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Protein

C-X-C motif chemokine 3

Gene

CXCL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ligand for CXCR2 (By similarity). Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiR-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 3
Alternative name(s):
GRO-gamma(1-73)
Growth-regulated protein gamma
Short name:
GRO-gamma
Macrophage inflammatory protein 2-beta
Short name:
MIP2-beta
Cleaved into the following chain:
Gene namesi
Name:CXCL3
Synonyms:GRO3, GROG, SCYB3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000163734.4
HGNCiHGNC:4604 CXCL3
MIMi139111 gene
neXtProtiNX_P19876

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi2921
OpenTargetsiENSG00000163734
PharmGKBiPA35052

Polymorphism and mutation databases

BioMutaiCXCL3
DMDMi127086

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 341 PublicationAdd BLAST34
ChainiPRO_000000506535 – 107C-X-C motif chemokine 3Add BLAST73
ChainiPRO_000000506639 – 107GRO-gamma(5-73)Add BLAST69

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi43 ↔ 69By similarity
Disulfide bondi45 ↔ 85By similarity

Post-translational modificationi

N-terminal processed form GRO-gamma(5-73) is produced by proteolytic cleavage after secretion from peripheral blood monocytes.1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiP19876
PaxDbiP19876
PeptideAtlasiP19876
PRIDEiP19876
ProteomicsDBi53698

Expressioni

Gene expression databases

BgeeiENSG00000163734 Expressed in 140 organ(s), highest expression level in smooth muscle tissue
CleanExiHS_CXCL3
GenevisibleiP19876 HS

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109178, 5 interactors
DIPiDIP-5909N
IntActiP19876, 4 interactors
STRINGi9606.ENSP00000296026

Structurei

3D structure databases

ProteinModelPortaliP19876
SMRiP19876
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3WE Eukaryota
ENOG410ZT1C LUCA
GeneTreeiENSGT00530000062901
HOGENOMiHOG000220915
HOVERGENiHBG107789
InParanoidiP19876
KOiK05505
OMAiANSHCEK
OrthoDBiEOG091G14TE
PhylomeDBiP19876
TreeFamiTF333433

Family and domain databases

CDDicd00273 Chemokine_CXC, 1 hit
InterProiView protein in InterPro
IPR001089 Chemokine_CXC
IPR018048 Chemokine_CXC_CS
IPR001811 Chemokine_IL8-like_dom
IPR033899 CXC_Chemokine_domain
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR10179 PTHR10179, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
PRINTSiPR00437 SMALLCYTKCXC
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00471 SMALL_CYTOKINES_CXC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19876-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAHATLSAAP SNPRLLRVAL LLLLLVAASR RAAGASVVTE LRCQCLQTLQ
60 70 80 90 100
GIHLKNIQSV NVRSPGPHCA QTEVIATLKN GKKACLNPAS PMVQKIIEKI

LNKGSTN
Length:107
Mass (Da):11,342
Last modified:February 1, 1991 - v1
Checksum:i97A69946B7F1F070
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27 – 28AA → G in AAA63184 (PubMed:2217207).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0592103H → R. Corresponds to variant dbSNP:rs352043Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53800 mRNA Translation: CAA37809.1
M36821 mRNA Translation: AAA63184.1
AC097709 Genomic DNA Translation: AAY41006.1
CH471057 Genomic DNA Translation: EAX05698.1
BC016308 mRNA Translation: AAH16308.1
BC065743 mRNA Translation: AAH65743.1
CCDSiCCDS34007.1
PIRiJH0282 B38290
RefSeqiNP_002081.2, NM_002090.2
UniGeneiHs.89690

Genome annotation databases

EnsembliENST00000296026; ENSP00000296026; ENSG00000163734
GeneIDi2921
KEGGihsa:2921
UCSCiuc003hhl.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

CXCL3 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53800 mRNA Translation: CAA37809.1
M36821 mRNA Translation: AAA63184.1
AC097709 Genomic DNA Translation: AAY41006.1
CH471057 Genomic DNA Translation: EAX05698.1
BC016308 mRNA Translation: AAH16308.1
BC065743 mRNA Translation: AAH65743.1
CCDSiCCDS34007.1
PIRiJH0282 B38290
RefSeqiNP_002081.2, NM_002090.2
UniGeneiHs.89690

3D structure databases

ProteinModelPortaliP19876
SMRiP19876
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109178, 5 interactors
DIPiDIP-5909N
IntActiP19876, 4 interactors
STRINGi9606.ENSP00000296026

Polymorphism and mutation databases

BioMutaiCXCL3
DMDMi127086

Proteomic databases

EPDiP19876
PaxDbiP19876
PeptideAtlasiP19876
PRIDEiP19876
ProteomicsDBi53698

Protocols and materials databases

DNASUi2921
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296026; ENSP00000296026; ENSG00000163734
GeneIDi2921
KEGGihsa:2921
UCSCiuc003hhl.5 human

Organism-specific databases

CTDi2921
DisGeNETi2921
EuPathDBiHostDB:ENSG00000163734.4
GeneCardsiCXCL3
HGNCiHGNC:4604 CXCL3
MIMi139111 gene
neXtProtiNX_P19876
OpenTargetsiENSG00000163734
PharmGKBiPA35052
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J3WE Eukaryota
ENOG410ZT1C LUCA
GeneTreeiENSGT00530000062901
HOGENOMiHOG000220915
HOVERGENiHBG107789
InParanoidiP19876
KOiK05505
OMAiANSHCEK
OrthoDBiEOG091G14TE
PhylomeDBiP19876
TreeFamiTF333433

Enzyme and pathway databases

ReactomeiR-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events

Miscellaneous databases

GeneWikiiCXCL3
GenomeRNAii2921
PROiPR:P19876
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163734 Expressed in 140 organ(s), highest expression level in smooth muscle tissue
CleanExiHS_CXCL3
GenevisibleiP19876 HS

Family and domain databases

CDDicd00273 Chemokine_CXC, 1 hit
InterProiView protein in InterPro
IPR001089 Chemokine_CXC
IPR018048 Chemokine_CXC_CS
IPR001811 Chemokine_IL8-like_dom
IPR033899 CXC_Chemokine_domain
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR10179 PTHR10179, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
PRINTSiPR00437 SMALLCYTKCXC
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00471 SMALL_CYTOKINES_CXC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCXCL3_HUMAN
AccessioniPrimary (citable) accession number: P19876
Secondary accession number(s): Q4W5H9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: November 7, 2018
This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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