UniProtKB - P19838 (NFKB1_HUMAN)
Nuclear factor NF-kappa-B p105 subunit
NFKB1
Functioni
GO - Molecular functioni
- actinin binding Source: UniProtKB
- chromatin binding Source: Ensembl
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: ARUK-UCL
- DNA-binding transcription factor activity Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: MGI
- enzyme binding Source: ARUK-UCL
- identical protein binding Source: IntAct
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SB
- RNA polymerase II transcription coactivator binding Source: ARUK-UCL
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: ARUK-UCL
- transcription factor binding Source: MGI
- transcription regulatory region sequence-specific DNA binding Source: UniProtKB
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- cellular response to angiotensin Source: BHF-UCL
- cellular response to dsRNA Source: Ensembl
- cellular response to interleukin-1 Source: BHF-UCL
- cellular response to interleukin-6 Source: BHF-UCL
- cellular response to lipopolysaccharide Source: MGI
- cellular response to mechanical stimulus Source: UniProtKB
- cellular response to nicotine Source: BHF-UCL
- cellular response to tumor necrosis factor Source: Ensembl
- Fc-epsilon receptor signaling pathway Source: Reactome
- inflammatory response Source: UniProtKB
- interleukin-1-mediated signaling pathway Source: Reactome
- membrane protein intracellular domain proteolysis Source: Reactome
- negative regulation of apoptotic process Source: UniProtKB
- negative regulation of calcidiol 1-monooxygenase activity Source: BHF-UCL
- negative regulation of cellular protein metabolic process Source: BHF-UCL
- negative regulation of cholesterol transport Source: BHF-UCL
- negative regulation of gene expression Source: BHF-UCL
- negative regulation of inflammatory response Source: Ensembl
- negative regulation of interleukin-12 production Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- negative regulation of vitamin D biosynthetic process Source: BHF-UCL
- neutrophil degranulation Source: Reactome
- positive regulation of canonical Wnt signaling pathway Source: UniProtKB
- positive regulation of hyaluronan biosynthetic process Source: UniProtKB
- positive regulation of lipid storage Source: BHF-UCL
- positive regulation of macrophage derived foam cell differentiation Source: BHF-UCL
- positive regulation of miRNA metabolic process Source: BHF-UCL
- positive regulation of NF-kappaB transcription factor activity Source: Reactome
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: ARUK-UCL
- positive regulation of type I interferon production Source: Reactome
- response to muscle stretch Source: Ensembl
- stimulatory C-type lectin receptor signaling pathway Source: Reactome
- stress-activated MAPK cascade Source: Reactome
- T cell receptor signaling pathway Source: Reactome
- transcription by RNA polymerase II Source: UniProtKB
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Apoptosis, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | P19838 |
