UniProtKB - P20023 (CR2_HUMAN)
Protein
Complement receptor type 2
Gene
CR2
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for complement C3, for the Epstein-Barr virus on human B-cells and T-cells and for HNRNPU (PubMed:7753047). Participates in B lymphocytes activation (PubMed:7753047).1 Publication
(Microbial infection) Acts as a receptor for Epstein-Barr virus.1 Publication
GO - Molecular functioni
- complement binding Source: UniProtKB
- complement receptor activity Source: ProtInc
- DNA binding Source: UniProtKB
- protein homodimerization activity Source: MGI
- transmembrane signaling receptor activity Source: UniProtKB
- virus receptor activity Source: UniProtKB-KW
GO - Biological processi
- B cell differentiation Source: UniProtKB
- B cell proliferation Source: UniProtKB
- complement activation, classical pathway Source: UniProtKB-KW
- immune response Source: UniProtKB
- innate immune response Source: UniProtKB-KW
- regulation of complement activation Source: Reactome
Keywordsi
Molecular function | Host cell receptor for virus entry, Receptor |
Biological process | Complement pathway, Host-virus interaction, Immunity, Innate immunity |
Enzyme and pathway databases
PathwayCommonsi | P20023 |
Reactomei | R-HSA-977606, Regulation of Complement cascade |
SIGNORi | P20023 |
Names & Taxonomyi
Protein namesi | Recommended name: Complement receptor type 2Short name: Cr2 Alternative name(s): Complement C3d receptor Epstein-Barr virus receptor Short name: EBV receptor CD_antigen: CD21 |
Gene namesi | Name:CR2 Synonyms:C3DR |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000117322.16 |
HGNCi | HGNC:2336, CR2 |
MIMi | 120650, gene |
neXtProti | NX_P20023 |
Subcellular locationi
Plasma membrane
- Cell membrane 2 Publications; Single-pass type I membrane protein
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- integral component of membrane Source: UniProtKB
- receptor complex Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 21 – 971 | ExtracellularSequence analysisAdd BLAST | 951 | |
Transmembranei | 972 – 999 | HelicalSequence analysisAdd BLAST | 28 | |
Topological domaini | 1000 – 1033 | CytoplasmicSequence analysisAdd BLAST | 34 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Involvement in diseasei
Systemic lupus erythematosus 9 (SLEB9)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
Related information in OMIMImmunodeficiency, common variable, 7 (CVID7)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.
Related information in OMIMMutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 103 | R → A: No effect on affinity for C3. 1 Publication | 1 | |
Mutagenesisi | 112 | D → A: Reduced affinity for C3. 1 Publication | 1 | |
Mutagenesisi | 128 | K → A: Strongly reduced affinity for C3. 1 Publication | 1 |
Keywords - Diseasei
Systemic lupus erythematosusOrganism-specific databases
DisGeNETi | 1380 |
MalaCardsi | CR2 |
MIMi | 610927, phenotype 614699, phenotype |
OpenTargetsi | ENSG00000117322 |
Orphaneti | 1572, Common variable immunodeficiency 536, Systemic lupus erythematosus |
PharmGKBi | PA26857 |
Miscellaneous databases
Pharosi | P20023, Tbio |
Polymorphism and mutation databases
BioMutai | CR2 |
DMDMi | 215273962 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Add BLAST | 20 | |
ChainiPRO_0000006010 | 21 – 1033 | Complement receptor type 2Add BLAST | 1013 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 23 ↔ 65 | Combined sources3 Publications | ||
Disulfide bondi | 51 ↔ 82 | Combined sources3 Publications | ||
Disulfide bondi | 91 ↔ 132 | Combined sources3 Publications | ||
