UniProtKB - P19945 (RLA0_RAT)
Protein
60S acidic ribosomal protein P0
Gene
Rplp0
Organism
Rattus norvegicus (Rat)
Status
Functioni
Ribosomal protein P0 is the functional equivalent of E.coli protein L10.
GO - Molecular functioni
- large ribosomal subunit rRNA binding Source: GO_Central
- peptide binding Source: RGD
- structural constituent of ribosome Source: RGD
GO - Biological processi
- cellular response to cAMP Source: RGD
- cellular response to interleukin-4 Source: RGD
- cellular response to phorbol 13-acetate 12-myristate Source: RGD
- cellular response to Thyroid stimulating hormone Source: RGD
- cytoplasmic translation Source: GO_Central
- lactation Source: RGD
- response to selenium ion Source: RGD
- ribosomal large subunit assembly Source: GO_Central
Keywordsi
Molecular function | Ribonucleoprotein, Ribosomal protein |
Enzyme and pathway databases
Reactomei | R-RNO-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-RNO-1799339, SRP-dependent cotranslational protein targeting to membrane R-RNO-6791226, Major pathway of rRNA processing in the nucleolus and cytosol R-RNO-72689, Formation of a pool of free 40S subunits R-RNO-72706, GTP hydrolysis and joining of the 60S ribosomal subunit R-RNO-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-RNO-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
Names & Taxonomyi
Protein namesi | Recommended name: 60S acidic ribosomal protein P0Alternative name(s): 60S ribosomal protein L10E |
Gene namesi | Name:Rplp0 Synonyms:Arbp |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 621247, Rplp0 |
Subcellular locationi
Cytosol
- cytosolic large ribosomal subunit Source: RGD
Nucleus
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- cytoplasmic ribonucleoprotein granule Source: RGD
- dendrite Source: RGD
- membrane Source: RGD
- postsynapse Source: RGD
- postsynaptic density Source: RGD
- ribonucleoprotein complex Source: UniProtKB
- synapse Source: SynGO
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000154761 | 1 – 317 | 60S acidic ribosomal protein P0Add BLAST | 317 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 24 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 59 | PhosphothreonineBy similarity | 1 | |
Cross-linki | 297 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity | ||
Cross-linki | 297 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity | ||
Modified residuei | 304 | PhosphoserineCombined sources | 1 | |
Modified residuei | 307 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | P19945 |
PaxDbi | P19945 |
PRIDEi | P19945 |
PTM databases
iPTMneti | P19945 |
PhosphoSitePlusi | P19945 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000001148, Expressed in spleen and 21 other tissues |
Genevisiblei | P19945, RN |
Interactioni
Subunit structurei
P0 forms a pentameric complex by interaction with dimers of P1 and P2.
Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.
Interacts with APEX1.
Interacts with FMR1.
By similarityProtein-protein interaction databases
BioGRIDi | 249011, 6 interactors |
IntActi | P19945, 8 interactors |
STRINGi | 10116.ENSRNOP00000001518 |
Family & Domainsi
Sequence similaritiesi
Belongs to the universal ribosomal protein uL10 family.Curated
Phylogenomic databases
eggNOGi | KOG0815, Eukaryota |
GeneTreei | ENSGT00390000017839 |
HOGENOMi | CLU_053173_1_1_1 |
InParanoidi | P19945 |
OMAi | VWVPAGN |
OrthoDBi | 1102823at2759 |
PhylomeDBi | P19945 |
TreeFami | TF300849 |
Family and domain databases
Gene3Di | 3.30.70.1730, 1 hit 3.90.105.20, 1 hit |
InterProi | View protein in InterPro IPR030670, L10E_eukaryotes IPR043141, Ribosomal_L10-like_sf IPR001790, Ribosomal_L10P IPR043164, RL10_insert_sf IPR040637, RL10P_insert |
Pfami | View protein in Pfam PF00466, Ribosomal_L10, 1 hit PF17777, RL10P_insert, 1 hit |
PIRSFi | PIRSF039087, L10E, 1 hit |
SUPFAMi | SSF160369, SSF160369, 1 hit |
i Sequence
Sequence statusi: Complete.
