UniProtKB - P19883 (FST_HUMAN)
Protein
Follistatin
Gene
FST
Organism
Homo sapiens (Human)
Status
Functioni
Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).
GO - Molecular functioni
- activin binding Source: UniProtKB
- activin receptor antagonist activity Source: UniProtKB
- heparan sulfate proteoglycan binding Source: Ensembl
GO - Biological processi
- BMP signaling pathway Source: Ensembl
- cell differentiation Source: GO_Central
- female gonad development Source: Ensembl
- gamete generation Source: Ensembl
- hair follicle morphogenesis Source: Ensembl
- hematopoietic progenitor cell differentiation Source: UniProtKB
- keratinocyte proliferation Source: Ensembl
- multicellular organism development Source: GO_Central
- negative regulation of activin receptor signaling pathway Source: UniProtKB
- negative regulation of cell differentiation Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- odontogenesis of dentin-containing tooth Source: Ensembl
- pattern specification process Source: Ensembl
- positive regulation of hair follicle development Source: MGI
- regulation of BMP signaling pathway Source: GO_Central
- skeletal system development Source: Ensembl
Enzyme and pathway databases
PathwayCommonsi | P19883 |
Reactomei | R-HSA-2473224, Antagonism of Activin by Follistatin |
SIGNORi | P19883 |
Protein family/group databases
MEROPSi | I01.966 |
Names & Taxonomyi
Protein namesi | Recommended name: Follistatin1 PublicationShort name: FS Alternative name(s): Activin-binding proteinBy similarity |
Gene namesi | Name:FSTImported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3971, FST |
MIMi | 136470, gene |
neXtProti | NX_P19883 |
VEuPathDBi | HostDB:ENSG00000134363.11 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: GO_Central
Nucleus
- nucleus Source: Ensembl
Other locations
- cytoplasm Source: Ensembl
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 10468 |
OpenTargetsi | ENSG00000134363 |
PharmGKBi | PA28388 |
Miscellaneous databases
Pharosi | P19883, Tbio |
Chemistry databases
DrugBanki | DB01666, D-Myo-Inositol-Hexasulphate |
Genetic variation databases
BioMutai | FST |
DMDMi | 23831079 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 29 | 1 PublicationAdd BLAST | 29 | |
ChainiPRO_0000010103 | 30 – 344 | FollistatinAdd BLAST | 315 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 32 ↔ 55 | PROSITE-ProRule annotationCombined sources4 Publications | ||
Disulfide bondi | 42 ↔ 88 | PROSITE-ProRule annotationCombined sources4 Publications | ||
Disulfide bondi | 56 ↔ 91 | PROSITE-ProRule annotationCombined sources4 Publications | ||
Disulfide bondi | 95 ↔ 106 | Combined sources4 Publications | ||
Disulfide bondi | 100 ↔ 116 | Combined sources4 Publications | ||
Disulfide bondi | 118 ↔ 150 | Combined sources4 Publications | ||
Disulfide bondi | 122 ↔ 143 | Combined sources4 Publications | ||
Glycosylationi | 124 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 132 ↔ 164 | Combined sources4 Publications | ||
Disulfide bondi | 168 ↔ 179 | Combined sources4 Publications | ||
Disulfide bondi | 173 ↔ 189 | Combined sources4 Publications | ||
Disulfide bondi | 192 ↔ 225 | Combined sources4 Publications | ||
Disulfide bondi | 196 ↔ 218 | Combined sources4 Publications | ||
Disulfide bondi | 207 ↔ 239 | Combined sources4 Publications | ||
Disulfide bondi | 245 ↔ 256 | Combined sources4 Publications | ||
Disulfide bondi | 250 ↔ 267 | Combined sources4 Publications | ||
Disulfide bondi | 270 ↔ 302 | Combined sources4 Publications | ||
Disulfide bondi | 274 ↔ 295 | Combined sources4 Publications | ||
Disulfide bondi | 284 ↔ 316 | Combined sources4 Publications | ||
Glycosylationi | 288 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MassIVEi | P19883 |
MaxQBi | P19883 |
PaxDbi | P19883 |
PeptideAtlasi | P19883 |
PRIDEi | P19883 |
ProteomicsDBi | 53700 [P19883-1] 53701 [P19883-2] |
PTM databases
GlyConnecti | 1251, 1 N-Linked glycan (1 site) |
