UniProtKB - P19785 (ESR1_MOUSE)
Estrogen receptor
Esr1
Functioni
Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3.
2 PublicationsRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 189 – 254 | Nuclear receptorPROSITE-ProRule annotationAdd BLAST | 66 | |
Zinc fingeri | 189 – 209 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 225 – 249 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- ATPase binding Source: MGI
- beta-catenin binding Source: MGI
- chromatin binding Source: MGI
- DNA binding Source: MGI
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI
- enzyme binding Source: MGI
- estrogen receptor activity Source: MGI
- estrogen receptor binding Source: MGI
- estrogen response element binding Source: MGI
- hormone binding Source: MGI
- identical protein binding Source: MGI
- nuclear receptor activity Source: MGI
- phosphatidylinositol 3-kinase regulatory subunit binding Source: MGI
- promoter-specific chromatin binding Source: MGI
- protein-containing complex binding Source: MGI
- protein kinase binding Source: MGI
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: MGI
- sequence-specific DNA binding Source: UniProtKB
- sequence-specific double-stranded DNA binding Source: MGI
- steroid binding Source: UniProtKB
- steroid hormone receptor activity Source: MGI
- TBP-class protein binding Source: MGI
- TFIIB-class transcription factor binding Source: MGI
- transcription coactivator binding Source: MGI
- transcription coregulator binding Source: MGI
- transcription corepressor binding Source: MGI
- transcription factor binding Source: UniProtKB
- type 1 metabotropic glutamate receptor binding Source: MGI
- zinc ion binding Source: InterPro
GO - Biological processi
- androgen metabolic process Source: MGI
- antral ovarian follicle growth Source: MGI
- cellular response to estradiol stimulus Source: UniProtKB
- cellular response to estrogen stimulus Source: MGI
- epithelial cell development Source: MGI
- epithelial cell proliferation involved in mammary gland duct elongation Source: MGI
- intracellular estrogen receptor signaling pathway Source: MGI
- intracellular steroid hormone receptor signaling pathway Source: UniProtKB
- male gonad development Source: MGI
- mammary gland alveolus development Source: MGI
- mammary gland branching involved in pregnancy Source: MGI
- negative regulation of DNA-binding transcription factor activity Source: UniProtKB
- negative regulation of gene expression Source: MGI
- negative regulation of glucose import Source: MGI
- negative regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
- negative regulation of mitotic nuclear division Source: UniProtKB
- negative regulation of neuron death Source: MGI
- negative regulation of production of miRNAs involved in gene silencing by miRNA Source: MGI
- negative regulation of smooth muscle cell proliferation Source: MGI
- negative regulation of transcription by RNA polymerase II Source: MGI
- negative regulation of triglyceride metabolic process Source: MGI
- phospholipase C-activating G protein-coupled receptor signaling pathway Source: UniProtKB
- positive regulation of cytosolic calcium ion concentration Source: UniProtKB
- positive regulation of DNA-binding transcription factor activity Source: UniProtKB
- positive regulation of epidermal growth factor receptor signaling pathway Source: MGI
- positive regulation of epithelial cell proliferation Source: MGI
- positive regulation of ERK1 and ERK2 cascade Source: MGI
- positive regulation of fibroblast proliferation Source: MGI
- positive regulation of nitric oxide biosynthetic process Source: UniProtKB
- positive regulation of nitric-oxide synthase activity Source: UniProtKB
- positive regulation of phospholipase C activity Source: UniProtKB
