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Protein

Neutrophil cytosol factor 2

Gene

NCF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • electron transfer activity Source: UniProtKB
  • protein C-terminus binding Source: UniProtKB
  • Rac GTPase binding Source: Ensembl
  • superoxide-generating NADPH oxidase activator activity Source: InterPro
  • superoxide-generating NADPH oxidase activity Source: Ensembl

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1222556 ROS, RNS production in phagocytes
R-HSA-1236973 Cross-presentation of particulate exogenous antigens (phagosomes)
R-HSA-3299685 Detoxification of Reactive Oxygen Species
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-5668599 RHO GTPases Activate NADPH Oxidases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P19878

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neutrophil cytosol factor 2
Short name:
NCF-2
Alternative name(s):
67 kDa neutrophil oxidase factor
NADPH oxidase activator 2
Neutrophil NADPH oxidase factor 2
p67-phox
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NCF2
Synonyms:NOXA2, P67PHOX
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000116701.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7661 NCF2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608515 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P19878

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Granulomatous disease, chronic, cytochrome-b-positive 2, autosomal recessive (CGD2)10 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections.
See also OMIM:233710
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01738719 – 21Missing in CGD2. 1 Publication3
Natural variantiVAR_06500242N → S in CGD2. 1 PublicationCorresponds to variant dbSNP:rs137854514EnsemblClinVar.1
Natural variantiVAR_06500344G → C in CGD2. 1 PublicationCorresponds to variant dbSNP:rs137854510EnsemblClinVar.1
Natural variantiVAR_06500444G → R in CGD2. 2 PublicationsCorresponds to variant dbSNP:rs137854510EnsemblClinVar.1
Natural variantiVAR_06500558Missing in CGD2. 1 Publication1
Natural variantiVAR_01738877R → Q in CGD2. 2 PublicationsCorresponds to variant dbSNP:rs119103275EnsemblClinVar.1
Natural variantiVAR_00890478G → E in CGD2. 1 PublicationCorresponds to variant dbSNP:rs137854519EnsemblClinVar.1
Natural variantiVAR_06500793D → E in CGD2. 2 PublicationsCorresponds to variant dbSNP:rs137854507EnsemblClinVar.1
Natural variantiVAR_06500896Missing in CGD2. 1 Publication1
Natural variantiVAR_065009102R → P in CGD2. 1 PublicationCorresponds to variant dbSNP:rs137854515EnsemblClinVar.1
Natural variantiVAR_065010108D → V in CGD2. 1 PublicationCorresponds to variant dbSNP:rs137854509EnsemblClinVar.1
Natural variantiVAR_017389128A → V in CGD2. 1 PublicationCorresponds to variant dbSNP:rs119103274EnsemblClinVar.1
Natural variantiVAR_065011137W → R in CGD2. 1 PublicationCorresponds to variant dbSNP:rs137854516EnsemblClinVar.1
Natural variantiVAR_065012140A → D in CGD2. 1 PublicationCorresponds to variant dbSNP:rs137854520EnsemblClinVar.1
Natural variantiVAR_017390160 – 161DK → EV in CGD2. 2
Natural variantiVAR_065013169Q → E in CGD2. 1 PublicationCorresponds to variant dbSNP:rs137854517EnsemblClinVar.1
Natural variantiVAR_065014184R → P in CGD2. 1 PublicationCorresponds to variant dbSNP:rs137854518EnsemblClinVar.1
Natural variantiVAR_065015196Missing in CGD2. 1 Publication1
Natural variantiVAR_065016202A → V in CGD2. 2 PublicationsCorresponds to variant dbSNP:rs137854508EnsemblClinVar.1

Keywords - Diseasei

Chronic granulomatous disease, Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
4688

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
NCF2

MalaCards human disease database

More...
MalaCardsi
NCF2
MIMi233710 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000116701

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
379 Chronic granulomatous disease

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31464

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB00514 Dextromethorphan

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NCF2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1346669

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001063611 – 526Neutrophil cytosol factor 2Add BLAST526

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei233PhosphothreonineBy similarity1
Modified residuei399PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P19878

