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Protein

Neutrophil cytosol factor 2

Gene

NCF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).1 Publication

GO - Molecular functioni

  • electron transfer activity Source: UniProtKB
  • protein C-terminus binding Source: UniProtKB
  • Rac GTPase binding Source: Ensembl
  • superoxide-generating NADPH oxidase activator activity Source: InterPro
  • superoxide-generating NADPH oxidase activity Source: Ensembl

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-1222556 ROS, RNS production in phagocytes
R-HSA-1236973 Cross-presentation of particulate exogenous antigens (phagosomes)
R-HSA-3299685 Detoxification of Reactive Oxygen Species
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-5668599 RHO GTPases Activate NADPH Oxidases
SIGNORiP19878

Names & Taxonomyi

Protein namesi
Recommended name:
Neutrophil cytosol factor 2
Short name:
NCF-2
Alternative name(s):
67 kDa neutrophil oxidase factor
NADPH oxidase activator 2
Neutrophil NADPH oxidase factor 2
p67-phox
Gene namesi
Name:NCF2
Synonyms:NOXA2, P67PHOX
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000116701.14
HGNCiHGNC:7661 NCF2
MIMi608515 gene
neXtProtiNX_P19878

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

Granulomatous disease, chronic, cytochrome-b-positive 2, autosomal recessive (CGD2)10 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections.
See also OMIM:233710
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01738719 – 21Missing in CGD2. 1 Publication3
Natural variantiVAR_06500242N → S in CGD2. 1 PublicationCorresponds to variant dbSNP:rs137854514EnsemblClinVar.1
Natural variantiVAR_06500344G → C in CGD2. 1 PublicationCorresponds to variant dbSNP:rs137854510EnsemblClinVar.1
Natural variantiVAR_06500444G → R in CGD2. 2 PublicationsCorresponds to variant dbSNP:rs137854510EnsemblClinVar.1
Natural variantiVAR_06500558Missing in CGD2. 1 Publication1
Natural variantiVAR_01738877R → Q in CGD2. 2 PublicationsCorresponds to variant dbSNP:rs119103275EnsemblClinVar.1
Natural variantiVAR_00890478G → E in CGD2. 1 PublicationCorresponds to variant dbSNP:rs137854519EnsemblClinVar.1
Natural variantiVAR_06500793D → E in CGD2. 2 PublicationsCorresponds to variant dbSNP:rs137854507EnsemblClinVar.1
Natural variantiVAR_06500896Missing in CGD2. 1 Publication1
Natural variantiVAR_065009102R → P in CGD2. 1 PublicationCorresponds to variant dbSNP:rs137854515EnsemblClinVar.1
Natural variantiVAR_065010108D → V in CGD2. 1 PublicationCorresponds to variant dbSNP:rs137854509EnsemblClinVar.1
Natural variantiVAR_017389128A → V in CGD2. 1 PublicationCorresponds to variant dbSNP:rs119103274EnsemblClinVar.1
Natural variantiVAR_065011137W → R in CGD2. 1 PublicationCorresponds to variant dbSNP:rs137854516EnsemblClinVar.1
Natural variantiVAR_065012140A → D in CGD2. 1 PublicationCorresponds to variant dbSNP:rs137854520EnsemblClinVar.1
Natural variantiVAR_017390160 – 161DK → EV in CGD2. 2
Natural variantiVAR_065013169Q → E in CGD2. 1 PublicationCorresponds to variant dbSNP:rs137854517EnsemblClinVar.1
Natural variantiVAR_065014184R → P in CGD2. 1 PublicationCorresponds to variant dbSNP:rs137854518EnsemblClinVar.1
Natural variantiVAR_065015196Missing in CGD2. 1 Publication1
Natural variantiVAR_065016202A → V in CGD2. 2 PublicationsCorresponds to variant dbSNP:rs137854508EnsemblClinVar.1

Keywords - Diseasei

Chronic granulomatous disease, Disease mutation

Organism-specific databases

DisGeNETi4688
GeneReviewsiNCF2
MalaCardsiNCF2
MIMi233710 phenotype
OpenTargetsiENSG00000116701
Orphaneti379 Chronic granulomatous disease
PharmGKBiPA31464