Reactomei | R-HSA-1169091, Activation of NF-kappaB in B cells R-HSA-1810476, RIP-mediated NFkB activation via ZBP1 R-HSA-193692, Regulated proteolysis of p75NTR R-HSA-202424, Downstream TCR signaling R-HSA-209560, NF-kB is activated and signals survival R-HSA-2559582, Senescence-Associated Secretory Phenotype (SASP) R-HSA-2871837, FCERI mediated NF-kB activation R-HSA-3134963, DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3214841, PKMTs methylate histone lysines R-HSA-381340, Transcriptional regulation of white adipocyte differentiation R-HSA-445989, TAK1 activates NFkB by phosphorylation and activation of IKKs complex R-HSA-448706, Interleukin-1 processing R-HSA-5603029, IkBA variant leads to EDA-ID R-HSA-5607764, CLEC7A (Dectin-1) signaling R-HSA-5621575, CD209 (DC-SIGN) signaling R-HSA-5660668, CLEC7A/inflammasome pathway R-HSA-5684264, MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-6798695, Neutrophil degranulation R-HSA-844456, The NLRP3 inflammasome R-HSA-8853884, Transcriptional Regulation by VENTX R-HSA-9020702, Interleukin-1 signaling R-HSA-933542, TRAF6 mediated NF-kB activation R-HSA-9609690, HCMV Early Events R-HSA-9660826, Purinergic signaling in leishmaniasis infection |
SignaLinki | P19838 |
SIGNORi | P19838 |
Names & Taxonomyi
Protein namesi | Recommended name: Nuclear factor NF-kappa-B p105 subunitAlternative name(s): DNA-binding factor KBF1 EBP-1 Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Cleaved into the following chain: |
Gene namesi | Name:NFKB1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000109320.11 |
HGNCi | HGNC:7794, NFKB1 |
MIMi | 164011, gene |
neXtProti | NX_P19838 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Extracellular region or secreted
- extracellular region Source: Reactome
Mitochondrion
- mitochondrion Source: HPA
Nucleus
- nuclear chromatin Source: NTNU_SB
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- I-kappaB/NF-kappaB complex Source: BHF-UCL
- secretory granule lumen Source: Reactome
- specific granule lumen Source: Reactome
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Involvement in diseasei
Immunodeficiency, common variable, 12 (CVID12)1 Publication
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 61 | C → S: Suppresses S-nitrosylation-induced inhibition of DNA-binding activity. Loss of S-(15-deoxy-Delta12,14-prostaglandin J2-9-yl)cysteine-induced inhibition of DNA-binding activity. 2 Publications | 1 | |
Mutagenesisi | 678 | N → A: Fails to promote HIF1AN-dependent 2-oxoglutarate decarboxylation. 1 Publication | 1 | |
Mutagenesisi | 903 | S → A: Prevents p105 proteolysis in response to TNF-alpha. 1 Publication | 1 | |
Mutagenesisi | 907 | S → A: Prevents p105 proteolysis in response to TNF-alpha. 1 Publication | 1 | |
Mutagenesisi | 921 | S → A: Decrease in stimuli-induced phosphorylation. Loss of phosphorylation; when associated with A-923 and A-932. 1 Publication | 1 | |
Mutagenesisi | 923 | S → A: Decrease in stimuli-induced phosphorylation. Loss of phosphorylation; when associated with A-921 and A-932. 1 Publication | 1 | |
Mutagenesisi | 932 | S → A: Decrease in stimuli-induced phosphorylation. Loss of phosphorylation; when associated with A-921 and A-923. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 4790 |
MalaCardsi | NFKB1 |
MIMi | 616576, phenotype |
OpenTargetsi | ENSG00000109320 |
Orphaneti | 1572, Common variable immunodeficiency |
PharmGKBi | PA248 |
Miscellaneous databases
Pharosi | P19838, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3251 |
DrugBanki | DB05767, Andrographolide DB05487, Custirsen DB00843, Donepezil DB13961, Fish oil DB13751, Glycyrrhizic acid DB05212, HE3286 DB05559, NF-kappaB Decoy DB05464, NOX-700 DB05451, P54 DB01411, Pranlukast DB00852, Pseudoephedrine DB14059, SC-236 DB05471, SGN-30 DB01041, Thalidomide DB08814, Triflusal |
DrugCentrali | P19838 |
Polymorphism and mutation databases