Disulfide bondi | 118 ↔ 146 | Combined sources3 Publications | ||
Glycosylationi | 121 | N-linked (GlcNAc...) asparagineCombined sources1 Publication | 1 | |
Glycosylationi | 127 | N-linked (GlcNAc...) asparagineCombined sources1 Publication | 1 | |
Disulfide bondi | 154 ↔ 197 | PROSITE-ProRule annotation | ||
Disulfide bondi | 183 ↔ 210 | PROSITE-ProRule annotation | ||
Disulfide bondi | 215 ↔ 256 | PROSITE-ProRule annotation | ||
Disulfide bondi | 242 ↔ 271 | PROSITE-ProRule annotation | ||
Disulfide bondi | 276 ↔ 325 | PROSITE-ProRule annotation | ||
Glycosylationi | 294 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 305 ↔ 342 | PROSITE-ProRule annotation | ||
Disulfide bondi | 351 ↔ 393 | PROSITE-ProRule annotation | ||
Glycosylationi | 372 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 379 ↔ 406 | PROSITE-ProRule annotation | ||
Disulfide bondi | 410 ↔ 453 | PROSITE-ProRule annotation | ||
Disulfide bondi | 439 ↔ 466 | PROSITE-ProRule annotation | ||
Disulfide bondi | 471 ↔ 509 | PROSITE-ProRule annotation | ||
Glycosylationi | 492 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 495 ↔ 522 | PROSITE-ProRule annotation | ||
Disulfide bondi | 527 ↔ 576 | PROSITE-ProRule annotation | ||
Disulfide bondi | 556 ↔ 593 | PROSITE-ProRule annotation | ||
Disulfide bondi | 602 ↔ 644 | PROSITE-ProRule annotation | ||
Glycosylationi | 623 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 630 ↔ 657 | PROSITE-ProRule annotation | ||
Disulfide bondi | 662 ↔ 699 | PROSITE-ProRule annotation | ||
Glycosylationi | 682 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 685 ↔ 714 | PROSITE-ProRule annotation | ||
Disulfide bondi | 719 ↔ 762 | PROSITE-ProRule annotation | ||
Disulfide bondi | 748 ↔ 779 | PROSITE-ProRule annotation | ||
Disulfide bondi | 788 ↔ 830 | PROSITE-ProRule annotation | ||
Glycosylationi | 800 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 816 ↔ 843 | PROSITE-ProRule annotation | ||
Glycosylationi | 823 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 851 ↔ 894 | PROSITE-ProRule annotation | ||
Glycosylationi | 861 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 880 ↔ 907 | PROSITE-ProRule annotation | ||
Glycosylationi | 911 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 912 ↔ 955 | PROSITE-ProRule annotation | ||
Disulfide bondi | 941 ↔ 968 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MassIVEi | P20023 |
PeptideAtlasi | P20023 |
PRIDEi | P20023 |
ProteomicsDBi | 53712 [P20023-1] 53713 [P20023-2] 53714 [P20023-3] 53715 [P20023-4] |
PTM databases
GlyGeni | P20023, 13 sites |
iPTMneti | P20023 |
PhosphoSitePlusi | P20023 |
Expressioni
Tissue specificityi
Mature B-lymphocytes, T-lymphocytes, pharyngeal epithelial cells, astrocytes and follicular dendritic cells of the spleen.
Gene expression databases
Bgeei | ENSG00000117322, Expressed in tonsil and 110 other tissues |
ExpressionAtlasi | P20023, baseline and differential |
Genevisiblei | P20023, HS |
Organism-specific databases
HPAi | ENSG00000117322, Tissue enriched (lymphoid) |
Interactioni
Subunit structurei
(Microbial infection) Interacts with Epstein-Barr virus gp350 protein.
1 PublicationGO - Molecular functioni
- complement binding Source: UniProtKB
- protein homodimerization activity Source: MGI
Protein-protein interaction databases
BioGRIDi | 107771, 7 interactors |
CORUMi | P20023 |
IntActi | P20023, 1 interactor |
STRINGi | 9606.ENSP00000356024 |
Miscellaneous databases
RNActi | P20023, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P20023 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P20023 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 21 – 84 | Sushi 1PROSITE-ProRule annotationAdd BLAST | 64 | |
