DNA-binding protein inhibitor ID-1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• identical protein binding Source: MGI
• proteasome binding Source: MGI
• protein C-terminus binding Source: MGI
• protein dimerization activity Source: InterPro
• protein N-terminus binding Source: MGI
• protein self-association Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Inhibition of endothelial cell activation by bHLH protein E2-2 and its impairment of angiogenesis."
    Tanaka A., Itoh F., Nishiyama K., Takezawa T., Kurihara H., Itoh S., Kato M.
    Blood 115:4138-4147(2010) [PubMed] [Europe PMC] [Abstract]
• transcription coactivator activity Source: UniProtKBInferred from direct assayⁱ
  • "Id sustains Hes1 expression to inhibit precocious neurogenesis by releasing negative autoregulation of Hes1."
    Bai G., Sheng N., Xie Z., Bian W., Yokota Y., Benezra R., Kageyama R., Guillemot F., Jing N.
    Dev. Cell 13:283-297(2007) [PubMed] [Europe PMC] [Abstract]
• transcription factor binding Source: MGI

GO - Biological processⁱ

• BMP signaling pathway Source: MGIInferred from direct assayⁱ
  • "Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation."
    Yamashita M., Ying S.X., Zhang G.M., Li C., Cheng S.Y., Deng C.X., Zhang Y.E.
    Cell 121:101-113(2005) [PubMed] [Europe PMC] [Abstract]
• brain development Source: Ensembl
• cell-abiotic substrate adhesion Source: Ensembl
• cell differentiation Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cellular response to dopamine Source: Ensembl
• cellular response to epidermal growth factor stimulus Source: Ensembl
• cellular response to nerve growth factor stimulus Source: Ensembl
• cellular response to peptide Source: Ensembl
• cellular response to transforming growth factor beta stimulus Source: Ensembl
• circadian regulation of gene expression Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• circadian rhythm Source: UniProtKB <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • Ref.8

    "A role for Id2 in regulating photic entrainment of the mammalian circadian system."
    Duffield G.E., Watson N.P., Mantani A., Peirson S.N., Robles-Murguia M., Loros J.J., Israel M.A., Dunlap J.C.
    Curr. Biol. 19:297-304(2009) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INDUCTION.
• collagen metabolic process Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Inhibitor of differentiation 1 promotes endothelial survival in a bleomycin model of lung injury in mice."
    Zhang H., Lawson W.E., Polosukhin V.V., Pozzi A., Blackwell T.S., Litingtung Y., Chiang C.
    Am. J. Pathol. 171:1113-1126(2007) [PubMed] [Europe PMC] [Abstract]
• endothelial cell morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "Inhibitor of differentiation 1 promotes endothelial survival in a bleomycin model of lung injury in mice."
    Zhang H., Lawson W.E., Polosukhin V.V., Pozzi A., Blackwell T.S., Litingtung Y., Chiang C.
    Am. J. Pathol. 171:1113-1126(2007) [PubMed] [Europe PMC] [Abstract]
• heart development Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Rescue of cardiac defects in id knockout embryos by injection of embryonic stem cells."
    Fraidenraich D., Stillwell E., Romero E., Wilkes D., Manova K., Basson C.T., Benezra R.
    Science 306:247-252(2004) [PubMed] [Europe PMC] [Abstract]
• lung morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "Inhibitor of differentiation 1 promotes endothelial survival in a bleomycin model of lung injury in mice."
    Zhang H., Lawson W.E., Polosukhin V.V., Pozzi A., Blackwell T.S., Litingtung Y., Chiang C.
    Am. J. Pathol. 171:1113-1126(2007) [PubMed] [Europe PMC] [Abstract]
• lung vasculature development Source: MGIInferred from mutant phenotypeⁱ
  • "Inhibitor of differentiation 1 promotes endothelial survival in a bleomycin model of lung injury in mice."
    Zhang H., Lawson W.E., Polosukhin V.V., Pozzi A., Blackwell T.S., Litingtung Y., Chiang C.
    Am. J. Pathol. 171:1113-1126(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of apoptotic process Source: MGIInferred from mutant phenotypeⁱ
  • "Inhibitor of differentiation 1 promotes endothelial survival in a bleomycin model of lung injury in mice."
    Zhang H., Lawson W.E., Polosukhin V.V., Pozzi A., Blackwell T.S., Litingtung Y., Chiang C.
    Am. J. Pathol. 171:1113-1126(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cold-induced thermogenesis Source: YuBioLabInferred from mutant phenotypeⁱ
  • "Id1 Promotes Obesity by Suppressing Brown Adipose Thermogenesis and White Adipose Browning."
    Patil M., Sharma B.K., Elattar S., Chang J., Kapil S., Yuan J., Satyanarayana A.
    Diabetes 66:1611-1625(2017) [PubMed] [Europe PMC] [Abstract]
• negative regulation of dendrite morphogenesis Source: MGI
• negative regulation of DNA binding Source: MGIInferred from direct assayⁱ
  • "Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix-loop-helix proteins."
    Sun X.H., Copeland N.G., Jenkins N.A., Baltimore D.
    Mol. Cell. Biol. 11:5603-5611(1991) [PubMed] [Europe PMC] [Abstract]
• negative regulation of DNA-binding transcription factor activity Source: MGI
• negative regulation of endothelial cell differentiation Source: MGI
• negative regulation of gene expression Source: MGIInferred from mutant phenotypeⁱ
  • "Inhibition of endothelial cell activation by bHLH protein E2-2 and its impairment of angiogenesis."
    Tanaka A., Itoh F., Nishiyama K., Takezawa T., Kurihara H., Itoh S., Kato M.
    Blood 115:4138-4147(2010) [PubMed] [Europe PMC] [Abstract]
• negative regulation of osteoblast differentiation Source: MGIInferred from genetic interactionⁱ
  • "Inhibitor of DNA binding/differentiation helix-loop-helix proteins mediate bone morphogenetic protein-induced osteoblast differentiation of mesenchymal stem cells."
    Peng Y., Kang Q., Luo Q., Jiang W., Si W., Liu B.A., Luu H.H., Park J.K., Li X., Luo J., Montag A.G., Haydon R.C., He T.C.
    J. Biol. Chem. 279:32941-32949(2004) [PubMed] [Europe PMC] [Abstract]
• negative regulation of protein binding Source: MGI
• negative regulation of transcription, DNA-templated Source: UniProtKBInferred from direct assayⁱ
  • Ref.8