- positive regulation of RNA polymerase II transcription preinitiation complex assembly Source: MGI
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: MGI
- prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis Source: MGI
- prostate epithelial cord elongation Source: MGI
- protein localization to chromatin Source: MGI
- regulation of apoptotic process Source: MGI
- regulation of branching involved in prostate gland morphogenesis Source: MGI
- regulation of inflammatory response Source: MGI
- regulation of neuron apoptotic process Source: MGI
- regulation of toll-like receptor signaling pathway Source: MGI
- regulation of transcription, DNA-templated Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
- response to estradiol Source: MGI
- response to estrogen Source: MGI
- Sertoli cell proliferation Source: MGI
- stem cell differentiation Source: CAFA
- uterus development Source: MGI
- vagina development Source: MGI
Keywordsi
Molecular function | Activator, DNA-binding, Receptor |
Biological process | Transcription, Transcription regulation |
Ligand | Lipid-binding, Metal-binding, Steroid-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-1251985, Nuclear signaling by ERBB4 R-MMU-1257604, PIP3 activates AKT signaling R-MMU-383280, Nuclear Receptor transcription pathway R-MMU-4090294, SUMOylation of intracellular receptors R-MMU-5689896, Ovarian tumor domain proteases R-MMU-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-MMU-8866910, TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-MMU-8931987, RUNX1 regulates estrogen receptor mediated transcription R-MMU-8939211, ESR-mediated signaling R-MMU-9009391, Extra-nuclear estrogen signaling R-MMU-9018519, Estrogen-dependent gene expression |
Names & Taxonomyi
Protein namesi | Recommended name: Estrogen receptorShort name: ER Alternative name(s): ER-alpha Estradiol receptor Nuclear receptor subfamily 3 group A member 1 |
Gene namesi | Name:Esr1 Synonyms:Esr, Estr, Estra, Nr3a1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1352467, Esr1 |
VEuPathDBi | HostDB:ENSMUSG00000019768 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity
Golgi apparatus
- Golgi apparatus By similarity
Nucleus
- Nucleus PROSITE-ProRule annotation
Cytoplasm and Cytosol
- Cytoplasm By similarity
Note: Colocalizes with ZDHHC7 and ZDHHC21 in the Golgi apparatus where most probably palmitoylation occurs. Associated with the plasma membrane when palmitoylated.By similarity
Golgi apparatus
- Golgi apparatus Source: UniProtKB-SubCell
Mitochondrion
- mitochondrion Source: MGI
Nucleus
- nucleus Source: MGI
Plasma Membrane
- plasma membrane Source: MGI
- T-tubule Source: MGI
Other locations
- chromatin Source: MGI
- cytoplasm Source: MGI
- euchromatin Source: MGI
- neuron projection Source: MGI
- perikaryon Source: MGI
- perinuclear region of cytoplasm Source: MGI
- protein-containing complex Source: MGI
- terminal bouton Source: MGI
- transcription preinitiation complex Source: MGI
- transcription regulator complex Source: MGI
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Golgi apparatus, Membrane, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 362 | I → A: No effect on transcriptional activity and estrogen-induced interaction with NCOA1. Abolishes estrogen-induced interaction with NCOA1; when associated with A-376 and A-380. 1 Publication | 1 | |
Mutagenesisi | 362 | I → D: Abolishes transcriptional activity and estrogen-induced interaction with NCOA1. 1 Publication | 1 | |
Mutagenesisi | 366 | K → A: Greatly reduces transcriptional activity and estrogen-induced interaction with NCOA1. 1 Publication | 1 | |
Mutagenesisi | 366 | K → D: Abolishes transcriptional activity and estrogen-induced interaction with NCOA1. 1 Publication | 1 | |
Mutagenesisi | 366 | K → L: Reduces transcriptional activity and estrogen-induced interaction with NCOA1. 1 Publication | 1 | |
