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Protein

Amiloride-sensitive amine oxidase [copper-containing]

Gene

AOC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function.

Miscellaneous

Inhibited by amiloride in a competitive manner.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by isoniazid, cimetidine, clonidine, pentamidine, berenil and pentamidine.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei373Proton acceptor1 Publication1
Active sitei461Schiff-base intermediate with substrate; via topaquinoneCombined sources1 Publication1
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi510Copper; via tele nitrogenCombined sources1 Publication1
Metal bindingi512Copper; via tele nitrogenCombined sources1 Publication1
Metal bindingi519Calcium 1Combined sources1 Publication1
Metal bindingi520Calcium 1; via carbonyl oxygenCombined sources1 Publication1
Metal bindingi521Calcium 1Combined sources1 Publication1
Metal bindingi562Calcium 2Combined sources1 Publication1
Metal bindingi653Calcium 2; via carbonyl oxygenCombined sources1 Publication1
Metal bindingi656Calcium 2Combined sources1 Publication1
Metal bindingi658Calcium 2Combined sources1 Publication1
Metal bindingi664Calcium 1Combined sources1 Publication1
Metal bindingi665Calcium 1; via carbonyl oxygenCombined sources1 Publication1
Metal bindingi675Copper; via pros nitrogenCombined sources1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHeparin-binding, Oxidoreductase
LigandCalcium, Copper, Metal-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS00083-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.4.3.22 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-211945 Phase I - Functionalization of compounds
R-HSA-6798695 Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Amiloride-sensitive amine oxidase [copper-containing] (EC:1.4.3.221 Publication)
Short name:
DAO
Short name:
Diamine oxidase
Alternative name(s):
Amiloride-binding protein 1
Amine oxidase copper domain-containing protein 1
Histaminase
Kidney amine oxidase
Short name:
KAO
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AOC1
Synonyms:ABP1, DAO1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000002726.19

Human Gene Nomenclature Database

More...
HGNCi
HGNC:80 AOC1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
104610 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P19801

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
26

Open Targets

More...
OpenTargetsi
ENSG00000002726

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24416

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2118

Drug and drug target database

More...
DrugBanki
DB00594 Amiloride
DB03608 Diminazene

Polymorphism and mutation databases

Domain mapping of disease mutations (DMDM)

More...
DMDMi
251757489

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 191 PublicationAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003566620 – 751Amiloride-sensitive amine oxidase [copper-containing]Add BLAST732

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi110N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Glycosylationi168N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi177 ↔ 181Combined sources1 Publication
Disulfide bondi391 ↔ 417Combined sources1 Publication
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei4612',4',5'-topaquinone1 Publication1
Glycosylationi538N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Disulfide bondi736InterchainCombined sources1 Publication
Glycosylationi745N-linked (GlcNAc...) asparagineCombined sources1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, TPQ

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P19801

PeptideAtlas

More...
PeptideAtlasi
P19801

PRoteomics IDEntifications database

More...
PRIDEi
P19801

ProteomicsDB human proteome resource

More...
ProteomicsDBi
53688
53689 [P19801-2]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P19801-1 [P19801-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P19801

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P19801

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Placenta and kidney.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000002726 Expressed in 98 organ(s), highest expression level in decidua

CleanEx database of gene expression profiles

More...
CleanExi
HS_ABP1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P19801 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P19801 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA031032
HPA031033

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; disulfide-linked.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
106544, 1 interactor

Protein interaction database and analysis system

More...
IntActi
P19801, 10 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000354193

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P19801

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1751
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P19801

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P19801

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P19801

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni371 – 381Substrate bindingCombined sources1 PublicationAdd BLAST11
Regioni458 – 463Substrate bindingCombined sources1 Publication6
Regioni568 – 575Heparin-bindingBy similarity8

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the copper/topaquinone oxidase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1186 Eukaryota
COG3733 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154676

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000233919

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG004164

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P19801

KEGG Orthology (KO)

