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Protein

Annexin A7

Gene

ANXA7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis.

GO - Molecular functioni

  • calcium-dependent phospholipid binding Source: UniProtKB-KW
  • calcium-dependent protein binding Source: UniProtKB
  • calcium ion binding Source: InterPro
  • integrin binding Source: UniProtKB
  • RNA binding Source: UniProtKB

GO - Biological processi

  • autophagy Source: UniProtKB
  • cell proliferation Source: Ensembl
  • cellular calcium ion homeostasis Source: Ensembl
  • cellular water homeostasis Source: Ensembl
  • epithelial cell differentiation Source: UniProtKB
  • hemostasis Source: Ensembl
  • membrane fusion Source: Ensembl
  • negative regulation of gene expression Source: UniProtKB
  • regulation of cell shape Source: Ensembl
  • response to calcium ion Source: Ensembl
  • response to organic cyclic compound Source: Ensembl
  • response to salt stress Source: Ensembl
  • social behavior Source: UniProtKB

Keywordsi

LigandCalcium, Calcium/phospholipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A7
Alternative name(s):
Annexin VII
Annexin-7
Synexin
Gene namesi
Name:ANXA7
Synonyms:ANX7, SNX
ORF Names:OK/SW-cl.95
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000138279.15
HGNCiHGNC:545 ANXA7
MIMi186360 gene
neXtProtiNX_P20073

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi310
OpenTargetsiENSG00000138279
PharmGKBiPA24835

Polymorphism and mutation databases

BioMutaiANXA7
DMDMi215274186

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000674991 – 488Annexin A7Add BLAST488

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei233N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP20073
MaxQBiP20073
PaxDbiP20073
PeptideAtlasiP20073
PRIDEiP20073
ProteomicsDBi53722
53723 [P20073-2]
TopDownProteomicsiP20073-1 [P20073-1]

2D gel databases

REPRODUCTION-2DPAGEiIPI00002460

PTM databases

iPTMnetiP20073
PhosphoSitePlusiP20073
SwissPalmiP20073

Expressioni

Tissue specificityi

Isoform 1 is expressed in brain, heart and skeletal muscle. Isoform 2 is more abundant in liver, lung, kidney, spleen, fibroblasts and placenta.1 Publication

Gene expression databases

BgeeiENSG00000138279
CleanExiHS_ANXA7
ExpressionAtlasiP20073 baseline and differential
GenevisibleiP20073 HS

Organism-specific databases

HPAiCAB004312
HPA064290

Interactioni

Subunit structurei

Interacts with PDCD6.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SRIP30626-12EBI-2338704,EBI-10816740

GO - Molecular functioni

  • calcium-dependent protein binding Source: UniProtKB
  • integrin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi106807, 140 interactors
CORUMiP20073
ELMiP20073
IntActiP20073, 118 interactors
MINTiP20073
STRINGi9606.ENSP00000362010

Structurei

3D structure databases

ProteinModelPortaliP20073
SMRiP20073
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati5 – 915
Repeati10 – 1425
Repeati16 – 2035
Repeati189 – 254Annexin 1Add BLAST66
Repeati266 – 326Annexin 2Add BLAST61
Repeati349 – 409Annexin 3Add BLAST61
Repeati425 – 485Annexin 4Add BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 143Repeat-rich regionAdd BLAST143
Regioni5 – 203 X 5 AA tandem repeats of G-Y-P-P-XAdd BLAST16

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiKOG0819 Eukaryota
ENOG410XPUN LUCA
GeneTreeiENSGT00760000118972
HOGENOMiHOG000158803
HOVERGENiHBG061815
InParanoidiP20073
KOiK17095
OMAiSQMYQKT
OrthoDBiEOG091G0H6H
PhylomeDBiP20073
TreeFamiTF105452

Family and domain databases

Gene3Di1.10.220.10, 4 hits
InterProiView protein in InterPro
IPR001464 Annexin
IPR018502 Annexin_repeat
IPR018252 Annexin_repeat_CS
IPR037104 Annexin_sf
IPR013286 ANX7
IPR034309 ANX7_chordates
PANTHERiPTHR10502:SF110 PTHR10502:SF110, 1 hit
PfamiView protein in Pfam
PF00191 Annexin, 4 hits
PRINTSiPR00196 ANNEXIN
PR01871 ANNEXINVII
SMARTiView protein in SMART
SM00335 ANX, 4 hits
PROSITEiView protein in PROSITE
PS00223 ANNEXIN, 4 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P20073-1) [UniParc]FASTAAdd to basket
Also known as: Annexin VIIb