BioMutai | NFKB1 |
DMDMi | 21542418 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000030310 | 1 – 968 | Nuclear factor NF-kappa-B p105 subunitAdd BLAST | 968 | |
ChainiPRO_0000030311 | 1 – 433 | Nuclear factor NF-kappa-B p50 subunitAdd BLAST | 433 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 61 | S-nitrosocysteine; alternate1 Publication | 1 | |
Lipidationi | 61 | S-(15-deoxy-Delta12,14-prostaglandin J2-9-yl)cysteine; alternate1 Publication | 1 | |
Cross-linki | 325 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 337 | Phosphoserine; by PKASequence analysis | 1 | |
Modified residuei | 431 | N6-acetyllysine; by EP3001 Publication | 1 | |
Modified residuei | 440 | N6-acetyllysine; by EP3001 Publication | 1 | |
Modified residuei | 441 | N6-acetyllysine; by EP3001 Publication | 1 | |
Modified residuei | 449 | PhosphoserineBy similarity | 1 | |
Modified residuei | 678 | (3S)-3-hydroxyasparagine; by HIF1AN; partial1 Publication | 1 | |
Modified residuei | 759 | PhosphoserineBy similarity | 1 | |
Modified residuei | 892 | PhosphoserineCombined sources | 1 | |
Modified residuei | 903 | Phosphoserine; by GSK3-beta; in vitroCombined sources1 Publication | 1 | |
Modified residuei | 907 | Phosphoserine; by GSK3-beta; in vitroCombined sources1 Publication | 1 | |
Modified residuei | 927 | Phosphoserine; by IKKB2 Publications | 1 | |
Modified residuei | 932 | Phosphoserine; by IKKB1 Publication | 1 | |
Modified residuei | 937 | PhosphoserineCombined sources | 1 | |
Modified residuei | 943 | PhosphothreonineBy similarity | 1 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 433 – 434 | Cleavage (when cotranslationally processed) | 2 |
Keywords - PTMi
Acetylation, Hydroxylation, Isopeptide bond, Lipoprotein, Phosphoprotein, S-nitrosylation, Ubl conjugationProteomic databases
CPTACi | CPTAC-1260 CPTAC-1330 |
EPDi | P19838 |
jPOSTi | P19838 |
MassIVEi | P19838 |
MaxQBi | P19838 |
PaxDbi | P19838 |
PeptideAtlasi | P19838 |
PRIDEi | P19838 |
ProteomicsDBi | 53694 [P19838-1] 53695 [P19838-2] 53696 [P19838-3] |
PTM databases
iPTMneti | P19838 |
MetOSitei | P19838 |
PhosphoSitePlusi | P19838 |
Expressioni
Inductioni
Gene expression databases
Bgeei | ENSG00000109320, Expressed in bone marrow and 212 other tissues |
ExpressionAtlasi | P19838, baseline and differential |
Genevisiblei | P19838, HS |
Organism-specific databases
HPAi | ENSG00000109320, Low tissue specificity |
Interactioni
Subunit structurei
Component of the NF-kappa-B p65-p50 complex.
Component of the NF-kappa-B p65-p50 complex. Homodimer; component of the NF-kappa-B p50-p50 complex.
Component of the NF-kappa-B p105-p50 complex.
Component of the NF-kappa-B p50-c-Rel complex.
Component of a complex consisting of the NF-kappa-B p50-p50 homodimer and BCL3.
Also interacts with MAP3K8. NF-kappa-B p50 subunit interacts with NCOA3 coactivator, which may coactivate NF-kappa-B dependent expression via its histone acetyltransferase activity.
Interacts with DSIPI; this interaction prevents nuclear translocation and DNA-binding.
Interacts with SPAG9 and UNC5CL. NFKB1/p105 interacts with CFLAR; the interaction inhibits p105 processing into p50. NFKB1/p105 forms a ternary complex with MAP3K8 and TNIP2.
Interacts with GSK3B; the interaction prevents processing of p105 to p50. NFKB1/p50 interacts with NFKBIE. NFKB1/p50 interacts with NFKBIZ. Nuclear factor NF-kappa-B p50 subunit interacts with NFKBID (By similarity). Directly interacts with MEN1.
Interacts with HIF1AN.
