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Protein

Vinculin

Gene

deb-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in cell adhesion (By similarity). May be involved in the attachment of the actin-based microfilaments to the plasma membrane (PubMed:17326220). Involved in ovulation (PubMed:17326220).By similarity1 Publication

GO - Molecular functioni

  • actin filament binding Source: InterPro
  • structural constituent of cytoskeleton Source: UniProtKB

GO - Biological processi

  • cell adhesion Source: UniProtKB-KW
  • cytoskeletal anchoring at plasma membrane Source: UniProtKB
  • positive regulation of ovulation Source: UniProtKB

Keywordsi

Molecular functionActin-binding
Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-CEL-114608 Platelet degranulation
R-CEL-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Vinculin
Alternative name(s):
P107B
Gene namesi
Name:deb-1
ORF Names:ZC477.9
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiZC477.9a ; CE31396 ; WBGene00000942 ; deb-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Disruption phenotypei

RNAi-mediated knockdown causes an accumulation in the proximal gonad of endomitotic mature oocytes in 30 percent of animals.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000642581 – 1010VinculinAdd BLAST1010

Proteomic databases

EPDiP19826
PaxDbiP19826
PeptideAtlasiP19826
PRIDEiP19826

PTM databases

iPTMnetiP19826

Expressioni

Tissue specificityi

Expressed in gonadal sheath cells and spermatheca.1 Publication

Gene expression databases

BgeeiWBGene00000942
ExpressionAtlasiP19826 baseline and differential

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi42601, 5 interactors
IntActiP19826, 3 interactors
STRINGi6239.ZC477.9a

Structurei

3D structure databases

ProteinModelPortaliP19826
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati259 – 3661Sequence analysisAdd BLAST108
Repeati375 – 4812Sequence analysisAdd BLAST107

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni259 – 4812 X repeatsSequence analysisAdd BLAST223

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi786 – 807Pro-richPROSITE-ProRule annotationAdd BLAST22

Sequence similaritiesi

Belongs to the vinculin/alpha-catenin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3681 Eukaryota
ENOG410XSRU LUCA
GeneTreeiENSGT00550000074411
HOGENOMiHOG000007828
InParanoidiP19826
PhylomeDBiP19826

Family and domain databases

InterProiView protein in InterPro
IPR036723 Alpha-catenin/vinculin-like_sf
IPR017997 Vinculin
IPR006077 Vinculin/catenin
IPR000633 Vinculin_CS
PANTHERiPTHR18914 PTHR18914, 1 hit
PTHR18914:SF1 PTHR18914:SF1, 1 hit
PfamiView protein in Pfam
PF01044 Vinculin, 1 hit
SUPFAMiSSF47220 SSF47220, 6 hits
PROSITEiView protein in PROSITE
PS00663 VINCULIN_1, 1 hit
PS00664 VINCULIN_2, 2 hits

Sequencei

Sequence statusi: Complete.

P19826-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVFHTKTIE NILEPVAQQV SRLVILHEEA NDGNAMPDLT GPVGMVSRAV
60 70 80 90 100
GNLIQVGYDT CDHSDDRILQ QDMPPALQRV EGSSKLLEES SYSLKHDPYS
110 120 130 140 150
VPARKKLIDG ARGILQGTSA LLLCFDESEV RKIIRVCRKA NDYVAVSEVI
160 170 180 190 200
ESMADLQQFV KDISPVLHDV TNDVNLRQQE LTHQVHREIL IRCMDSIKVI
210 220 230 240 250
APILICSMKT SIELGTPHPR QGHAEAIANR NFMSQRMTEE MNEIIRVLQL
260 270 280 290 300
TTYDEDEWDA DNVTVMRKAL SAAKSLLTAA LDWLADPHAR SGAVGEKAIR
310 320 330 340 350
RICEYADRIS ARALPEDAQS IKRSIFEITS FTDELCNLRN NGQPDRENLA
360 370 380 390 400
AQTARRLKDL VGSQNSSGLM GDALQNAQRH GGANPAHTAA GRLEQALRWL
410 420 430 440 450
DNPGLDDGGL GLQALRLLTA DARKLADRLN PQDRNRLLGL CSDIDRLAAQ
460 470 480 490 500
LADLERRGLG NSPEAHQIRN QLKNALRDLG DFMRRVLTDR VVDDFADITT
510 520 530 540 550
PLKQFVEAVH ADPYDPNREQ NFVDKSQRLT DHSQSMTTTA RLVASCGPSK
560 570 580 590 600
SKKTVEAILD TAEKVEQLTP QLVNAGRVRL HNPGSEQHFE NIHKQYADAL
610 620 630 640 650
HRLRSHVDDA IDTGEFVRAS ETAMRRYTNH CEGAINGADA HGLVNNSSQI
660 670 680 690 700
ARLGNRVLMT AQNEADNSEE PSFVSRVRNA ADQLHNAIPP MVNNAKQIAQ
710 720 730 740 750
NPHDQYAAQN WRGTNDHLLN SVRAVGDAIT GVPMSNGRHS SYQESISRAS
760 770 780 790 800
PYNPPPPSSQ VIRSVNASPP TAPIIHNKMI IREDIPAPPR PPPPVELSPP
810 820 830 840 850
PRPPPPPEYD EEEETRAFWE RYPLPQASHQ PMLAAAHNLH NELKQWSSQE
860 870 880 890 900
NDIVAAAKRM AILMARLSQL VRGEGGTKKD LINCSKAIAD SSEEVTRLAV
910 920 930 940 950
QLARLCTDIK MRTALLQVSE RIPTIATQLK VLSTVKATML GSANVIGPYG
960 970 980 990 1000
QPVEGSEEDD EAMQQLVHNA QNLMQSVKDV VRAAEAASIK IRTNSGLRLR
1010
WLRKPMWSNF
Length:1,010
Mass (Da):111,922
Last modified:February 1, 1991 - v1
Checksum:iDAF789EA4C786721
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04804 Genomic DNA Translation: AAA28002.1
FO080772 Genomic DNA Translation: CCD66633.1
PIRiA33509
RefSeqiNP_501104.2, NM_068703.5
UniGeneiCel.17854

Genome annotation databases

EnsemblMetazoaiZC477.9a; ZC477.9a; WBGene00000942
GeneIDi177482
UCSCiZC477.9b c. elegans

Similar proteinsi

Entry informationi

Entry nameiVINC_CAEEL
AccessioniPrimary (citable) accession number: P19826
Secondary accession number(s): Q9BI32
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: July 18, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

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