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Entry version 113 (07 Oct 2020)
Sequence version 1 (01 Feb 1991)
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Protein

N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase

Gene

PCBAB

Organism
Penicillium chrysogenum (Penicillium notatum)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Each of the constituent amino acids of the tripeptide acv are activated as aminoacyl-adenylates with peptide bonds formed through the participation of amino acid thioester intermediates.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

pantetheine 4'-phosphateNote: Binds 3 phosphopantetheines covalently.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: penicillin G biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes penicillin G from L-alpha-aminoadipate and L-cysteine and L-valine.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase (PCBAB), N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase (PCBAB)
  2. Isopenicillin N synthase (pcbC)
  3. Acyl-coenzyme A:6-aminopenicillanic-acid-acyltransferase 40 kDa form (penDE)
This subpathway is part of the pathway penicillin G biosynthesis, which is itself part of Antibiotic biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes penicillin G from L-alpha-aminoadipate and L-cysteine and L-valine, the pathway penicillin G biosynthesis and in Antibiotic biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei3599For thioesterase activityBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase, Multifunctional enzyme
Biological processAntibiotic biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:MONOMER-13331

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00149;UER00239

Protein family/group databases

ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

More...
ESTHERi
pench-acvt, Thioesterase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase (EC:6.3.2.26)
Alternative name(s):
Delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase
Short name:
ACV synthetase
Short name:
ACVS
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PCBAB
Synonyms:ACVA
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPenicillium chrysogenum (Penicillium notatum)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5076 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaePenicilliumPenicillium chrysogenum species complex

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001930601 – 3746N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthaseAdd BLAST3746

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei855O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei1939O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei3026O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P19787

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini818 – 895Carrier 1PROSITE-ProRule annotationAdd BLAST78
Domaini1902 – 1979Carrier 2PROSITE-ProRule annotationAdd BLAST78
Domaini2991 – 3066Carrier 3PROSITE-ProRule annotationAdd BLAST76

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni307 – 883Domain 1 (adipate-activating)Add BLAST577
Regioni1400 – 1967Domain 2 (cysteine-activating)Add BLAST568
Regioni2483 – 3053Domain 3 (valine-activating)Add BLAST571