By similarity17 PublicationsBinary interactionsi
Hide detailsP19838
Isoform 1 [P19838-1]
With | #Exp. | IntAct |
---|---|---|
TNIP2 [Q8NFZ5] | 8 | EBI-1452239,EBI-359372 |
Nuclear factor NF-kappa-B p50 subunit (PRO_0000030311)
GO - Molecular functioni
- actinin binding Source: UniProtKB
- enzyme binding Source: ARUK-UCL
- identical protein binding Source: IntAct
- RNA polymerase II transcription coactivator binding Source: ARUK-UCL
- transcription factor binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 110857, 201 interactors |
ComplexPortali | CPX-5828, NF-kappaB DNA-binding transcription factor complex, p50/p65 CPX-5832, NF-kappaB DNA-binding transcription factor complex, p50/c-Rel CPX-5833, NF-kappaB DNA-binding transcription factor complex, p50/RelB CPX-5837, NF-kappaB transcription regulation complex complex, p50/p52 CPX-5838, NF-kappaB transcription regulation complex, p50/p50 |
CORUMi | P19838 |
DIPi | DIP-106N |
ELMi | P19838 |
IntActi | P19838, 489 interactors |
MINTi | P19838 |
STRINGi | 9606.ENSP00000226574 |
Chemistry databases
BindingDBi | P19838 |
Miscellaneous databases
RNActi | P19838, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P19838 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P19838 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 42 – 367 | RHDPROSITE-ProRule annotationAdd BLAST | 326 | |
Repeati | 542 – 571 | ANK 1Add BLAST | 30 | |
Repeati | 581 – 610 | ANK 2Add BLAST | 30 | |
Repeati | 614 – 643 | ANK 3Add BLAST | 30 | |
Repeati | 650 – 679 | ANK 4Add BLAST | 30 | |
Repeati | 684 – 714 | ANK 5Add BLAST | 31 | |
Repeati | 718 – 747 | ANK 6Add BLAST | 30 | |
Repeati | 771 – 801 | ANK 7Add BLAST | 31 | |
Domaini | 805 – 892 | DeathAdd BLAST | 88 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 372 – 394 | GRRAdd BLAST | 23 | |
Regioni | 435 – 968 | Interaction with CFLAR1 PublicationAdd BLAST | 534 | |
Regioni | 650 – 684 | Essential for interaction with HIF1AN1 PublicationAdd BLAST | 35 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 360 – 365 | Nuclear localization signalSequence analysis | 6 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 375 – 433 | Gly-richAdd BLAST | 59 |
Domaini
Keywords - Domaini
ANK repeat, RepeatPhylogenomic databases
eggNOGi | KOG0504, Eukaryota |
GeneTreei | ENSGT00940000158625 |
HOGENOMi | CLU_004343_1_0_1 |
InParanoidi | P19838 |
OMAi | CAIHLAV |
OrthoDBi | 916931at2759 |
PhylomeDBi | P19838 |
TreeFami | TF325632 |
Family and domain databases
CDDi | cd01177, IPT_NFkappaB, 1 hit |
Gene3Di | 1.25.40.20, 1 hit 2.60.40.10, 1 hit 2.60.40.340, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR011029, DEATH-like_dom_sf IPR000488, Death_domain IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR002909, IPT_dom IPR033926, IPT_NFkappaB IPR030503, NF-kB_p105 IPR000451, NFkB/Dor IPR008967, p53-like_TF_DNA-bd IPR030492, RHD_CS IPR032397, RHD_dimer IPR011539, RHD_DNA_bind_dom IPR037059, RHD_DNA_bind_dom_sf |
PANTHERi | PTHR24169, PTHR24169, 1 hit PTHR24169:SF9, PTHR24169:SF9, 1 hit |