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P19878

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P19878

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P19878

PeptideAtlas

More...
PeptideAtlasi
P19878

PRoteomics IDEntifications database

More...
PRIDEi
P19878

ProteomicsDB human proteome resource

More...
ProteomicsDBi
53699

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P19878

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P19878

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000116701 Expressed in 147 organ(s), highest expression level in blood

CleanEx database of gene expression profiles

More...
CleanExi
HS_NCF2

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P19878 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P19878 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB022160
HPA002327
HPA006040

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4. Interacts with NCF4. Interacts (via the C-terminal SH3 domain) with NCF1 (via C-terminus). Interacts with SYTL1 and RAC1. May interact with NOXO1. Interacts with S100A8 and calprotectin (S100A8/9).8 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110768, 24 interactors

Database of interacting proteins

More...
DIPi
DIP-76N

Protein interaction database and analysis system

More...
IntActi
P19878, 15 interactors

Molecular INTeraction database

More...
MINTi
P19878

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000356505

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1526
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1E96X-ray2.40B1-203[»]
1HH8X-ray1.80A1-213[»]
1K4UNMR-S455-516[»]
1OEYX-ray2.00A/B/C/D352-429[»]
1WM5X-ray1.95A1-203[»]
2DMONMR-A243-297[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P19878

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P19878

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P19878

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati37 – 70TPR 1Add BLAST34
Repeati71 – 104TPR 2Add BLAST34
Repeati121 – 154TPR 3Add BLAST34
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini240 – 299SH3 1PROSITE-ProRule annotationAdd BLAST60
Domaini351 – 429PB1PROSITE-ProRule annotationAdd BLAST79
Domaini457 – 516SH3 2PROSITE-ProRule annotationAdd BLAST60

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The OPR/PB1 domain mediates the association with NCF4/p40-PHOX.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NCF2/NOXA1 family.Curated

Keywords - Domaini

Repeat, SH3 domain, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4225 Eukaryota
ENOG41110AD LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063843

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000237312

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG001521

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P19878

KEGG Orthology (KO)

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KOi
K08010

Identification of Orthologs from Complete Genome Data

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OMAi
KLFRPNE

Database of Orthologous Groups

More...
OrthoDBi
1457094at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P19878

TreeFam database of animal gene trees

More...
TreeFami
TF329087

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06406 PB1_P67, 1 hit
cd11871 SH3_p67phox_N, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR034889 P67-PHOX
IPR035546 p67phox_SH3_1
IPR000270 PB1_dom
IPR034885 PB1_P67
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat

The PANTHER Classification System

More...
PANTHERi
PTHR15175:SF3 PTHR15175:SF3, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00564 PB1, 1 hit
PF00018 SH3_1, 2 hits
PF13181 TPR_8, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00452 SH3DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00666 PB1, 1 hit
SM00326 SH3, 2 hits
SM00028 TPR, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452 SSF48452, 1 hit
SSF50044 SSF50044, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51745 PB1, 1 hit
PS50002 SH3, 2 hits
PS50005 TPR, 3 hits
PS50293 TPR_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P19878-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLVEAISLW NEGVLAADKK DWKGALDAFS AVQDPHSRIC FNIGCMYTIL
60 70 80 90 100
KNMTEAEKAF TRSINRDKHL AVAYFQRGML YYQTEKYDLA IKDLKEALIQ
110 120 130 140 150
LRGNQLIDYK ILGLQFKLFA CEVLYNIAFM YAKKEEWKKA EEQLALATSM
160 170 180 190 200
KSEPRHSKID KAMECVWKQK LYEPVVIPVG KLFRPNERQV AQLAKKDYLG
210 220 230 240 250
KATVVASVVD QDSFSGFAPL QPQAAEPPPR PKTPEIFRAL EGEAHRVLFG
260 270 280 290 300
FVPETKEELQ VMPGNIVFVL KKGNDNWATV MFNGQKGLVP CNYLEPVELR
310 320 330 340 350
IHPQQQPQEE SSPQSDIPAP PSSKAPGRPQ LSPGQKQKEE PKEVKLSVPM
360 370 380 390 400
PYTLKVHYKY TVVMKTQPGL PYSQVRDMVS KKLELRLEHT KLSYRPRDSN
410 420 430 440 450
ELVPLSEDSM KDAWGQVKNY CLTLWCENTV GDQGFPDEPK ESEKADANNQ
460 470 480 490 500
TTEPQLKKGS QVEALFSYEA TQPEDLEFQE GDIILVLSKV NEEWLEGECK
510 520
GKVGIFPKVF VEDCATTDLE STRREV
Length:526
Mass (Da):59,762
Last modified:February 1, 1996 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEC136766E1915376
GO
Isoform 2 (identifier: P19878-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     123-203: Missing.
     502-526: Missing.

