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Protein

Ligninase C

Gene
N/A
Organism
Trametes versicolor (White-rot fungus) (Coriolus versicolor)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Depolymerization of lignin. Catalyzes the C(alpha)-C(beta) cleavage of the propyl side chains of lignin.By similarity

Catalytic activityi

1-(3,4-dimethoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2 = 3,4-dimethoxybenzaldehyde + 2-methoxyphenol + glycolaldehyde + H2O.1 Publication
2 (3,4-dimethoxyphenyl)methanol + H2O2 = 2 (3,4-dimethoxyphenyl)methanol radical + 2 H2O.1 Publication

Cofactori

Protein has several cofactor binding sites:
  • Ca2+PROSITE-ProRule annotationNote: Binds 2 calcium ions per subunit.PROSITE-ProRule annotation
  • heme bBy similarityNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.By similarity

Pathwayi: lignin degradation

This protein is involved in the pathway lignin degradation, which is part of Secondary metabolite metabolism.
View all proteins of this organism that are known to be involved in the pathway lignin degradation and in Secondary metabolite metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei70Transition state stabilizerPROSITE-ProRule annotation1
Active sitei74Proton acceptorPROSITE-ProRule annotation1
Metal bindingi75Calcium 1PROSITE-ProRule annotation1
Metal bindingi93Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi95Calcium 1PROSITE-ProRule annotation1
Metal bindingi97Calcium 1PROSITE-ProRule annotation1
Metal bindingi205Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi206Calcium 2PROSITE-ProRule annotation1
Metal bindingi223Calcium 2PROSITE-ProRule annotation1
Metal bindingi225Calcium 2PROSITE-ProRule annotation1
Metal bindingi228Calcium 2; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi230Calcium 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide, Lignin degradation
LigandCalcium, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayi
UPA00892

Protein family/group databases

CAZyiAA2 Auxiliary Activities 2
mycoCLAPiLPO2C_TRAVE
PeroxiBasei2420 TvLiP12_PRL572

Names & Taxonomyi

Protein namesi
Recommended name:
Ligninase C (EC:1.11.1.141 Publication)
Alternative name(s):
Diarylpropane peroxidase
Lignin peroxidase
OrganismiTrametes versicolor (White-rot fungus) (Coriolus versicolor)
Taxonomic identifieri5325 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesPolyporalesPolyporaceaeTrametes

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 261 PublicationAdd BLAST26
ChainiPRO_000002377727 – 372Ligninase CAdd BLAST346

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi129N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Expressioni

Developmental stagei

Ligninases are expressed during secondary metabolism, and are triggered by nutrient limitation.

Structurei

3D structure databases

ProteinModelPortaliP20013
SMRiP20013
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Ligninase subfamily.Curated

Keywords - Domaini

Signal

Family and domain databases

CDDicd00692 ligninase, 1 hit
InterProiView protein in InterPro
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR001621 Ligninase
IPR024589 Ligninase_C
IPR019794 Peroxidases_AS
PfamiView protein in Pfam
PF00141 peroxidase, 1 hit
PF11895 Peroxidase_ext, 1 hit
PRINTSiPR00462 LIGNINASE
PR00458 PEROXIDASE
SUPFAMiSSF48113 SSF48113, 1 hit
PROSITEiView protein in PROSITE
PS00436 PEROXIDASE_2, 1 hit
PS50873 PEROXIDASE_4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20013-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFKSLLSFV SVIGALQGAN AALTRRVACP DGVNTATNAA CCQLFAVRED
60 70 80 90 100
LQQNLFHGGL CTAEAHESLR LTFHDAIAIS PALEAQGIFG GGGADGSIAI
110 120 130 140 150
FPEIETNFHP NIGLDEIIEL QKPFIARHNI SVADFIQFAG AIGASNCAGA
160 170 180 190 200
PQLAAFVGRK DATQPAPDGL VPEPFHTPDQ IFDRLADASQ GEFDPILTVW
210 220 230 240 250
LLTAHTVAAA NDVDPTKSGL PFDSTPELWD TQFFLETQLR GTSFPGSGGN
260 270 280 290 300
QGEVESPLAG EMRLQSDHTI ARDSRTACEW QSFVDNQPKA QQMFQFVFHD
310 320 330 340 350
LSIFGQDINT LVDCTEVVPI PADPQGHTHF PAGLSNADIE QACAETPFPT
360 370
FPTDPGPKTA VAPVPKPPAA RK
Length:372
Mass (Da):39,625
Last modified:June 1, 1994 - v2
Checksum:i9F7A06AABAA9B25A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64993 Genomic DNA Translation: AAA34049.1
PIRiS32581

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64993 Genomic DNA Translation: AAA34049.1
PIRiS32581

3D structure databases

ProteinModelPortaliP20013
SMRiP20013
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiAA2 Auxiliary Activities 2
mycoCLAPiLPO2C_TRAVE
PeroxiBasei2420 TvLiP12_PRL572

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayi
UPA00892

Family and domain databases

CDDicd00692 ligninase, 1 hit
InterProiView protein in InterPro
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR001621 Ligninase
IPR024589 Ligninase_C
IPR019794 Peroxidases_AS
PfamiView protein in Pfam
PF00141 peroxidase, 1 hit
PF11895 Peroxidase_ext, 1 hit
PRINTSiPR00462 LIGNINASE
PR00458 PEROXIDASE
SUPFAMiSSF48113 SSF48113, 1 hit
PROSITEiView protein in PROSITE
PS00436 PEROXIDASE_2, 1 hit
PS50873 PEROXIDASE_4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLIGC_TRAVE
AccessioniPrimary (citable) accession number: P20013
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: June 1, 1994
Last modified: October 25, 2017
This is version 94 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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