Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
We will be switching to the new UniProt website soon. Please explore and share your feedback. Take me to the new website.

UniProtKB - P19736 (PRP9_YEAST)

Entry version 170 (23 Feb 2022)
Sequence version 1 (01 Feb 1991)
Previous versions | rss
Add a publicationFeedback
Protein

Pre-mRNA-splicing factor PRP9

Gene

PRP9

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

mRNA splicing factors, PRP9, PRP11, and PRP21, are necessary for binding of the U2 snRNP to the pre-mRNA in an early step of spliceosome assembly.

Miscellaneous

Present with 3920 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri280 – 310Matrin-type 1PROSITE-ProRule annotationAdd BLAST31
Zinc fingeri421 – 452Matrin-type 2PROSITE-ProRule annotationAdd BLAST32

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • RNA binding Source: SGD
  • zinc ion binding Source: InterPro
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processmRNA processing, mRNA splicing
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pre-mRNA-splicing factor PRP9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRP9
Ordered Locus Names:YDL030W
ORF Names:D2773
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

Saccharomyces Genome Database

More...SGDi		S000002188, PRP9

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		FungiDB:YDL030W

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus, Spliceosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001743211 – 530Pre-mRNA-splicing factor PRP9Add BLAST530

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		P19736

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P19736

PRoteomics IDEntifications database

More...PRIDEi		P19736

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Belongs to the CWC complex (or CEF1-associated complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome composed of the U2, U5 and U6 snRNAs and at least BUD13, BUD31, BRR2, CDC40, CEF1, CLF1, CUS1, CWC2, CWC15, CWC21, CWC22, CWC23, CWC24, CWC25, CWC27, ECM2, HSH155, IST3, ISY1, LEA1, MSL1, NTC20, PRP8, PRP9, PRP11, PRP19, PRP21, PRP22, PRP45, PRP46, SLU7, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, SNT309, SNU114, SPP2, SYF1, SYF2, RSE1 and YJU2.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		32026, 518 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-1648, SF3A complex
CPX-1651, PRP19-associated complex
CPX-26, U2 small nuclear ribonucleoprotein complex

Database of interacting proteins

More...DIPi		DIP-651N

Protein interaction database and analysis system

More...IntActi		P19736, 23 interactors

Molecular INTeraction database

More...MINTi		P19736

STRING: functional protein association networks

More...STRINGi		4932.YDL030W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P19736, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1530
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P19736

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni367 – 388DisorderedSequence analysisAdd BLAST22
Regioni488 – 516DisorderedSequence analysisAdd BLAST29

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SF3A3 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri280 – 310Matrin-type 1PROSITE-ProRule annotationAdd BLAST31
Zinc fingeri421 – 452Matrin-type 2PROSITE-ProRule annotationAdd BLAST32

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2636, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00530000063402

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_027160_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P19736

Identification of Orthologs from Complete Genome Data

More...OMAi		RYPNEQA

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000690, Matrin/U1-C_Znf_C2H2
IPR003604, Matrin/U1-like-C_Znf_C2H2
IPR031590, PRP9_N
IPR031776, SF3A3
IPR031774, SF3A3_dom
IPR024598, SF3a60/Prp9_C
IPR022755, Znf_C2H2_jaz
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

