FST

Functionⁱ

Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).

GO - Molecular functionⁱ

activin binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 12697670
activin receptor antagonist activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 12702211
heparan sulfate proteoglycan binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

hematopoietic progenitor cell differentiation
Source: UniProtKB
Inferred from direct assayⁱ
- 15451575
negative regulation of activin receptor signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 11948405
- 12697670
negative regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
- 12702211
positive regulation of hair follicle development
Source: MGI
Inferred from direct assayⁱ
- 12514121

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2473224 Antagonism of Activin by Follistatin
SIGNORⁱ	P19883

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	I01.966

MEROPSⁱ

I01.966

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Follistatin Short name: FS Alternative name(s): Activin-binding protein
Gene namesⁱ	Name:FST
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000134363.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3971 FST
MIMⁱ	136470 gene
neXtProtⁱ	NX_P19883

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10468
Open Targets More...OpenTargetsⁱ	ENSG00000134363
Orphanetⁱ	3185 Polycystic ovary syndrome
PharmGKBⁱ	PA28388

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB01666 D-Myo-Inositol-Hexasulphate

DrugBankⁱ

DB01666 D-Myo-Inositol-Hexasulphate

Polymorphism and mutation databases

BioMutaⁱ	FST
DMDMⁱ	23831079

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 29	1 PublicationAdd BLAST		29
ChainⁱPRO_0000010103	30 – 344	FollistatinAdd BLAST		315

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	32 ↔ 55	PROSITE-ProRule annotationCombined sources4 Publications
Disulfide bondⁱ	42 ↔ 88	PROSITE-ProRule annotationCombined sources4 Publications
Disulfide bondⁱ	56 ↔ 91	PROSITE-ProRule annotationCombined sources4 Publications
Disulfide bondⁱ	95 ↔ 106	Combined sources4 Publications
Disulfide bondⁱ	100 ↔ 116	Combined sources4 Publications
Disulfide bondⁱ	118 ↔ 150	Combined sources4 Publications
Disulfide bondⁱ	122 ↔ 143	Combined sources4 Publications
Glycosylationⁱ	124	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	132 ↔ 164	Combined sources4 Publications
Disulfide bondⁱ	168 ↔ 179	Combined sources4 Publications
Disulfide bondⁱ	173 ↔ 189	Combined sources4 Publications
Disulfide bondⁱ	192 ↔ 225	Combined sources4 Publications
Disulfide bondⁱ	196 ↔ 218	Combined sources4 Publications
Disulfide bondⁱ	207 ↔ 239	Combined sources4 Publications
Disulfide bondⁱ	245 ↔ 256	Combined sources4 Publications
Disulfide bondⁱ	250 ↔ 267	Combined sources4 Publications
Disulfide bondⁱ	270 ↔ 302	Combined sources4 Publications
Disulfide bondⁱ	274 ↔ 295	Combined sources4 Publications
Disulfide bondⁱ	284 ↔ 316	Combined sources4 Publications
Glycosylationⁱ	288	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

EPDⁱ	P19883
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P19883
PaxDbⁱ	P19883
PeptideAtlas More...PeptideAtlasⁱ	P19883
PRIDEⁱ	P19883
ProteomicsDBⁱ	53700 53701 [P19883-2]

PTM databases

iPTMnetⁱ	P19883
PhosphoSitePlusⁱ	P19883
UniCarbKBⁱ	P19883

Expressionⁱ

Tissue specificityⁱ

Isoform 1 is the predominant isoform in serum but is undetectable in follicular fluid.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000134363 Expressed in 186 organ(s), highest expression level in female gonad
CleanExⁱ	HS_FST
ExpressionAtlasⁱ	P19883 baseline and differential
Genevisibleⁱ	P19883 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB026025

HPAⁱ

CAB026025

Interactionⁱ

Subunit structureⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
ANG	P03950	3	EBI-1571188,EBI-525291
DIP2A	Q14689	2	EBI-1571188,EBI-2564275

GO - Molecular functionⁱ

activin receptor antagonist activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 12702211
heparan sulfate proteoglycan binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	115731, 8 interactors
IntActⁱ	P19883, 16 interactors
Molecular INTeraction database More...MINTⁱ	P19883
STRINGⁱ	9606.ENSP00000256759

