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Protein

Thymidine phosphorylase

Gene

TYMP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro.1 Publication
Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: dTMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes dTMP from thymine.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Thymidine phosphorylase (TYMP), Thymidine phosphorylase, Thymidine phosphorylase (TYMP)
  2. no protein annotated in this organism
This subpathway is part of the pathway dTMP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dTMP from thymine, the pathway dTMP biosynthesis via salvage pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei116Substrate1
Binding sitei202Substrate1
Binding sitei217Substrate1
Binding sitei221Substrate1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Glycosyltransferase, Growth factor, Transferase
Biological processAngiogenesis, Chemotaxis, Differentiation

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS00442-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.4.2.4 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-73614 Pyrimidine salvage
R-HSA-73621 Pyrimidine catabolism

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P19971

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00578;UER00638

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...
MoonDBi
P19971 Curated

MoonProt database of moonlighting proteins

More...
MoonProti
P19971

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Thymidine phosphorylase (EC:2.4.2.4)
Short name:
TP
Alternative name(s):
Gliostatin
Platelet-derived endothelial cell growth factor
Short name:
PD-ECGF
TdRPase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TYMP
Synonyms:ECGF1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000025708.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3148 TYMP

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
131222 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P19971

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Mitochondrial DNA depletion syndrome 1, MNGIE type (MTDPS1)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA multisystem disease associated with mitochondrial dysfunction. It is clinically characterized by onset between the second and fifth decades of life, ptosis, progressive external ophthalmoplegia, gastrointestinal dysmotility (often pseudoobstruction), diffuse leukoencephalopathy, cachexia, peripheral neuropathy, and myopathy.
See also OMIM:603041
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01677744R → Q in MTDPS1. 1 PublicationCorresponds to variant dbSNP:rs28931613EnsemblClinVar.1
Natural variantiVAR_007643145G → R in MTDPS1. 1 PublicationCorresponds to variant dbSNP:rs121913037EnsemblClinVar.1
Natural variantiVAR_007644153G → S in MTDPS1. 1 PublicationCorresponds to variant dbSNP:rs121913038EnsemblClinVar.1
Natural variantiVAR_007645222K → R in MTDPS1. 1 PublicationCorresponds to variant dbSNP:rs149977726Ensembl.1
Natural variantiVAR_007646289E → A in MTDPS1. 1 PublicationCorresponds to variant dbSNP:rs121913036Ensembl.1
Natural variantiVAR_007647397 – 398Missing in MTDPS1. 1 Publication2

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi199Y → A: Abolishes catalytic activity. 1 Publication1
Mutagenesisi199Y → F: Reduced catalytic activity. 1 Publication1
Mutagenesisi199Y → L: Reduced catalytic activity. 1 Publication1

Keywords - Diseasei

Disease mutation, Primary mitochondrial disease, Progressive external ophthalmoplegia

Organism-specific databases

DisGeNET

More...
DisGeNETi
1890

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
TYMP

MalaCards human disease database

More...
MalaCardsi
TYMP
MIMi603041 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000025708

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
298 Mitochondrial neurogastrointestinal encephalomyopathy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162407502

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3106

Drug and drug target database

More...
DrugBanki
DB01101 Capecitabine
DB00369 Cidofovir
DB00322 Floxuridine
DB00544 Fluorouracil
DB09343 Tipiracil
DB00432 Trifluridine

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TYMP

Domain mapping of disease mutations (DMDM)

More...
DMDMi
67477361

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_00000358741 – 1010
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003587511 – 482Thymidine phosphorylaseAdd BLAST472

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei6PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P19971

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P19971

MaxQB - The MaxQuant DataBase

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MaxQBi
P19971

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P19971

PeptideAtlas

More...
PeptideAtlasi
P19971

PRoteomics IDEntifications database

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PRIDEi
P19971

ProteomicsDB human proteome resource

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ProteomicsDBi
53705

2D gel databases

USC-OGP 2-DE database

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OGPi
P19971

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P19971

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P19971

SwissPalm database of S-palmitoylation events

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SwissPalmi
P19971

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000025708 Expressed in 199 organ(s), highest expression level in right uterine tube