The PANTHER Classification System

More...PANTHERi		PTHR12786:SF2, PTHR12786:SF2, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF16958, PRP9_N, 1 hit
PF16837, SF3A3, 1 hit
PF11931, SF3a60_Prp9_C, 1 hit
PF12171, zf-C2H2_jaz, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00355, ZnF_C2H2, 2 hits
SM00451, ZnF_U1, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57667, SSF57667, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50171, ZF_MATRIN, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P19736-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNLLETRRSL LEEMEIIENA IAERIQRNPE LYYHYIQESS KVFPDTKLPR 
        60         70         80         90        100
SSLIAENKIY KFKKVKRKRK QIILQQHEIN IFLRDYQEKQ QTFNKINRPE 
       110        120        130        140        150
ETQEDDKDLP NFERKLQQLE KELKNEDENF ELDINSKKDK YALFSSSSDP 
       160        170        180        190        200
SRRTNILSDR ARDLDLNEIF TRDEQYGEYM ELEQFHSLWL NVIKRGDCSL 
       210        220        230        240        250
LQFLDILELF LDDEKYLLTP PMDRKNDRYM AFLLKLSKYV ETFFFKSYAL 
       260        270        280        290        300
LDAAAVENLI KSDFEHSYCR GSLRSEAKGI YCPFCSRWFK TSSVFESHLV 
       310        320        330        340        350
GKIHKKNESK RRNFVYSEYK LHRYLKYLND EFSRTRSFVE RKLAFTANER 
       360        370        380        390        400
MAEMDILTQK YEAPAYDSTE KEGAEQVDGE QRDGQLQEEH LSGKSFDMPL 
       410        420        430        440        450
GPDGLPMPYW LYKLHGLDRE YRCEICSNKV YNGRRTFERH FNEERHIYHL 
       460        470        480        490        500
RCLGIEPSSV FKGITKIKEA QELWKNMQGQ SQLTSIAAVP PKPNPSQLKV 
       510        520        530
PTELELEEED EEGNVMSKKV YDELKKQGLV
Length:530
Mass (Da):63,029
Last modified:February 1, 1991 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9020885E620488F3
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X53466 Genomic DNA Translation: CAA37560.1
Z71781 Genomic DNA Translation: CAA96459.1
Z74078 Genomic DNA Translation: CAA98589.1
BK006938 Genomic DNA Translation: DAA11822.1

Protein sequence database of the Protein Information Resource

More...PIRi		S12320

NCBI Reference Sequences

More...RefSeqi		NP_010254.1, NM_001180089.1

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		YDL030W_mRNA; YDL030W; YDL030W

Database of genes from NCBI RefSeq genomes

More...GeneIDi		851531

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		sce:YDL030W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53466 Genomic DNA Translation: CAA37560.1
Z71781 Genomic DNA Translation: CAA96459.1
Z74078 Genomic DNA Translation: CAA98589.1
BK006938 Genomic DNA Translation: DAA11822.1
PIRiS12320
RefSeqiNP_010254.1, NM_001180089.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4DGWX-ray3.11A1-389[»]
5NRLelectron microscopy7.20T1-530[»]
5ZWMelectron microscopy3.40u1-530[»]
5ZWOelectron microscopy3.90u1-530[»]
6G90electron microscopy4.00T1-530[»]
7OQBelectron microscopy9.00T1-530[»]
7OQEelectron microscopy5.90T1-530[»]
SMRiP19736
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi32026, 518 interactors
ComplexPortaliCPX-1648, SF3A complex
CPX-1651, PRP19-associated complex
CPX-26, U2 small nuclear ribonucleoprotein complex
DIPiDIP-651N
IntActiP19736, 23 interactors
MINTiP19736
STRINGi4932.YDL030W

Proteomic databases

MaxQBiP19736
PaxDbiP19736
PRIDEiP19736

Genome annotation databases

EnsemblFungiiYDL030W_mRNA; YDL030W; YDL030W
GeneIDi851531
KEGGisce:YDL030W

Organism-specific databases

SGDiS000002188, PRP9
VEuPathDBiFungiDB:YDL030W

Phylogenomic databases

eggNOGiKOG2636, Eukaryota
GeneTreeiENSGT00530000063402
HOGENOMiCLU_027160_1_1_1
InParanoidiP19736
OMAiRYPNEQA

Miscellaneous databases

Protein Ontology

More...PROi		PR:P19736
RNActiP19736, protein

Family and domain databases

InterProiView protein in InterPro
IPR000690, Matrin/U1-C_Znf_C2H2
IPR003604, Matrin/U1-like-C_Znf_C2H2
IPR031590, PRP9_N
IPR031776, SF3A3
IPR031774, SF3A3_dom
IPR024598, SF3a60/Prp9_C
IPR022755, Znf_C2H2_jaz
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PANTHERiPTHR12786:SF2, PTHR12786:SF2, 1 hit
PfamiView protein in Pfam
PF16958, PRP9_N, 1 hit
PF16837, SF3A3, 1 hit
PF11931, SF3a60_Prp9_C, 1 hit
PF12171, zf-C2H2_jaz, 1 hit
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 2 hits
SM00451, ZnF_U1, 2 hits
SUPFAMiSSF57667, SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS50171, ZF_MATRIN, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPRP9_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P19736
Secondary accession number(s): D6VRW2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: February 23, 2022
This is version 170 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again