More...
KOi
K11182

Identification of Orthologs from Complete Genome Data

More...
OMAi
GIDCPEI

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0C1O

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P19801

TreeFam database of animal gene trees

More...
TreeFami
TF314750

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.70.98.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000269 Cu_amine_oxidase
IPR015798 Cu_amine_oxidase_C
IPR036460 Cu_amine_oxidase_C_sf
IPR016182 Cu_amine_oxidase_N-reg
IPR015800 Cu_amine_oxidase_N2
IPR015802 Cu_amine_oxidase_N3

The PANTHER Classification System

More...
PANTHERi
PTHR10638 PTHR10638, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01179 Cu_amine_oxid, 1 hit
PF02727 Cu_amine_oxidN2, 1 hit
PF02728 Cu_amine_oxidN3, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00766 CUDAOXIDASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49998 SSF49998, 1 hit
SSF54416 SSF54416, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01164 COPPER_AMINE_OXID_1, 1 hit
PS01165 COPPER_AMINE_OXID_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P19801-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPALGWAVAA ILMLQTAMAE PSPGTLPRKA GVFSDLSNQE LKAVHSFLWS
60 70 80 90 100
KKELRLQPSS TTTMAKNTVF LIEMLLPKKY HVLRFLDKGE RHPVREARAV
110 120 130 140 150
IFFGDQEHPN VTEFAVGPLP GPCYMRALSP RPGYQSSWAS RPISTAEYAL
160 170 180 190 200
LYHTLQEATK PLHQFFLNTT GFSFQDCHDR CLAFTDVAPR GVASGQRRSW
210 220 230 240 250
LIIQRYVEGY FLHPTGLELL VDHGSTDAGH WAVEQVWYNG KFYGSPEELA
260 270 280 290 300
RKYADGEVDV VVLEDPLPGG KGHDSTEEPP LFSSHKPRGD FPSPIHVSGP
310 320 330 340 350
RLVQPHGPRF RLEGNAVLYG GWSFAFRLRS SSGLQVLNVH FGGERIAYEV
360 370 380 390 400
SVQEAVALYG GHTPAGMQTK YLDVGWGLGS VTHELAPGID CPETATFLDT
410 420 430 440 450
FHYYDADDPV HYPRALCLFE MPTGVPLRRH FNSNFKGGFN FYAGLKGQVL
460 470 480 490 500
VLRTTSTVYN YDYIWDFIFY PNGVMEAKMH ATGYVHATFY TPEGLRHGTR
510 520 530 540 550
LHTHLIGNIH THLVHYRVDL DVAGTKNSFQ TLQMKLENIT NPWSPRHRVV
560 570 580 590 600
QPTLEQTQYS WERQAAFRFK RKLPKYLLFT SPQENPWGHK RTYRLQIHSM
610 620 630 640 650
ADQVLPPGWQ EEQAITWARY PLAVTKYRES ELCSSSIYHQ NDPWHPPVVF
660 670 680 690 700
EQFLHNNENI ENEDLVAWVT VGFLHIPHSE DIPNTATPGN SVGFLLRPFN
710 720 730 740 750
FFPEDPSLAS RDTVIVWPRD NGPNYVQRWI PEDRDCSMPP PFSYNGTYRP

V
Length:751
Mass (Da):85,378
Last modified:July 7, 2009 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i37114CD0D446639C
GO
Isoform 2 (identifier: P19801-2) [UniParc]FASTAAdd to basket
Also known as: DAO2

The sequence of this isoform differs from the canonical sequence as follows:
     618-618: A → ARTEGGQPRALSQAASPVPG