Domaini | 89 – 148 | Sushi 2PROSITE-ProRule annotationAdd BLAST | 60 | |
Domaini | 152 – 212 | Sushi 3PROSITE-ProRule annotationAdd BLAST | 61 | |
Domaini | 213 – 273 | Sushi 4PROSITE-ProRule annotationAdd BLAST | 61 | |
Domaini | 274 – 344 | Sushi 5PROSITE-ProRule annotationAdd BLAST | 71 | |
Domaini | 349 – 408 | Sushi 6PROSITE-ProRule annotationAdd BLAST | 60 | |
Domaini | 409 – 468 | Sushi 7PROSITE-ProRule annotationAdd BLAST | 60 | |
Domaini | 469 – 524 | Sushi 8PROSITE-ProRule annotationAdd BLAST | 56 | |
Domaini | 525 – 595 | Sushi 9PROSITE-ProRule annotationAdd BLAST | 71 | |
Domaini | 600 – 659 | Sushi 10PROSITE-ProRule annotationAdd BLAST | 60 | |
Domaini | 660 – 716 | Sushi 11PROSITE-ProRule annotationAdd BLAST | 57 | |
Domaini | 717 – 781 | Sushi 12PROSITE-ProRule annotationAdd BLAST | 65 | |
Domaini | 786 – 845 | Sushi 13PROSITE-ProRule annotationAdd BLAST | 60 | |
Domaini | 849 – 909 | Sushi 14PROSITE-ProRule annotationAdd BLAST | 61 | |
Domaini | 910 – 970 | Sushi 15PROSITE-ProRule annotationAdd BLAST | 61 |
Sequence similaritiesi
Belongs to the receptors of complement activation (RCA) family.Curated
Keywords - Domaini
Repeat, Signal, Sushi, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4297, Eukaryota |
GeneTreei | ENSGT00940000161110 |
HOGENOMi | CLU_005124_0_0_1 |
InParanoidi | P20023 |
OMAi | KVAECEP |
OrthoDBi | 702827at2759 |
PhylomeDBi | P20023 |
TreeFami | TF316872 |
Family and domain databases
CDDi | cd00033, CCP, 13 hits |
InterProi | View protein in InterPro IPR035976, Sushi/SCR/CCP_sf IPR000436, Sushi_SCR_CCP_dom |
Pfami | View protein in Pfam PF00084, Sushi, 13 hits |
SMARTi | View protein in SMART SM00032, CCP, 14 hits |
SUPFAMi | SSF57535, SSF57535, 15 hits |
PROSITEi | View protein in PROSITE PS50923, SUSHI, 15 hits |
s (4+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform A (identifier: P20023-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGAAGLLGVF LALVAPGVLG ISCGSPPPIL NGRISYYSTP IAVGTVIRYS
60 70 80 90 100
CSGTFRLIGE KSLLCITKDK VDGTWDKPAP KCEYFNKYSS CPEPIVPGGY
110 120 130 140 150
KIRGSTPYRH GDSVTFACKT NFSMNGNKSV WCQANNMWGP TRLPTCVSVF
160 170 180 190 200
PLECPALPMI HNGHHTSENV GSIAPGLSVT YSCESGYLLV GEKIINCLSS
210 220 230 240 250
GKWSAVPPTC EEARCKSLGR FPNGKVKEPP ILRVGVTANF FCDEGYRLQG
260 270 280 290 300
PPSSRCVIAG QGVAWTKMPV CEEIFCPSPP PILNGRHIGN SLANVSYGSI
310 320 330 340 350
VTYTCDPDPE EGVNFILIGE STLRCTVDSQ KTGTWSGPAP RCELSTSAVQ
360 370 380 390 400
CPHPQILRGR MVSGQKDRYT YNDTVIFACM FGFTLKGSKQ IRCNAQGTWE
410 420 430 440 450
PSAPVCEKEC QAPPNILNGQ KEDRHMVRFD PGTSIKYSCN PGYVLVGEES
460 470 480 490 500
IQCTSEGVWT PPVPQCKVAA CEATGRQLLT KPQHQFVRPD VNSSCGEGYK
510 520 530 540 550
LSGSVYQECQ GTIPWFMEIR LCKEITCPPP PVIYNGAHTG SSLEDFPYGT
560 570 580 590 600
TVTYTCNPGP ERGVEFSLIG ESTIRCTSND QERGTWSGPA PLCKLSLLAV
610 620 630 640 650
QCSHVHIANG YKISGKEAPY FYNDTVTFKC YSGFTLKGSS QIRCKADNTW
660 670 680 690 700
DPEIPVCEKE TCQHVRQSLQ ELPAGSRVEL VNTSCQDGYQ LTGHAYQMCQ
710 720 730 740 750
DAENGIWFKK IPLCKVIHCH PPPVIVNGKH TGMMAENFLY GNEVSYECDQ
760 770 780 790 800
GFYLLGEKKL QCRSDSKGHG SWSGPSPQCL RSPPVTRCPN PEVKHGYKLN
810 820 830 840 850
KTHSAYSHND IVYVDCNPGF IMNGSRVIRC HTDNTWVPGV PTCIKKAFIG
860 870 880 890 900
CPPPPKTPNG NHTGGNIARF SPGMSILYSC DQGYLLVGEA LLLCTHEGTW
910 920 930 940 950
SQPAPHCKEV NCSSPADMDG IQKGLEPRKM YQYGAVVTLE CEDGYMLEGS
960 970 980 990 1000
PQSQCQSDHQ WNPPLAVCRS RSLAPVLCGI AAGLILLTFL IVITLYVISK
1010 1020 1030
HRARNYYTDT SQKEAFHLEA REVYSVDPYN PAS