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1200.10, 3 hits
3.30.559.10, 3 hits
3.40.50.12780, 3 hits
3.40.50.1820, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010071, AA_adenyl_domain
IPR029058, AB_hydrolase
IPR036736, ACP-like_sf
IPR025110, AMP-bd_C
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, AMP-dep_Synthh-like_sf
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site
IPR001031, Thioesterase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00501, AMP-binding, 3 hits
PF13193, AMP-binding_C, 2 hits
PF00668, Condensation, 3 hits
PF00550, PP-binding, 3 hits
PF00975, Thioesterase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00823, PKS_PP, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47336, SSF47336, 3 hits
SSF53474, SSF53474, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01733, AA-adenyl-dom, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00455, AMP_BINDING, 3 hits
PS50075, CARRIER, 3 hits
PS00012, PHOSPHOPANTETHEINE, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P19787-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGPSNPAMAY FKPSTRDTMD PCSGNAADGS IRVRFRGGIE RWKECVNQVP
60 70 80 90 100
ERCDLSGLTT DSTRYQLAST GFGDASAAYQ ERLMTVPVDV HAALQELCLE
110 120 130 140 150
RRVSVGSVIN FSVHQMLKGF GNGTHTITAS LHREQNLQNS SPSWVVSPTI
160 170 180 190 200
VTHENRDGWS VAQAVESIEA GRGSEKESVT AIDSGSSLVK MGLFDLLVSF
210 220 230 240 250
VDADDARIPC FDFPLAVIVR ECDANLSLTL RFSDCLFNEE TICNFTDALN
260 270 280 290 300
ILLAEAVIGR VTPVADIELL SAEQKQQLEE WNNTDGEYPS SKRLHHLIEE
310 320 330 340 350
VVERHEDKIA VVCDERELTY GELNAQGNSL ARYLRSIGIL PEQLVALFLD
360 370 380 390 400
KSEKLIVTIL GVWKSGAAYV PIDPTYPDER VRFVLDDTKA RAIIASNQHV
410 420 430 440 450
ERLQREVIGD RNLCIIRLEP LLASLAQDSS KFPAHNLDDL PLTSQQLAYV
460 470 480 490 500
TYTSGTTGFP KGIFKQHTNV VNSITDLSAR YGVAGQHHEA ILLFSACVFE
510 520 530 540 550
PFVRQTLMAL VNGHLLAVIN DVEKYDADTL LPFIRRHSIT YLNGTASVLQ
560 570 580 590 600
EYDFSDCPSL NRIILVGENL TEARYLALRQ RFKNRILNEY GFTESAFVTA
610 620 630 640 650
LKIFDPESTR KDTSLGRPVR NVKCYILNPS LKRVPIGATG ELHIGGLGIS
660 670 680 690 700
KGYLNRPELT PHRFIPNPFQ TDCEKQLGIN SLMYKTGDLA RWLPNGEVEY
710 720 730 740 750
LGRADFQIKL RGIRIEPGEI ETMLAMYPRV RTSLVVSKKL RNGPEETTNE
760 770 780 790 800
HLVGYYVCDS ASVSEADLLS FLEKKLPRYM IPTRLVQLSQ IPVNVNGKAD
810 820 830 840 850
LRALPAVDIS NSTEVRSDLR GDTEIALGEI WADVLGARQR SVSRNDNFFR
860 870 880 890 900
LGGHSITCIQ LIARIRQRLS VSISVEDVFA TRTLERMADL LQNKQQEKCD
910 920 930 940 950
KPHEAPTELL EENAATDNIY LANSLQQGFV YHYLKSMEQS DAYVMQSVLR
960 970 980 990 1000
YNTTLSPDLF QRAWKHAQQS FPALRLRFSW EKEVFQLLDQ DPPLDWRFLY
1010 1020 1030 1040 1050
FTDVAAGAVE DRKLEDLRRQ DLTERFKLDV GRLFRVYLIK HSENRFTCLF
1060 1070 1080 1090 1100
SCHHAILDGW SLPLLFEKVH ETYLQLLHGD NLTSSMDDPY TRTQRYLHAH
1110 1120 1130 1140 1150
REDHLDFWAG VVQKINERCD MNALLNERSR YKVQLADYDQ VQEQRQLTIA
1160 1170 1180 1190 1200
LSGDAWLADL RQTCSAQGIT LHSILQFVWH AVLHAYGGGT HTITGTTISG
1210 1220 1230 1240 1250
RNLPILGIER AVGPYINTLP LVLDHSTFKD KTIMEAIEDV QAKVNVMNSR
1260 1270 1280 1290 1300
GNVELGRLHK TDLKHGLFDS LFVLENYPNL DKSRTLEHQT ELGYSIEGGT
1310 1320 1330 1340 1350
EKLNYPLAVI AREVETTGGF TVSICYASEL FEEVMISELL HMVQDTLMQV
1360 1370 1380 1390 1400
ARGLNEPVGS LEYLSSIQLE QLAAWNATEA EFPDTTLHEM FENEASQKPD
1410 1420 1430 1440 1450
KIAVVYEETS LTYRELNERA NRMAHQLRSD VSPNPNEVIA LVMDKSEHMI
1460 1470 1480 1490 1500
VNILAVWKSG GAYVPIDPGY PNDRIQYILE DTQALAVIAD SCYLPRIKGM
1510 1520 1530 1540 1550
AASGTLLYPS VLPANPDSKW SVSNPSPLSR STDLAYIIYT SGTTGRPKGV
1560 1570 1580 1590 1600
TVEHHGVVNL QVSLSKVFGL RDTDDEVILS FSNYVFDHFV EQMTDAILNG
1610 1620 1630 1640 1650
QTLLVLNDGM RGDKERLYRY IEKNRVTYLS GTPSVVSMYE FSRFKDHLRR
1660 1670 1680 1690 1700