Pfami | View protein in Pfam PF12796, Ank_2, 2 hits PF00531, Death, 1 hit PF16179, RHD_dimer, 1 hit PF00554, RHD_DNA_bind, 1 hit |
PRINTSi | PR01415, ANKYRIN PR00057, NFKBTNSCPFCT |
SMARTi | View protein in SMART SM00248, ANK, 6 hits SM00005, DEATH, 1 hit SM00429, IPT, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF48403, SSF48403, 1 hit SSF49417, SSF49417, 1 hit SSF81296, SSF81296, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 5 hits PS01204, REL_1, 1 hit PS50254, REL_2, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAEDDPYLGR PEQMFHLDPS LTHTIFNPEV FQPQMALPTD GPYLQILEQP
60 70 80 90 100
KQRGFRFRYV CEGPSHGGLP GASSEKNKKS YPQVKICNYV GPAKVIVQLV
110 120 130 140 150
TNGKNIHLHA HSLVGKHCED GICTVTAGPK DMVVGFANLG ILHVTKKKVF
160 170 180 190 200
ETLEARMTEA CIRGYNPGLL VHPDLAYLQA EGGGDRQLGD REKELIRQAA
210 220 230 240 250
LQQTKEMDLS VVRLMFTAFL PDSTGSFTRR LEPVVSDAIY DSKAPNASNL
260 270 280 290 300
KIVRMDRTAG CVTGGEEIYL LCDKVQKDDI QIRFYEEEEN GGVWEGFGDF
310 320 330 340 350
SPTDVHRQFA IVFKTPKYKD INITKPASVF VQLRRKSDLE TSEPKPFLYY
360 370 380 390 400
PEIKDKEEVQ RKRQKLMPNF SDSFGGGSGA GAGGGGMFGS GGGGGGTGST
410 420 430 440 450
GPGYSFPHYG FPTYGGITFH PGTTKSNAGM KHGTMDTESK KDPEGCDKSD
460 470 480 490 500
DKNTVNLFGK VIETTEQDQE PSEATVGNGE VTLTYATGTK EESAGVQDNL
510 520 530 540 550
FLEKAMQLAK RHANALFDYA VTGDVKMLLA VQRHLTAVQD ENGDSVLHLA
560 570 580 590 600
IIHLHSQLVR DLLEVTSGLI SDDIINMRND LYQTPLHLAV ITKQEDVVED
610 620 630 640 650
LLRAGADLSL LDRLGNSVLH LAAKEGHDKV LSILLKHKKA ALLLDHPNGD
660 670 680 690 700
GLNAIHLAMM SNSLPCLLLL VAAGADVNAQ EQKSGRTALH LAVEHDNISL
710 720 730 740 750
AGCLLLEGDA HVDSTTYDGT TPLHIAAGRG STRLAALLKA AGADPLVENF
760 770 780 790 800
EPLYDLDDSW ENAGEDEGVV PGTTPLDMAT SWQVFDILNG KPYEPEFTSD
810 820 830 840 850
DLLAQGDMKQ LAEDVKLQLY KLLEIPDPDK NWATLAQKLG LGILNNAFRL
860 870 880 890 900
SPAPSKTLMD NYEVSGGTVR ELVEALRQMG YTEAIEVIQA ASSPVKTTSQ
910 920 930 940 950
AHSLPLSPAS TRQQIDELRD SDSVCDSGVE TSFRKLSFTE SLTSGASLLT
960
LNKMPHDYGQ EGPLEGKI
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A494C1E9 | A0A494C1E9_HUMAN | Nuclear factor NF-kappa-B p105 subu... | NFKB1 | 511 | Annotation score: | ||
D6RF93 | D6RF93_HUMAN | Nuclear factor NF-kappa-B p105 subu... | NFKB1 | 196 | Annotation score: | ||
D6RH30 | D6RH30_HUMAN | Nuclear factor NF-kappa-B p105 subu... | NFKB1 | 198 | Annotation score: | ||
D6RC45 | D6RC45_HUMAN | Nuclear factor NF-kappa-B p105 subu... | NFKB1 | 144 | Annotation score: | ||
D6RDI9 | D6RDI9_HUMAN | Nuclear factor NF-kappa-B p105 subu... | NFKB1 | 74 | Annotation score: | ||
A0A494C157 | A0A494C157_HUMAN | Nuclear factor NF-kappa-B p105 subu... | NFKB1 | 253 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 243 | K → SE in CAB94757 (PubMed:8825636).Curated | 1 | |
Sequence conflicti | 361 | R → G in CAH18336 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 551 – 552 | II → SS in CAB94757 (PubMed:8825636).Curated | 2 | |
Sequence conflicti | 573 | D → G in BAF84139 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 726 | A → V in CAB94757 (PubMed:8825636).Curated | 1 | |
Sequence conflicti | 825 | I → T in CAH18336 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 869 | V → I in CAB94757 (PubMed:8825636).Curated | 1 | |
