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Protein

Nuclear factor NF-kappa-B p105 subunit

Gene

NFKB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post-translationally. p50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. In a complex with MAP3K8, NFKB1/p105 represses MAP3K8-induced MAPK signaling; active MAP3K8 is released by proteasome-dependent degradation of NFKB1/p105.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processApoptosis, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-1169091 Activation of NF-kappaB in B cells
R-HSA-1810476 RIP-mediated NFkB activation via ZBP1
R-HSA-193692 Regulated proteolysis of p75NTR
R-HSA-202424 Downstream TCR signaling
R-HSA-209560 NF-kB is activated and signals survival
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-3134963 DEx/H-box helicases activate type I IFN and inflammatory cytokines production
R-HSA-3214841 PKMTs methylate histone lysines
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-HSA-448706 Interleukin-1 processing
R-HSA-5603029 IkBA variant leads to EDA-ID
R-HSA-5607764 CLEC7A (Dectin-1) signaling
R-HSA-5621575 CD209 (DC-SIGN) signaling
R-HSA-5660668 CLEC7A/inflammasome pathway
R-HSA-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation
R-HSA-6798695 Neutrophil degranulation
R-HSA-844456 The NLRP3 inflammasome
R-HSA-9020702 Interleukin-1 signaling
R-HSA-933542 TRAF6 mediated NF-kB activation
SignaLinkiP19838
SIGNORiP19838

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear factor NF-kappa-B p105 subunit
Alternative name(s):
DNA-binding factor KBF1
EBP-1
Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
Cleaved into the following chain:
Gene namesi
Name:NFKB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000109320.11
HGNCiHGNC:7794 NFKB1
MIMi164011 gene
neXtProtiNX_P19838

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

Immunodeficiency, common variable, 12 (CVID12)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen.
See also OMIM:616576

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi61C → S: Suppresses S-nitrosylation-induced inhibition of DNA-binding activity. Loss of S-(15-deoxy-Delta12,14-prostaglandin J2-9-yl)cysteine-induced inhibition of DNA-binding activity. 2 Publications1
Mutagenesisi678N → A: Fails to promote HIF1AN-dependent 2-oxoglutarate decarboxylation. 1 Publication1
Mutagenesisi903S → A: Prevents p105 proteolysis in response to TNF-alpha. 1 Publication1
Mutagenesisi907S → A: Prevents p105 proteolysis in response to TNF-alpha. 1 Publication1
Mutagenesisi921S → A: Decrease in stimuli-induced phosphorylation. Loss of phosphorylation; when associated with A-923 and A-932. 1 Publication1
Mutagenesisi923S → A: Decrease in stimuli-induced phosphorylation. Loss of phosphorylation; when associated with A-921 and A-932. 1 Publication1
Mutagenesisi932S → A: Decrease in stimuli-induced phosphorylation. Loss of phosphorylation; when associated with A-921 and A-923. 1 Publication1

Organism-specific databases

DisGeNETi4790
MalaCardsiNFKB1
MIMi616576 phenotype
OpenTargetsiENSG00000109320
Orphaneti1572 Common variable immunodeficiency
PharmGKBiPA248

Chemistry databases

ChEMBLiCHEMBL3251
DrugBankiDB00945 Acetylsalicylic acid
DB05487 CC-8490
DB05212 HE3286
DB05767 HMPL-004
DB05464 NOX-700
DB05451 P54
DB01411 Pranlukast
DB05471 SGN-30
DB01041 Thalidomide
DB08814 Triflusal

Polymorphism and mutation databases

BioMutaiNFKB1
DMDMi21542418

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000303101 – 968Nuclear factor NF-kappa-B p105 subunitAdd BLAST968
ChainiPRO_00000303111 – 433Nuclear factor NF-kappa-B p50 subunitAdd BLAST433