VDCVGEAFSE PVFDKIRETF HGLVINGYGP TEVSITTHKR LYPFPERRMD
1710 1720 1730 1740 1750
KSIGQQVHNS TSYVLNEDMK RTPIGSVGEL YLGGEGVVRG YHNRADVTAE
1760 1770 1780 1790 1800
RFIPNPFQSE EDKREGRNSR LYKTGDLVRW IPGSSGEVEY LGRNDFQVKI
1810 1820 1830 1840 1850
RGLRIELGEI EAILSSYHGI KQSVVIAKDC REGAQKFLVG YYVADAALPS
1860 1870 1880 1890 1900
AAIRRFMQSR LPGYMVPSRL ILVSKFPVTP SGKLDTKALP PAEEESEIDV
1910 1920 1930 1940 1950
VPPRSEIERS LCDIWAELLE MHPEEIGIYS DFFSLGGDSL KSTKLSFMIH
1960 1970 1980 1990 2000
ESFNRAVSVS ALFCHRTVEA QTHLILNDAA DVHEITPIDC NDTQMIPVSR
2010 2020 2030 2040 2050
AQERLLFIHE FENGSNAYNI DAAFELPGSV DASLLEQALR GNLARHEALR
2060 2070 2080 2090 2100
TLLVKDHATG IYLQKVLSPD EAQGMFSVNV DTAKQVERLD QEIASLSQHV
2110 2120 2130 2140 2150
FRLDDELPWE ARILKLESGG LYLILAFHHT CFDAWSLKVF EQELRALYAA
2160 2170 2180 2190 2200
LQKTKSAANL PALKAQYKEY ALYHRRQLSG DRMRNLSDFW LRKLIGLEPL
2210 2220 2230 2240 2250
QLITDRPRPV QFKYDGDDLS IELSKKETEN LRGVAKRCKS SLYVVLVSVY
2260 2270 2280 2290 2300
CVMLASYANQ SDVSVGIPVS HRTHPQFQSV IGFFVNLVVL RVDISQSAIC
2310 2320 2330 2340 2350
GLIRRVMKEL VDAQLHQDMP FQEVTKLLQV DNDPSRHPLV QNVFNFESRA
2360 2370 2380 2390 2400
NGEHDARSED EGSLAFNQYR PVQPVDSVAK FDLNATVTEL ESGLRVNFNY
2410 2420 2430 2440 2450
ATSLFNKSTI QGFLHTYEYL LRQLSELSAE GINEDTQLSL VRPTENGDLH
2460 2470 2480 2490 2500
LPLAQSPLAT TAEEQKVASL NQAFEREAFL AAEKIAVVQG DRALSYADLN
2510 2520 2530 2540 2550
GQANQLARYI QSVSCIGADD GIALMLEKSI DTIICILAIW KAGAAYVPLD
2560 2570 2580 2590 2600
PTYPPGRVQL ILEEIKAKAV LVHSSHASKC ERHGAKVIAV DSPAIETAVS
2610 2620 2630 2640 2650
QQSAADLPTI ASLGNLAYII FTSGTSGKPK GVLVEQKAVL LLRDALRERY
2660 2670 2680 2690 2700
FGRDCTKHHG VLFLSNYVFD FSVEQLVLSV LSGHKLIVPP AEFVADDEFY
2710 2720 2730 2740 2750
RMASTHGLSY LSGTPSLLQK IDLARLDHLQ VVTAAGEELH ATQYEKMRRR
2760 2770 2780 2790 2800
FNGPIYNAYG VTETTVYNII AEFTTNSIFE NALREVLPGT RAYVLNAALQ
2810 2820 2830 2840 2850
PVPFDAVGEL YLAGDSVTRG YLNQPLLTDQ RFIPNPFCKE EDIAMGRFAR
2860 2870 2880 2890 2900
LYKTGDLVRS RFNRQQQPQL EYLGRGDLQI KMRGYRIEIS EVQNVLTSSP
2910 2920 2930 2940 2950
GVREGAVVAK YENNDTYSRT AHSLVGYYTT DNETVSEADI LTFMKARLPT
2960 2970 2980 2990 3000
YMVPSHLCCL EGALPVTING KLDVRRLPEI INDSAQSSYS PPRNIIEAKM
3010 3020 3030 3040 3050
CRLWESALGM ERCGIDDDLF KLGGDSITSL HLVAQIHNQV GCKITVRDIF
3060 3070 3080 3090 3100
EHRTARALHD HVFMKDSDRS NVTQFRTEQG PVIGEAPLLP IQDWFLSKAL
3110 3120 3130 3140 3150
QHPMYWNHTF YVRTPELDVD SLSAAVRDLQ QYHDVFRMRL KREEVGFVQS
3160 3170 3180 3190 3200
FAEDFSPAQL RVLNVKDVDG SAAVNEILDG WQSGFNLENG PIGSIGYLHG
3210 3220 3230 3240 3250
YEDRSARVWF SVHHMAIDTV SWQILVRDLQ TLYRNGSLGS KGSSFRQWAE
3260 3270 3280 3290 3300
AIQNYKASDS ERNHWNKLVM ETASSISALP TSTGSRVRLS RSLSPEKTAS
3310 3320 3330 3340 3350
LIQGGIDRQD VSVYDSLLTS VGLALQHIAP TGPSMVTIEG HGREEVDQTL
3360 3370 3380 3390 3400
DVSRTMGWFT TMYPFEIPRL STENIVQGVV AVSERFRQVP ARGVGYGTLY
3410 3420 3430 3440 3450
GYTQHPLPQV TVNYLGQLAR KQSKPKEWVL AVGDNEFEYG LMTSPEDKDR
3460 3470 3480 3490 3500
SSSAVDVTAV CIDGTMIIDV DSAWSLEESE QFISSIEEGL NKILDGRASQ
3510 3520 3530 3540 3550
QTSRFPDVPQ PAETYTPYFE YLEPPRQGPT LFLLPPGEGG AESYFNNIVK
3560 3570 3580 3590 3600
RLRQTNMVVF NNYYLHSKRL RTFEELAEMY LDQVRGIQPH GPYHFIGWSF
3610 3620 3630 3640 3650
GGILAMEMSR RLVASDEKIG FLGIIDTYFN VRGATRTIGL GDTEILDPIH
3660 3670 3680 3690 3700
HIYNPDPANF QRLPSATDRI VLFKAMRPNN KYESENQRRL YEYYDGTRLN
3710 3720 3730 3740
GLDSLLPSDS DVQLVPLTDD THFSWVGNPQ QVEQMCATIK EHLARY
Length:3,746
Mass (Da):421,076
Last modified:February 1, 1991 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i449BCC73253ED589
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X54296 Genomic DNA Translation: CAA38195.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S13134, YGPLV3