P19945-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPREDRATWK SNYFLKIIQL LDDYPKCFIV GADNVGSKQM QQIRMSLRGK
60 70 80 90 100
AVVLMGKNTM MRKAIRGHLE NNPALEKLLP HIRGNVGFVF TKEDLTEIRD
110 120 130 140 150
MLLANKVPAA ARAGAIAPCE VTVPAQNTGL GPEKTSFFQA LGITTKISRG
160 170 180 190 200
TIEILSDVQL IKTGDKVGAS EATLLNMLNI SPFSFGLIIQ QVFDNGSIYS
210 220 230 240 250
PEVLDITEQA LHTRFLEGVR NVASVCLQIG YPTVASVPHS IINGYKRVLA
260 270 280 290 300
LSVETDYTFP LAEKVKAFLA DPSAFAAAAP VAAATTAAPA AAAAPAKVEA
310
KEESEESDED MGFGLFD
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 281 | V → L in CAA33199 (PubMed:1742361).Curated | 1 | |
Sequence conflicti | 287 | A → L in CAA33199 (PubMed:1742361).Curated | 1 | |
Sequence conflicti | 294 | Missing in CAA33199 (PubMed:1742361).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X15096 mRNA Translation: CAA33199.1 Z29530 mRNA Translation: CAA82647.1 BC062028 mRNA Translation: AAH62028.1 |
PIRi | S08021, R5RT10 |
RefSeqi | NP_071797.1, NM_022402.2 |
Genome annotation databases
Ensembli | ENSRNOT00000001518; ENSRNOP00000001518; ENSRNOG00000001148 |
GeneIDi | 64205 |
KEGGi | rno:64205 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X15096 mRNA Translation: CAA33199.1 Z29530 mRNA Translation: CAA82647.1 BC062028 mRNA Translation: AAH62028.1 |
PIRi | S08021, R5RT10 |
RefSeqi | NP_071797.1, NM_022402.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 249011, 6 interactors |
IntActi | P19945, 8 interactors |
STRINGi | 10116.ENSRNOP00000001518 |
PTM databases
iPTMneti | P19945 |
PhosphoSitePlusi | P19945 |
Proteomic databases
jPOSTi | P19945 |
PaxDbi | P19945 |
PRIDEi | P19945 |
Genome annotation databases
Ensembli | ENSRNOT00000001518; ENSRNOP00000001518; ENSRNOG00000001148 |
GeneIDi | 64205 |
KEGGi | rno:64205 |
Organism-specific databases
CTDi | 6175 |
RGDi | 621247, Rplp0 |
Phylogenomic databases
eggNOGi | KOG0815, Eukaryota |
GeneTreei | ENSGT00390000017839 |
HOGENOMi | CLU_053173_1_1_1 |
InParanoidi | P19945 |
OMAi | VWVPAGN |
OrthoDBi | 1102823at2759 |
PhylomeDBi | P19945 |
TreeFami | TF300849 |
Enzyme and pathway databases
Reactomei | R-RNO-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-RNO-1799339, SRP-dependent cotranslational protein targeting to membrane R-RNO-6791226, Major pathway of rRNA processing in the nucleolus and cytosol R-RNO-72689, Formation of a pool of free 40S subunits R-RNO-72706, GTP hydrolysis and joining of the 60S ribosomal subunit R-RNO-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-RNO-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
Miscellaneous databases
PROi | PR:P19945 |
Gene expression databases
Bgeei | ENSRNOG00000001148, Expressed in spleen and 21 other tissues |
Genevisiblei | P19945, RN |
Family and domain databases
Gene3Di | 3.30.70.1730, 1 hit 3.90.105.20, 1 hit |
InterProi | View protein in InterPro IPR030670, L10E_eukaryotes IPR043141, Ribosomal_L10-like_sf IPR001790, Ribosomal_L10P IPR043164, RL10_insert_sf IPR040637, RL10P_insert |
Pfami | View protein in Pfam PF00466, Ribosomal_L10, 1 hit PF17777, RL10P_insert, 1 hit |
PIRSFi | PIRSF039087, L10E, 1 hit |
SUPFAMi | SSF160369, SSF160369, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RLA0_RAT | |
Accessioni | P19945Primary (citable) accession number: P19945 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1991 |
Last sequence update: | February 1, 1995 | |
Last modified: | December 2, 2020 | |
This is version 155 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Ribosomal proteins
Ribosomal proteins families and list of entries