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	31 – 36	Combined sources	6
Beta strandⁱ	42 – 49	Combined sources	8
Helixⁱ	52 – 55	Combined sources	4
Beta strandⁱ	64 – 66	Combined sources	3
Helixⁱ	72 – 81	Combined sources	10
Beta strandⁱ	82 – 87	Combined sources	6
Beta strandⁱ	89 – 91	Combined sources	3
Beta strandⁱ	93 – 95	Combined sources	3
Beta strandⁱ	104 – 108	Combined sources	5
Turnⁱ	110 – 112	Combined sources	3
Beta strandⁱ	114 – 118	Combined sources	5
Helixⁱ	123 – 125	Combined sources	3
Beta strandⁱ	131 – 133	Combined sources	3
Beta strandⁱ	138 – 141	Combined sources	4
Helixⁱ	142 – 151	Combined sources	10
Beta strandⁱ	158 – 163	Combined sources	6
Beta strandⁱ	166 – 168	Combined sources	3
Beta strandⁱ	178 – 181	Combined sources	4
Beta strandⁱ	185 – 190	Combined sources	6
Beta strandⁱ	202 – 204	Combined sources	3
Beta strandⁱ	206 – 208	Combined sources	3
Beta strandⁱ	213 – 216	Combined sources	4
Helixⁱ	217 – 227	Combined sources	11
Beta strandⁱ	233 – 237	Combined sources	5
Helixⁱ	245 – 247	Combined sources	3
Turnⁱ	251 – 253	Combined sources	3
Beta strandⁱ	255 – 259	Combined sources	5
Turnⁱ	260 – 263	Combined sources	4
Beta strandⁱ	264 – 268	Combined sources	5
Beta strandⁱ	283 – 285	Combined sources	3
Beta strandⁱ	290 – 293	Combined sources	4
Helixⁱ	294 – 304	Combined sources	11
Beta strandⁱ	310 – 314	Combined sources	5

Show more details

3D structure databases

ProteinModelPortalⁱ	P19883
SMRⁱ	P19883
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P19883

EvolutionaryTraceⁱ

P19883

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	30 – 103	TBPROSITE-ProRule annotationAdd BLAST	74
Domainⁱ	94 – 117	Follistatin-like 1Add BLAST	24
Domainⁱ	112 – 166	Kazal-like 1PROSITE-ProRule annotationAdd BLAST	55
Domainⁱ	167 – 190	Follistatin-like 2Add BLAST	24
Domainⁱ	186 – 241	Kazal-like 2PROSITE-ProRule annotationAdd BLAST	56
Domainⁱ	244 – 268	Follistatin-like 3Add BLAST	25
Domainⁱ	264 – 318	Kazal-like 3PROSITE-ProRule annotationAdd BLAST	55

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	321 – 333	Asp/Glu-rich (highly acidic)Add BLAST		13

Keywords - Domainⁱ

Repeat, Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IP0F Eukaryota ENOG410YM8Q LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00440000033501
HOGENOMⁱ	HOG000261649
HOVERGENⁱ	HBG051666
InParanoidⁱ	P19883
KEGG Orthology (KO) More...KOⁱ	K04661
OMAⁱ	DEAVCAS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09I0
PhylomeDBⁱ	P19883
TreeFamⁱ	TF106409

Family and domain databases

Gene3Dⁱ	3.90.290.10, 1 hit
InterProⁱ	View protein in InterPro IPR003645 Fol_N IPR015369 Follistatin/Osteonectin_EGF IPR002350 Kazal_dom IPR036058 Kazal_dom_sf IPR017878 TB_dom IPR036773 TB_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF09289 FOLN, 1 hit PF07648 Kazal_2, 3 hits
SMARTⁱ	View protein in SMART SM00274 FOLN, 3 hits SM00280 KAZAL, 3 hits
SUPFAMⁱ	SSF100895 SSF100895, 3 hits SSF57581 SSF57581, 1 hit
PROSITEⁱ	View protein in PROSITE PS51465 KAZAL_2, 3 hits PS51364 TB, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.ⁱShow all

Isoform 1 (identifier: P19883-1) [UniParc]FASTA Add to basket

Also known as: FS315, FS-315

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVRARHQPGG LCLLLLLLCQ FMEDRSAQAG NCWLRQAKNG RCQVLYKTEL 
        60         70         80         90        100
SKEECCSTGR LSTSWTEEDV NDNTLFKWMI FNGGAPNCIP CKETCENVDC 
       110        120        130        140        150
GPGKKCRMNK KNKPRCVCAP DCSNITWKGP VCGLDGKTYR NECALLKARC 
       160        170        180        190        200
KEQPELEVQY QGRCKKTCRD VFCPGSSTCV VDQTNNAYCV TCNRICPEPA 
       210        220        230        240        250
SSEQYLCGND GVTYSSACHL RKATCLLGRS IGLAYEGKCI KAKSCEDIQC 
       260        270        280        290        300
TGGKKCLWDF KVGRGRCSLC DELCPDSKSD EPVCASDNAT YASECAMKEA 
       310        320        330        340 
ACSSGVLLEV KHSGSCNSIS EDTEEEEEDE DQDYSFPISS ILEW