CleanEx database of gene expression profiles

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CleanExi
HS_TYMP

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P19971 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P19971 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB002518
HPA000530
HPA001072

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.3 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
108219, 23 interactors

Protein interaction database and analysis system

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IntActi
P19971, 3 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000252029

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P19971

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1482
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UOUX-ray2.11A12-482[»]
2J0FX-ray2.31A/B/C/D1-482[»]
2WK5X-ray2.99A/B/C/D1-482[»]
2WK6X-ray2.50A/B1-482[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P19971

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P19971

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P19971

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati265 – 279R-V-A-A-A-L-X(5,6)-L-G-RAdd BLAST15
Repeati329 – 342R-V-A-A-A-L-X(5,6)-L-G-RAdd BLAST14
Repeati393 – 401R-A-L-X-X-A-L-V-L9
Repeati453 – 461R-A-L-X-X-A-L-V-L9

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IIV8 Eukaryota
COG0213 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000009250

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000047313

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG000082

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P19971

KEGG Orthology (KO)

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KOi
K00758

Identification of Orthologs from Complete Genome Data

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OMAi
VHSIGGV

Database of Orthologous Groups

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OrthoDBi
1214417at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P19971

TreeFam database of animal gene trees

More...
TreeFami
TF332198

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.1030.10, 1 hit
3.90.1170.30, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000312 Glycosyl_Trfase_fam3
IPR017459 Glycosyl_Trfase_fam3_N_dom
IPR036320 Glycosyl_Trfase_fam3_N_dom)sf
IPR035902 Nuc_phospho_transferase
IPR036566 PYNP-like_C_sf
IPR013102 PYNP_C
IPR018090 Pyrmidine_PPas_bac/euk
IPR017872 Pyrmidine_PPase_CS
IPR000053 Thymidine/pyrmidine_PPase

The PANTHER Classification System

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PANTHERi
PTHR10515 PTHR10515, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF02885 Glycos_trans_3N, 1 hit
PF00591 Glycos_transf_3, 1 hit
PF07831 PYNP_C, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000478 TP_PyNP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00941 PYNP_C, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47648 SSF47648, 1 hit
SSF52418 SSF52418, 1 hit
SSF54680 SSF54680, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR02644 Y_phosphoryl, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00647 THYMID_PHOSPHORYLASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P19971-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAALMTPGTG APPAPGDFSG EGSQGLPDPS PEPKQLPELI RMKRDGGRLS
60 70 80 90 100
EADIRGFVAA VVNGSAQGAQ IGAMLMAIRL RGMDLEETSV LTQALAQSGQ
110 120 130 140 150
QLEWPEAWRQ QLVDKHSTGG VGDKVSLVLA PALAACGCKV PMISGRGLGH
160 170 180 190 200
TGGTLDKLES IPGFNVIQSP EQMQVLLDQA GCCIVGQSEQ LVPADGILYA
210 220 230 240 250
ARDVTATVDS LPLITASILS KKLVEGLSAL VVDVKFGGAA VFPNQEQARE
260 270 280 290 300
LAKTLVGVGA SLGLRVAAAL TAMDKPLGRC VGHALEVEEA LLCMDGAGPP
310 320 330 340 350
DLRDLVTTLG GALLWLSGHA GTQAQGAARV AAALDDGSAL GRFERMLAAQ
360 370 380 390 400
GVDPGLARAL CSGSPAERRQ LLPRAREQEE LLAPADGTVE LVRALPLALV
410 420 430 440 450
LHELGAGRSR AGEPLRLGVG AELLVDVGQR LRRGTPWLRV HRDGPALSGP
460 470 480
QSRALQEALV LSDRAPFAAP SPFAELVLPP QQ
Length:482
Mass (Da):49,955
Last modified:June 7, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0652FA0B8F3BDE28
GO
Isoform 2 (identifier: P19971-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     386-386: D → DAPLPA