Note: No experimental confirmation available.
Show »
Length:420
Mass (Da):47,515
Checksum:iD45BFF944F0CE53C
GO
Isoform 3 (identifier: P19878-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     123-167: Missing.

Note: No experimental confirmation available.
Show »
Length:481
Mass (Da):54,446
Checksum:i4A15D34EA01887D6
GO
Isoform 4 (identifier: P19878-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     123-203: Missing.

Note: No experimental confirmation available.
Show »
Length:445
Mass (Da):50,337
Checksum:i88E274CACEDFFBC7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1ALB7B1ALB7_HUMAN
Neutrophil cytosol factor 2
NCF2
143Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1ALB6B1ALB6_HUMAN
Neutrophil cytosol factor 2
NCF2
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01738719 – 21Missing in CGD2. 1 Publication3
Natural variantiVAR_06500242N → S in CGD2. 1 PublicationCorresponds to variant dbSNP:rs137854514EnsemblClinVar.1
Natural variantiVAR_06500344G → C in CGD2. 1 PublicationCorresponds to variant dbSNP:rs137854510EnsemblClinVar.1
Natural variantiVAR_06500444G → R in CGD2. 2 PublicationsCorresponds to variant dbSNP:rs137854510EnsemblClinVar.1
Natural variantiVAR_06500558Missing in CGD2. 1 Publication1
Natural variantiVAR_01738877R → Q in CGD2. 2 PublicationsCorresponds to variant dbSNP:rs119103275EnsemblClinVar.1
Natural variantiVAR_00890478G → E in CGD2. 1 PublicationCorresponds to variant dbSNP:rs137854519EnsemblClinVar.1
Natural variantiVAR_06500679M → V1 PublicationCorresponds to variant dbSNP:rs137854512EnsemblClinVar.1
Natural variantiVAR_06500793D → E in CGD2. 2 PublicationsCorresponds to variant dbSNP:rs137854507EnsemblClinVar.1
Natural variantiVAR_06500896Missing in CGD2. 1 Publication1
Natural variantiVAR_065009102R → P in CGD2. 1 PublicationCorresponds to variant dbSNP:rs137854515EnsemblClinVar.1
Natural variantiVAR_065010108D → V in CGD2. 1 PublicationCorresponds to variant dbSNP:rs137854509EnsemblClinVar.1
Natural variantiVAR_017389128A → V in CGD2. 1 PublicationCorresponds to variant dbSNP:rs119103274EnsemblClinVar.1
Natural variantiVAR_065011137W → R in CGD2. 1 PublicationCorresponds to variant dbSNP:rs137854516EnsemblClinVar.1
Natural variantiVAR_065012140A → D in CGD2. 1 PublicationCorresponds to variant dbSNP:rs137854520EnsemblClinVar.1
Natural variantiVAR_017390160 – 161DK → EV in CGD2. 2
Natural variantiVAR_065013169Q → E in CGD2. 1 PublicationCorresponds to variant dbSNP:rs137854517EnsemblClinVar.1
Natural variantiVAR_018477181K → R7 PublicationsCorresponds to variant dbSNP:rs2274064EnsemblClinVar.1
Natural variantiVAR_065014184R → P in CGD2. 1 PublicationCorresponds to variant dbSNP:rs137854518EnsemblClinVar.1
Natural variantiVAR_065015196Missing in CGD2. 1 Publication1
Natural variantiVAR_065016202A → V in CGD2. 2 PublicationsCorresponds to variant dbSNP:rs137854508EnsemblClinVar.1
Natural variantiVAR_034129279T → M. Corresponds to variant dbSNP:rs13306581EnsemblClinVar.1
Natural variantiVAR_034130297V → A. Corresponds to variant dbSNP:rs35937854EnsemblClinVar.1
Natural variantiVAR_018478328R → K2 PublicationsCorresponds to variant dbSNP:rs137854511EnsemblClinVar.1
Natural variantiVAR_065017369G → R1 PublicationCorresponds to variant dbSNP:rs137854513EnsemblClinVar.1
Natural variantiVAR_052620389H → Q4 PublicationsCorresponds to variant dbSNP:rs17849502EnsemblClinVar.1
Natural variantiVAR_008905395R → W Impairs interaction with NCF4. 2 PublicationsCorresponds to variant dbSNP:rs13306575EnsemblClinVar.1
Natural variantiVAR_052621419N → I3 PublicationsCorresponds to variant dbSNP:rs35012521EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_045259123 – 203Missing in isoform 2 and isoform 4. 1 PublicationAdd BLAST81
Alternative sequenceiVSP_045260123 – 167Missing in isoform 3. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_045261502 – 526Missing in isoform 2. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M32011 mRNA Translation: AAA36379.1
U00788
, U00776, U00777, U00778, U00779, U00780, U00781, U00782, U00783, U00784, U00785, U00786, U00787 Genomic DNA Translation: AAB60320.1
AF527950 mRNA Translation: AAM89263.1
BT007439 mRNA Translation: AAP36107.1
AK296672 mRNA Translation: BAG59269.1
AK298713 mRNA Translation: BAG60869.1
AK312666 mRNA Translation: BAG35548.1
DQ314879 Genomic DNA Translation: ABC40738.1
AL137800 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91160.1
BC001606 mRNA Translation: AAH01606.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1356.1 [P19878-1]
CCDS53446.1 [P19878-4]
CCDS53447.1 [P19878-3]