Sequence conflicti | 927 | S → T in AAA36361 (PubMed:2203531).Curated | 1 | |
Sequence conflicti | 927 | S → T in AAA36360 (PubMed:1992489).Curated | 1 | |
Sequence conflicti | 927 | S → T in CAB94757 (PubMed:8825636).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_016268 | 489 | T → I1 PublicationCorresponds to variant dbSNP:rs4648065Ensembl. | 1 | |
Natural variantiVAR_016269 | 506 | M → V1 PublicationCorresponds to variant dbSNP:rs4648072Ensembl. | 1 | |
Natural variantiVAR_016270 | 566 | T → I1 PublicationCorresponds to variant dbSNP:rs4648085Ensembl. | 1 | |
Natural variantiVAR_016271 | 578 | R → K1 PublicationCorresponds to variant dbSNP:rs4648086Ensembl. | 1 | |
Natural variantiVAR_016272 | 711 | H → Q1 PublicationCorresponds to variant dbSNP:rs4648099Ensembl. | 1 | |
Natural variantiVAR_016273 | 901 | A → T1 PublicationCorresponds to variant dbSNP:rs4648118Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_042869 | 1 – 180 | Missing in isoform 3. 1 PublicationAdd BLAST | 180 | |
Alternative sequenceiVSP_021025 | 39 | T → TA in isoform 2. 3 Publications | 1 | |
Alternative sequenceiVSP_042870 | 181 – 189 | EGGGDRQLG → MNGLCCMAL in isoform 3. 1 Publication | 9 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M55643 mRNA Translation: AAA36361.1 M58603 mRNA Translation: AAA36360.1 Z47748 , Z47749, Z47750, Z47751, Z47752, Z47753, Z47754, Z47755, Z47734, Z47735, Z47736, Z47737, Z47738, Z47739, Z47740, Z47741, Z47742, Z47743, Z47744 Genomic DNA Translation: CAB94757.1 AF213884 Genomic DNA Translation: AAF35232.1 AK122850 mRNA Translation: BAG53760.1 AK291450 mRNA Translation: BAF84139.1 CR749522 mRNA Translation: CAH18336.1 AY223820 Genomic DNA Translation: AAO30127.1 BC033210 mRNA Translation: AAH33210.1 BC051765 mRNA Translation: AAH51765.1 |
CCDSi | CCDS3657.1 [P19838-2] CCDS54783.1 [P19838-1] |
PIRi | A37867 |
RefSeqi | NP_001158884.1, NM_001165412.1 [P19838-1] NP_001306155.1, NM_001319226.1 [P19838-1] NP_003989.2, NM_003998.3 [P19838-2] |
Genome annotation databases
Ensembli | ENST00000226574; ENSP00000226574; ENSG00000109320 [P19838-2] ENST00000394820; ENSP00000378297; ENSG00000109320 [P19838-1] ENST00000505458; ENSP00000424790; ENSG00000109320 [P19838-1] ENST00000600343; ENSP00000469340; ENSG00000109320 [P19838-3] |
GeneIDi | 4790 |
KEGGi | hsa:4790 |
UCSCi | uc011cep.2, human [P19838-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M55643 mRNA Translation: AAA36361.1 M58603 mRNA Translation: AAA36360.1 Z47748 , Z47749, Z47750, Z47751, Z47752, Z47753, Z47754, Z47755, Z47734, Z47735, Z47736, Z47737, Z47738, Z47739, Z47740, Z47741, Z47742, Z47743, Z47744 Genomic DNA Translation: CAB94757.1 AF213884 Genomic DNA Translation: AAF35232.1 AK122850 mRNA Translation: BAG53760.1 AK291450 mRNA Translation: BAF84139.1 CR749522 mRNA Translation: CAH18336.1 AY223820 Genomic DNA Translation: AAO30127.1 BC033210 mRNA Translation: AAH33210.1 BC051765 mRNA Translation: AAH51765.1 |
CCDSi | CCDS3657.1 [P19838-2] CCDS54783.1 [P19838-1] |
PIRi | A37867 |