Chemistry databases

DrugBankiDB00514 Dextromethorphan

Polymorphism and mutation databases

BioMutaiNCF2
DMDMi1346669

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001063611 – 526Neutrophil cytosol factor 2Add BLAST526

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei233PhosphothreonineBy similarity1
Modified residuei399PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP19878
MaxQBiP19878
PaxDbiP19878
PeptideAtlasiP19878
PRIDEiP19878
ProteomicsDBi53699

PTM databases

iPTMnetiP19878
PhosphoSitePlusiP19878

Expressioni

Gene expression databases

BgeeiENSG00000116701 Expressed in 147 organ(s), highest expression level in blood
CleanExiHS_NCF2
ExpressionAtlasiP19878 baseline and differential
GenevisibleiP19878 HS

Organism-specific databases

HPAiCAB022160
HPA002327
HPA006040

Interactioni

Subunit structurei

Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4. Interacts with NCF4. Interacts (via the C-terminal SH3 domain) with NCF1 (via C-terminus). Interacts with SYTL1 and RAC1. May interact with NOXO1. Interacts with S100A8 and calprotectin (S100A8/9).8 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110768, 24 interactors
DIPiDIP-76N
IntActiP19878, 15 interactors
MINTiP19878
STRINGi9606.ENSP00000356505

Structurei

Secondary structure

1526
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP19878
SMRiP19878
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP19878

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati37 – 70TPR 1Add BLAST34
Repeati71 – 104TPR 2Add BLAST34
Repeati121 – 154TPR 3Add BLAST34
Domaini240 – 299SH3 1PROSITE-ProRule annotationAdd BLAST60
Domaini351 – 429PB1PROSITE-ProRule annotationAdd BLAST79
Domaini457 – 516SH3 2PROSITE-ProRule annotationAdd BLAST60

Domaini

The OPR/PB1 domain mediates the association with NCF4/p40-PHOX.1 Publication

Sequence similaritiesi

Belongs to the NCF2/NOXA1 family.Curated

Keywords - Domaini

Repeat, SH3 domain, TPR repeat

Phylogenomic databases

eggNOGiKOG4225 Eukaryota
ENOG41110AD LUCA
GeneTreeiENSGT00530000063843
HOGENOMiHOG000237312
HOVERGENiHBG001521
InParanoidiP19878
KOiK08010
OMAiCNYLEPV
OrthoDBiEOG091G04T7
PhylomeDBiP19878
TreeFamiTF329087

Family and domain databases

CDDicd06406 PB1_P67, 1 hit
cd11871 SH3_p67phox_N, 1 hit
Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR034889 P67-PHOX
IPR035546 p67phox_SH3_1
IPR000270 PB1_dom
IPR034885 PB1_P67
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PANTHERiPTHR15175:SF3 PTHR15175:SF3, 1 hit
PfamiView protein in Pfam
PF00564 PB1, 1 hit
PF00018 SH3_1, 2 hits
PF13181 TPR_8, 2 hits
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00666 PB1, 1 hit
SM00326 SH3, 2 hits
SM00028 TPR, 3 hits
SUPFAMiSSF48452 SSF48452, 1 hit
SSF50044 SSF50044, 2 hits
PROSITEiView protein in PROSITE
PS51745 PB1, 1 hit
PS50002 SH3, 2 hits
PS50005 TPR, 3 hits
PS50293 TPR_REGION, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P19878-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLVEAISLW NEGVLAADKK DWKGALDAFS AVQDPHSRIC FNIGCMYTIL
60 70 80 90 100
KNMTEAEKAF TRSINRDKHL AVAYFQRGML YYQTEKYDLA IKDLKEALIQ
110 120 130 140 150
LRGNQLIDYK ILGLQFKLFA CEVLYNIAFM YAKKEEWKKA EEQLALATSM
160 170 180 190 200
KSEPRHSKID KAMECVWKQK LYEPVVIPVG KLFRPNERQV AQLAKKDYLG
210 220 230 240 250
KATVVASVVD QDSFSGFAPL QPQAAEPPPR PKTPEIFRAL EGEAHRVLFG
260 270 280 290 300
FVPETKEELQ VMPGNIVFVL KKGNDNWATV MFNGQKGLVP CNYLEPVELR
310 320 330 340 350
IHPQQQPQEE SSPQSDIPAP PSSKAPGRPQ LSPGQKQKEE PKEVKLSVPM
360 370 380 390 400
PYTLKVHYKY TVVMKTQPGL PYSQVRDMVS KKLELRLEHT KLSYRPRDSN
410 420 430 440 450
ELVPLSEDSM KDAWGQVKNY CLTLWCENTV GDQGFPDEPK ESEKADANNQ
460 470 480 490 500
TTEPQLKKGS QVEALFSYEA TQPEDLEFQE GDIILVLSKV NEEWLEGECK
510 520
GKVGIFPKVF VEDCATTDLE STRREV
Length:526
Mass (Da):59,762
Last modified:February 1, 1996 - v2
Checksum:iEC136766E1915376
GO
Isoform 2 (identifier: P19878-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     123-203: Missing.
     502-526: Missing.