Mutagenesisi | 371 | F → A: Abolishes estrogen-dependent NF-kappa B transcriptional repression, impairs transcriptional activity, abolishes estrogen-induced interaction with NCOA1. 1 Publication | 1 | |
Mutagenesisi | 376 | L → A: Reduces transcriptional activity, no effect on estrogen-induced interaction with NCOA1. Abolishes estrogen-induced interaction with NCOA1; when associated with A-362 and A-380. 1 Publication | 1 | |
Mutagenesisi | 376 | L → D: Reduces transcriptional activity and estrogen-induced interaction with NCOA1. 1 Publication | 1 | |
Mutagenesisi | 380 | V → A: No effect on transcriptional activity and estrogen-induced interaction with NCOA1. Abolishes estrogen-induced interaction with NCOA1; when associated with A-362 and A-376. 1 Publication | 1 | |
Mutagenesisi | 380 | V → D: Abolishes transcriptional activity and estrogen-induced interaction with NCOA1. 1 Publication | 1 | |
Mutagenesisi | 451 | C → A: Loss of ZDHHC7 and ZDHHC21 binding. Loss of palmitoylation. 1 Publication | 1 | |
Mutagenesisi | 508 | L → A: Reduces DNA-binding, attenuates transcriptional activity, does not effect estrogen-dependent NF-kappa B transcriptional repression; when associated with E-512 and E-515. 1 Publication | 1 | |
Mutagenesisi | 508 | L → E: Abolishes DNA-binding, abolishes transcriptional activity and estrogen-dependent NF-kappa B transcriptional repression; when associated with E-512 and E-515. 1 Publication | 1 | |
Mutagenesisi | 509 | A → E: Reduces DNA-binding,, attenuates transcriptional activity, does not effect estrogen-dependent NF-kappa B transcriptional repression. 1 Publication | 1 | |
Mutagenesisi | 512 | L → A: Reduces DNA-binding, attenuates transcriptional activity, does not effect estrogen-dependent NF-kappa B transcriptional repression; when associated with E-508 and E-515. 1 Publication | 1 | |
Mutagenesisi | 512 | L → E: Abolishes DNA-binding, abolishes transcriptional activity and estrogen-dependent NF-kappa B transcriptional repression; when associated with E-508 and E-515. 1 Publication | 1 | |
Mutagenesisi | 515 | L → A: Reduces DNA-binding, attenuates transcriptional activity, does not effect estrogen-dependent NF-kappa B transcriptional repression; when associated with E-508 and E-512. 1 Publication | 1 | |
Mutagenesisi | 515 | L → E: Abolishes DNA-binding, abolishes transcriptional activity and estrogen-dependent NF-kappa B transcriptional repression; when associated with E-508 and E-512. 1 Publication | 1 | |
Mutagenesisi | 525 | G → R: Abolishes estrogen binding; impairs repression of NF-kappa activity. 1 Publication | 1 | |
Mutagenesisi | 542 | D → N: Abolishes estrogen-dependent NF-kappa B transcriptional repression, impairs transcriptional activity, impairs estrogen-induced interaction with NCOA1; when associated with Q-546 and N-548. 1 Publication | 1 | |
Mutagenesisi | 543 – 544 | LL → AA: Abolishes estrogen-dependent NF-kappa B transcriptional repression, abolishes estrogen-induced interaction with NCOA1. 1 Publication | 2 | |
Mutagenesisi | 543 | L → A: Abolishes estrogen-induced interaction with NCOA1. 1 Publication | 1 | |
Mutagenesisi | 546 | E → Q: Abolishes estrogen-dependent NF-kappa B transcriptional repression, impairs transcriptional activity, impairs estrogen-induced interaction with NCOA1; when associated with N-542 and N-548. 1 Publication | 1 | |
Mutagenesisi | 547 – 548 | ML → AA: No effect on estrogen-dependent NF-kappa B transcriptional repression, greatly impairs transcriptional activity, abolishes estrogen-induced interaction with NCOA1. 1 Publication | 2 | |
Mutagenesisi | 549 | D → N: Abolishes estrogen-dependent NF-kappa B transcriptional repression, impairs transcriptional activity, impairs estrogen-induced interaction with NCOA1; when associated with N-542 and Q-546. 1 Publication | 1 |