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54296 Genomic DNA Translation: CAA38195.1
PIRiS13134, YGPLV3

3D structure databases

SMRiP19787
ModBaseiSearch...

Protein family/group databases

ESTHERipench-acvt, Thioesterase

Enzyme and pathway databases

UniPathwayiUPA00149;UER00239
BioCyciMetaCyc:MONOMER-13331

Family and domain databases

Gene3Di1.10.1200.10, 3 hits
3.30.559.10, 3 hits
3.40.50.12780, 3 hits
3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR010071, AA_adenyl_domain
IPR029058, AB_hydrolase
IPR036736, ACP-like_sf
IPR025110, AMP-bd_C
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, AMP-dep_Synthh-like_sf
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site
IPR001031, Thioesterase
PfamiView protein in Pfam
PF00501, AMP-binding, 3 hits
PF13193, AMP-binding_C, 2 hits
PF00668, Condensation, 3 hits
PF00550, PP-binding, 3 hits
PF00975, Thioesterase, 1 hit
SMARTiView protein in SMART
SM00823, PKS_PP, 3 hits
SUPFAMiSSF47336, SSF47336, 3 hits
SSF53474, SSF53474, 1 hit
TIGRFAMsiTIGR01733, AA-adenyl-dom, 3 hits
PROSITEiView protein in PROSITE
PS00455, AMP_BINDING, 3 hits
PS50075, CARRIER, 3 hits
PS00012, PHOSPHOPANTETHEINE, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiACVS1_PENCH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P19787
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: October 7, 2020
This is version 113 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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