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ5SR47 | Q5SR47_HUMAN | Complement receptor type 2 | CR2 | 971 | Annotation score: | ||
A0A1W2PPV2 | A0A1W2PPV2_HUMAN | Complement receptor type 2 | CR2 | 39 | Annotation score: |
Sequence cautioni
The sequence AAA35784 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Sequence conflicti | 457 | Missing in CAA68674 (PubMed:2832506).Curated | 1 | ||
Sequence conflicti | 646 | A → R in AAA35784 (PubMed:2827171).Curated | 1 | ||
Sequence conflicti | 667 | Q → D AA sequence (PubMed:3016712).Curated | 1 | ||
Sequence conflicti | 774 | G → E in AAA35784 (PubMed:2827171).Curated | 1 | ||
Sequence conflicti | 783 – 787 | PPVTR → L in AAA35784 (PubMed:2827171).Curated | 5 | ||
Sequence conflicti | 844 | I → M in AAA35786 (PubMed:2563370).Curated | 1 | ||
Sequence conflicti | 844 | I → M in AAB04638 (PubMed:2563370).Curated | 1 | ||
Sequence conflicti | 886 | L → V in AAA35784 (PubMed:2827171).Curated | 1 | ||
Sequence conflicti | 890 | A → P in AAA35784 (PubMed:2827171).Curated | 1 | ||
Sequence conflicti | 902 | Q → G AA sequence (PubMed:3016712).Curated | 1 | ||
Sequence conflicti | 906 | H → L AA sequence (PubMed:3016712).Curated | 1 | ||
Isoform C (identifier: P20023-3) | |||||
Sequence conflicti | 663 | S → P in AAA35784 (PubMed:2827171).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_016164 | 639 | S → N2 PublicationsCorresponds to variant dbSNP:rs17615EnsemblClinVar. | 1 | |
Natural variantiVAR_016165 | 993 | I → V1 PublicationCorresponds to variant dbSNP:rs17618Ensembl. | 1 | |
Natural variantiVAR_016166 | 1003 | A → E2 PublicationsCorresponds to variant dbSNP:rs17617Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_001208 | 499 – 524 | Missing in isoform B. 1 PublicationAdd BLAST | 26 | |
Alternative sequenceiVSP_001209 | 525 – 556 | ITCPP…VTYTC → NHLPTTPCYLQWGTHREFLR RFSIWNHGHLHM in isoform B. 1 PublicationAdd BLAST | 32 | |
Alternative sequenceiVSP_001210 | 659 | K → KGCQSPPGLHHGRHTGGNTV FFVSGMTVDYTCDPGYLLVG NKSIHCMPSGNWSPSAPRCE in isoform C and isoform D. 5 Publications | 1 | |
Alternative sequenceiVSP_001211 | 716 – 723 | Missing in isoform D. 1 Publication | 8 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M26004 mRNA Translation: AAA35786.1 M26016 , M24007, M24008, M24009, M24010, M24011, M26009, M26010, M26011, M26012, M26013, M26014, M26015 Genomic DNA Translation: AAB04638.1 Y00649 mRNA Translation: CAA68674.1 J03565 mRNA Translation: AAA35784.1 Frameshift. AK223627 mRNA Translation: BAD97347.1 AK301496 mRNA Translation: BAG63007.1 EF064746 Genomic DNA Translation: ABK41929.1 AL391597 Genomic DNA No translation available. AL691452 Genomic DNA No translation available. BC090937 mRNA Translation: AAH90937.1 BC136394 mRNA Translation: AAI36395.1 S62696 mRNA Translation: AAB27186.1 |
CCDSi | CCDS1478.1 [P20023-1] CCDS31007.1 [P20023-3] |
PIRi | JL0028, PL0009 |
RefSeqi | NP_001006659.1, NM_001006658.2 [P20023-3] NP_001868.2, NM_001877.4 [P20023-1] |
Genome annotation databases
Ensembli | ENST00000367057; ENSP00000356024; ENSG00000117322 [P20023-3] ENST00000367058; ENSP00000356025; ENSG00000117322 [P20023-1] |
GeneIDi | 1380 |
KEGGi | hsa:1380 |
UCSCi | uc001hfv.4, human [P20023-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M26004 mRNA Translation: AAA35786.1 M26016 , M24007, M24008, M24009, M24010, M24011, M26009, M26010, M26011, M26012, M26013, M26014, M26015 Genomic DNA Translation: AAB04638.1 Y00649 mRNA Translation: CAA68674.1 J03565 mRNA Translation: AAA35784.1 Frameshift. AK223627 mRNA Translation: BAD97347.1 AK301496 mRNA Translation: BAG63007.1 EF064746 Genomic DNA Translation: ABK41929.1 AL391597 Genomic DNA No translation available. AL691452 Genomic DNA No translation available. BC090937 mRNA Translation: AAH90937.1 BC136394 mRNA Translation: AAI36395.1 S62696 mRNA Translation: AAB27186.1 |