Note: No experimental confirmation available.
Show »
Length:487
Mass (Da):50,405
Checksum:iC2F16246C51DCE00
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JGI3C9JGI3_HUMAN
Thymidine phosphorylase
TYMP
445Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti195D → E in AAH18160 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01677744R → Q in MTDPS1. 1 PublicationCorresponds to variant dbSNP:rs28931613EnsemblClinVar.1
Natural variantiVAR_007643145G → R in MTDPS1. 1 PublicationCorresponds to variant dbSNP:rs121913037EnsemblClinVar.1
Natural variantiVAR_007644153G → S in MTDPS1. 1 PublicationCorresponds to variant dbSNP:rs121913038EnsemblClinVar.1
Natural variantiVAR_007645222K → R in MTDPS1. 1 PublicationCorresponds to variant dbSNP:rs149977726Ensembl.1
Natural variantiVAR_007646289E → A in MTDPS1. 1 PublicationCorresponds to variant dbSNP:rs121913036Ensembl.1
Natural variantiVAR_007647397 – 398Missing in MTDPS1. 1 Publication2
Natural variantiVAR_007648471S → L2 PublicationsCorresponds to variant dbSNP:rs11479EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_045556386D → DAPLPA in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M63193 mRNA Translation: AAA60043.1
AK225269 mRNA No translation available.
U62317 Genomic DNA Translation: AAB03344.2
BC018160 mRNA Translation: AAH18160.1
BC052211 mRNA Translation: AAH52211.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14096.1 [P19971-1]
CCDS58811.1 [P19971-2]

Protein sequence database of the Protein Information Resource

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PIRi
S03904

NCBI Reference Sequences

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RefSeqi
NP_001107227.1, NM_001113755.2 [P19971-1]
NP_001107228.1, NM_001113756.2 [P19971-1]
NP_001244917.1, NM_001257988.1 [P19971-1]
NP_001244918.1, NM_001257989.1 [P19971-2]
NP_001944.1, NM_001953.4 [P19971-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.180903
Hs.730607

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000252029; ENSP00000252029; ENSG00000025708 [P19971-1]
ENST00000395678; ENSP00000379036; ENSG00000025708 [P19971-1]
ENST00000395680; ENSP00000379037; ENSG00000025708 [P19971-1]
ENST00000395681; ENSP00000379038; ENSG00000025708 [P19971-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
1890

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1890

UCSC genome browser

More...
UCSCi
uc003bmb.7 human [P19971-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63193 mRNA Translation: AAA60043.1
AK225269 mRNA No translation available.
U62317 Genomic DNA Translation: AAB03344.2
BC018160 mRNA Translation: AAH18160.1
BC052211 mRNA Translation: AAH52211.1
CCDSiCCDS14096.1 [P19971-1]
CCDS58811.1 [P19971-2]
PIRiS03904
RefSeqiNP_001107227.1, NM_001113755.2 [P19971-1]
NP_001107228.1, NM_001113756.2 [P19971-1]
NP_001244917.1, NM_001257988.1 [P19971-1]
NP_001244918.1, NM_001257989.1 [P19971-2]
NP_001944.1, NM_001953.4 [P19971-1]
UniGeneiHs.180903
Hs.730607

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UOUX-ray2.11A12-482[»]
2J0FX-ray2.31A/B/C/D1-482[»]
2WK5X-ray2.99A/B/C/D1-482[»]
2WK6X-ray2.50A/B1-482[»]
ProteinModelPortaliP19971
SMRiP19971
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108219, 23 interactors
IntActiP19971, 3 interactors
STRINGi9606.ENSP00000252029

Chemistry databases

BindingDBiP19971
ChEMBLiCHEMBL3106
DrugBankiDB01101 Capecitabine
DB00369 Cidofovir
DB00322 Floxuridine
DB00544 Fluorouracil
DB09343 Tipiracil
DB00432 Trifluridine