Note: No experimental confirmation available.
Show »
Length:420
Mass (Da):47,515
Checksum:iD45BFF944F0CE53C
GO
Isoform 3 (identifier: P19878-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     123-167: Missing.

Note: No experimental confirmation available.
Show »
Length:481
Mass (Da):54,446
Checksum:i4A15D34EA01887D6
GO
Isoform 4 (identifier: P19878-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     123-203: Missing.

Note: No experimental confirmation available.
Show »
Length:445
Mass (Da):50,337
Checksum:i88E274CACEDFFBC7
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1ALB7B1ALB7_HUMAN
Neutrophil cytosol factor 2
NCF2
143Annotation score:
B1ALB6B1ALB6_HUMAN
Neutrophil cytosol factor 2
NCF2
56Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01738719 – 21Missing in CGD2. 1 Publication3
Natural variantiVAR_06500242N → S in CGD2. 1 PublicationCorresponds to variant dbSNP:rs137854514EnsemblClinVar.1
Natural variantiVAR_06500344G → C in CGD2. 1 PublicationCorresponds to variant dbSNP:rs137854510EnsemblClinVar.1
Natural variantiVAR_06500444G → R in CGD2. 2 PublicationsCorresponds to variant dbSNP:rs137854510EnsemblClinVar.1
Natural variantiVAR_06500558Missing in CGD2. 1 Publication1
Natural variantiVAR_01738877R → Q in CGD2. 2 PublicationsCorresponds to variant dbSNP:rs119103275EnsemblClinVar.1
Natural variantiVAR_00890478G → E in CGD2. 1 PublicationCorresponds to variant dbSNP:rs137854519EnsemblClinVar.1
Natural variantiVAR_06500679M → V1 PublicationCorresponds to variant dbSNP:rs137854512EnsemblClinVar.1
Natural variantiVAR_06500793D → E in CGD2. 2 PublicationsCorresponds to variant dbSNP:rs137854507EnsemblClinVar.1
Natural variantiVAR_06500896Missing in CGD2. 1 Publication1
Natural variantiVAR_065009102R → P in CGD2. 1 PublicationCorresponds to variant dbSNP:rs137854515EnsemblClinVar.1
Natural variantiVAR_065010108D → V in CGD2. 1 PublicationCorresponds to variant dbSNP:rs137854509EnsemblClinVar.1
Natural variantiVAR_017389128A → V in CGD2. 1 PublicationCorresponds to variant dbSNP:rs119103274EnsemblClinVar.1
Natural variantiVAR_065011137W → R in CGD2. 1 PublicationCorresponds to variant dbSNP:rs137854516EnsemblClinVar.1
Natural variantiVAR_065012140A → D in CGD2. 1 PublicationCorresponds to variant dbSNP:rs137854520EnsemblClinVar.1
Natural variantiVAR_017390160 – 161DK → EV in CGD2. 2
Natural variantiVAR_065013169Q → E in CGD2. 1 PublicationCorresponds to variant dbSNP:rs137854517EnsemblClinVar.1
Natural variantiVAR_018477181K → R7 PublicationsCorresponds to variant dbSNP:rs2274064EnsemblClinVar.1
Natural variantiVAR_065014184R → P in CGD2. 1 PublicationCorresponds to variant dbSNP:rs137854518EnsemblClinVar.1
Natural variantiVAR_065015196Missing in CGD2. 1 Publication1
Natural variantiVAR_065016202A → V in CGD2. 2 PublicationsCorresponds to variant dbSNP:rs137854508EnsemblClinVar.1
Natural variantiVAR_034129279T → M. Corresponds to variant dbSNP:rs13306581EnsemblClinVar.1
Natural variantiVAR_034130297V → A. Corresponds to variant dbSNP:rs35937854EnsemblClinVar.1
Natural variantiVAR_018478328R → K2 PublicationsCorresponds to variant dbSNP:rs137854511EnsemblClinVar.1
Natural variantiVAR_065017369G → R1 PublicationCorresponds to variant dbSNP:rs137854513EnsemblClinVar.1
Natural variantiVAR_052620389H → Q4 PublicationsCorresponds to variant dbSNP:rs17849502EnsemblClinVar.1
Natural variantiVAR_008905395R → W Impairs interaction with NCF4. 2 PublicationsCorresponds to variant dbSNP:rs13306575EnsemblClinVar.1
Natural variantiVAR_052621419N → I3 PublicationsCorresponds to variant dbSNP:rs35012521EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_045259123 – 203Missing in isoform 2 and isoform 4. 1 PublicationAdd BLAST81
Alternative sequenceiVSP_045260123 – 167Missing in isoform 3. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_045261502 – 526Missing in isoform 2. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32011 mRNA Translation: AAA36379.1
U00788
, U00776, U00777, U00778, U00779, U00780, U00781, U00782, U00783, U00784, U00785, U00786, U00787 Genomic DNA Translation: AAB60320.1
AF527950 mRNA Translation: AAM89263.1
BT007439 mRNA Translation: AAP36107.1
AK296672 mRNA Translation: BAG59269.1
AK298713 mRNA Translation: BAG60869.1
AK312666 mRNA Translation: BAG35548.1
DQ314879 Genomic DNA Translation: ABC40738.1
AL137800 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91160.1
BC001606 mRNA Translation: AAH01606.1
CCDSiCCDS1356.1 [P19878-1]
CCDS53446.1 [P19878-4]
CCDS53447.1 [P19878-3]
PIRiA34855
RefSeqiNP_000424.2, NM_000433.3 [P19878-1]
NP_001121123.1, NM_001127651.2 [P19878-1]
NP_001177718.1, NM_001190789.1 [P19878-4]
NP_001177723.1, NM_001190794.1 [P19878-3]
XP_011507882.1, XM_011509580.1 [P19878-1]
XP_011507883.1, XM_011509581.1 [P19878-1]
UniGeneiHs.587558