RefSeqi | NP_001158884.1, NM_001165412.1 [P19838-1] NP_001306155.1, NM_001319226.1 [P19838-1] NP_003989.2, NM_003998.3 [P19838-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1MDI | NMR | - | B | 55-67 | [»] | |
1MDJ | NMR | - | B | 55-67 | [»] | |
1MDK | NMR | - | B | 55-67 | [»] | |
1NFI | X-ray | 2.70 | B/D | 248-354 | [»] | |
1SVC | X-ray | 2.60 | P | 2-365 | [»] | |
2DBF | NMR | - | A | 806-893 | [»] | |
2O61 | X-ray | 2.80 | B | 40-352 | [»] | |
3GUT | X-ray | 3.59 | B/D/F/H | 41-352 | [»] | |
SMRi | P19838 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110857, 201 interactors |
ComplexPortali | CPX-5828, NF-kappaB DNA-binding transcription factor complex, p50/p65 CPX-5832, NF-kappaB DNA-binding transcription factor complex, p50/c-Rel CPX-5833, NF-kappaB DNA-binding transcription factor complex, p50/RelB CPX-5837, NF-kappaB transcription regulation complex complex, p50/p52 CPX-5838, NF-kappaB transcription regulation complex, p50/p50 |
CORUMi | P19838 |
DIPi | DIP-106N |
ELMi | P19838 |
IntActi | P19838, 489 interactors |
MINTi | P19838 |
STRINGi | 9606.ENSP00000226574 |
Chemistry databases
BindingDBi | P19838 |
ChEMBLi | CHEMBL3251 |
DrugBanki | DB05767, Andrographolide DB05487, Custirsen DB00843, Donepezil DB13961, Fish oil DB13751, Glycyrrhizic acid DB05212, HE3286 DB05559, NF-kappaB Decoy DB05464, NOX-700 DB05451, P54 DB01411, Pranlukast DB00852, Pseudoephedrine DB14059, SC-236 DB05471, SGN-30 DB01041, Thalidomide DB08814, Triflusal |
DrugCentrali | P19838 |
PTM databases
iPTMneti | P19838 |
MetOSitei | P19838 |
PhosphoSitePlusi | P19838 |
Polymorphism and mutation databases
BioMutai | NFKB1 |
DMDMi | 21542418 |
Proteomic databases
CPTACi | CPTAC-1260 CPTAC-1330 |
EPDi | P19838 |
jPOSTi | P19838 |
MassIVEi | P19838 |
MaxQBi | P19838 |
PaxDbi | P19838 |
PeptideAtlasi | P19838 |
PRIDEi | P19838 |
ProteomicsDBi | 53694 [P19838-1] 53695 [P19838-2] 53696 [P19838-3] |
Protocols and materials databases
Antibodypediai | 3415, 2305 antibodies |
DNASUi | 4790 |
Genome annotation databases
Ensembli | ENST00000226574; ENSP00000226574; ENSG00000109320 [P19838-2] ENST00000394820; ENSP00000378297; ENSG00000109320 [P19838-1] ENST00000505458; ENSP00000424790; ENSG00000109320 [P19838-1] ENST00000600343; ENSP00000469340; ENSG00000109320 [P19838-3] |
GeneIDi | 4790 |
KEGGi | hsa:4790 |
UCSCi | uc011cep.2, human [P19838-1] |
Organism-specific databases
CTDi | 4790 |
DisGeNETi | 4790 |
EuPathDBi | HostDB:ENSG00000109320.11 |
GeneCardsi | NFKB1 |
HGNCi | HGNC:7794, NFKB1 |
HPAi | ENSG00000109320, Low tissue specificity |
MalaCardsi | NFKB1 |
MIMi | 164011, gene 616576, phenotype |
neXtProti | NX_P19838 |
OpenTargetsi | ENSG00000109320 |
Orphaneti | 1572, Common variable immunodeficiency |
PharmGKBi | PA248 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0504, Eukaryota |
GeneTreei | ENSGT00940000158625 |
HOGENOMi | CLU_004343_1_0_1 |
InParanoidi | P19838 |
OMAi | CAIHLAV |
OrthoDBi | 916931at2759 |
PhylomeDBi | P19838 |
TreeFami | TF325632 |
Enzyme and pathway databases
PathwayCommonsi | P19838 |