Chemistry databases
ChEMBLi | CHEMBL3065 |
DrugCentrali | P19785 |
GuidetoPHARMACOLOGYi | 620 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000053621 | 1 – 599 | Estrogen receptorAdd BLAST | 599 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 10 | O-linked (GlcNAc) serine1 Publication | 1 | |
Glycosylationi | 50 | O-linked (GlcNAc) threonine1 Publication | 1 | |
Modified residuei | 108 | Phosphoserine; by CDK2By similarity | 1 | |
Modified residuei | 110 | Phosphoserine; by CDK2By similarity | 1 | |
Modified residuei | 122 | PhosphoserineBy similarity | 1 | |
Modified residuei | 171 | Phosphoserine; by CK2By similarity | 1 | |
Modified residuei | 264 | Asymmetric dimethylarginine; by PRMT1By similarity | 1 | |
Lipidationi | 451 | S-palmitoyl cysteine1 Publication | 1 | |
Modified residuei | 541 | Phosphotyrosine; by Tyr-kinasesBy similarity | 1 | |
GlycosylationiCAR_000137 | 575 | O-linked (GlcNAc) threonine2 Publications | 1 |
Post-translational modificationi
Keywords - PTMi
Glycoprotein, Lipoprotein, Methylation, Palmitate, Phosphoprotein, Ubl conjugationProteomic databases
PaxDbi | P19785 |
PRIDEi | P19785 |
ProteomicsDBi | 275478 |
PTM databases
GlyConnecti | 145, 1 O-Linked glycan (1 site) |
GlyGeni | P19785, 3 sites, 1 O-linked glycan (1 site) |
iPTMneti | P19785 |
PhosphoSitePlusi | P19785 |
SwissPalmi | P19785 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000019768, Expressed in uterus and 247 other tissues |
Genevisiblei | P19785, MM |
Interactioni
Subunit structurei
Interacts with BCAS3. Binds DNA as a homodimer (By similarity). Can form a heterodimer with ESR2 (By similarity).
Interacts with coactivator NCOA5.
Interacts with PELP1, the interaction is enhanced by 17-beta-estradiol; the interaction increases ESR1 transcriptional activity (By similarity).
Interacts with NCOA7; the interaction is ligand-inducible.
Interacts with AKAP13, CUEDC2, HEXIM1, KDM5A, MAP1S, SMARD1, and UBE1C.
Interacts with MUC1; the interaction is stimulated by 7 beta-estradiol (E2) and enhances ESR1-mediated transcription.
Interacts with DNTTIP2, and UIMC1.
Interacts with KMT2D/MLL2.
Interacts with ATAD2; the interaction is enhanced by estradiol.
Interacts with KIF18A and LDB1.
Interacts with RLIM (via its C-terminus).
Interacts with MACROD1.
Interacts with SH2D4A and PLCG.
Interacts with SH2D4A; the interaction blocks binding to PLCG and inhibits estrogen-induced cell proliferation.
Interacts with DYNLL1.
Interacts with CCDC62; the interaction requires estradiol and appears to enhance the transcription of target genes.
Interacts with NR2C1; the interaction prevents homodimerization of ESR1 and suppresses its transcriptional activity and cell growth.
Interacts with DNAAF4.
Interacts with PRMT2.
Interacts with RBFOX2.
Interacts with EP300; the interaction is estrogen-dependent and enhanced by CITED1.
Interacts with CITED1; the interaction is estrogen-dependent (By similarity).
Interacts with FAM120B, FOXL2, PHB2 and SLC30A9.
Interacts with coactivators NCOA3 and NCOA6.
Interacts with STK3/MST2 only in the presence of SAV1 and vice-versa. Binds to CSNK1D.
Interacts with NCOA2; NCOA2 can interact with ESR1 AF-1 and AF-2 domains simultaneously and mediate their transcriptional synergy.
Interacts with DDX5.
Interacts with NCOA1; the interaction seems to require a self-association of N-terminal and C-terminal regions.
Interacts with ZNF366, DDX17, NFKB1, RELA, SP1 and SP3.
Interacts with NRIP1 (By similarity).
Interacts with GPER1; the interaction occurs in an estrogen-dependent manner.
Interacts with CLOCK and the interaction is stimulated by estrogen (By similarity).
Interacts with BCAS3.
Interacts with TRIP4 (ufmylated); estrogen dependent (By similarity).
