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Protein

Transcobalamin-2

Gene

TCN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei104Cobalamin2 Publications1
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi190Cobalt (cobalamin axial ligand)1
Binding sitei242Cobalamin1 Publication1
Binding sitei245Cobalamin2 Publications1
Binding sitei291Cobalamin1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cobalamin binding Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCobalt transport, Ion transport, Transport
LigandCobalt, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism
R-HSA-3359454 Defective TCN2 causes hereditary megaloblastic anemia
R-HSA-3359485 Defective CD320 causes methylmalonic aciduria

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P20062

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcobalamin-2
Short name:
TC-2
Alternative name(s):
Transcobalamin II
Short name:
TC II
Short name:
TCII
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TCN2
Synonyms:TC2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000185339.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11653 TCN2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613441 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P20062

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Transcobalamin II deficiency (TCN2 deficiency)
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionResults in various forms of anemia.
See also OMIM:275350

Organism-specific databases

DisGeNET

More...
DisGeNETi
6948

MalaCards human disease database

More...
MalaCardsi
TCN2
MIMi275350 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000185339

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
859 Transcobalamin deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36404

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB00115 Cyanocobalamin
DB00200 Hydroxocobalamin

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TCN2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
224471876

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 181 PublicationAdd BLAST18
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000556419 – 427Transcobalamin-2Add BLAST409

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi21 ↔ 267Combined sources2 Publications
Disulfide bondi83 ↔ 96Combined sources1 Publication
Disulfide bondi116 ↔ 309Combined sources2 Publications
Disulfide bondi165 ↔ 205Combined sources2 Publications

Keywords - PTMi

Disulfide bond

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P20062

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P20062

PeptideAtlas

More...
PeptideAtlasi
P20062

PRoteomics IDEntifications database

More...
PRIDEi
P20062

ProteomicsDB human proteome resource

More...
ProteomicsDBi
53720
53721 [P20062-2]

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000185339 Expressed in 136 organ(s), highest expression level in esophagus

CleanEx database of gene expression profiles

More...
CleanExi
HS_TCN2

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P20062 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P20062 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA000837

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CD320 (via LDL-receptor class A domains).1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112808, 5 interactors

Protein interaction database and analysis system

More...
IntActi
P20062, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000215838

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1427
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BB5X-ray3.20A/B19-427[»]
4ZRPX-ray2.10A/B19-427[»]
4ZRQX-ray2.60A/B19-427[»]
5NO0X-ray1.57A325-427[»]
5NP4X-ray1.43A325-427[»]
5NRPX-ray1.57A325-427[»]
5NSAX-ray1.27A325-427[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P20062

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P20062

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P20062

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni152 – 156Cobalamin binding1 Publication5
Regioni190 – 194Cobalamin binding1 Publication5
Regioni395 – 397Cobalamin binding1 Publication3

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IDZK Eukaryota
ENOG410XSU1 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063370

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000074060

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG001328

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P20062

KEGG Orthology (KO)

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KOi
K14619

Identification of Orthologs from Complete Genome Data

More...
OMAi
PSIYVGL

Database of Orthologous Groups

More...
OrthoDBi
1233171at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P20062

TreeFam database of animal gene trees

More...
TreeFami
TF333092

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002157 Cbl-bd_prot
IPR027954 DUF4430
IPR008930 Terpenoid_cyclase/PrenylTrfase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01122 Cobalamin_bind, 1 hit
PF14478 DUF4430, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48239 SSF48239, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00468 COBALAMIN_BINDING, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P20062-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRHLGAFLFL LGVLGALTEM CEIPEMDSHL VEKLGQHLLP WMDRLSLEHL
60 70 80 90 100
NPSIYVGLRL SSLQAGTKED LYLHSLKLGY QQCLLGSAFS EDDGDCQGKP
110 120 130 140 150
SMGQLALYLL ALRANCEFVR GHKGDRLVSQ LKWFLEDEKR AIGHDHKGHP
160 170 180 190 200
HTSYYQYGLG ILALCLHQKR VHDSVVDKLL YAVEPFHQGH HSVDTAAMAG
210 220 230 240 250
LAFTCLKRSN FNPGRRQRIT MAIRTVREEI LKAQTPEGHF GNVYSTPLAL
260 270 280 290 300
QFLMTSPMRG AELGTACLKA RVALLASLQD GAFQNALMIS QLLPVLNHKT
310 320 330 340 350
YIDLIFPDCL APRVMLEPAA ETIPQTQEII SVTLQVLSLL PPYRQSISVL
360 370 380 390 400
AGSTVEDVLK KAHELGGFTY ETQASLSGPY LTSVMGKAAG EREFWQLLRD
410 420
PNTPLLQGIA DYRPKDGETI ELRLVSW
Length:427
Mass (Da):47,535
Last modified:March 3, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFD04A110941989DB
GO
Isoform 2 (identifier: P20062-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     116-143: CEFVRGHKGDRLVSQLKWFLEDEKRAIG → W

