP20081

PTM databases

iPTMnetiP20081

Interactioni

Subunit structurei

Interacts with HMO1. Interacts with FAP1.2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi35691, 315 interactors
DIPiDIP-1263N
IntActiP20081, 66 interactors
MINTiP20081
STRINGi4932.YNL135C

Structurei

Secondary structure

1114
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP20081
SMRiP20081
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP20081

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 114PPIase FKBP-typePROSITE-ProRule annotationAdd BLAST89

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00760000119159
HOGENOMiHOG000154887
InParanoidiP20081
KOiK09568
OMAiRVIAGWD
OrthoDBiEOG092C52SD

Family and domain databases

InterProiView protein in InterPro
IPR023566 PPIase_FKBP
IPR001179 PPIase_FKBP_dom
PANTHERiPTHR10516 PTHR10516, 1 hit
PfamiView protein in Pfam
PF00254 FKBP_C, 1 hit
PROSITEiView protein in PROSITE
PS50059 FKBP_PPIASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20081-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEVIEGNVK IDRISPGDGA TFPKTGDLVT IHYTGTLENG QKFDSSVDRG
60 70 80 90 100
SPFQCNIGVG QVIKGWDVGI PKLSVGEKAR LTIPGPYAYG PRGFPGLIPP
110
NSTLVFDVEL LKVN
Length:114
Mass (Da):12,158
Last modified:May 1, 1991 - v2
Checksum:i65C134830D300C06
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46843 Genomic DNA Translation: CAA86890.1
M57967 Unassigned DNA Translation: AAA03564.1
M60877 Genomic DNA Translation: AAA34607.1
M63892 mRNA Translation: AAA34962.1
Z71411 Genomic DNA Translation: CAA96017.1
AY557997 Genomic DNA Translation: AAS56323.1
BK006947 Genomic DNA Translation: DAA10413.1
PIRiA37870 A33146
RefSeqiNP_014264.1, NM_001182973.1

Genome annotation databases

EnsemblFungiiYNL135C; YNL135C; YNL135C
GeneIDi855587
KEGGisce:YNL135C

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46843 Genomic DNA Translation: CAA86890.1
M57967 Unassigned DNA Translation: AAA03564.1
M60877 Genomic DNA Translation: AAA34607.1
M63892 mRNA Translation: AAA34962.1
Z71411 Genomic DNA Translation: CAA96017.1
AY557997 Genomic DNA Translation: AAS56323.1
BK006947 Genomic DNA Translation: DAA10413.1
PIRiA37870 A33146
RefSeqiNP_014264.1, NM_001182973.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YATX-ray2.50A2-114[»]
ProteinModelPortaliP20081
SMRiP20081
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35691, 315 interactors
DIPiDIP-1263N
IntActiP20081, 66 interactors
MINTiP20081
STRINGi4932.YNL135C

PTM databases

iPTMnetiP20081

Proteomic databases

MaxQBiP20081
PaxDbiP20081
PRIDEiP20081
TopDownProteomicsiP20081

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNL135C; YNL135C; YNL135C
GeneIDi855587
KEGGisce:YNL135C

Organism-specific databases

EuPathDBiFungiDB:YNL135C
SGDiS000005079 FPR1

Phylogenomic databases

GeneTreeiENSGT00760000119159
HOGENOMiHOG000154887
InParanoidiP20081
KOiK09568
OMAiRVIAGWD
OrthoDBiEOG092C52SD

Enzyme and pathway databases

BioCyciYEAST:YNL135C-MONOMER
ReactomeiR-SCE-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-SCE-3371568 Attenuation phase
R-SCE-8939211 ESR-mediated signaling

Miscellaneous databases

EvolutionaryTraceiP20081
PROiPR:P20081

Family and domain databases

InterProiView protein in InterPro
IPR023566 PPIase_FKBP
IPR001179 PPIase_FKBP_dom
PANTHERiPTHR10516 PTHR10516, 1 hit
PfamiView protein in Pfam
PF00254 FKBP_C, 1 hit
PROSITEiView protein in PROSITE
PS50059 FKBP_PPIASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFKBP_YEAST
AccessioniPrimary (citable) accession number: P20081
Secondary accession number(s): D6W147
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: May 1, 1991
Last modified: September 12, 2018
This is version 179 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
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Main funding by: National Institutes of Health

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