Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Heat shock protein 60, mitochondrial

Gene

HSP60

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May participate in assembly and/or disassembly of proteins imported into the mitochondrion. HSP60 are ATPases and have affinity for unfolded proteins.

GO - Molecular functioni

  • ATPase activity Source: SGD
  • ATP binding Source: UniProtKB-KW
  • chaperone binding Source: SGD
  • DNA replication origin binding Source: SGD
  • protein binding involved in protein folding Source: GO_Central
  • single-stranded DNA binding Source: SGD
  • unfolded protein binding Source: SGD

GO - Biological processi

  • 'de novo' protein folding Source: SGD
  • apoptotic mitochondrial changes Source: GO_Central
  • chaperone-mediated protein complex assembly Source: SGD
  • chaperone-mediated protein folding Source: GO_Central
  • protein import into mitochondrial intermembrane space Source: SGD
  • protein maturation Source: SGD
  • protein refolding Source: SGD
  • protein stabilization Source: SGD

Keywordsi

Molecular functionChaperone
Biological processStress response
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-32361-MONOMER
ReactomeiR-SCE-1268020 Mitochondrial protein import

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein 60, mitochondrial
Alternative name(s):
CPN60
P66
Stimulator factor I 66 kDa component
Gene namesi
Name:HSP60
Synonyms:MIF4
Ordered Locus Names:YLR259C
ORF Names:L8479.10
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR259C
SGDiS000004249 HSP60

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 25MitochondrionSequence analysisAdd BLAST25
ChainiPRO_000000504426 – 572Heat shock protein 60, mitochondrialAdd BLAST547

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei102PhosphothreonineCombined sources1
Modified residuei485PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP19882
PaxDbiP19882
PRIDEiP19882

2D gel databases

SWISS-2DPAGEiP19882
UCD-2DPAGEiP19882

PTM databases

CarbonylDBiP19882
iPTMnetiP19882

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • chaperone binding Source: SGD
  • protein binding involved in protein folding Source: GO_Central
  • unfolded protein binding Source: SGD

Protein-protein interaction databases

BioGridi31527, 308 interactors
DIPiDIP-7648N
IntActiP19882, 330 interactors
MINTiP19882
STRINGi4932.YLR259C

Structurei

3D structure databases

ProteinModelPortaliP19882
SMRiP19882
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

GeneTreeiENSGT00390000005727
HOGENOMiHOG000076290
InParanoidiP19882
KOiK04077
OMAiTDTDKME
OrthoDBiEOG092C1JWK

Family and domain databases

CDDicd03344 GroEL, 1 hit
Gene3Di1.10.560.10, 2 hits
3.30.260.10, 2 hits
3.50.7.10, 1 hit
HAMAPiMF_00600 CH60, 1 hit
InterProiView protein in InterPro
IPR018370 Chaperonin_Cpn60_CS
IPR001844 Chaprnin_Cpn60
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00298 CHAPERONIN60
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 1 hit
TIGRFAMsiTIGR02348 GroEL, 1 hit
PROSITEiView protein in PROSITE
PS00296 CHAPERONINS_CPN60, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19882-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRSSVVRSR ATLRPLLRRA YSSHKELKFG VEGRASLLKG VETLAEAVAA
60 70 80 90 100
TLGPKGRNVL IEQPFGPPKI TKDGVTVAKS IVLKDKFENM GAKLLQEVAS
110 120 130 140 150
KTNEAAGDGT TSATVLGRAI FTESVKNVAA GCNPMDLRRG SQVAVEKVIE
160 170 180 190 200
FLSANKKEIT TSEEIAQVAT ISANGDSHVG KLLASAMEKV GKEGVITIRE
210 220 230 240 250
GRTLEDELEV TEGMRFDRGF ISPYFITDPK SSKVEFEKPL LLLSEKKISS
260 270 280 290 300
IQDILPALEI SNQSRRPLLI IAEDVDGEAL AACILNKLRG QVKVCAVKAP
310 320 330 340 350
GFGDNRKNTI GDIAVLTGGT VFTEELDLKP EQCTIENLGS CDSITVTKED
360 370 380 390 400
TVILNGSGPK EAIQERIEQI KGSIDITTTN SYEKEKLQER LAKLSGGVAV
410 420 430 440 450
IRVGGASEVE VGEKKDRYDD ALNATRAAVE EGILPGGGTA LVKASRVLDE
460 470 480 490 500
VVVDNFDQKL GVDIIRKAIT RPAKQIIENA GEEGSVIIGK LIDEYGDDFA
510 520 530 540 550
KGYDASKSEY TDMLATGIID PFKVVRSGLV DASGVASLLA TTEVAIVDAP
560 570
EPPAAAGAGG MPGGMPGMPG MM
Length:572
Mass (Da):60,752
Last modified:February 1, 1991 - v1
Checksum:i279DC3AF5A2B0A3E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33301 Genomic DNA Translation: AAA34690.1
U17244 Genomic DNA Translation: AAB67380.1
BK006945 Genomic DNA Translation: DAA09572.1
PIRiJQ0157
RefSeqiNP_013360.1, NM_001182146.1

Genome annotation databases

EnsemblFungiiYLR259C; YLR259C; YLR259C
GeneIDi850963
KEGGisce:YLR259C

Similar proteinsi

Entry informationi

Entry nameiHSP60_YEAST
AccessioniPrimary (citable) accession number: P19882
Secondary accession number(s): D6VYQ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: July 18, 2018
This is version 184 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health