CXCL3

Functionⁱ

Ligand for CXCR2 (By similarity). Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes.By similarity1 Publication

GO - Molecular functionⁱ

chemokine activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

antimicrobial humoral immune response mediated by antimicrobial peptide
Source: UniProtKB
Inferred from direct assayⁱ
- 12949249
cellular response to lipopolysaccharide
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
chemokine-mediated signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
G protein-coupled receptor signaling pathway Source: Reactome
immune response
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
inflammatory response
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
killing of cells of other organism
Source: UniProtKB
Inferred from direct assayⁱ
- 12949249
leukocyte chemotaxis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
neutrophil chemotaxis Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Cytokine
Biological process	Chemotaxis, Inflammatory response

Enzyme and pathway databases

Reactomeⁱ	R-HSA-380108 Chemokine receptors bind chemokines R-HSA-418594 G alpha (i) signalling events

Reactomeⁱ

R-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: C-X-C motif chemokine 3 Alternative name(s): GRO-gamma(1-73) Growth-regulated protein gamma Short name: GRO-gamma Macrophage inflammatory protein 2-beta Short name: MIP2-beta Cleaved into the following chain: GRO-gamma(5-73)
Gene namesⁱ	Name:CXCL3 Synonyms:GRO3, GROG, SCYB3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000163734.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4604 CXCL3
MIMⁱ	139111 gene
neXtProtⁱ	NX_P19876

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2921
Open Targets More...OpenTargetsⁱ	ENSG00000163734
PharmGKBⁱ	PA35052

Polymorphism and mutation databases

BioMutaⁱ	CXCL3
DMDMⁱ	127086

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 34	1 PublicationAdd BLAST	34
ChainⁱPRO_0000005065	35 – 107	C-X-C motif chemokine 3Add BLAST	73
ChainⁱPRO_0000005066	39 – 107	GRO-gamma(5-73)Add BLAST	69

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Disulfide bondⁱ	43 ↔ 69	By similarity
Disulfide bondⁱ	45 ↔ 85	By similarity

Post-translational modificationⁱ

N-terminal processed form GRO-gamma(5-73) is produced by proteolytic cleavage after secretion from peripheral blood monocytes.1 Publication

Keywords - PTMⁱ

Disulfide bond

Proteomic databases

EPDⁱ	P19876
PaxDbⁱ	P19876
PeptideAtlas More...PeptideAtlasⁱ	P19876
PRIDEⁱ	P19876
ProteomicsDBⁱ	53698

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000163734 Expressed in 140 organ(s), highest expression level in smooth muscle tissue
CleanExⁱ	HS_CXCL3
Genevisibleⁱ	P19876 HS

Interactionⁱ

GO - Molecular functionⁱ

chemokine activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	109178, 5 interactors
Database of interacting proteins More...DIPⁱ	DIP-5909N
IntActⁱ	P19876, 4 interactors
STRINGⁱ	9606.ENSP00000296026

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P19876
SMRⁱ	P19876
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the intercrine alpha (chemokine CxC) family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410J3WE Eukaryota ENOG410ZT1C LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000062901
HOGENOMⁱ	HOG000220915
HOVERGENⁱ	HBG107789
InParanoidⁱ	P19876
KEGG Orthology (KO) More...KOⁱ	K05505
OMAⁱ	ANSHCEK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G14TE
PhylomeDBⁱ	P19876
TreeFamⁱ	TF333433

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00273 Chemokine_CXC, 1 hit
InterProⁱ	View protein in InterPro IPR001089 Chemokine_CXC IPR018048 Chemokine_CXC_CS IPR001811 Chemokine_IL8-like_dom IPR033899 CXC_Chemokine_domain IPR036048 Interleukin_8-like_sf
PANTHERⁱ	PTHR10179 PTHR10179, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00048 IL8, 1 hit
PRINTSⁱ	PR00437 SMALLCYTKCXC
SMARTⁱ	View protein in SMART SM00199 SCY, 1 hit
SUPFAMⁱ	SSF54117 SSF54117, 1 hit
PROSITEⁱ	View protein in PROSITE PS00471 SMALL_CYTOKINES_CXC, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P19876-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAHATLSAAP SNPRLLRVAL LLLLLVAASR RAAGASVVTE LRCQCLQTLQ 
        60         70         80         90        100
GIHLKNIQSV NVRSPGPHCA QTEVIATLKN GKKACLNPAS PMVQKIIEKI 

LNKGSTN

Length:107

Mass (Da):11,342

Last modified:February 1, 1991 - v1

Checksum:ⁱ97A69946B7F1F070

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	27 – 28	AA → G in AAA63184 (PubMed:2217207).Curated		2

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_059210	3	H → R. Corresponds to variant dbSNP:rs352043Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X53800 mRNA Translation: CAA37809.1 M36821 mRNA Translation: AAA63184.1 AC097709 Genomic DNA Translation: AAY41006.1 CH471057 Genomic DNA Translation: EAX05698.1 BC016308 mRNA Translation: AAH16308.1 BC065743 mRNA Translation: AAH65743.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34007.1
PIRⁱ	JH0282 B38290
NCBI Reference Sequences More...RefSeqⁱ	NP_002081.2, NM_002090.2
UniGeneⁱ	Hs.89690

Genome annotation databases

Ensemblⁱ	ENST00000296026; ENSP00000296026; ENSG00000163734
GeneIDⁱ	2921
KEGGⁱ	hsa:2921
UCSC genome browser More...UCSCⁱ	uc003hhl.5 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P19876	Melanoma growth stimulatory activity gamma (Fragment)		HUMAN		33	UniRef100_P19876

Protein	Similar proteins		Species	Score	Length	Source
P19876	Melanoma growth stimulatory activity gamma (Fragment)		HUMAN		33	UniRef90_P19876
C-X-C motif chemokine		PANTR		107
C-X-C motif chemokine		PONAB		107
C-X-C motif chemokine		PANPA		107
C-X-C motif chemokine		GORGO		103
+7

Protein	Similar proteins		Species	Score	Length	Source
P19876	Melanoma growth stimulatory activity gamma (Fragment)		HUMAN		33	UniRef50_P19876
C-X-C motif chemokine		PANTR		107
C-X-C motif chemokine		PANPA		107
C-X-C motif chemokine		PONAB		107
C-X-C motif chemokine		GORGO		103
+23

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

CXCL3 entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X53800 mRNA Translation: CAA37809.1 M36821 mRNA Translation: AAA63184.1 AC097709 Genomic DNA Translation: AAY41006.1 CH471057 Genomic DNA Translation: EAX05698.1 BC016308 mRNA Translation: AAH16308.1 BC065743 mRNA Translation: AAH65743.1
CCDSⁱ	CCDS34007.1
PIRⁱ	JH0282 B38290
RefSeqⁱ	NP_002081.2, NM_002090.2
UniGeneⁱ	Hs.89690

3D structure databases

ProteinModelPortalⁱ	P19876
SMRⁱ	P19876
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109178, 5 interactors
DIPⁱ	DIP-5909N
IntActⁱ	P19876, 4 interactors
STRINGⁱ	9606.ENSP00000296026

Polymorphism and mutation databases

BioMutaⁱ	CXCL3
DMDMⁱ	127086

Proteomic databases

EPDⁱ	P19876
PaxDbⁱ	P19876
PeptideAtlasⁱ	P19876
PRIDEⁱ	P19876
ProteomicsDBⁱ	53698

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	2921
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000296026; ENSP00000296026; ENSG00000163734
GeneIDⁱ	2921
KEGGⁱ	hsa:2921
UCSCⁱ	uc003hhl.5 human

Organism-specific databases

CTDⁱ	2921
DisGeNETⁱ	2921
EuPathDBⁱ	HostDB:ENSG00000163734.4
GeneCardsⁱ	CXCL3
HGNCⁱ	HGNC:4604 CXCL3
MIMⁱ	139111 gene
neXtProtⁱ	NX_P19876
OpenTargetsⁱ	ENSG00000163734
PharmGKBⁱ	PA35052
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410J3WE Eukaryota ENOG410ZT1C LUCA
GeneTreeⁱ	ENSGT00530000062901
HOGENOMⁱ	HOG000220915
HOVERGENⁱ	HBG107789
InParanoidⁱ	P19876
KOⁱ	K05505
OMAⁱ	ANSHCEK
OrthoDBⁱ	EOG091G14TE
PhylomeDBⁱ	P19876
TreeFamⁱ	TF333433

Enzyme and pathway databases

Reactomeⁱ	R-HSA-380108 Chemokine receptors bind chemokines R-HSA-418594 G alpha (i) signalling events

Reactomeⁱ

R-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events

Miscellaneous databases

GeneWikiⁱ	CXCL3
GenomeRNAiⁱ	2921
Protein Ontology More...PROⁱ	PR:P19876
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000163734 Expressed in 140 organ(s), highest expression level in smooth muscle tissue
CleanExⁱ	HS_CXCL3
Genevisibleⁱ	P19876 HS

Family and domain databases

CDDⁱ	cd00273 Chemokine_CXC, 1 hit
InterProⁱ	View protein in InterPro IPR001089 Chemokine_CXC IPR018048 Chemokine_CXC_CS IPR001811 Chemokine_IL8-like_dom IPR033899 CXC_Chemokine_domain IPR036048 Interleukin_8-like_sf
PANTHERⁱ	PTHR10179 PTHR10179, 1 hit
Pfamⁱ	View protein in Pfam PF00048 IL8, 1 hit
PRINTSⁱ	PR00437 SMALLCYTKCXC
SMARTⁱ	View protein in SMART SM00199 SCY, 1 hit
SUPFAMⁱ	SSF54117 SSF54117, 1 hit
PROSITEⁱ	View protein in PROSITE PS00471 SMALL_CYTOKINES_CXC, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CXCL3_HUMAN
Accessionⁱ	P19876Primary (citable) accession number: P19876 Secondary accession number(s): Q4W5H9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
	Last sequence update:	February 1, 1991
	Last modified:	November 7, 2018
	This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P19876 (CXCL3_HUMAN)

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C-X-C motif chemokine 3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