Interacts with LMTK3; the interaction phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation.
Interacts with CCAR2 (via N-terminus) in a ligand-independent manner.
Interacts with ZFHX3 (By similarity).
Interacts with SFR1 in a ligand-dependent and -independent manner (By similarity).
Interacts with DCAF13, LATS1 and DCAF1; regulates ESR1 ubiquitination and ubiquitin-mediated proteasomal degradation (By similarity).
Interacts (via DNA-binding domain) with POU4F2 isoform 2 (C-terminus); this interaction increases the estrogen receptor ESR1 transcriptional activity in a DNA- and ligand 17-beta-estradiol-independent manner (PubMed:9448000).
Interacts with ESRRB isoform 1 (By similarity).
Interacts with UBE3A and WBP2 (By similarity).
Interacts with GTF2B (By similarity).
Interacts with RBM39 (PubMed:11704680). In the absence of hormonal ligand, interacts with TACC1 (By similarity).
Interacts with PI3KR1 or PI3KR2 and PTK2/FAK1 (By similarity).
Interacts with SRC (By similarity).
By similarity10 PublicationsBinary interactionsi
P19785
With | #Exp. | IntAct |
---|---|---|
Pgr [Q00175] | 5 | EBI-346765,EBI-346821 |
NCOA1 [Q15788] from Homo sapiens. | 3 | EBI-346765,EBI-455189 |
URI1 [O94763] from Homo sapiens. | 2 | EBI-346765,EBI-357067 |
GO - Molecular functioni
- ATPase binding Source: MGI
- beta-catenin binding Source: MGI
- enzyme binding Source: MGI
- estrogen receptor binding Source: MGI
- identical protein binding Source: MGI
- phosphatidylinositol 3-kinase regulatory subunit binding Source: MGI
- protein kinase binding Source: MGI
- TBP-class protein binding Source: MGI
- TFIIB-class transcription factor binding Source: MGI
- transcription coactivator binding Source: MGI
- transcription coregulator binding Source: MGI
- transcription corepressor binding Source: MGI
- transcription factor binding Source: UniProtKB
- type 1 metabotropic glutamate receptor binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 199521, 33 interactors |
IntActi | P19785, 9 interactors |
MINTi | P19785 |
STRINGi | 10090.ENSMUSP00000070070 |
Chemistry databases
BindingDBi | P19785 |
Miscellaneous databases
RNActi | P19785, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 315 – 551 | NR LBDPROSITE-ProRule annotationAdd BLAST | 237 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 188 | Modulating (transactivation AF-1); mediates interaction with MACROD1By similarityAdd BLAST | 188 | |
Regioni | 35 – 178 | Interaction with DDX5; self-associationBy similarityAdd BLAST | 144 | |
Regioni | 35 – 47 | Required for interaction with NCOA1By similarityAdd BLAST | 13 | |
Regioni | 147 – 175 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 189 – 314 | Mediates interaction with DNTTIP2By similarityAdd BLAST | 126 | |
Regioni | 255 – 314 | HingeAdd BLAST | 60 | |
Regioni | 266 – 599 | Interaction with AKAP13By similarityAdd BLAST | 334 | |
Regioni | 268 – 599 | Self-associationBy similarityAdd BLAST | 332 | |
Regioni | 315 – 599 | Transactivation AF-2By similarityAdd BLAST | 285 | |
Regioni | 557 – 581 | DisorderedSequence analysisAdd BLAST | 25 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 564 – 581 | Polar residuesSequence analysisAdd BLAST | 18 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 189 – 209 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 225 – 249 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00940000158133 |