CCDSi | CCDS1478.1 [P20023-1] CCDS31007.1 [P20023-3] |
PIRi | JL0028, PL0009 |
RefSeqi | NP_001006659.1, NM_001006658.2 [P20023-3] NP_001868.2, NM_001877.4 [P20023-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1GHQ | X-ray | 2.04 | B/C | 21-153 | [»] | |
1LY2 | X-ray | 1.80 | A | 22-148 | [»] | |
1W2R | X-ray | - | A | 21-153 | [»] | |
1W2S | X-ray | - | B | 21-153 | [»] | |
2ATY | X-ray | - | A/B | 21-153 | [»] | |
2GSX | X-ray | - | A | 21-971 | [»] | |
3OED | X-ray | 3.16 | C/D | 20-153 | [»] | |
SMRi | P20023 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107771, 7 interactors |
CORUMi | P20023 |
IntActi | P20023, 1 interactor |
STRINGi | 9606.ENSP00000356024 |
PTM databases
GlyGeni | P20023, 13 sites |
iPTMneti | P20023 |
PhosphoSitePlusi | P20023 |
Polymorphism and mutation databases
BioMutai | CR2 |
DMDMi | 215273962 |
Proteomic databases
MassIVEi | P20023 |
PeptideAtlasi | P20023 |
PRIDEi | P20023 |
ProteomicsDBi | 53712 [P20023-1] 53713 [P20023-2] 53714 [P20023-3] 53715 [P20023-4] |
Protocols and materials databases
ABCDi | P20023, 1 sequenced antibody |
Antibodypediai | 3624, 1393 antibodies |
Genome annotation databases
Ensembli | ENST00000367057; ENSP00000356024; ENSG00000117322 [P20023-3] ENST00000367058; ENSP00000356025; ENSG00000117322 [P20023-1] |
GeneIDi | 1380 |
KEGGi | hsa:1380 |
UCSCi | uc001hfv.4, human [P20023-1] |
Organism-specific databases
CTDi | 1380 |
DisGeNETi | 1380 |
EuPathDBi | HostDB:ENSG00000117322.16 |
GeneCardsi | CR2 |
HGNCi | HGNC:2336, CR2 |
HPAi | ENSG00000117322, Tissue enriched (lymphoid) |
MalaCardsi | CR2 |
MIMi | 120650, gene 610927, phenotype 614699, phenotype |
neXtProti | NX_P20023 |
OpenTargetsi | ENSG00000117322 |
Orphaneti | 1572, Common variable immunodeficiency 536, Systemic lupus erythematosus |
PharmGKBi | PA26857 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4297, Eukaryota |
GeneTreei | ENSGT00940000161110 |
HOGENOMi | CLU_005124_0_0_1 |
InParanoidi | P20023 |
OMAi | KVAECEP |
OrthoDBi | 702827at2759 |
PhylomeDBi | P20023 |
TreeFami | TF316872 |
Enzyme and pathway databases
PathwayCommonsi | P20023 |
Reactomei | R-HSA-977606, Regulation of Complement cascade |
SIGNORi | P20023 |
Miscellaneous databases
BioGRID-ORCSi | 1380, 2 hits in 841 CRISPR screens |
ChiTaRSi | CR2, human |
EvolutionaryTracei | P20023 |
GeneWikii | Complement_receptor_2 |
GenomeRNAii | 1380 |
Pharosi | P20023, Tbio |
PROi | PR:P20023 |
RNActi | P20023, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000117322, Expressed in tonsil and 110 other tissues |
ExpressionAtlasi | P20023, baseline and differential |
Genevisiblei | P20023, HS |
Family and domain databases
CDDi | cd00033, CCP, 13 hits |
InterProi | View protein in InterPro IPR035976, Sushi/SCR/CCP_sf IPR000436, Sushi_SCR_CCP_dom |
Pfami | View protein in Pfam PF00084, Sushi, 13 hits |
SMARTi | View protein in SMART SM00032, CCP, 14 hits |
SUPFAMi | SSF57535, SSF57535, 15 hits |
PROSITEi | View protein in PROSITE PS50923, SUSHI, 15 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CR2_HUMAN | |
Accessioni | P20023Primary (citable) accession number: P20023 Secondary accession number(s): C9JHD2 Q5SR48 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1991 |
Last sequence update: | November 25, 2008 | |
Last modified: | December 2, 2020 | |
This is version 210 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries