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UniProtKB - P19876 (CXCL3_HUMAN)
Protein
C-X-C motif chemokine 3
Gene
CXCL3
Organism
Homo sapiens (Human)
Status
Functioni
Ligand for CXCR2 (By similarity).
Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes.
By similarity1 PublicationGO - Molecular functioni
- chemokine activity Source: UniProtKB
- CXCR chemokine receptor binding Source: GO_Central
GO - Biological processi
- antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
- cellular response to lipopolysaccharide Source: GO_Central
- chemokine-mediated signaling pathway Source: GO_Central
- inflammatory response Source: GO_Central
- killing of cells of another organism Source: UniProtKB
- neutrophil chemotaxis Source: UniProtKB
Keywordsi
Molecular function | Cytokine |
Biological process | Chemotaxis, Inflammatory response |
Enzyme and pathway databases
PathwayCommonsi | P19876 |
Reactomei | R-HSA-380108, Chemokine receptors bind chemokines R-HSA-418594, G alpha (i) signalling events |
SignaLinki | P19876 |
Names & Taxonomyi
Protein namesi | Recommended name: C-X-C motif chemokine 3Alternative name(s): GRO-gamma(1-73) Growth-regulated protein gamma Short name: GRO-gamma Macrophage inflammatory protein 2-beta Short name: MIP2-beta Cleaved into the following chain: |
Gene namesi | Name:CXCL3 Synonyms:GRO3, GROG, SCYB3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4604, CXCL3 |
MIMi | 139111, gene |
neXtProti | NX_P19876 |
VEuPathDBi | HostDB:ENSG00000163734 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: UniProtKB
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 2921 |
OpenTargetsi | ENSG00000163734 |
PharmGKBi | PA35052 |
Miscellaneous databases
Pharosi | P19876, Tbio |
Genetic variation databases
BioMutai | CXCL3 |
DMDMi | 127086 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 34 | 1 PublicationAdd BLAST | 34 | |
ChainiPRO_0000005065 | 35 – 107 | C-X-C motif chemokine 3Add BLAST | 73 | |
ChainiPRO_0000005066 | 39 – 107 | GRO-gamma(5-73)Add BLAST | 69 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 43 ↔ 69 | By similarity | ||
Disulfide bondi | 45 ↔ 85 | By similarity |
Post-translational modificationi
N-terminal processed form GRO-gamma(5-73) is produced by proteolytic cleavage after secretion from peripheral blood monocytes.1 Publication
Keywords - PTMi
Disulfide bondProteomic databases
EPDi | P19876 |
MassIVEi | P19876 |
PaxDbi | P19876 |
PeptideAtlasi | P19876 |
PRIDEi | P19876 |
ProteomicsDBi | 53698 |
Expressioni
Gene expression databases
Bgeei | ENSG00000163734, Expressed in smooth muscle tissue and 163 other tissues |
Genevisiblei | P19876, HS |
Organism-specific databases
HPAi | ENSG00000163734, Tissue enhanced (adipose tissue, cervix) |
Interactioni
GO - Molecular functioni
- chemokine activity Source: UniProtKB
- CXCR chemokine receptor binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 109178, 12 interactors |
DIPi | DIP-5909N |
IntActi | P19876, 4 interactors |
STRINGi | 9606.ENSP00000296026 |
Miscellaneous databases
RNActi | P19876, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the intercrine alpha (chemokine CxC) family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S7MM, Eukaryota |
GeneTreei | ENSGT00940000163986 |
HOGENOMi | CLU_143902_1_1_1 |
InParanoidi | P19876 |
OMAi | QPEVIAM |
OrthoDBi | 1618797at2759 |
PhylomeDBi | P19876 |
TreeFami | TF333433 |
Family and domain databases
CDDi | cd00273, Chemokine_CXC, 1 hit |
InterProi | View protein in InterPro IPR001089, Chemokine_CXC IPR018048, Chemokine_CXC_CS IPR001811, Chemokine_IL8-like_dom IPR033899, CXC_Chemokine_domain IPR036048, Interleukin_8-like_sf |
PANTHERi | PTHR10179, PTHR10179, 1 hit |
Pfami | View protein in Pfam PF00048, IL8, 1 hit |
PRINTSi | PR00437, SMALLCYTKCXC |
SMARTi | View protein in SMART SM00199, SCY, 1 hit |
SUPFAMi | SSF54117, SSF54117, 1 hit |
PROSITEi | View protein in PROSITE PS00471, SMALL_CYTOKINES_CXC, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P19876-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAHATLSAAP SNPRLLRVAL LLLLLVAASR RAAGASVVTE LRCQCLQTLQ
60 70 80 90 100