HOGENOMi | CLU_007368_11_1_1 |
InParanoidi | P19785 |
OMAi | QCDARDE |
OrthoDBi | 487299at2759 |
PhylomeDBi | P19785 |
TreeFami | TF323751 |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR024178, Est_rcpt/est-rel_rcp IPR001292, Estr_rcpt IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR024736, Oestrogen-typ_rcpt_final_C_dom IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF12743, ESR1_C, 1 hit PF00104, Hormone_recep, 1 hit PF02159, Oest_recep, 1 hit PF00105, zf-C4, 1 hit |
PIRSFi | PIRSF500101, ER-a, 1 hit PIRSF002527, ER-like_NR, 1 hit |
PRINTSi | PR00543, OESTROGENR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MTMTLHTKAS GMALLHQIQG NELEPLNRPQ LKMPMERALG EVYVDNSKPT
60 70 80 90 100
VFNYPEGAAY EFNAAAAAAA AASAPVYGQS GIAYGPGSEA AAFSANSLGA
110 120 130 140 150
FPQLNSVSPS PLMLLHPPPQ LSPFLHPHGQ QVPYYLENEP SAYAVRDTGP
160 170 180 190 200
PAFYRSNSDN RRQNGRERLS SSNEKGNMIM ESAKETRYCA VCNDYASGYH
210 220 230 240 250
YGVWSCEGCK AFFKRSIQGH NDYMCPATNQ CTIDKNRRKS CQACRLRKCY
260 270 280 290 300
EVGMMKGGIR KDRRGGRMLK HKRQRDDLEG RNEMGASGDM RAANLWPSPL
310 320 330 340 350
VIKHTKKNSP ALSLTADQMV SALLDAEPPM IYSEYDPSRP FSEASMMGLL
360 370 380 390 400
TNLADRELVH MINWAKRVPG FGDLNLHDQV HLLECAWLEI LMIGLVWRSM
410 420 430 440 450
EHPGKLLFAP NLLLDRNQGK CVEGMVEIFD MLLATSSRFR MMNLQGEEFV
460 470 480 490 500
CLKSIILLNS GVYTFLSSTL KSLEEKDHIH RVLDKITDTL IHLMAKAGLT
510 520 530 540 550
LQQQHRRLAQ LLLILSHIRH MSNKGMEHLY NMKCKNVVPL YDLLLEMLDA
560 570 580 590
HRLHAPASRM GVPPEEPSQT QLATTSSTSA HSLQTYYIPP EAEGFPNTI
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketD3Z6V3 | D3Z6V3_MOUSE | Estrogen receptor | Esr1 | 499 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 269 | L → M in AAF22561 (Ref. 4) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 591 | E → Q in strain: SJL/J. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M38651 mRNA Translation: AAA37580.1 AK036627 mRNA Translation: BAC29510.1 AK041525 mRNA Translation: BAC30973.1 AJ276597 Genomic DNA Translation: CAB85618.1 AF128221 mRNA Translation: AAF22562.1 AF128220 mRNA Translation: AAF22561.1 |
CCDSi | CCDS56678.1 |
PIRi | A40061, QRMSE |
RefSeqi | NP_001289460.1, NM_001302531.1 NP_001289461.1, NM_001302532.1 NP_031982.1, NM_007956.5 XP_006512496.1, XM_006512433.3 XP_006512497.1, XM_006512434.3 XP_006512498.1, XM_006512435.2 XP_011241368.1, XM_011243066.2 XP_011241369.1, XM_011243067.2 XP_011241370.1, XM_011243068.2 |
Genome annotation databases
Ensembli | ENSMUST00000067086; ENSMUSP00000070070; ENSMUSG00000019768 ENSMUST00000105589; ENSMUSP00000101214; ENSMUSG00000019768 ENSMUST00000105590; ENSMUSP00000101215; ENSMUSG00000019768 |
GeneIDi | 13982 |
KEGGi | mmu:13982 |
UCSCi | uc007egu.3, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M38651 mRNA Translation: AAA37580.1 AK036627 mRNA Translation: BAC29510.1 AK041525 mRNA Translation: BAC30973.1 AJ276597 Genomic DNA Translation: CAB85618.1 AF128221 mRNA Translation: AAF22562.1 AF128220 mRNA Translation: AAF22561.1 |
CCDSi | CCDS56678.1 |
PIRi | A40061, QRMSE |