Show »
Length:770
Mass (Da):87,239
Checksum:iCA4864D23DB6D7CC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J2J4C9J2J4_HUMAN
Amine oxidase
AOC1
337Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J0G8C9J0G8_HUMAN
Amine oxidase
AOC1
249Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA58358 differs from that shown. Reason: Frameshift at positions 266, 284, 328, 494, 497, 514, 707 and 729.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti28R → A AA sequence (PubMed:8144586).Curated1
Sequence conflicti280P → A in AAA58358 (PubMed:2217167).Curated1
Sequence conflicti290D → T in AAA58358 (PubMed:2217167).Curated1
Sequence conflicti572K → R in AAA58358 (PubMed:2217167).Curated1
Sequence conflicti592T → S in AAA58358 (PubMed:2217167).Curated1
Sequence conflicti592T → S in CAA55046 (PubMed:8182053).Curated1
Sequence conflicti592T → S in AAC50270 (PubMed:8595053).Curated1
Sequence conflicti592T → S in AAB60381 (PubMed:8595053).Curated1
Sequence conflicti592T → S in AAH14093 (PubMed:15489334).Curated1
Isoform 2 (identifier: P19801-2)
Sequence conflicti632A → R in AAB60381 (PubMed:8595053).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02507816T → M1 PublicationCorresponds to variant dbSNP:rs10156191Ensembl.1
Natural variantiVAR_025079332S → F2 PublicationsCorresponds to variant dbSNP:rs1049742Ensembl.1
Natural variantiVAR_025080479M → I1 PublicationCorresponds to variant dbSNP:rs45558339Ensembl.1
Natural variantiVAR_007542645H → D4 PublicationsCorresponds to variant dbSNP:rs1049793Ensembl.1
Natural variantiVAR_025081659N → H1 PublicationCorresponds to variant dbSNP:rs35070995Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_055190618A → ARTEGGQPRALSQAASPVPG in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M55602 mRNA Translation: AAA58358.1 Frameshift.
X78212 Genomic DNA Translation: CAA55046.1
U11862 mRNA Translation: AAC50270.1
U11863 mRNA Translation: AAB60381.1
AY948960 Genomic DNA Translation: AAX81409.1
AC006343 Genomic DNA No translation available.
AC006479 Genomic DNA No translation available.
BC014093 mRNA Translation: AAH14093.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43679.1 [P19801-1]
CCDS64797.1 [P19801-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
A54053

NCBI Reference Sequences

More...
RefSeqi
NP_001082.2, NM_001091.3 [P19801-1]
NP_001259001.1, NM_001272072.1 [P19801-2]
XP_016867433.1, XM_017011944.1 [P19801-2]
XP_016867434.1, XM_017011945.1 [P19801-2]
XP_016867435.1, XM_017011946.1 [P19801-2]
XP_016867436.1, XM_017011947.1 [P19801-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.647097
Hs.733889

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000360937; ENSP00000354193; ENSG00000002726 [P19801-1]
ENST00000416793; ENSP00000411613; ENSG00000002726 [P19801-2]
ENST00000467291; ENSP00000418328; ENSG00000002726 [P19801-1]
ENST00000493429; ENSP00000418614; ENSG00000002726 [P19801-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
26

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:26

UCSC genome browser

More...
UCSCi
uc003whz.3 human [P19801-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55602 mRNA Translation: AAA58358.1 Frameshift.
X78212 Genomic DNA Translation: CAA55046.1
U11862 mRNA Translation: AAC50270.1
U11863 mRNA Translation: AAB60381.1
AY948960 Genomic DNA Translation: AAX81409.1
AC006343 Genomic DNA No translation available.
AC006479 Genomic DNA No translation available.
BC014093 mRNA Translation: AAH14093.1
CCDSiCCDS43679.1 [P19801-1]
CCDS64797.1 [P19801-2]
PIRiA54053
RefSeqiNP_001082.2, NM_001091.3 [P19801-1]
NP_001259001.1, NM_001272072.1 [P19801-2]
XP_016867433.1, XM_017011944.1 [P19801-2]
XP_016867434.1, XM_017011945.1 [P19801-2]
XP_016867435.1, XM_017011946.1 [P19801-2]
XP_016867436.1, XM_017011947.1 [P19801-1]
UniGeneiHs.647097
Hs.733889

