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Protein

Lymphocyte-specific protein 1

Gene

Lsp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in mediating neutrophil activation and chemotaxis.1 Publication

GO - Molecular functioni

  • actin binding Source: MGI

GO - Biological processi

  • apoptotic process Source: MGI
  • chemotaxis Source: MGI
  • cytoskeleton organization Source: MGI
  • defense response Source: MGI
  • signal transduction Source: InterPro

Names & Taxonomyi

Protein namesi
Recommended name:
Lymphocyte-specific protein 1
Alternative name(s):
52 kDa phosphoprotein
Short name:
pp52
Lymphocyte-specific antigen WP34
S37 protein
Gene namesi
Name:Lsp1
Synonyms:Pp52, S37, Wp34
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:96832 Lsp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi195S → A: No effect on phosphorylation by PKC, PKA, MAPKAPK2 and CaMK2. 1 Publication1
Mutagenesisi243S → A: Complete loss of phosphorylation by MAPKAPK2, partial loss of phosphorylation by PKA, no effect on phosphorylation by PKC and CaMK2. 1 Publication1
Mutagenesisi243S → E: Complete loss of phosphorylation by MAPKAPK2, partial loss of phosphorylation by PKA, no effect on phosphorylation by PKC and CaMK2. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000845041 – 330Lymphocyte-specific protein 1Add BLAST330

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei77Phosphoserine; by CK2Sequence analysis1
Modified residuei78Phosphoserine; by CK2Sequence analysis1
Modified residuei166PhosphothreonineCombined sources1
Modified residuei168PhosphoserineCombined sources1
Modified residuei179PhosphoserineBy similarity1
Modified residuei180PhosphoserineCombined sources1
Modified residuei184PhosphoserineCombined sources1
Modified residuei243Phosphoserine; by MAPKAPK2Combined sources1 Publication1
Modified residuei318N6-acetyllysineBy similarity1

Post-translational modificationi

Phosphorylated by casein kinase II, protein kinase C and MAPKAPK2. Phosphorylation by PKC induces translocation from membrane to cytoplasm. Phosphorylation by MAPKAPK2 may regulate neutrophil chemotaxis.3 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP19973
MaxQBiP19973
PaxDbiP19973
PeptideAtlasiP19973
PRIDEiP19973

PTM databases

iPTMnetiP19973
PhosphoSitePlusiP19973

Expressioni

Tissue specificityi

Isoform 1 is expressed in normal mouse B and T-lymphocytes and in transformed B-cells but not (or in smaller amounts) in nine T-lymphoma lines tested. Isoform 2 is expressed in non-lymphoid cell lines (myocytes, stromal cells, fibroblasts).

Gene expression databases

BgeeiENSMUSG00000018819 Expressed in 231 organ(s), highest expression level in bone marrow
CleanExiMM_LSP1
ExpressionAtlasiP19973 baseline and differential
GenevisibleiP19973 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201211, 3 interactors
IntActiP19973, 1 interactor
STRINGi10090.ENSMUSP00000018963

Structurei

3D structure databases

ProteinModelPortaliP19973
SMRiP19973
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00730000111324
HOVERGENiHBG001610
InParanoidiP19973
KOiK14957
OrthoDBiEOG091G0I0H
PhylomeDBiP19973
TreeFamiTF336257

Family and domain databases

InterProiView protein in InterPro
IPR006018 Caldesmon_LSP
IPR002211 Lymphspecific
PANTHERiPTHR18949 PTHR18949, 2 hits
PfamiView protein in Pfam
PF02029 Caldesmon, 1 hit
PRINTSiPR01083 LYMPHSPCIFIC

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P19973-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEAAIDPRC EEQEELHAED SEGLTTQWRE EDEEEAAREQ RQRERERQLQ
60 70 80 90 100
DQDKDKEDDG GHSLEQPGQQ TLISLKSSEL DEDEGFGDWS QKPEPRQQFW
110 120 130 140 150
GNEGTAEGTE PSQSERPEEK QTEESSHQAK VHLEESNLSY REPDPEDAVG
160 170 180 190 200
GSGEAEEHLI RHQVRTPSPL ALEDTVELSS PPLSPTTKLA DRTESLNRSI
210 220 230 240 250
KKSNSVKKSQ PTLPISTIDE RLQQYTQATE SSGRTPKLSR QPSIELPSMA
260 270 280 290 300
VASTKTLWET GEVQSQSASK TPSCQDIVAG DMSKKSLWEQ KGGSKISSTI
310 320 330
KSTPSGKRYK FVATGHGKYE KVLVDEGSAP
Length:330
Mass (Da):36,714
Last modified:February 1, 1996 - v2
Checksum:iCCC27150F02859FB
GO
Isoform 2 (identifier: P19973-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MAEAAIDPRCEEQEELHAEDSEG → MNGPALLRRNASKRGLEKLLR