Note: No experimental confirmation available.
Show »
Length:400
Mass (Da):44,421
Checksum:i38C59B8CF61DC15D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B5MBX2B5MBX2_HUMAN
Transcobalamin-2
TCN2
423Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WE86F8WE86_HUMAN
Transcobalamin-2
TCN2
402Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Pro/Arg-259 polymorphism affects TCN2 plasma concentration and may interfere in vitamin B(12) cellular availability and homocysteine metabolism (PubMed:11159542).1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05453923I → V. Corresponds to variant dbSNP:rs9606756EnsemblClinVar.1
Natural variantiVAR_05454089F → L. Corresponds to variant dbSNP:rs35915865EnsemblClinVar.1
Natural variantiVAR_001638198M → T1 Publication1
Natural variantiVAR_054541215R → W. Corresponds to variant dbSNP:rs35838082EnsemblClinVar.1
Natural variantiVAR_001639219I → L1 Publication1
Natural variantiVAR_054542227R → Q1 PublicationCorresponds to variant dbSNP:rs17849434Ensembl.1
Natural variantiVAR_001640259R → P3 PublicationsCorresponds to variant dbSNP:rs1801198EnsemblClinVar.1
Natural variantiVAR_054543348S → F. Corresponds to variant dbSNP:rs9621049EnsemblClinVar.1
Natural variantiVAR_001641376L → S1 PublicationCorresponds to variant dbSNP:rs1131603EnsemblClinVar.1
Natural variantiVAR_054544399R → Q. Corresponds to variant dbSNP:rs4820889EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_043711116 – 143CEFVR…KRAIG → W in isoform 2. 1 PublicationAdd BLAST28

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M60396 mRNA Translation: AAA61054.1
L02647 mRNA Translation: AAA61056.1
L02648 mRNA Translation: AAA61057.1
AF047576 Genomic DNA Translation: AAC05491.1
CR456591 mRNA Translation: CAG30477.1
AC005006 Genomic DNA No translation available.
BC001176 mRNA Translation: AAH01176.1
BC011239 mRNA Translation: AAH11239.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13881.1 [P20062-1]
CCDS54519.1 [P20062-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
A39744

NCBI Reference Sequences

More...
RefSeqi
NP_000346.2, NM_000355.3 [P20062-1]
NP_001171655.1, NM_001184726.1 [P20062-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.417948

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000215838; ENSP00000215838; ENSG00000185339 [P20062-1]
ENST00000407817; ENSP00000384914; ENSG00000185339 [P20062-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6948

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6948

UCSC genome browser

More...
UCSCi
uc003aip.3 human [P20062-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

TCN2base

TCN2 mutation db

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60396 mRNA Translation: AAA61054.1
L02647 mRNA Translation: AAA61056.1
L02648 mRNA Translation: AAA61057.1
AF047576 Genomic DNA Translation: AAC05491.1
CR456591 mRNA Translation: CAG30477.1
AC005006 Genomic DNA No translation available.
BC001176 mRNA Translation: AAH01176.1
BC011239 mRNA Translation: AAH11239.1
CCDSiCCDS13881.1 [P20062-1]
CCDS54519.1 [P20062-2]
PIRiA39744
RefSeqiNP_000346.2, NM_000355.3 [P20062-1]
NP_001171655.1, NM_001184726.1 [P20062-2]
UniGeneiHs.417948

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BB5X-ray3.20A/B19-427[»]
4ZRPX-ray2.10A/B19-427[»]
4ZRQX-ray2.60A/B19-427[»]
5NO0X-ray1.57A325-427[»]
5NP4X-ray1.43A325-427[»]
5NRPX-ray1.57A325-427[»]
5NSAX-ray1.27A325-427[»]
ProteinModelPortaliP20062
SMRiP20062
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112808, 5 interactors
IntActiP20062, 2 interactors
STRINGi9606.ENSP00000215838

Chemistry databases

DrugBankiDB00115 Cyanocobalamin
DB00200 Hydroxocobalamin

Polymorphism and mutation databases

BioMutaiTCN2
DMDMi224471876

Proteomic databases

jPOSTiP20062
PaxDbiP20062
PeptideAtlasiP20062
PRIDEiP20062
ProteomicsDBi53720
53721 [P20062-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
6948
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000215838; ENSP00000215838; ENSG00000185339 [P20062-1]
ENST00000407817; ENSP00000384914; ENSG00000185339 [P20062-2]
GeneIDi6948
KEGGihsa:6948
UCSCiuc003aip.3 human [P20062-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6948
DisGeNETi6948
EuPathDBiHostDB:ENSG00000185339.8

GeneCards: human genes, protein and diseases

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GeneCardsi
TCN2
HGNCiHGNC:11653 TCN2
HPAiHPA000837
MalaCardsiTCN2
MIMi275350 phenotype
613441 gene
neXtProtiNX_P20062
OpenTargetsiENSG00000185339
Orphaneti859 Transcobalamin deficiency
PharmGKBiPA36404

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IDZK Eukaryota
ENOG410XSU1 LUCA
GeneTreeiENSGT00530000063370
HOGENOMiHOG000074060
HOVERGENiHBG001328
InParanoidiP20062
KOiK14619
OMAiPSIYVGL
OrthoDBi1233171at2759
PhylomeDBiP20062
TreeFamiTF333092

Enzyme and pathway databases

ReactomeiR-HSA-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism
R-HSA-3359454 Defective TCN2 causes hereditary megaloblastic anemia
R-HSA-3359485 Defective CD320 causes methylmalonic aciduria
SABIO-RKiP20062

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TCN2 human
EvolutionaryTraceiP20062

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6948

Protein Ontology

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PROi
PR:P20062

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000185339 Expressed in 136 organ(s), highest expression level in esophagus
CleanExiHS_TCN2
ExpressionAtlasiP20062 baseline and differential
GenevisibleiP20062 HS

Family and domain databases

InterProiView protein in InterPro
IPR002157 Cbl-bd_prot
IPR027954 DUF4430
IPR008930 Terpenoid_cyclase/PrenylTrfase
PfamiView protein in Pfam
PF01122 Cobalamin_bind, 1 hit
PF14478 DUF4430, 1 hit
SUPFAMiSSF48239 SSF48239, 1 hit
PROSITEiView protein in PROSITE
PS00468 COBALAMIN_BINDING, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTCO2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P20062
Secondary accession number(s): Q96FD4
, Q9BVI8, Q9UCI5, Q9UCI6, Q9UDM0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: March 3, 2009
Last modified: January 16, 2019
This is version 186 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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