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Protein

Endothelin-3

Gene

EDN3

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Endothelins are endothelium-derived vasoconstrictor peptides.

GO - Biological processi

Keywordsi

Molecular functionVasoactive, Vasoconstrictor

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin-3
Short name:
ET-3
Alternative name(s):
Preproendothelin-3
Short name:
PPET3
Gene namesi
Name:EDN3
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
PropeptideiPRO_000000811718 – 86Add BLAST69
PeptideiPRO_000000811889 – 109Endothelin-3Add BLAST21
PropeptideiPRO_0000008119110 – ›114›5

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi89 ↔ 103By similarity
Disulfide bondi91 ↔ 99By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei109 – 110Cleavage; by KELBy similarity2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PRIDEiP19998

Structurei

3D structure databases

SMRiP19998
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the endothelin/sarafotoxin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000231110
HOVERGENiHBG051442
InParanoidiP19998

Family and domain databases

InterProiView protein in InterPro
IPR020475 Endothelin
IPR019764 Endothelin_toxin_CS
IPR001928 Endothln-like_toxin
PfamiView protein in Pfam
PF00322 Endothelin, 1 hit
PRINTSiPR00365 ENDOTHELIN
SMARTiView protein in SMART
SM00272 END, 1 hit
PROSITEiView protein in PROSITE
PS00270 ENDOTHELIN, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

P19998-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPGLWILLG LTVTAAAGFV PCPQTGGAGR TSVPRAPRVA GSEGDCEDSV
60 70 80 90 100
ASPRRQTVAP TAGKGPSPGS PGRGQAAEGD PGHRRVRRCT CFTYKDKECV
110
YYCHLDIIWI NTPE
Length:114
Mass (Da):12,041
Last modified:February 1, 1991 - v1
Checksum:i5E515B3478AF67F8
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G1TRJ7G1TRJ7_RABIT
Endothelin-3
EDN3
211Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1141

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15724 Genomic DNA Translation: CAB59224.1
PIRiS07898

Similar proteinsi

Entry informationi

Entry nameiEDN3_RABIT
AccessioniPrimary (citable) accession number: P19998
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: December 20, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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