    "A role for Id2 in regulating photic entrainment of the mammalian circadian system."
    Duffield G.E., Watson N.P., Mantani A., Peirson S.N., Robles-Murguia M., Loros J.J., Israel M.A., Dunlap J.C.
    Curr. Biol. 19:297-304(2009) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INDUCTION.
• negative regulation of transcription by RNA polymerase II Source: MGIInferred from direct assayⁱ
  • "Id1 regulates angiogenesis through transcriptional repression of thrombospondin-1."
    Volpert O.V., Pili R., Sikder H.A., Nelius T., Zaichuk T., Morris C., Shiflett C.B., Devlin M.K., Conant K., Alani R.M.
    Cancer Cell 2:473-483(2002) [PubMed] [Europe PMC] [Abstract]
• neuron differentiation Source: Ensembl
• positive regulation of actin filament bundle assembly Source: MGI
• positive regulation of epithelial cell proliferation Source: MGI
• positive regulation of gene expression Source: UniProtKBInferred from direct assayⁱ
  • "Id sustains Hes1 expression to inhibit precocious neurogenesis by releasing negative autoregulation of Hes1."
    Bai G., Sheng N., Xie Z., Bian W., Yokota Y., Benezra R., Kageyama R., Guillemot F., Jing N.
    Dev. Cell 13:283-297(2007) [PubMed] [Europe PMC] [Abstract]
• protein destabilization Source: MGIInferred from direct assayⁱ
  • "Myogenin protein stability is decreased by BMP-2 through a mechanism implicating Id1."
    Vinals F., Ventura F.
    J. Biol. Chem. 279:45766-45772(2004) [PubMed] [Europe PMC] [Abstract]
• regulation of angiogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "Id1 regulates angiogenesis through transcriptional repression of thrombospondin-1."
    Volpert O.V., Pili R., Sikder H.A., Nelius T., Zaichuk T., Morris C., Shiflett C.B., Devlin M.K., Conant K., Alani R.M.
    Cancer Cell 2:473-483(2002) [PubMed] [Europe PMC] [Abstract]
• regulation of MAPK cascade Source: MGIInferred from mutant phenotypeⁱ
  • "Inhibitor of differentiation 1 promotes endothelial survival in a bleomycin model of lung injury in mice."
    Zhang H., Lawson W.E., Polosukhin V.V., Pozzi A., Blackwell T.S., Litingtung Y., Chiang C.
    Am. J. Pathol. 171:1113-1126(2007) [PubMed] [Europe PMC] [Abstract]
• regulation of vasculature development Source: MGI
• response to antibiotic Source: MGIInferred from mutant phenotypeⁱ
  • "Inhibitor of differentiation 1 promotes endothelial survival in a bleomycin model of lung injury in mice."
    Zhang H., Lawson W.E., Polosukhin V.V., Pozzi A., Blackwell T.S., Litingtung Y., Chiang C.
    Am. J. Pathol. 171:1113-1126(2007) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• identical protein binding Source: MGI
• protein C-terminus binding Source: MGI
• protein dimerization activity Source: InterPro
• protein N-terminus binding Source: MGI
• protein self-association Source: MGIInferred from direct assayⁱ
  • "Inhibition of endothelial cell activation by bHLH protein E2-2 and its impairment of angiogenesis."
    Tanaka A., Itoh F., Nishiyama K., Takezawa T., Kurihara H., Itoh S., Kato M.
    Blood 115:4138-4147(2010) [PubMed] [Europe PMC] [Abstract]
• transcription factor binding Source: MGI

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Motif

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MKVASGSAAA AAGPSCSLKA GRTAGEVVLG LSEQSVAISR CAGTRLPALL 
        60         70         80         90        100
DEQQVNVLLY DMNGCYSRLK ELVPTLPQNR KVSKVEILQH VIDYIRDLQL 
       110        120        130        140        150
ELNSESEVGT TGGRGLPVRA PLSTLNGEIS ALAAEVRSES EYYIILQWET 
       160 
EATGGGCPPS LLFRRIAI                                    

        10         20         30         40         50
MKVASGSAAA AAGPSCSLKA GRTAGEVVLG LSEQSVAISR CAGTRLPALL 
        60         70         80         90        100
DEQQVNVLLY DMNGCYSRLK ELVPTLPQNR KVSKVEILQH VIDYIRDLQL 
       110        120        130        140 
ELNSESEVGT TGGRGLPVRA PLSTLNGEIS ALAAEAACVP ADDRILCR   

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
2. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references