Length:344

Mass (Da):38,007

Last modified:October 10, 2002 - v2

Checksum:ⁱD9BB45055D84AC90

GO

Isoform 2 (identifier: P19883-2) [UniParc]FASTA Add to basket

Also known as: FS288, FS-288

The sequence of this isoform differs from the canonical sequence as follows:
318-344: Missing.

« Hide

        10         20         30         40         50
MVRARHQPGG LCLLLLLLCQ FMEDRSAQAG NCWLRQAKNG RCQVLYKTEL 
        60         70         80         90        100
SKEECCSTGR LSTSWTEEDV NDNTLFKWMI FNGGAPNCIP CKETCENVDC 
       110        120        130        140        150
GPGKKCRMNK KNKPRCVCAP DCSNITWKGP VCGLDGKTYR NECALLKARC 
       160        170        180        190        200
KEQPELEVQY QGRCKKTCRD VFCPGSSTCV VDQTNNAYCV TCNRICPEPA 
       210        220        230        240        250
SSEQYLCGND GVTYSSACHL RKATCLLGRS IGLAYEGKCI KAKSCEDIQC 
       260        270        280        290        300
TGGKKCLWDF KVGRGRCSLC DELCPDSKSD EPVCASDNAT YASECAMKEA 
       310 
ACSSGVLLEV KHSGSCN

Show »

Length:317

Mass (Da):34,803

Checksum:ⁱB516643224C7F8FF

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation
	H0YA75	H0YA75_HUMAN		Follistatin Follistatin	FST	215	Annotation score:
	H0YAF9	H0YAF9_HUMAN		Follistatin Follistatin	FST	102	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_049091	152	E → Q. Corresponds to variant dbSNP:rs11745088Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_001565	318 – 344	Missing in isoform 2. 1 PublicationAdd BLAST		27

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M19481, M19480 Genomic DNA Translation: AAA35851.1 AB451330 mRNA Translation: BAG70144.1 AB451474 mRNA Translation: BAG70288.1 CH471123 Genomic DNA Translation: EAW54880.1 BC004107 mRNA Translation: AAH04107.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3959.1 [P19883-1] CCDS43315.1 [P19883-2]
PIRⁱ	A32141
NCBI Reference Sequences More...RefSeqⁱ	NP_006341.1, NM_006350.3 [P19883-2] NP_037541.1, NM_013409.2 [P19883-1]
UniGeneⁱ	Hs.9914

Genome annotation databases

Ensemblⁱ	ENST00000256759; ENSP00000256759; ENSG00000134363 [P19883-1] ENST00000396947; ENSP00000380151; ENSG00000134363 [P19883-2]
GeneIDⁱ	10468
KEGGⁱ	hsa:10468
UCSC genome browser More...UCSCⁱ	uc003jpc.4 human [P19883-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P19883	Follistatin, isoform CRA_c		HUMAN		344	UniRef100_P19883
FST isoform 1		PANTR		344
FST isoform 2		PANTR		317
Isoform 2 of Follistatin		HUMAN		317

Protein	Similar proteins		Species	Score	Length	Source
P19883	Follistatin		BOVIN		344	UniRef90_P19883
Follistatin		BUBBU		344
Follistatin		HORSE		344
Follistatin		MOUSE		344
Follistatin		PIG		344
+196

Protein	Similar proteins		Species	Score	Length	Source
P19883	Follistatin		BUBBU		344	UniRef50_P19883
Follistatin		MOUSE		344
Follistatin	)	RAT		344
Follistatin		PIG		344
Follistatin		HORSE		344
+333

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M19481, M19480 Genomic DNA Translation: AAA35851.1 AB451330 mRNA Translation: BAG70144.1 AB451474 mRNA Translation: BAG70288.1 CH471123 Genomic DNA Translation: EAW54880.1 BC004107 mRNA Translation: AAH04107.1
CCDSⁱ	CCDS3959.1 [P19883-1] CCDS43315.1 [P19883-2]
PIRⁱ	A32141
RefSeqⁱ	NP_006341.1, NM_006350.3 [P19883-2] NP_037541.1, NM_013409.2 [P19883-1]
UniGeneⁱ	Hs.9914