Reactomei | R-HSA-1169091, Activation of NF-kappaB in B cells R-HSA-1810476, RIP-mediated NFkB activation via ZBP1 R-HSA-193692, Regulated proteolysis of p75NTR R-HSA-202424, Downstream TCR signaling R-HSA-209560, NF-kB is activated and signals survival R-HSA-2559582, Senescence-Associated Secretory Phenotype (SASP) R-HSA-2871837, FCERI mediated NF-kB activation R-HSA-3134963, DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3214841, PKMTs methylate histone lysines R-HSA-381340, Transcriptional regulation of white adipocyte differentiation R-HSA-445989, TAK1 activates NFkB by phosphorylation and activation of IKKs complex R-HSA-448706, Interleukin-1 processing R-HSA-5603029, IkBA variant leads to EDA-ID R-HSA-5607764, CLEC7A (Dectin-1) signaling R-HSA-5621575, CD209 (DC-SIGN) signaling R-HSA-5660668, CLEC7A/inflammasome pathway R-HSA-5684264, MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-6798695, Neutrophil degranulation R-HSA-844456, The NLRP3 inflammasome R-HSA-8853884, Transcriptional Regulation by VENTX R-HSA-9020702, Interleukin-1 signaling R-HSA-933542, TRAF6 mediated NF-kB activation R-HSA-9609690, HCMV Early Events R-HSA-9660826, Purinergic signaling in leishmaniasis infection |
SignaLinki | P19838 |
SIGNORi | P19838 |
Miscellaneous databases
BioGRID-ORCSi | 4790, 13 hits in 872 CRISPR screens |
ChiTaRSi | NFKB1, human |
EvolutionaryTracei | P19838 |
GeneWikii | NFKB1 |
GenomeRNAii | 4790 |
Pharosi | P19838, Tchem |
PROi | PR:P19838 |
RNActi | P19838, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000109320, Expressed in bone marrow and 212 other tissues |
ExpressionAtlasi | P19838, baseline and differential |
Genevisiblei | P19838, HS |
Family and domain databases
CDDi | cd01177, IPT_NFkappaB, 1 hit |
Gene3Di | 1.25.40.20, 1 hit 2.60.40.10, 1 hit 2.60.40.340, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR011029, DEATH-like_dom_sf IPR000488, Death_domain IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR002909, IPT_dom IPR033926, IPT_NFkappaB IPR030503, NF-kB_p105 IPR000451, NFkB/Dor IPR008967, p53-like_TF_DNA-bd IPR030492, RHD_CS IPR032397, RHD_dimer IPR011539, RHD_DNA_bind_dom IPR037059, RHD_DNA_bind_dom_sf |
PANTHERi | PTHR24169, PTHR24169, 1 hit PTHR24169:SF9, PTHR24169:SF9, 1 hit |
Pfami | View protein in Pfam PF12796, Ank_2, 2 hits PF00531, Death, 1 hit PF16179, RHD_dimer, 1 hit PF00554, RHD_DNA_bind, 1 hit |
PRINTSi | PR01415, ANKYRIN PR00057, NFKBTNSCPFCT |
SMARTi | View protein in SMART SM00248, ANK, 6 hits SM00005, DEATH, 1 hit SM00429, IPT, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF48403, SSF48403, 1 hit SSF49417, SSF49417, 1 hit SSF81296, SSF81296, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 5 hits PS01204, REL_1, 1 hit PS50254, REL_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NFKB1_HUMAN | |
Accessioni | P19838Primary (citable) accession number: P19838 Secondary accession number(s): A8K5Y5 Q9NZC0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1991 |
Last sequence update: | June 20, 2002 | |
Last modified: | December 2, 2020 | |
This is version 253 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations