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UniProtKB - P19883 (FST_HUMAN)

Entry version 201 (07 Apr 2021)
Sequence version 2 (10 Oct 2002)
Previous versions | rss
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Protein

Follistatin

Gene

FST

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • activin binding Source: UniProtKB
  • activin receptor antagonist activity Source: UniProtKB
  • heparan sulfate proteoglycan binding Source: Ensembl
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P19883

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2473224, Antagonism of Activin by Follistatin

SIGNOR Signaling Network Open Resource

More...SIGNORi		P19883

Protein family/group databases

MEROPS protease database

More...MEROPSi		I01.966

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Follistatin1 Publication
Short name:
FS
Alternative name(s):
Activin-binding proteinBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FSTImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:3971, FST

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		136470, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P19883

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000134363.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		10468

Open Targets

More...OpenTargetsi		ENSG00000134363

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA28388

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P19883, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB01666, D-Myo-Inositol-Hexasulphate

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		FST

Domain mapping of disease mutations (DMDM)

More...DMDMi		23831079

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 291 PublicationAdd BLAST29
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001010330 – 344FollistatinAdd BLAST315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi32 ↔ 55PROSITE-ProRule annotationCombined sources4 Publications
Disulfide bondi42 ↔ 88PROSITE-ProRule annotationCombined sources4 Publications
Disulfide bondi56 ↔ 91PROSITE-ProRule annotationCombined sources4 Publications
Disulfide bondi95 ↔ 106Combined sources4 Publications
Disulfide bondi100 ↔ 116Combined sources4 Publications
Disulfide bondi118 ↔ 150Combined sources4 Publications
Disulfide bondi122 ↔ 143Combined sources4 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi124N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi132 ↔ 164Combined sources4 Publications
Disulfide bondi168 ↔ 179Combined sources4 Publications
Disulfide bondi173 ↔ 189Combined sources4 Publications
Disulfide bondi192 ↔ 225Combined sources4 Publications
Disulfide bondi196 ↔ 218Combined sources4 Publications
Disulfide bondi207 ↔ 239Combined sources4 Publications
Disulfide bondi245 ↔ 256Combined sources4 Publications
Disulfide bondi250 ↔ 267Combined sources4 Publications
Disulfide bondi270 ↔ 302Combined sources4 Publications
Disulfide bondi274 ↔ 295Combined sources4 Publications
Disulfide bondi284 ↔ 316Combined sources4 Publications
Glycosylationi288N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P19883

MaxQB - The MaxQuant DataBase

More...MaxQBi		P19883

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P19883

PeptideAtlas

More...PeptideAtlasi		P19883

PRoteomics IDEntifications database

More...PRIDEi		P19883

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		53700 [P19883-1]
53701 [P19883-2]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1251, 1 N-Linked glycan (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P19883, 3 sites, 8 N-linked glycans (2 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P19883

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P19883

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 is the predominant isoform in serum but is undetectable in follicular fluid.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000134363, Expressed in female gonad and 201 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P19883, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P19883, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000134363, Tissue enhanced (liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer. Isoform 2/FS-288 interacts with GDF11 (PubMed:28257634).

Curated1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115731, 15 interactors

Protein interaction database and analysis system

More...IntActi		P19883, 18 interactors

Molecular INTeraction database

More...MINTi		P19883

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000256759

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P19883, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1344
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P19883

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P19883

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 103TBPROSITE-ProRule annotationAdd BLAST74
Domaini94 – 117Follistatin-like 1Add BLAST24
Domaini112 – 166Kazal-like 1PROSITE-ProRule annotationAdd BLAST55
Domaini167 – 190Follistatin-like 2Add BLAST24
Domaini186 – 241Kazal-like 2PROSITE-ProRule annotationAdd BLAST56
Domaini244 – 268Follistatin-like 3Add BLAST25
Domaini264 – 318Kazal-like 3PROSITE-ProRule annotationAdd BLAST55

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi321 – 333Asp/Glu-rich (highly acidic)Add BLAST13

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3649, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157072

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_050745_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P19883

Identification of Orthologs from Complete Genome Data

More...OMAi		ETCPESR

Database of Orthologous Groups

More...OrthoDBi		1460520at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P19883

TreeFam database of animal gene trees

More...TreeFami		TF106409

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.90.290.10, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00339

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003645, Fol_N
IPR015369, Follistatin/Osteonectin_EGF
IPR002350, Kazal_dom
IPR036058, Kazal_dom_sf
IPR017878, TB_dom
IPR036773, TB_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF09289, FOLN, 1 hit
PF07648, Kazal_2, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00274, FOLN, 3 hits
SM00280, KAZAL, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF100895, SSF100895, 3 hits
SSF57581, SSF57581, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51465, KAZAL_2, 3 hits
PS51364, TB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P19883-1) [UniParc]FASTAAdd to basket
Also known as: FS315, FS-315

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVRARHQPGG LCLLLLLLCQ FMEDRSAQAG NCWLRQAKNG RCQVLYKTEL 
        60         70         80         90        100
SKEECCSTGR LSTSWTEEDV NDNTLFKWMI FNGGAPNCIP CKETCENVDC 
       110        120        130        140        150
GPGKKCRMNK KNKPRCVCAP DCSNITWKGP VCGLDGKTYR NECALLKARC 
       160        170        180        190        200
KEQPELEVQY QGRCKKTCRD VFCPGSSTCV VDQTNNAYCV TCNRICPEPA 
       210        220        230        240        250
SSEQYLCGND GVTYSSACHL RKATCLLGRS IGLAYEGKCI KAKSCEDIQC 
       260        270        280        290        300
TGGKKCLWDF KVGRGRCSLC DELCPDSKSD EPVCASDNAT YASECAMKEA 
       310        320        330        340 
ACSSGVLLEV KHSGSCNSIS EDTEEEEEDE DQDYSFPISS ILEW
Length:344
Mass (Da):38,007
Last modified:October 10, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD9BB45055D84AC90
GO
Isoform 2 (identifier: P19883-2) [UniParc]FASTAAdd to basket
Also known as: FS288, FS-288

The sequence of this isoform differs from the canonical sequence as follows:
     318-344: Missing.