Show »
Length:328
Mass (Da):36,548
Checksum:i43522E589AF1F6F0
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A6J7A2A6J7_MOUSE
Lymphocyte-specific protein 1
Lsp1
324Annotation score:
A2A6J4A2A6J4_MOUSE
Lymphocyte-specific protein 1
Lsp1
322Annotation score:
A0A1B0GRF5A0A1B0GRF5_MOUSE
Lymphocyte specific 1, isoform CRA_...
Lsp1 mCG_11072
82Annotation score:
A0A1B0GSH0A0A1B0GSH0_MOUSE
Lymphocyte-specific protein 1
Lsp1
10Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti125 – 127SSH → RQV in BAC27463 (PubMed:16141072).Curated3
Sequence conflicti155 – 156AE → PK (PubMed:3263441).Curated2
Sequence conflicti158 – 163Missing in AAH03796 (PubMed:15489334).Curated6
Sequence conflicti160I → T (PubMed:3263441).Curated1
Sequence conflicti168S → N (PubMed:3263441).Curated1
Sequence conflicti253S → G (PubMed:3263441).Curated1
Sequence conflicti283S → T (PubMed:7775393).Curated1
Sequence conflicti283S → T (PubMed:8537319).Curated1
Isoform 2 (identifier: P19973-2)
Sequence conflicti16L → Q in AAB37543 (PubMed:8838798).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0043131 – 23MAEAA…EDSEG → MNGPALLRRNASKRGLEKLL R in isoform 2. 4 PublicationsAdd BLAST23

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M90316 mRNA Translation: AAA65108.1
S74179 mRNA Translation: AAB32257.1
M89956 mRNA Translation: AAB48537.1
D49691 mRNA Translation: BAA08541.1
AL603651 Genomic DNA Translation: CAM23282.1
AL603651 Genomic DNA Translation: CAM23283.1
BC003796 mRNA Translation: AAH03796.1
U30942, U30939, U30941 Genomic DNA Translation: AAB37542.1
U30942, U30940, U30941 Genomic DNA Translation: AAB37543.1
AK031587 mRNA Translation: BAC27463.1
CCDSiCCDS40193.1 [P19973-2]
CCDS52450.1 [P19973-1]
PIRiA30533
A46521
RefSeqiNP_001129543.1, NM_001136071.2 [P19973-1]
NP_001258437.1, NM_001271508.1
NP_001258439.1, NM_001271510.1 [P19973-1]
NP_062264.1, NM_019391.3 [P19973-2]
UniGeneiMm.234003

Genome annotation databases

EnsembliENSMUST00000018963; ENSMUSP00000018963; ENSMUSG00000018819 [P19973-1]
ENSMUST00000038946; ENSMUSP00000040637; ENSMUSG00000018819 [P19973-2]
ENSMUST00000105968; ENSMUSP00000101588; ENSMUSG00000018819 [P19973-1]
GeneIDi16985
KEGGimmu:16985
UCSCiuc009knb.3 mouse [P19973-1]
uc009knf.2 mouse [P19973-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M90316 mRNA Translation: AAA65108.1
S74179 mRNA Translation: AAB32257.1
M89956 mRNA Translation: AAB48537.1
D49691 mRNA Translation: BAA08541.1
AL603651 Genomic DNA Translation: CAM23282.1
AL603651 Genomic DNA Translation: CAM23283.1
BC003796 mRNA Translation: AAH03796.1
U30942, U30939, U30941 Genomic DNA Translation: AAB37542.1
U30942, U30940, U30941 Genomic DNA Translation: AAB37543.1
AK031587 mRNA Translation: BAC27463.1
CCDSiCCDS40193.1 [P19973-2]
CCDS52450.1 [P19973-1]
PIRiA30533
A46521
RefSeqiNP_001129543.1, NM_001136071.2 [P19973-1]
NP_001258437.1, NM_001271508.1
NP_001258439.1, NM_001271510.1 [P19973-1]
NP_062264.1, NM_019391.3 [P19973-2]
UniGeneiMm.234003

3D structure databases

ProteinModelPortaliP19973
SMRiP19973
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201211, 3 interactors
IntActiP19973, 1 interactor
STRINGi10090.ENSMUSP00000018963

PTM databases

iPTMnetiP19973
PhosphoSitePlusiP19973

Proteomic databases

EPDiP19973
MaxQBiP19973
PaxDbiP19973
PeptideAtlasiP19973
PRIDEiP19973

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000018963; ENSMUSP00000018963; ENSMUSG00000018819 [P19973-1]
ENSMUST00000038946; ENSMUSP00000040637; ENSMUSG00000018819 [P19973-2]
ENSMUST00000105968; ENSMUSP00000101588; ENSMUSG00000018819 [P19973-1]
GeneIDi16985
KEGGimmu:16985
UCSCiuc009knb.3 mouse [P19973-1]
uc009knf.2 mouse [P19973-2]

Organism-specific databases

CTDi4046
MGIiMGI:96832 Lsp1

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00730000111324
HOVERGENiHBG001610
InParanoidiP19973
KOiK14957
OrthoDBiEOG091G0I0H
PhylomeDBiP19973
TreeFamiTF336257

Miscellaneous databases

PROiPR:P19973
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000018819 Expressed in 231 organ(s), highest expression level in bone marrow
CleanExiMM_LSP1
ExpressionAtlasiP19973 baseline and differential
GenevisibleiP19973 MM

Family and domain databases

InterProiView protein in InterPro
IPR006018 Caldesmon_LSP
IPR002211 Lymphspecific
PANTHERiPTHR18949 PTHR18949, 2 hits
PfamiView protein in Pfam
PF02029 Caldesmon, 1 hit
PRINTSiPR01083 LYMPHSPCIFIC
ProtoNetiSearch...

Entry informationi

Entry nameiLSP1_MOUSE
AccessioniPrimary (citable) accession number: P19973
Secondary accession number(s): A2A6J5
, A2A6J6, P97339, Q04950, Q62022, Q62023, Q62024, Q8CD28, Q99L65
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1996
Last modified: November 7, 2018
This is version 161 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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