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3HI7X-ray1.80A/B21-751[»]
3HIGX-ray2.09A/B21-751[»]
3HIIX-ray2.15A/B21-751[»]
3K5TX-ray2.11A21-751[»]
3MPHX-ray2.05A/B21-751[»]
ProteinModelPortaliP19801
SMRiP19801
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106544, 1 interactor
IntActiP19801, 10 interactors
STRINGi9606.ENSP00000354193

Chemistry databases

BindingDBiP19801
ChEMBLiCHEMBL2118
DrugBankiDB00594 Amiloride
DB03608 Diminazene

PTM databases

iPTMnetiP19801
PhosphoSitePlusiP19801

Polymorphism and mutation databases

DMDMi251757489

Proteomic databases

PaxDbiP19801
PeptideAtlasiP19801
PRIDEiP19801
ProteomicsDBi53688
53689 [P19801-2]
TopDownProteomicsiP19801-1 [P19801-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
26
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360937; ENSP00000354193; ENSG00000002726 [P19801-1]
ENST00000416793; ENSP00000411613; ENSG00000002726 [P19801-2]
ENST00000467291; ENSP00000418328; ENSG00000002726 [P19801-1]
ENST00000493429; ENSP00000418614; ENSG00000002726 [P19801-1]
GeneIDi26
KEGGihsa:26
UCSCiuc003whz.3 human [P19801-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
26
DisGeNETi26
EuPathDBiHostDB:ENSG00000002726.19

GeneCards: human genes, protein and diseases

More...
GeneCardsi
AOC1

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0007216
HGNCiHGNC:80 AOC1
HPAiHPA031032
HPA031033
MIMi104610 gene
neXtProtiNX_P19801
OpenTargetsiENSG00000002726
PharmGKBiPA24416

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1186 Eukaryota
COG3733 LUCA
GeneTreeiENSGT00940000154676
HOGENOMiHOG000233919
HOVERGENiHBG004164
InParanoidiP19801
KOiK11182
OMAiGIDCPEI
OrthoDBiEOG091G0C1O
PhylomeDBiP19801
TreeFamiTF314750

Enzyme and pathway databases

BioCyciMetaCyc:HS00083-MONOMER
BRENDAi1.4.3.22 2681
ReactomeiR-HSA-211945 Phase I - Functionalization of compounds
R-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
AOC1 human
EvolutionaryTraceiP19801

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
26

Protein Ontology

More...
PROi
PR:P19801

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000002726 Expressed in 98 organ(s), highest expression level in decidua
CleanExiHS_ABP1
ExpressionAtlasiP19801 baseline and differential
GenevisibleiP19801 HS

Family and domain databases

Gene3Di2.70.98.20, 1 hit
InterProiView protein in InterPro
IPR000269 Cu_amine_oxidase
IPR015798 Cu_amine_oxidase_C
IPR036460 Cu_amine_oxidase_C_sf
IPR016182 Cu_amine_oxidase_N-reg
IPR015800 Cu_amine_oxidase_N2
IPR015802 Cu_amine_oxidase_N3
PANTHERiPTHR10638 PTHR10638, 1 hit
PfamiView protein in Pfam
PF01179 Cu_amine_oxid, 1 hit
PF02727 Cu_amine_oxidN2, 1 hit
PF02728 Cu_amine_oxidN3, 1 hit
PRINTSiPR00766 CUDAOXIDASE
SUPFAMiSSF49998 SSF49998, 1 hit
SSF54416 SSF54416, 2 hits
PROSITEiView protein in PROSITE
PS01164 COPPER_AMINE_OXID_1, 1 hit
PS01165 COPPER_AMINE_OXID_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAOC1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P19801
Secondary accession number(s): C9J690
, Q16683, Q16684, Q56II4, Q6GU42
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: July 7, 2009
Last modified: December 5, 2018
This is version 189 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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