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2B0U	X-ray	2.80	C/D	30-317	[»]
	2P6A	X-ray	3.40	C/D	30-344	[»]
	3HH2	X-ray	2.15	C/D	30-317	[»]
	5JHW	X-ray	2.35	C/D	30-317	[»]
ProteinModelPortalⁱ	P19883
SMRⁱ	P19883
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115731, 8 interactors
IntActⁱ	P19883, 16 interactors
MINTⁱ	P19883
STRINGⁱ	9606.ENSP00000256759

Chemistry databases

DrugBankⁱ	DB01666 D-Myo-Inositol-Hexasulphate

DrugBankⁱ

DB01666 D-Myo-Inositol-Hexasulphate

Protein family/group databases

MEROPSⁱ	I01.966

MEROPSⁱ

I01.966

PTM databases

iPTMnetⁱ	P19883
PhosphoSitePlusⁱ	P19883
UniCarbKBⁱ	P19883

Polymorphism and mutation databases

BioMutaⁱ	FST
DMDMⁱ	23831079

Proteomic databases

EPDⁱ	P19883
MaxQBⁱ	P19883
PaxDbⁱ	P19883
PeptideAtlasⁱ	P19883
PRIDEⁱ	P19883
ProteomicsDBⁱ	53700 53701 [P19883-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	10468
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000256759; ENSP00000256759; ENSG00000134363 [P19883-1] ENST00000396947; ENSP00000380151; ENSG00000134363 [P19883-2]
GeneIDⁱ	10468
KEGGⁱ	hsa:10468
UCSCⁱ	uc003jpc.4 human [P19883-1]

Organism-specific databases

CTDⁱ	10468
DisGeNETⁱ	10468
EuPathDBⁱ	HostDB:ENSG00000134363.11
GeneCardsⁱ	FST
HGNCⁱ	HGNC:3971 FST
HPAⁱ	CAB026025
MIMⁱ	136470 gene
neXtProtⁱ	NX_P19883
OpenTargetsⁱ	ENSG00000134363
Orphanetⁱ	3185 Polycystic ovary syndrome
PharmGKBⁱ	PA28388
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IP0F Eukaryota ENOG410YM8Q LUCA
GeneTreeⁱ	ENSGT00440000033501
HOGENOMⁱ	HOG000261649
HOVERGENⁱ	HBG051666
InParanoidⁱ	P19883
KOⁱ	K04661
OMAⁱ	DEAVCAS
OrthoDBⁱ	EOG091G09I0
PhylomeDBⁱ	P19883
TreeFamⁱ	TF106409

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2473224 Antagonism of Activin by Follistatin
SIGNORⁱ	P19883

Miscellaneous databases

ChiTaRSⁱ	FST human
EvolutionaryTraceⁱ	P19883
GeneWikiⁱ	Follistatin
GenomeRNAiⁱ	10468
Protein Ontology More...PROⁱ	PR:P19883
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000134363 Expressed in 186 organ(s), highest expression level in female gonad
CleanExⁱ	HS_FST
ExpressionAtlasⁱ	P19883 baseline and differential
Genevisibleⁱ	P19883 HS

Family and domain databases

Gene3Dⁱ	3.90.290.10, 1 hit
InterProⁱ	View protein in InterPro IPR003645 Fol_N IPR015369 Follistatin/Osteonectin_EGF IPR002350 Kazal_dom IPR036058 Kazal_dom_sf IPR017878 TB_dom IPR036773 TB_dom_sf
Pfamⁱ	View protein in Pfam PF09289 FOLN, 1 hit PF07648 Kazal_2, 3 hits
SMARTⁱ	View protein in SMART SM00274 FOLN, 3 hits SM00280 KAZAL, 3 hits
SUPFAMⁱ	SSF100895 SSF100895, 3 hits SSF57581 SSF57581, 1 hit
PROSITEⁱ	View protein in PROSITE PS51465 KAZAL_2, 3 hits PS51364 TB, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FST_HUMAN
Accessionⁱ	P19883Primary (citable) accession number: P19883 Secondary accession number(s): B5BU94, Q9BTH0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
	Last sequence update:	October 10, 2002
	Last modified:	September 12, 2018
	This is version 181 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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Proteomes

Annotation systems

Supporting data

UniProtKB - P19883 (FST_HUMAN)

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Follistatin

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Computationally mapped potential isoform sequencesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