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei61S-nitrosocysteine; alternate1 Publication1
Lipidationi61S-(15-deoxy-Delta12,14-prostaglandin J2-9-yl)cysteine; alternate1 Publication1
Cross-linki325Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei337Phosphoserine; by PKASequence analysis1
Modified residuei431N6-acetyllysine; by EP3001 Publication1
Modified residuei440N6-acetyllysine; by EP3001 Publication1
Modified residuei441N6-acetyllysine; by EP3001 Publication1
Modified residuei449PhosphoserineBy similarity1
Modified residuei678(3S)-3-hydroxyasparagine; by HIF1AN; partial1 Publication1
Modified residuei759PhosphoserineBy similarity1
Modified residuei892PhosphoserineCombined sources1
Modified residuei903Phosphoserine; by GSK3-beta; in vitroCombined sources1 Publication1
Modified residuei907Phosphoserine; by GSK3-beta; in vitroCombined sources1 Publication1
Modified residuei927Phosphoserine; by IKKB2 Publications1
Modified residuei932Phosphoserine; by IKKB1 Publication1
Modified residuei937PhosphoserineCombined sources1
Modified residuei943PhosphothreonineBy similarity1

Post-translational modificationi

While translation occurs, the particular unfolded structure after the GRR repeat promotes the generation of p50 making it an acceptable substrate for the proteasome. This process is known as cotranslational processing. The processed form is active and the unprocessed form acts as an inhibitor (I kappa B-like), being able to form cytosolic complexes with NF-kappa B, trapping it in the cytoplasm. Complete folding of the region downstream of the GRR repeat precludes processing.1 Publication
Phosphorylation at 'Ser-903' and 'Ser-907' primes p105 for proteolytic processing in response to TNF-alpha stimulation. Phosphorylation at 'Ser-927' and 'Ser-932' are required for BTRC/BTRCP-mediated proteolysis.4 Publications
Polyubiquitination seems to allow p105 processing.2 Publications
S-nitrosylation of Cys-61 affects DNA binding.2 Publications
The covalent modification of cysteine by 15-deoxy-Delta12,14-prostaglandin-J2 is autocatalytic and reversible. It may occur as an alternative to other cysteine modifications, such as S-nitrosylation and S-palmitoylation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei433 – 434Cleavage (when cotranslationally processed)2

Keywords - PTMi

Acetylation, Hydroxylation, Isopeptide bond, Lipoprotein, Phosphoprotein, S-nitrosylation, Ubl conjugation

Proteomic databases

EPDiP19838
MaxQBiP19838
PaxDbiP19838
PeptideAtlasiP19838
PRIDEiP19838
ProteomicsDBi53694
53695 [P19838-2]
53696 [P19838-3]

PTM databases

iPTMnetiP19838
PhosphoSitePlusiP19838

Miscellaneous databases

PMAP-CutDBiP19838

Expressioni

Inductioni

By phorbol ester and TNF.

Gene expression databases

BgeeiENSG00000109320 Expressed in 198 organ(s), highest expression level in leukocyte
CleanExiHS_NFKB1
ExpressionAtlasiP19838 baseline and differential
GenevisibleiP19838 HS

Organism-specific databases

HPAiCAB004031
HPA027305

Interactioni

Subunit structurei

Component of the NF-kappa-B p65-p50 complex. Component of the NF-kappa-B p65-p50 complex. Homodimer; component of the NF-kappa-B p50-p50 complex. Component of the NF-kappa-B p105-p50 complex. Component of the NF-kappa-B p50-c-Rel complex. Component of a complex consisting of the NF-kappa-B p50-p50 homodimer and BCL3. Also interacts with MAP3K8. NF-kappa-B p50 subunit interacts with NCOA3 coactivator, which may coactivate NF-kappa-B dependent expression via its histone acetyltransferase activity. Interacts with DSIPI; this interaction prevents nuclear translocation and DNA-binding. Interacts with SPAG9 and UNC5CL. NFKB1/p105 interacts with CFLAR; the interaction inhibits p105 processing into p50. NFKB1/p105 forms a ternary complex with MAP3K8 and TNIP2. Interacts with GSK3B; the interaction prevents processing of p105 to p50. NFKB1/p50 interacts with NFKBIE. NFKB1/p50 interacts with NFKBIZ. Nuclear factor NF-kappa-B p50 subunit interacts with NFKBID (By similarity). Directly interacts with MEN1. Interacts with HIF1AN.By similarity17 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110857, 158 interactors
CORUMiP19838
DIPiDIP-106N
ELMiP19838
IntActiP19838, 476 interactors
MINTiP19838
STRINGi9606.ENSP00000226574

Chemistry databases

BindingDBiP19838

Structurei

Secondary structure

1968
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP19838
SMRiP19838
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP19838

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 367RHDPROSITE-ProRule annotationAdd BLAST326
Repeati542 – 571ANK 1Add BLAST30
Repeati581 – 610ANK 2Add BLAST30
Repeati614 – 643ANK 3Add BLAST30
Repeati650 – 679ANK 4Add BLAST30
Repeati684 – 714ANK 5Add BLAST31
Repeati718 – 747ANK 6Add BLAST30
Repeati771 – 801ANK 7Add BLAST31
Domaini805 – 892DeathAdd BLAST88

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni372 – 394GRRAdd BLAST23
Regioni435 – 968Interaction with CFLAR1 PublicationAdd BLAST534
Regioni650 – 684Essential for interaction with HIF1AN1 PublicationAdd BLAST35

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi360 – 365Nuclear localization signalSequence analysis6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi375 – 433Gly-richAdd BLAST59

Domaini

The C-terminus of p105 might be involved in cytoplasmic retention, inhibition of DNA-binding, and transcription activation.
Glycine-rich region (GRR) appears to be a critical element in the generation of p50.

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00500000044765
HOGENOMiHOG000004822
HOVERGENiHBG052613
InParanoidiP19838
KOiK02580
OMAiMTWIPRK
OrthoDBiEOG091G03PF
PhylomeDBiP19838
TreeFamiTF325632

Family and domain databases

CDDicd00204 ANK, 1 hit
cd01177 IPT_NFkappaB, 1 hit
Gene3Di1.25.40.20, 1 hit
2.60.40.10, 1 hit
2.60.40.340, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR033926 IPT_NFkappaB
IPR030503 NF-kB_p105
IPR000451 NFkB/Dor
IPR008967 p53-like_TF_DNA-bd
IPR030492 RHD_CS
IPR032397 RHD_dimer
IPR011539 RHD_DNA_bind_dom
IPR037059 RHD_DNA_bind_dom_sf
PANTHERiPTHR24169 PTHR24169, 1 hit
PTHR24169:SF9 PTHR24169:SF9, 1 hit
PfamiView protein in Pfam
PF00023 Ank, 1 hit
PF12796 Ank_2, 1 hit
PF00531 Death, 1 hit
PF16179 RHD_dimer, 1 hit
PF00554 RHD_DNA_bind, 1 hit
PRINTSiPR01415 ANKYRIN
PR00057 NFKBTNSCPFCT
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SM00005 DEATH, 1 hit
SM00429 IPT, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF48403 SSF48403, 1 hit
SSF49417 SSF49417, 1 hit
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 5 hits
PS01204 REL_1, 1 hit
PS50254 REL_2, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P19838-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEDDPYLGR PEQMFHLDPS LTHTIFNPEV FQPQMALPTD GPYLQILEQP
60 70 80 90 100
KQRGFRFRYV CEGPSHGGLP GASSEKNKKS YPQVKICNYV GPAKVIVQLV
110 120 130 140 150
TNGKNIHLHA HSLVGKHCED GICTVTAGPK DMVVGFANLG ILHVTKKKVF
160 170 180 190 200
ETLEARMTEA CIRGYNPGLL VHPDLAYLQA EGGGDRQLGD REKELIRQAA
210 220 230 240 250
LQQTKEMDLS VVRLMFTAFL PDSTGSFTRR LEPVVSDAIY DSKAPNASNL
260 270 280 290 300
KIVRMDRTAG CVTGGEEIYL LCDKVQKDDI QIRFYEEEEN GGVWEGFGDF
310 320 330 340 350
SPTDVHRQFA IVFKTPKYKD INITKPASVF VQLRRKSDLE TSEPKPFLYY
360 370 380 390 400
PEIKDKEEVQ RKRQKLMPNF SDSFGGGSGA GAGGGGMFGS GGGGGGTGST
410 420 430 440 450
GPGYSFPHYG FPTYGGITFH PGTTKSNAGM KHGTMDTESK KDPEGCDKSD
460 470 480 490 500
DKNTVNLFGK VIETTEQDQE PSEATVGNGE VTLTYATGTK EESAGVQDNL
510 520 530 540 550
FLEKAMQLAK RHANALFDYA VTGDVKMLLA VQRHLTAVQD ENGDSVLHLA
560 570 580 590 600
IIHLHSQLVR DLLEVTSGLI SDDIINMRND LYQTPLHLAV ITKQEDVVED
610 620 630 640 650
LLRAGADLSL LDRLGNSVLH LAAKEGHDKV LSILLKHKKA ALLLDHPNGD
660 670 680 690 700
GLNAIHLAMM SNSLPCLLLL VAAGADVNAQ EQKSGRTALH LAVEHDNISL
710 720 730 740 750
AGCLLLEGDA HVDSTTYDGT TPLHIAAGRG STRLAALLKA AGADPLVENF
760 770 780 790 800
EPLYDLDDSW ENAGEDEGVV PGTTPLDMAT SWQVFDILNG KPYEPEFTSD
810 820 830 840 850
DLLAQGDMKQ LAEDVKLQLY KLLEIPDPDK NWATLAQKLG LGILNNAFRL
860 870 880 890 900
SPAPSKTLMD NYEVSGGTVR ELVEALRQMG YTEAIEVIQA ASSPVKTTSQ
910 920 930 940 950
AHSLPLSPAS TRQQIDELRD SDSVCDSGVE TSFRKLSFTE SLTSGASLLT
960
LNKMPHDYGQ EGPLEGKI
Length:968
Mass (Da):105,356
Last modified:June 20, 2002 - v2
Checksum:i2A7C8FF86A10D1A8
GO
Isoform 2 (identifier: P19838-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     39-39: T → TA

Show »
Length:969
Mass (Da):105,427
Checksum:iB4D57AC8A410941D
GO
Isoform 3 (identifier: P19838-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-180: Missing.
     181-189: EGGGDRQLG → MNGLCCMAL

Note: No experimental confirmation available.
Show »
Length:788
Mass (Da):85,520
Checksum:i7B9913B97F25DD3F
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RF93D6RF93_HUMAN
Nuclear factor NF-kappa-B p105 subu...
NFKB1
196Annotation score:
D6RH30D6RH30_HUMAN
Nuclear factor NF-kappa-B p105 subu...
NFKB1
198Annotation score:
D6RC45D6RC45_HUMAN
Nuclear factor NF-kappa-B p105 subu...
NFKB1
144Annotation score:
D6RDI9D6RDI9_HUMAN
Nuclear factor NF-kappa-B p105 subu...
NFKB1
74Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti243K → SE in CAB94757 (PubMed:8825636).Curated1
Sequence conflicti361R → G in CAH18336 (PubMed:17974005).Curated1
Sequence conflicti551 – 552II → SS in CAB94757 (PubMed:8825636).Curated2
Sequence conflicti573D → G in BAF84139 (PubMed:14702039).Curated1
Sequence conflicti726A → V in CAB94757 (PubMed:8825636).Curated1
Sequence conflicti825I → T in CAH18336 (PubMed:17974005).Curated1
Sequence conflicti869V → I in CAB94757 (PubMed:8825636).Curated1
Sequence conflicti927S → T in AAA36361 (PubMed:2203531).Curated1
Sequence conflicti927S → T in AAA36360 (PubMed:1992489).Curated1
Sequence conflicti927S → T in CAB94757 (PubMed:8825636).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_016268489T → I1 PublicationCorresponds to variant dbSNP:rs4648065Ensembl.1
Natural variantiVAR_016269506M → V1 PublicationCorresponds to variant dbSNP:rs4648072Ensembl.1
Natural variantiVAR_016270566T → I1 PublicationCorresponds to variant dbSNP:rs4648085Ensembl.1
Natural variantiVAR_016271578R → K1 PublicationCorresponds to variant dbSNP:rs4648086Ensembl.1
Natural variantiVAR_016272711H → Q1 PublicationCorresponds to variant dbSNP:rs4648099Ensembl.1
Natural variantiVAR_016273901A → T1 PublicationCorresponds to variant dbSNP:rs4648118Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0428691 – 180Missing in isoform 3. 1 PublicationAdd BLAST180
Alternative sequenceiVSP_02102539T → TA in isoform 2. 3 Publications1
Alternative sequenceiVSP_042870181 – 189EGGGDRQLG → MNGLCCMAL in isoform 3. 1 Publication9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55643 mRNA Translation: AAA36361.1
M58603 mRNA Translation: AAA36360.1
Z47748
, Z47749, Z47750, Z47751, Z47752, Z47753, Z47754, Z47755, Z47734, Z47735, Z47736, Z47737, Z47738, Z47739, Z47740, Z47741, Z47742, Z47743, Z47744 Genomic DNA Translation: CAB94757.1
AF213884 Genomic DNA Translation: AAF35232.1
AK122850 mRNA Translation: BAG53760.1
AK291450 mRNA Translation: BAF84139.1
CR749522 mRNA Translation: CAH18336.1
AY223820 Genomic DNA Translation: AAO30127.1
BC033210 mRNA Translation: AAH33210.1
BC051765 mRNA Translation: AAH51765.1
CCDSiCCDS3657.1 [P19838-2]
CCDS54783.1 [P19838-1]
PIRiA37867
RefSeqiNP_001158884.1, NM_001165412.1 [P19838-1]
NP_001306155.1, NM_001319226.1 [P19838-1]
NP_003989.2, NM_003998.3 [P19838-2]
UniGeneiHs.618430

Genome annotation databases

EnsembliENST00000226574; ENSP00000226574; ENSG00000109320 [P19838-2]
ENST00000394820; ENSP00000378297; ENSG00000109320 [P19838-1]
ENST00000505458; ENSP00000424790; ENSG00000109320 [P19838-1]
ENST00000600343; ENSP00000469340; ENSG00000109320 [P19838-3]
GeneIDi4790
KEGGihsa:4790
UCSCiuc011cep.2 human [P19838-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55643 mRNA Translation: AAA36361.1
M58603 mRNA Translation: AAA36360.1
Z47748
, Z47749, Z47750, Z47751, Z47752, Z47753, Z47754, Z47755, Z47734, Z47735, Z47736, Z47737, Z47738, Z47739, Z47740, Z47741, Z47742, Z47743, Z47744 Genomic DNA Translation: CAB94757.1
AF213884 Genomic DNA Translation: AAF35232.1
AK122850 mRNA Translation: BAG53760.1
AK291450 mRNA Translation: BAF84139.1
CR749522 mRNA Translation: CAH18336.1
AY223820 Genomic DNA Translation: AAO30127.1
BC033210 mRNA Translation: AAH33210.1
BC051765 mRNA Translation: AAH51765.1
CCDSiCCDS3657.1 [P19838-2]
CCDS54783.1 [P19838-1]
PIRiA37867
RefSeqiNP_001158884.1, NM_001165412.1 [P19838-1]
NP_001306155.1, NM_001319226.1 [P19838-1]
NP_003989.2, NM_003998.3 [P19838-2]
UniGeneiHs.618430

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MDINMR-B55-67[»]
1MDJNMR-B55-67[»]
1MDKNMR-B55-67[»]
1NFIX-ray2.70B/D248-354[»]
1SVCX-ray2.60P2-365[»]
2DBFNMR-A806-893[»]
2O61X-ray2.80B40-352[»]
3GUTX-ray3.59B/D/F/H41-352[»]
ProteinModelPortaliP19838
SMRiP19838
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110857, 158 interactors
CORUMiP19838
DIPiDIP-106N
ELMiP19838
IntActiP19838, 476 interactors
MINTiP19838
STRINGi9606.ENSP00000226574

Chemistry databases

BindingDBiP19838
ChEMBLiCHEMBL3251
DrugBankiDB00945 Acetylsalicylic acid
DB05487 CC-8490
DB05212 HE3286
DB05767 HMPL-004
DB05464 NOX-700
DB05451 P54
DB01411 Pranlukast
DB05471 SGN-30
DB01041 Thalidomide
DB08814 Triflusal

PTM databases

iPTMnetiP19838
PhosphoSitePlusiP19838

Polymorphism and mutation databases

BioMutaiNFKB1
DMDMi21542418

Proteomic databases

EPDiP19838
MaxQBiP19838
PaxDbiP19838
PeptideAtlasiP19838
PRIDEiP19838
ProteomicsDBi53694
53695 [P19838-2]
53696 [P19838-3]