Genome annotation databases

EnsembliENST00000367535; ENSP00000356505; ENSG00000116701 [P19878-1]
ENST00000367536; ENSP00000356506; ENSG00000116701 [P19878-1]
ENST00000413720; ENSP00000399294; ENSG00000116701 [P19878-3]
ENST00000418089; ENSP00000407217; ENSG00000116701 [P19878-4]
GeneIDi4688
KEGGihsa:4688
UCSCiuc001gqj.5 human [P19878-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NCF2base

NCF2 deficiency database

Mendelian genes neutrophil cytosolic factor 2 (NCF2)

Leiden Open Variation Database (LOVD)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32011 mRNA Translation: AAA36379.1
U00788
, U00776, U00777, U00778, U00779, U00780, U00781, U00782, U00783, U00784, U00785, U00786, U00787 Genomic DNA Translation: AAB60320.1
AF527950 mRNA Translation: AAM89263.1
BT007439 mRNA Translation: AAP36107.1
AK296672 mRNA Translation: BAG59269.1
AK298713 mRNA Translation: BAG60869.1
AK312666 mRNA Translation: BAG35548.1
DQ314879 Genomic DNA Translation: ABC40738.1
AL137800 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91160.1
BC001606 mRNA Translation: AAH01606.1
CCDSiCCDS1356.1 [P19878-1]
CCDS53446.1 [P19878-4]
CCDS53447.1 [P19878-3]
PIRiA34855
RefSeqiNP_000424.2, NM_000433.3 [P19878-1]
NP_001121123.1, NM_001127651.2 [P19878-1]
NP_001177718.1, NM_001190789.1 [P19878-4]
NP_001177723.1, NM_001190794.1 [P19878-3]
XP_011507882.1, XM_011509580.1 [P19878-1]
XP_011507883.1, XM_011509581.1 [P19878-1]
UniGeneiHs.587558