Protein family/group databases

MoonDBiP19971 Curated
MoonProtiP19971

PTM databases

iPTMnetiP19971
PhosphoSitePlusiP19971
SwissPalmiP19971

Polymorphism and mutation databases

BioMutaiTYMP
DMDMi67477361

2D gel databases

OGPiP19971

Proteomic databases

EPDiP19971
jPOSTiP19971
MaxQBiP19971
PaxDbiP19971
PeptideAtlasiP19971
PRIDEiP19971
ProteomicsDBi53705

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1890
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252029; ENSP00000252029; ENSG00000025708 [P19971-1]
ENST00000395678; ENSP00000379036; ENSG00000025708 [P19971-1]
ENST00000395680; ENSP00000379037; ENSG00000025708 [P19971-1]
ENST00000395681; ENSP00000379038; ENSG00000025708 [P19971-2]
GeneIDi1890
KEGGihsa:1890
UCSCiuc003bmb.7 human [P19971-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1890
DisGeNETi1890
EuPathDBiHostDB:ENSG00000025708.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TYMP
GeneReviewsiTYMP
HGNCiHGNC:3148 TYMP
HPAiCAB002518
HPA000530
HPA001072
MalaCardsiTYMP
MIMi131222 gene
603041 phenotype
neXtProtiNX_P19971
OpenTargetsiENSG00000025708
Orphaneti298 Mitochondrial neurogastrointestinal encephalomyopathy
PharmGKBiPA162407502

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IIV8 Eukaryota
COG0213 LUCA
GeneTreeiENSGT00390000009250
HOGENOMiHOG000047313
HOVERGENiHBG000082
InParanoidiP19971
KOiK00758
OMAiVHSIGGV
OrthoDBi1214417at2759
PhylomeDBiP19971
TreeFamiTF332198

Enzyme and pathway databases

UniPathwayi
UPA00578;UER00638

BioCyciMetaCyc:HS00442-MONOMER
BRENDAi2.4.2.4 2681
ReactomeiR-HSA-73614 Pyrimidine salvage
R-HSA-73621 Pyrimidine catabolism
SABIO-RKiP19971

Miscellaneous databases

EvolutionaryTraceiP19971

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ECGF1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1890

Protein Ontology

More...
PROi
PR:P19971

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000025708 Expressed in 199 organ(s), highest expression level in right uterine tube
CleanExiHS_TYMP
ExpressionAtlasiP19971 baseline and differential
GenevisibleiP19971 HS

Family and domain databases

Gene3Di3.40.1030.10, 1 hit
3.90.1170.30, 1 hit
InterProiView protein in InterPro
IPR000312 Glycosyl_Trfase_fam3
IPR017459 Glycosyl_Trfase_fam3_N_dom
IPR036320 Glycosyl_Trfase_fam3_N_dom)sf
IPR035902 Nuc_phospho_transferase
IPR036566 PYNP-like_C_sf
IPR013102 PYNP_C
IPR018090 Pyrmidine_PPas_bac/euk
IPR017872 Pyrmidine_PPase_CS
IPR000053 Thymidine/pyrmidine_PPase
PANTHERiPTHR10515 PTHR10515, 1 hit
PfamiView protein in Pfam
PF02885 Glycos_trans_3N, 1 hit
PF00591 Glycos_transf_3, 1 hit
PF07831 PYNP_C, 1 hit
PIRSFiPIRSF000478 TP_PyNP, 1 hit
SMARTiView protein in SMART
SM00941 PYNP_C, 1 hit
SUPFAMiSSF47648 SSF47648, 1 hit
SSF52418 SSF52418, 1 hit
SSF54680 SSF54680, 1 hit
TIGRFAMsiTIGR02644 Y_phosphoryl, 1 hit
PROSITEiView protein in PROSITE
PS00647 THYMID_PHOSPHORYLASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTYPH_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P19971
Secondary accession number(s): A8MW15
, H9KVA0, Q13390, Q8WVB7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: June 7, 2005
Last modified: January 16, 2019
This is version 211 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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