GlyGeni | P19883, 3 sites, 8 N-linked glycans (2 sites) |
iPTMneti | P19883 |
PhosphoSitePlusi | P19883 |
Expressioni
Tissue specificityi
Isoform 1 is the predominant isoform in serum but is undetectable in follicular fluid.1 Publication
Gene expression databases
Bgeei | ENSG00000134363, Expressed in female gonad and 201 other tissues |
ExpressionAtlasi | P19883, baseline and differential |
Genevisiblei | P19883, HS |
Organism-specific databases
HPAi | ENSG00000134363, Tissue enhanced (liver) |
Interactioni
Subunit structurei
Binary interactionsi
Hide detailsP19883
GO - Molecular functioni
- activin receptor antagonist activity Source: UniProtKB
- heparan sulfate proteoglycan binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 115731, 15 interactors |
IntActi | P19883, 18 interactors |
MINTi | P19883 |
STRINGi | 9606.ENSP00000256759 |
Miscellaneous databases
RNActi | P19883, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P19883 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P19883 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 30 – 103 | TBPROSITE-ProRule annotationAdd BLAST | 74 | |
Domaini | 94 – 117 | Follistatin-like 1Add BLAST | 24 | |
Domaini | 112 – 166 | Kazal-like 1PROSITE-ProRule annotationAdd BLAST | 55 | |
Domaini | 167 – 190 | Follistatin-like 2Add BLAST | 24 | |
Domaini | 186 – 241 | Kazal-like 2PROSITE-ProRule annotationAdd BLAST | 56 | |
Domaini | 244 – 268 | Follistatin-like 3Add BLAST | 25 | |
Domaini | 264 – 318 | Kazal-like 3PROSITE-ProRule annotationAdd BLAST | 55 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 321 – 333 | Asp/Glu-rich (highly acidic)Add BLAST | 13 |
Keywords - Domaini
Repeat, SignalPhylogenomic databases
eggNOGi | KOG3649, Eukaryota |
GeneTreei | ENSGT00940000157072 |
HOGENOMi | CLU_050745_0_0_1 |
InParanoidi | P19883 |
OMAi | ETCPESR |
OrthoDBi | 1460520at2759 |
PhylomeDBi | P19883 |
TreeFami | TF106409 |
Family and domain databases
Gene3Di | 3.90.290.10, 1 hit |
IDEALi | IID00339 |
InterProi | View protein in InterPro IPR003645, Fol_N IPR015369, Follistatin/Osteonectin_EGF IPR002350, Kazal_dom IPR036058, Kazal_dom_sf IPR017878, TB_dom IPR036773, TB_dom_sf |
Pfami | View protein in Pfam PF09289, FOLN, 1 hit PF07648, Kazal_2, 3 hits |
SMARTi | View protein in SMART SM00274, FOLN, 3 hits SM00280, KAZAL, 3 hits |
SUPFAMi | SSF100895, SSF100895, 3 hits SSF57581, SSF57581, 1 hit |
PROSITEi | View protein in PROSITE PS51465, KAZAL_2, 3 hits PS51364, TB, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P19883-1) [UniParc]FASTAAdd to basket
Also known as: FS315, FS-315
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVRARHQPGG LCLLLLLLCQ FMEDRSAQAG NCWLRQAKNG RCQVLYKTEL
60 70 80 90 100
SKEECCSTGR LSTSWTEEDV NDNTLFKWMI FNGGAPNCIP CKETCENVDC
110 120 130 140 150
GPGKKCRMNK KNKPRCVCAP DCSNITWKGP VCGLDGKTYR NECALLKARC
160 170 180 190 200
KEQPELEVQY QGRCKKTCRD VFCPGSSTCV VDQTNNAYCV TCNRICPEPA
210 220 230 240 250
SSEQYLCGND GVTYSSACHL RKATCLLGRS IGLAYEGKCI KAKSCEDIQC
260 270 280 290 300
TGGKKCLWDF KVGRGRCSLC DELCPDSKSD EPVCASDNAT YASECAMKEA
310 320 330 340
ACSSGVLLEV KHSGSCNSIS EDTEEEEEDE DQDYSFPISS ILEW
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YA75 | H0YA75_HUMAN | Follistatin | FST | 215 | Annotation score: | ||
H0YAF9 | H0YAF9_HUMAN | Follistatin | FST | 102 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049091 | 152 | E → Q. Corresponds to variant dbSNP:rs11745088EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_001565 | 318 – 344 | Missing in isoform 2. 1 PublicationAdd BLAST | 27 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M19481, M19480 Genomic DNA Translation: AAA35851.1 AB451330 mRNA Translation: BAG70144.1 AB451474 mRNA Translation: BAG70288.1 CH471123 Genomic DNA Translation: EAW54880.1 BC004107 mRNA Translation: AAH04107.1 |
CCDSi | CCDS3959.1 [P19883-1] CCDS43315.1 [P19883-2] |
PIRi | A32141 |
RefSeqi | NP_006341.1, NM_006350.3 [P19883-2] NP_037541.1, NM_013409.2 [P19883-1] |
Genome annotation databases
Ensembli | ENST00000256759; ENSP00000256759; ENSG00000134363 [P19883-1] ENST00000396947; ENSP00000380151; ENSG00000134363 [P19883-2] |
GeneIDi | 10468 |
KEGGi | hsa:10468 |
UCSCi | uc003jpc.4, human [P19883-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M19481, M19480 Genomic DNA Translation: AAA35851.1 AB451330 mRNA Translation: BAG70144.1 AB451474 mRNA Translation: BAG70288.1 CH471123 Genomic DNA Translation: EAW54880.1 BC004107 mRNA Translation: AAH04107.1 |
CCDSi | CCDS3959.1 [P19883-1] CCDS43315.1 [P19883-2] |
PIRi | A32141 |
RefSeqi | NP_006341.1, NM_006350.3 [P19883-2] NP_037541.1, NM_013409.2 [P19883-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2B0U | X-ray | 2.80 | C/D | 30-317 | [»] | |
2P6A | X-ray | 3.40 | C/D | 30-344 | [»] | |
3HH2 | X-ray | 2.15 | C/D | 30-317 | [»] | |
5JHW | X-ray | 2.35 | C/D | 30-317 | [»] | |
SMRi | P19883 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115731, 15 interactors |
IntActi | P19883, 18 interactors |
MINTi | P19883 |
STRINGi | 9606.ENSP00000256759 |
Chemistry databases
DrugBanki | DB01666, D-Myo-Inositol-Hexasulphate |
Protein family/group databases
MEROPSi | I01.966 |
PTM databases
GlyConnecti | 1251, 1 N-Linked glycan (1 site) |
GlyGeni | P19883, 3 sites, 8 N-linked glycans (2 sites) |
iPTMneti | P19883 |
PhosphoSitePlusi | P19883 |
Genetic variation databases
BioMutai | FST |
DMDMi | 23831079 |
Proteomic databases
MassIVEi | P19883 |
MaxQBi | P19883 |
PaxDbi | P19883 |
PeptideAtlasi | P19883 |
PRIDEi | P19883 |
ProteomicsDBi | 53700 [P19883-1] 53701 [P19883-2] |
Protocols and materials databases
Antibodypediai | 11023, 577 antibodies |
DNASUi | 10468 |
Genome annotation databases
Ensembli | ENST00000256759; ENSP00000256759; ENSG00000134363 [P19883-1] ENST00000396947; ENSP00000380151; ENSG00000134363 [P19883-2] |
GeneIDi | 10468 |
KEGGi | hsa:10468 |
UCSCi | uc003jpc.4, human [P19883-1] |
Organism-specific databases
CTDi | 10468 |
DisGeNETi | 10468 |
GeneCardsi | FST |
HGNCi | HGNC:3971, FST |
HPAi | ENSG00000134363, Tissue enhanced (liver) |
MIMi | 136470, gene |
neXtProti | NX_P19883 |
OpenTargetsi | ENSG00000134363 |
PharmGKBi | PA28388 |
VEuPathDBi | HostDB:ENSG00000134363.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3649, Eukaryota |
GeneTreei | ENSGT00940000157072 |
HOGENOMi | CLU_050745_0_0_1 |
InParanoidi | P19883 |
OMAi | ETCPESR |
OrthoDBi | 1460520at2759 |
PhylomeDBi | P19883 |
TreeFami | TF106409 |
Enzyme and pathway databases
PathwayCommonsi | P19883 |
Reactomei | R-HSA-2473224, Antagonism of Activin by Follistatin |
SIGNORi | P19883 |
Miscellaneous databases
BioGRID-ORCSi | 10468, 8 hits in 995 CRISPR screens |
ChiTaRSi | FST, human |
EvolutionaryTracei | P19883 |
GeneWikii | Follistatin |
GenomeRNAii | 10468 |
Pharosi | P19883, Tbio |
PROi | PR:P19883 |
RNActi | P19883, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000134363, Expressed in female gonad and 201 other tissues |
ExpressionAtlasi | P19883, baseline and differential |
Genevisiblei | P19883, HS |
Family and domain databases
Gene3Di | 3.90.290.10, 1 hit |
IDEALi | IID00339 |
InterProi | View protein in InterPro IPR003645, Fol_N IPR015369, Follistatin/Osteonectin_EGF IPR002350, Kazal_dom IPR036058, Kazal_dom_sf IPR017878, TB_dom IPR036773, TB_dom_sf |
Pfami | View protein in Pfam PF09289, FOLN, 1 hit PF07648, Kazal_2, 3 hits |
SMARTi | View protein in SMART SM00274, FOLN, 3 hits SM00280, KAZAL, 3 hits |
SUPFAMi | SSF100895, SSF100895, 3 hits SSF57581, SSF57581, 1 hit |
PROSITEi | View protein in PROSITE PS51465, KAZAL_2, 3 hits PS51364, TB, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FST_HUMAN | |
Accessioni | P19883Primary (citable) accession number: P19883 Secondary accession number(s): B5BU94, Q9BTH0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1991 |
Last sequence update: | October 10, 2002 | |
Last modified: | April 7, 2021 | |
This is version 201 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references