GIHLKNIQSV NVRSPGPHCA QTEVIATLKN GKKACLNPAS PMVQKIIEKI
LNKGSTN
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 27 – 28 | AA → G in AAA63184 (PubMed:2217207).Curated | 2 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_059210 | 3 | H → R. Corresponds to variant dbSNP:rs352043Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X53800 mRNA Translation: CAA37809.1 M36821 mRNA Translation: AAA63184.1 AC097709 Genomic DNA Translation: AAY41006.1 CH471057 Genomic DNA Translation: EAX05698.1 BC016308 mRNA Translation: AAH16308.1 BC065743 mRNA Translation: AAH65743.1 |
CCDSi | CCDS34007.1 |
PIRi | JH0282, B38290 |
RefSeqi | NP_002081.2, NM_002090.2 |
Genome annotation databases
Ensembli | ENST00000296026.4; ENSP00000296026.4; ENSG00000163734.4 |
GeneIDi | 2921 |
KEGGi | hsa:2921 |
MANE-Selecti | ENST00000296026.4; ENSP00000296026.4; NM_002090.3; NP_002081.2 |
UCSCi | uc003hhl.5, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia CXCL3 entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X53800 mRNA Translation: CAA37809.1 M36821 mRNA Translation: AAA63184.1 AC097709 Genomic DNA Translation: AAY41006.1 CH471057 Genomic DNA Translation: EAX05698.1 BC016308 mRNA Translation: AAH16308.1 BC065743 mRNA Translation: AAH65743.1 |
CCDSi | CCDS34007.1 |
PIRi | JH0282, B38290 |
RefSeqi | NP_002081.2, NM_002090.2 |
3D structure databases
AlphaFoldDBi | P19876 |
SMRi | P19876 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 109178, 12 interactors |
DIPi | DIP-5909N |
IntActi | P19876, 4 interactors |
STRINGi | 9606.ENSP00000296026 |
Genetic variation databases
BioMutai | CXCL3 |
DMDMi | 127086 |
Proteomic databases
EPDi | P19876 |
MassIVEi | P19876 |
PaxDbi | P19876 |
PeptideAtlasi | P19876 |
PRIDEi | P19876 |
ProteomicsDBi | 53698 |
Protocols and materials databases
Antibodypediai | 13341, 288 antibodies from 29 providers |
DNASUi | 2921 |
Genome annotation databases
Ensembli | ENST00000296026.4; ENSP00000296026.4; ENSG00000163734.4 |
GeneIDi | 2921 |
KEGGi | hsa:2921 |
MANE-Selecti | ENST00000296026.4; ENSP00000296026.4; NM_002090.3; NP_002081.2 |
UCSCi | uc003hhl.5, human |
Organism-specific databases
CTDi | 2921 |
DisGeNETi | 2921 |
GeneCardsi | CXCL3 |
HGNCi | HGNC:4604, CXCL3 |
HPAi | ENSG00000163734, Tissue enhanced (adipose tissue, cervix) |
MIMi | 139111, gene |
neXtProti | NX_P19876 |
OpenTargetsi | ENSG00000163734 |
PharmGKBi | PA35052 |
VEuPathDBi | HostDB:ENSG00000163734 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S7MM, Eukaryota |
GeneTreei | ENSGT00940000163986 |
HOGENOMi | CLU_143902_1_1_1 |
InParanoidi | P19876 |
OMAi | QPEVIAM |
OrthoDBi | 1618797at2759 |
PhylomeDBi | P19876 |
TreeFami | TF333433 |
Enzyme and pathway databases
PathwayCommonsi | P19876 |
Reactomei | R-HSA-380108, Chemokine receptors bind chemokines R-HSA-418594, G alpha (i) signalling events |
SignaLinki | P19876 |
Miscellaneous databases
BioGRID-ORCSi | 2921, 15 hits in 1008 CRISPR screens |
GeneWikii | CXCL3 |
GenomeRNAii | 2921 |
Pharosi | P19876, Tbio |
PROi | PR:P19876 |
RNActi | P19876, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000163734, Expressed in smooth muscle tissue and 163 other tissues |
Genevisiblei | P19876, HS |
Family and domain databases
CDDi | cd00273, Chemokine_CXC, 1 hit |
InterProi | View protein in InterPro IPR001089, Chemokine_CXC IPR018048, Chemokine_CXC_CS IPR001811, Chemokine_IL8-like_dom IPR033899, CXC_Chemokine_domain IPR036048, Interleukin_8-like_sf |
PANTHERi | PTHR10179, PTHR10179, 1 hit |
Pfami | View protein in Pfam PF00048, IL8, 1 hit |
PRINTSi | PR00437, SMALLCYTKCXC |
SMARTi | View protein in SMART SM00199, SCY, 1 hit |
SUPFAMi | SSF54117, SSF54117, 1 hit |
PROSITEi | View protein in PROSITE PS00471, SMALL_CYTOKINES_CXC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CXCL3_HUMAN | |
Accessioni | P19876Primary (citable) accession number: P19876 Secondary accession number(s): Q4W5H9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1991 |
Last sequence update: | February 1, 1991 | |
Last modified: | May 25, 2022 | |
This is version 179 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families