Protein sequence database of the Protein Information Resource

More...
PIRi
A34855

NCBI Reference Sequences

More...
RefSeqi
NP_000424.2, NM_000433.3 [P19878-1]
NP_001121123.1, NM_001127651.2 [P19878-1]
NP_001177718.1, NM_001190789.1 [P19878-4]
NP_001177723.1, NM_001190794.1 [P19878-3]
XP_011507882.1, XM_011509580.1 [P19878-1]
XP_011507883.1, XM_011509581.1 [P19878-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.587558

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000367535; ENSP00000356505; ENSG00000116701 [P19878-1]
ENST00000367536; ENSP00000356506; ENSG00000116701 [P19878-1]
ENST00000413720; ENSP00000399294; ENSG00000116701 [P19878-3]
ENST00000418089; ENSP00000407217; ENSG00000116701 [P19878-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
4688

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:4688

UCSC genome browser

More...
UCSCi
uc001gqj.5 human [P19878-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NCF2base

NCF2 deficiency database

Mendelian genes neutrophil cytosolic factor 2 (NCF2)

Leiden Open Variation Database (LOVD)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32011 mRNA Translation: AAA36379.1
U00788
, U00776, U00777, U00778, U00779, U00780, U00781, U00782, U00783, U00784, U00785, U00786, U00787 Genomic DNA Translation: AAB60320.1
AF527950 mRNA Translation: AAM89263.1
BT007439 mRNA Translation: AAP36107.1
AK296672 mRNA Translation: BAG59269.1
AK298713 mRNA Translation: BAG60869.1
AK312666 mRNA Translation: BAG35548.1
DQ314879 Genomic DNA Translation: ABC40738.1
AL137800 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91160.1
BC001606 mRNA Translation: AAH01606.1
CCDSiCCDS1356.1 [P19878-1]
CCDS53446.1 [P19878-4]
CCDS53447.1 [P19878-3]
PIRiA34855
RefSeqiNP_000424.2, NM_000433.3 [P19878-1]
NP_001121123.1, NM_001127651.2 [P19878-1]
NP_001177718.1, NM_001190789.1 [P19878-4]
NP_001177723.1, NM_001190794.1 [P19878-3]
XP_011507882.1, XM_011509580.1 [P19878-1]
XP_011507883.1, XM_011509581.1 [P19878-1]
UniGeneiHs.587558

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1E96X-ray2.40B1-203[»]
1HH8X-ray1.80A1-213[»]
1K4UNMR-S455-516[»]
1OEYX-ray2.00A/B/C/D352-429[»]
1WM5X-ray1.95A1-203[»]
2DMONMR-A243-297[»]
ProteinModelPortaliP19878
SMRiP19878
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110768, 24 interactors
DIPiDIP-76N
IntActiP19878, 15 interactors
MINTiP19878
STRINGi9606.ENSP00000356505

Chemistry databases

DrugBankiDB00514 Dextromethorphan

PTM databases

iPTMnetiP19878
PhosphoSitePlusiP19878

Polymorphism and mutation databases

BioMutaiNCF2
DMDMi1346669

Proteomic databases

EPDiP19878
jPOSTiP19878
MaxQBiP19878
PaxDbiP19878
PeptideAtlasiP19878
PRIDEiP19878
ProteomicsDBi53699

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
4688
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367535; ENSP00000356505; ENSG00000116701 [P19878-1]
ENST00000367536; ENSP00000356506; ENSG00000116701 [P19878-1]
ENST00000413720; ENSP00000399294; ENSG00000116701 [P19878-3]
ENST00000418089; ENSP00000407217; ENSG00000116701 [P19878-4]
GeneIDi4688
KEGGihsa:4688
UCSCiuc001gqj.5 human [P19878-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4688
DisGeNETi4688
EuPathDBiHostDB:ENSG00000116701.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NCF2
GeneReviewsiNCF2
HGNCiHGNC:7661 NCF2
HPAiCAB022160
HPA002327
HPA006040
MalaCardsiNCF2
MIMi233710 phenotype
608515 gene
neXtProtiNX_P19878
OpenTargetsiENSG00000116701
Orphaneti379 Chronic granulomatous disease
PharmGKBiPA31464

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4225 Eukaryota
ENOG41110AD LUCA
GeneTreeiENSGT00530000063843
HOGENOMiHOG000237312
HOVERGENiHBG001521
InParanoidiP19878
KOiK08010
OMAiKLFRPNE
OrthoDBi1457094at2759
PhylomeDBiP19878
TreeFamiTF329087

Enzyme and pathway databases

ReactomeiR-HSA-1222556 ROS, RNS production in phagocytes
R-HSA-1236973 Cross-presentation of particulate exogenous antigens (phagosomes)
R-HSA-3299685 Detoxification of Reactive Oxygen Species
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-5668599 RHO GTPases Activate NADPH Oxidases
SIGNORiP19878

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NCF2 human
EvolutionaryTraceiP19878

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Neutrophil_cytosolic_factor_2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4688

Protein Ontology

More...
PROi
PR:P19878

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000116701 Expressed in 147 organ(s), highest expression level in blood
CleanExiHS_NCF2
ExpressionAtlasiP19878 baseline and differential
GenevisibleiP19878 HS

Family and domain databases

CDDicd06406 PB1_P67, 1 hit
cd11871 SH3_p67phox_N, 1 hit
Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR034889 P67-PHOX
IPR035546 p67phox_SH3_1
IPR000270 PB1_dom
IPR034885 PB1_P67
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PANTHERiPTHR15175:SF3 PTHR15175:SF3, 1 hit
PfamiView protein in Pfam
PF00564 PB1, 1 hit
PF00018 SH3_1, 2 hits
PF13181 TPR_8, 2 hits
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00666 PB1, 1 hit
SM00326 SH3, 2 hits
SM00028 TPR, 3 hits
SUPFAMiSSF48452 SSF48452, 1 hit
SSF50044 SSF50044, 2 hits
PROSITEiView protein in PROSITE
PS51745 PB1, 1 hit
PS50002 SH3, 2 hits
PS50005 TPR, 3 hits
PS50293 TPR_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNCF2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P19878
Secondary accession number(s): B2R6Q1
, B4DKQ7, B4DQA7, E9PHJ2, E9PHX3, Q2PP06, Q8NFC7, Q9BV51
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1996
Last modified: January 16, 2019
This is version 215 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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