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1E96X-ray2.40B1-203[»]
1HH8X-ray1.80A1-213[»]
1K4UNMR-S455-516[»]
1OEYX-ray2.00A/B/C/D352-429[»]
1WM5X-ray1.95A1-203[»]
2DMONMR-A243-297[»]
ProteinModelPortaliP19878
SMRiP19878
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110768, 24 interactors
DIPiDIP-76N
IntActiP19878, 15 interactors
MINTiP19878
STRINGi9606.ENSP00000356505

Chemistry databases

DrugBankiDB00514 Dextromethorphan

PTM databases

iPTMnetiP19878
PhosphoSitePlusiP19878

Polymorphism and mutation databases

BioMutaiNCF2
DMDMi1346669

Proteomic databases

EPDiP19878
MaxQBiP19878
PaxDbiP19878
PeptideAtlasiP19878
PRIDEiP19878
ProteomicsDBi53699

Protocols and materials databases

DNASUi4688
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367535; ENSP00000356505; ENSG00000116701 [P19878-1]
ENST00000367536; ENSP00000356506; ENSG00000116701 [P19878-1]
ENST00000413720; ENSP00000399294; ENSG00000116701 [P19878-3]
ENST00000418089; ENSP00000407217; ENSG00000116701 [P19878-4]
GeneIDi4688
KEGGihsa:4688
UCSCiuc001gqj.5 human [P19878-1]

Organism-specific databases

CTDi4688
DisGeNETi4688
EuPathDBiHostDB:ENSG00000116701.14
GeneCardsiNCF2
GeneReviewsiNCF2
HGNCiHGNC:7661 NCF2
HPAiCAB022160
HPA002327
HPA006040
MalaCardsiNCF2
MIMi233710 phenotype
608515 gene
neXtProtiNX_P19878
OpenTargetsiENSG00000116701
Orphaneti379 Chronic granulomatous disease
PharmGKBiPA31464
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4225 Eukaryota
ENOG41110AD LUCA
GeneTreeiENSGT00530000063843
HOGENOMiHOG000237312
HOVERGENiHBG001521
InParanoidiP19878
KOiK08010
OMAiCNYLEPV
OrthoDBiEOG091G04T7
PhylomeDBiP19878
TreeFamiTF329087

Enzyme and pathway databases

ReactomeiR-HSA-1222556 ROS, RNS production in phagocytes
R-HSA-1236973 Cross-presentation of particulate exogenous antigens (phagosomes)
R-HSA-3299685 Detoxification of Reactive Oxygen Species
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-5668599 RHO GTPases Activate NADPH Oxidases
SIGNORiP19878

Miscellaneous databases

ChiTaRSiNCF2 human
EvolutionaryTraceiP19878
GeneWikiiNeutrophil_cytosolic_factor_2
GenomeRNAii4688
PROiPR:P19878
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000116701 Expressed in 147 organ(s), highest expression level in blood
CleanExiHS_NCF2
ExpressionAtlasiP19878 baseline and differential
GenevisibleiP19878 HS

Family and domain databases

CDDicd06406 PB1_P67, 1 hit
cd11871 SH3_p67phox_N, 1 hit
Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR034889 P67-PHOX
IPR035546 p67phox_SH3_1
IPR000270 PB1_dom
IPR034885 PB1_P67
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PANTHERiPTHR15175:SF3 PTHR15175:SF3, 1 hit
PfamiView protein in Pfam
PF00564 PB1, 1 hit
PF00018 SH3_1, 2 hits
PF13181 TPR_8, 2 hits
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00666 PB1, 1 hit
SM00326 SH3, 2 hits
SM00028 TPR, 3 hits
SUPFAMiSSF48452 SSF48452, 1 hit
SSF50044 SSF50044, 2 hits
PROSITEiView protein in PROSITE
PS51745 PB1, 1 hit
PS50002 SH3, 2 hits
PS50005 TPR, 3 hits
PS50293 TPR_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNCF2_HUMAN
AccessioniPrimary (citable) accession number: P19878
Secondary accession number(s): B2R6Q1
, B4DKQ7, B4DQA7, E9PHJ2, E9PHX3, Q2PP06, Q8NFC7, Q9BV51
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1996
Last modified: September 12, 2018
This is version 213 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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