Protocols and materials databases

DNASUi4790
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000226574; ENSP00000226574; ENSG00000109320 [P19838-2]
ENST00000394820; ENSP00000378297; ENSG00000109320 [P19838-1]
ENST00000505458; ENSP00000424790; ENSG00000109320 [P19838-1]
ENST00000600343; ENSP00000469340; ENSG00000109320 [P19838-3]
GeneIDi4790
KEGGihsa:4790
UCSCiuc011cep.2 human [P19838-1]

Organism-specific databases

CTDi4790
DisGeNETi4790
EuPathDBiHostDB:ENSG00000109320.11
GeneCardsiNFKB1
HGNCiHGNC:7794 NFKB1
HPAiCAB004031
HPA027305
MalaCardsiNFKB1
MIMi164011 gene
616576 phenotype
neXtProtiNX_P19838
OpenTargetsiENSG00000109320
Orphaneti1572 Common variable immunodeficiency
PharmGKBiPA248
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00500000044765
HOGENOMiHOG000004822
HOVERGENiHBG052613
InParanoidiP19838
KOiK02580
OMAiMTWIPRK
OrthoDBiEOG091G03PF
PhylomeDBiP19838
TreeFamiTF325632

Enzyme and pathway databases

ReactomeiR-HSA-1169091 Activation of NF-kappaB in B cells
R-HSA-1810476 RIP-mediated NFkB activation via ZBP1
R-HSA-193692 Regulated proteolysis of p75NTR
R-HSA-202424 Downstream TCR signaling
R-HSA-209560 NF-kB is activated and signals survival
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-3134963 DEx/H-box helicases activate type I IFN and inflammatory cytokines production
R-HSA-3214841 PKMTs methylate histone lysines
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-HSA-448706 Interleukin-1 processing
R-HSA-5603029 IkBA variant leads to EDA-ID
R-HSA-5607764 CLEC7A (Dectin-1) signaling
R-HSA-5621575 CD209 (DC-SIGN) signaling
R-HSA-5660668 CLEC7A/inflammasome pathway
R-HSA-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation
R-HSA-6798695 Neutrophil degranulation
R-HSA-844456 The NLRP3 inflammasome
R-HSA-9020702 Interleukin-1 signaling
R-HSA-933542 TRAF6 mediated NF-kB activation
SignaLinkiP19838
SIGNORiP19838

Miscellaneous databases

ChiTaRSiNFKB1 human
EvolutionaryTraceiP19838
GeneWikiiNFKB1
GenomeRNAii4790
PMAP-CutDBiP19838
PROiPR:P19838
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000109320 Expressed in 198 organ(s), highest expression level in leukocyte
CleanExiHS_NFKB1
ExpressionAtlasiP19838 baseline and differential
GenevisibleiP19838 HS

Family and domain databases

CDDicd00204 ANK, 1 hit
cd01177 IPT_NFkappaB, 1 hit
Gene3Di1.25.40.20, 1 hit
2.60.40.10, 1 hit
2.60.40.340, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR033926 IPT_NFkappaB
IPR030503 NF-kB_p105
IPR000451 NFkB/Dor
IPR008967 p53-like_TF_DNA-bd
IPR030492 RHD_CS
IPR032397 RHD_dimer
IPR011539 RHD_DNA_bind_dom
IPR037059 RHD_DNA_bind_dom_sf
PANTHERiPTHR24169 PTHR24169, 1 hit
PTHR24169:SF9 PTHR24169:SF9, 1 hit
PfamiView protein in Pfam
PF00023 Ank, 1 hit
PF12796 Ank_2, 1 hit
PF00531 Death, 1 hit
PF16179 RHD_dimer, 1 hit
PF00554 RHD_DNA_bind, 1 hit
PRINTSiPR01415 ANKYRIN
PR00057 NFKBTNSCPFCT
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SM00005 DEATH, 1 hit
SM00429 IPT, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF48403 SSF48403, 1 hit
SSF49417 SSF49417, 1 hit
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 5 hits
PS01204 REL_1, 1 hit
PS50254 REL_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNFKB1_HUMAN
AccessioniPrimary (citable) accession number: P19838
Secondary accession number(s): A8K5Y5
, B3KVE8, Q68D84, Q86V43, Q8N4X7, Q9NZC0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: June 20, 2002
Last modified: November 7, 2018
This is version 237 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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