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Entry version 212 (29 Sep 2021)
Sequence version 2 (01 Dec 2000)
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Protein

Eukaryotic translation initiation factor 2 subunit 2

Gene

EIF2S2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri281 – 305C4-typeSequence analysisAdd BLAST25

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis
LigandMetal-binding, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.6.5.3, 2681

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P20042

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-156827, L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-381042, PERK regulates gene expression
R-HSA-382556, ABC-family proteins mediated transport
R-HSA-72649, Translation initiation complex formation
R-HSA-72695, Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702, Ribosomal scanning and start codon recognition
R-HSA-72706, GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72731, Recycling of eIF2:GDP
R-HSA-9633012, Response of EIF2AK4 (GCN2) to amino acid deficiency
R-HSA-9648895, Response of EIF2AK1 (HRI) to heme deficiency

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P20042

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Eukaryotic translation initiation factor 2 subunit 2
Alternative name(s):
Eukaryotic translation initiation factor 2 subunit beta
Short name:
eIF-2-beta
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EIF2S2
Synonyms:EIF2B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3266, EIF2S2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603908, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P20042

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000125977

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
8894

Open Targets

More...
OpenTargetsi
ENSG00000125977

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27696

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P20042, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
EIF2S2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
12644154

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001374062 – 333Eukaryotic translation initiation factor 2 subunit 2Add BLAST332

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei2PhosphoserineCombined sources1
Modified residuei13PhosphoserineCombined sources1
Modified residuei31PhosphothreonineCombined sources1
Modified residuei36PhosphothreonineCombined sources1
Modified residuei67PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki102Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei105PhosphoserineCombined sources1
Modified residuei111PhosphothreonineCombined sources1
Modified residuei158PhosphoserineCombined sources1
Modified residuei218PhosphoserineBy similarity1
Modified residuei265N6-acetyllysineCombined sources1
Modified residuei293N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P20042

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P20042

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P20042

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P20042

PeptideAtlas

More...
PeptideAtlasi
P20042

PRoteomics IDEntifications database

More...
PRIDEi
P20042

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
53718

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P20042

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
P20042, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P20042

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
P20042

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P20042

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P20042

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000125977, Expressed in pancreas and 169 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P20042, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P20042, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000125977, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotrimer composed of an alpha, a beta and a gamma chain (PubMed:23063529).

Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5 (By similarity).

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
114411, 138 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P20042

Protein interaction database and analysis system

More...
IntActi
P20042, 64 interactors

Molecular INTeraction database

More...
MINTi
P20042

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000364119

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P20042, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P20042

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 119DisorderedSequence analysisAdd BLAST119
Regioni139 – 164DisorderedSequence analysisAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi35 – 49Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi56 – 78Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi86 – 108Basic and acidic residuesSequence analysisAdd BLAST23

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the eIF-2-beta/eIF-5 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri281 – 305C4-typeSequence analysisAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2768, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000001804

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_026663_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P20042

Identification of Orthologs from Complete Genome Data

More...
OMAi
KRTEEHV

Database of Orthologous Groups

More...
OrthoDBi
1178655at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P20042

TreeFam database of animal gene trees

More...
TreeFami
TF101503

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002735, Transl_init_fac_IF2/IF5
IPR016189, Transl_init_fac_IF2/IF5_N
IPR016190, Transl_init_fac_IF2/IF5_Zn-bd

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01873, eIF-5_eIF-2B, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00653, eIF2B_5, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100966, SSF100966, 1 hit
SSF75689, SSF75689, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P20042-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGDEMIFDP TMSKKKKKKK KPFMLDEEGD TQTEETQPSE TKEVEPEPTE
60 70 80 90 100
DKDLEADEED TRKKDASDDL DDLNFFNQKK KKKKTKKIFD IDEAEEGVKD
110 120 130 140 150
LKIESDVQEP TEPEDDLDIM LGNKKKKKKN VKFPDEDEIL EKDEALEDED
160 170 180 190 200
NKKDDGISFS NQTGPAWAGS ERDYTYEELL NRVFNIMREK NPDMVAGEKR
210 220 230 240 250
KFVMKPPQVV RVGTKKTSFV NFTDICKLLH RQPKHLLAFL LAELGTSGSI
260 270 280 290 300
DGNNQLVIKG RFQQKQIENV LRRYIKEYVT CHTCRSPDTI LQKDTRLYFL
310 320 330
QCETCHSRCS VASIKTGFQA VTGKRAQLRA KAN
Length:333
Mass (Da):38,388
Last modified:December 1, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3E9FD4B48AA61A51
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti295T → I in AAA52383 (PubMed:3044606).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048909177E → D1 PublicationCorresponds to variant dbSNP:rs17856024Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M29536 mRNA Translation: AAA52383.1
AL031668 Genomic DNA No translation available.
BC000461 mRNA Translation: AAH00461.1
BC000934 mRNA Translation: AAH00934.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13231.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A31226