Show »
Length:317
Mass (Da):34,803
Checksum:iB516643224C7F8FF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YA75H0YA75_HUMAN
Follistatin
FST
215Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YAF9H0YAF9_HUMAN
Follistatin
FST
102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_049091152E → Q. Corresponds to variant dbSNP:rs11745088EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_001565318 – 344Missing in isoform 2. 1 PublicationAdd BLAST27

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M19481, M19480 Genomic DNA Translation: AAA35851.1
AB451330 mRNA Translation: BAG70144.1
AB451474 mRNA Translation: BAG70288.1
CH471123 Genomic DNA Translation: EAW54880.1
BC004107 mRNA Translation: AAH04107.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3959.1 [P19883-1]
CCDS43315.1 [P19883-2]

Protein sequence database of the Protein Information Resource

More...PIRi		A32141

NCBI Reference Sequences

More...RefSeqi		NP_006341.1, NM_006350.3 [P19883-2]
NP_037541.1, NM_013409.2 [P19883-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000256759; ENSP00000256759; ENSG00000134363 [P19883-1]
ENST00000396947; ENSP00000380151; ENSG00000134363 [P19883-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10468

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10468

UCSC genome browser

More...UCSCi		uc003jpc.4, human [P19883-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19481, M19480 Genomic DNA Translation: AAA35851.1
AB451330 mRNA Translation: BAG70144.1
AB451474 mRNA Translation: BAG70288.1
CH471123 Genomic DNA Translation: EAW54880.1
BC004107 mRNA Translation: AAH04107.1
CCDSiCCDS3959.1 [P19883-1]
CCDS43315.1 [P19883-2]
PIRiA32141
RefSeqiNP_006341.1, NM_006350.3 [P19883-2]
NP_037541.1, NM_013409.2 [P19883-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B0UX-ray2.80C/D30-317[»]
2P6AX-ray3.40C/D30-344[»]
3HH2X-ray2.15C/D30-317[»]
5JHWX-ray2.35C/D30-317[»]
SMRiP19883
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi115731, 15 interactors
IntActiP19883, 18 interactors
MINTiP19883
STRINGi9606.ENSP00000256759

Chemistry databases

DrugBankiDB01666, D-Myo-Inositol-Hexasulphate

Protein family/group databases

MEROPSiI01.966

PTM databases

GlyConnecti1251, 1 N-Linked glycan (1 site)
GlyGeniP19883, 3 sites, 8 N-linked glycans (2 sites)
iPTMnetiP19883
PhosphoSitePlusiP19883

Genetic variation databases

BioMutaiFST
DMDMi23831079

Proteomic databases

MassIVEiP19883
MaxQBiP19883
PaxDbiP19883
PeptideAtlasiP19883
PRIDEiP19883
ProteomicsDBi53700 [P19883-1]
53701 [P19883-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		11023, 577 antibodies

The DNASU plasmid repository

More...DNASUi		10468

Genome annotation databases

EnsembliENST00000256759; ENSP00000256759; ENSG00000134363 [P19883-1]
ENST00000396947; ENSP00000380151; ENSG00000134363 [P19883-2]
GeneIDi10468
KEGGihsa:10468
UCSCiuc003jpc.4, human [P19883-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10468
DisGeNETi10468

GeneCards: human genes, protein and diseases

More...GeneCardsi		FST
HGNCiHGNC:3971, FST
HPAiENSG00000134363, Tissue enhanced (liver)
MIMi136470, gene
neXtProtiNX_P19883
OpenTargetsiENSG00000134363
PharmGKBiPA28388
VEuPathDBiHostDB:ENSG00000134363.11

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3649, Eukaryota
GeneTreeiENSGT00940000157072
HOGENOMiCLU_050745_0_0_1
InParanoidiP19883
OMAiETCPESR
OrthoDBi1460520at2759
PhylomeDBiP19883
TreeFamiTF106409

Enzyme and pathway databases

PathwayCommonsiP19883
ReactomeiR-HSA-2473224, Antagonism of Activin by Follistatin
SIGNORiP19883

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		10468, 8 hits in 995 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		FST, human
EvolutionaryTraceiP19883

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Follistatin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10468
PharosiP19883, Tbio

Protein Ontology

More...PROi		PR:P19883
RNActiP19883, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000134363, Expressed in female gonad and 201 other tissues
ExpressionAtlasiP19883, baseline and differential
GenevisibleiP19883, HS

Family and domain databases

Gene3Di3.90.290.10, 1 hit
IDEALiIID00339
InterProiView protein in InterPro
IPR003645, Fol_N
IPR015369, Follistatin/Osteonectin_EGF
IPR002350, Kazal_dom
IPR036058, Kazal_dom_sf
IPR017878, TB_dom
IPR036773, TB_dom_sf
PfamiView protein in Pfam
PF09289, FOLN, 1 hit
PF07648, Kazal_2, 3 hits
SMARTiView protein in SMART
SM00274, FOLN, 3 hits
SM00280, KAZAL, 3 hits
SUPFAMiSSF100895, SSF100895, 3 hits
SSF57581, SSF57581, 1 hit
PROSITEiView protein in PROSITE
PS51465, KAZAL_2, 3 hits
PS51364, TB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFST_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P19883
Secondary accession number(s): B5BU94, Q9BTH0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: October 10, 2002
Last modified: April 7, 2021
This is version 201 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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