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSYPGYPPTG YPPFPGYPPA GQESSFPPSG QYPYPSGFPP MGGGAYPQVP
60 70 80 90 100
SSGYPGAGGY PAPGGYPAPG GYPGAPQPGG APSYPGVPPG QGFGVPPGGA
110 120 130 140 150
GFSGYPQPPS QSYGGGPAQV PLPGGFPGGQ MPSQYPGGQP TYPSQINTDS
160 170 180 190 200
FSSYPVFSPV SLDYSSEPAT VTQVTQGTIR PAANFDAIRD AEILRKAMKG
210 220 230 240 250
FGTDEQAIVD VVANRSNDQR QKIKAAFKTS YGKDLIKDLK SELSGNMEEL
260 270 280 290 300
ILALFMPPTY YDAWSLRKAM QGAGTQERVL IEILCTRTNQ EIREIVRCYQ
310 320 330 340 350
SEFGRDLEKD IRSDTSGHFE RLLVSMCQGN RDENQSINHQ MAQEDAQRLY
360 370 380 390 400
QAGEGRLGTD ESCFNMILAT RSFPQLRATM EAYSRMANRD LLSSVSREFS
410 420 430 440 450
GYVESGLKTI LQCALNRPAF FAERLYYAMK GAGTDDSTLV RIVVTRSEID
460 470 480
LVQIKQMFAQ MYQKTLGTMI AGDTSGDYRR LLLAIVGQ
Length:488
Mass (Da):52,739
Last modified:November 25, 2008 - v3
Checksum:iBFC688479D8CC2A0
GO
Isoform 2 (identifier: P20073-2) [UniParc]FASTAAdd to basket
Also known as: Annexin VIIa

The sequence of this isoform differs from the canonical sequence as follows:
     146-167: Missing.

Show »
Length:466
Mass (Da):50,316
Checksum:i09A6760729D45FCD
GO

Sequence cautioni

The sequence CAI52483 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048253441R → Q. Corresponds to variant dbSNP:rs3750575Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011843146 – 167Missing in isoform 2. 6 PublicationsAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04543 mRNA Translation: AAA36616.1
AB062429 mRNA Translation: BAB93492.1
BT007187 mRNA Translation: AAP35851.1
CR407686 mRNA Translation: CAG28614.1
AL512656, AL353731 Genomic DNA Translation: CAI15290.1
AL512656, AL353731 Genomic DNA Translation: CAI15291.1
AL353731 Genomic DNA Translation: CAI52483.1 Sequence problems.
AL353731, AL512656 Genomic DNA Translation: CAI52484.1
AL353731, AL512656 Genomic DNA Translation: CAI52485.1
CH471083 Genomic DNA Translation: EAW54493.1
CH471083 Genomic DNA Translation: EAW54494.1
BC002632 mRNA Translation: AAH02632.1
CCDSiCCDS7325.1 [P20073-2]
CCDS7326.1 [P20073-1]
PIRiA54467 LUHU7
RefSeqiNP_001147.1, NM_001156.4 [P20073-2]
NP_004025.1, NM_004034.3 [P20073-1]
XP_016871651.1, XM_017016162.1 [P20073-1]
XP_016871652.1, XM_017016163.1 [P20073-2]
UniGeneiHs.631827

Genome annotation databases

EnsembliENST00000372919; ENSP00000362010; ENSG00000138279 [P20073-1]
ENST00000372921; ENSP00000362012; ENSG00000138279 [P20073-2]
GeneIDi310
KEGGihsa:310
UCSCiuc001jtz.3 human [P20073-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiANXA7_HUMAN
AccessioniPrimary (citable) accession number: P20073
Secondary accession number(s): Q5F2H3, Q5T0M6, Q5T0M7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: November 25, 2008
Last modified: June 20, 2018
This is version 182 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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