NCBI Reference Sequences

More...
RefSeqi
NP_003899.2, NM_003908.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000374980; ENSP00000364119; ENSG00000125977

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8894

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8894

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29536 mRNA Translation: AAA52383.1
AL031668 Genomic DNA No translation available.
BC000461 mRNA Translation: AAH00461.1
BC000934 mRNA Translation: AAH00934.1
CCDSiCCDS13231.1
PIRiA31226
RefSeqiNP_003899.2, NM_003908.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6K71electron microscopy4.30M1-333[»]
6K72electron microscopy4.60M1-333[»]
6YBVelectron microscopy3.80s1-333[»]
6ZMWelectron microscopy3.70s1-333[»]
6ZP4electron microscopy2.9041-333[»]
7A09electron microscopy3.5041-333[»]
7D43electron microscopy4.30M1-333[»]
SMRiP20042
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114411, 138 interactors
CORUMiP20042
IntActiP20042, 64 interactors
MINTiP20042
STRINGi9606.ENSP00000364119

PTM databases

GlyGeniP20042, 1 site, 1 O-linked glycan (1 site)
iPTMnetiP20042
MetOSiteiP20042
PhosphoSitePlusiP20042
SwissPalmiP20042

Genetic variation databases

BioMutaiEIF2S2
DMDMi12644154

Proteomic databases

EPDiP20042
jPOSTiP20042
MassIVEiP20042
PaxDbiP20042
PeptideAtlasiP20042
PRIDEiP20042
ProteomicsDBi53718
TopDownProteomicsiP20042

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
25771, 338 antibodies

The DNASU plasmid repository

More...
DNASUi
8894

Genome annotation databases

EnsembliENST00000374980; ENSP00000364119; ENSG00000125977
GeneIDi8894
KEGGihsa:8894

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8894
DisGeNETi8894

GeneCards: human genes, protein and diseases

More...
GeneCardsi
EIF2S2
HGNCiHGNC:3266, EIF2S2
HPAiENSG00000125977, Low tissue specificity
MIMi603908, gene
neXtProtiNX_P20042
OpenTargetsiENSG00000125977
PharmGKBiPA27696
VEuPathDBiHostDB:ENSG00000125977

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2768, Eukaryota
GeneTreeiENSGT00390000001804
HOGENOMiCLU_026663_0_1_1
InParanoidiP20042
OMAiKRTEEHV
OrthoDBi1178655at2759
PhylomeDBiP20042
TreeFamiTF101503

Enzyme and pathway databases

BRENDAi3.6.5.3, 2681
PathwayCommonsiP20042
ReactomeiR-HSA-156827, L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-381042, PERK regulates gene expression
R-HSA-382556, ABC-family proteins mediated transport
R-HSA-72649, Translation initiation complex formation
R-HSA-72695, Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702, Ribosomal scanning and start codon recognition
R-HSA-72706, GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72731, Recycling of eIF2:GDP
R-HSA-9633012, Response of EIF2AK4 (GCN2) to amino acid deficiency
R-HSA-9648895, Response of EIF2AK1 (HRI) to heme deficiency
SIGNORiP20042

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
8894, 605 hits in 968 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
EIF2S2, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
EIF2S2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
8894
PharosiP20042, Tbio

Protein Ontology

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PROi
PR:P20042
RNActiP20042, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000125977, Expressed in pancreas and 169 other tissues
ExpressionAtlasiP20042, baseline and differential
GenevisibleiP20042, HS

Family and domain databases

InterProiView protein in InterPro
IPR002735, Transl_init_fac_IF2/IF5
IPR016189, Transl_init_fac_IF2/IF5_N
IPR016190, Transl_init_fac_IF2/IF5_Zn-bd
PfamiView protein in Pfam
PF01873, eIF-5_eIF-2B, 1 hit
SMARTiView protein in SMART
SM00653, eIF2B_5, 1 hit
SUPFAMiSSF100966, SSF100966, 1 hit
SSF75689, SSF75689, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIF2B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P20042
Secondary accession number(s): Q9BVU0, Q9UJE4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: December 1, 2000
Last modified: September 29, 2021
This is version 212 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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