RefSeqi | NP_001289460.1, NM_001302531.1 NP_001289461.1, NM_001302532.1 NP_031982.1, NM_007956.5 XP_006512496.1, XM_006512433.3 XP_006512497.1, XM_006512434.3 XP_006512498.1, XM_006512435.2 XP_011241368.1, XM_011243066.2 XP_011241369.1, XM_011243067.2 XP_011241370.1, XM_011243068.2 |
3D structure databases
AlphaFoldDBi | P19785 |
SMRi | P19785 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 199521, 33 interactors |
IntActi | P19785, 9 interactors |
MINTi | P19785 |
STRINGi | 10090.ENSMUSP00000070070 |
Chemistry databases
BindingDBi | P19785 |
ChEMBLi | CHEMBL3065 |
DrugCentrali | P19785 |
GuidetoPHARMACOLOGYi | 620 |
PTM databases
GlyConnecti | 145, 1 O-Linked glycan (1 site) |
GlyGeni | P19785, 3 sites, 1 O-linked glycan (1 site) |
iPTMneti | P19785 |
PhosphoSitePlusi | P19785 |
SwissPalmi | P19785 |
Proteomic databases
PaxDbi | P19785 |
PRIDEi | P19785 |
ProteomicsDBi | 275478 |
Protocols and materials databases
Antibodypediai | 739, 4121 antibodies from 54 providers |
DNASUi | 13982 |
Genome annotation databases
Ensembli | ENSMUST00000067086; ENSMUSP00000070070; ENSMUSG00000019768 ENSMUST00000105589; ENSMUSP00000101214; ENSMUSG00000019768 ENSMUST00000105590; ENSMUSP00000101215; ENSMUSG00000019768 |
GeneIDi | 13982 |
KEGGi | mmu:13982 |
UCSCi | uc007egu.3, mouse |
Organism-specific databases
CTDi | 2099 |
MGIi | MGI:1352467, Esr1 |
VEuPathDBi | HostDB:ENSMUSG00000019768 |
Phylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00940000158133 |
HOGENOMi | CLU_007368_11_1_1 |
InParanoidi | P19785 |
OMAi | QCDARDE |
OrthoDBi | 487299at2759 |
PhylomeDBi | P19785 |
TreeFami | TF323751 |
Enzyme and pathway databases
Reactomei | R-MMU-1251985, Nuclear signaling by ERBB4 R-MMU-1257604, PIP3 activates AKT signaling R-MMU-383280, Nuclear Receptor transcription pathway R-MMU-4090294, SUMOylation of intracellular receptors R-MMU-5689896, Ovarian tumor domain proteases R-MMU-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-MMU-8866910, TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-MMU-8931987, RUNX1 regulates estrogen receptor mediated transcription R-MMU-8939211, ESR-mediated signaling R-MMU-9009391, Extra-nuclear estrogen signaling R-MMU-9018519, Estrogen-dependent gene expression |
Miscellaneous databases
BioGRID-ORCSi | 13982, 5 hits in 77 CRISPR screens |
ChiTaRSi | Esr1, mouse |
PROi | PR:P19785 |
RNActi | P19785, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000019768, Expressed in uterus and 247 other tissues |
Genevisiblei | P19785, MM |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR024178, Est_rcpt/est-rel_rcp IPR001292, Estr_rcpt IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR024736, Oestrogen-typ_rcpt_final_C_dom IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF12743, ESR1_C, 1 hit PF00104, Hormone_recep, 1 hit PF02159, Oest_recep, 1 hit PF00105, zf-C4, 1 hit |
PIRSFi | PIRSF500101, ER-a, 1 hit PIRSF002527, ER-like_NR, 1 hit |
PRINTSi | PR00543, OESTROGENR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ESR1_MOUSE | |
Accessioni | P19785Primary (citable) accession number: P19785 Secondary accession number(s): Q9JJT5, Q9QY51, Q9QY52 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1991 |
Last sequence update: | February 1, 1991 | |
Last modified: | May 25, 2022 | |
This is version 237 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families