UniProtKB - P19736 (PRP9_YEAST)

BLAST

>sp|P19736|PRP9_YEAST Pre-mRNA-splicing factor PRP9 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=PRP9 PE=1 SV=1
MNLLETRRSLLEEMEIIENAIAERIQRNPELYYHYIQESSKVFPDTKLPRSSLIAENKIY
KFKKVKRKRKQIILQQHEINIFLRDYQEKQQTFNKINRPEETQEDDKDLPNFERKLQQLE
KELKNEDENFELDINSKKDKYALFSSSSDPSRRTNILSDRARDLDLNEIFTRDEQYGEYM
ELEQFHSLWLNVIKRGDCSLLQFLDILELFLDDEKYLLTPPMDRKNDRYMAFLLKLSKYV
ETFFFKSYALLDAAAVENLIKSDFEHSYCRGSLRSEAKGIYCPFCSRWFKTSSVFESHLV
GKIHKKNESKRRNFVYSEYKLHRYLKYLNDEFSRTRSFVERKLAFTANERMAEMDILTQK
YEAPAYDSTEKEGAEQVDGEQRDGQLQEEHLSGKSFDMPLGPDGLPMPYWLYKLHGLDRE
YRCEICSNKVYNGRRTFERHFNEERHIYHLRCLGIEPSSVFKGITKIKEAQELWKNMQGQ
SQLTSIAAVPPKPNPSQLKVPTELELEEEDEEGNVMSKKVYDELKKQGLV

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History
Entry version 153 (07 Nov 2018)
Sequence version 1 (01 Feb 1991)
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Protein

Pre-mRNA-splicing factor PRP9

Gene

PRP9

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

mRNA splicing factors, PRP9, PRP11, and PRP21, are necessary for binding of the U2 snRNP to the pre-mRNA in an early step of spliceosome assembly.

Miscellaneous

Present with 3920 molecules/cell in log phase SD medium.1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	280 – 310	Matrin-type 1PROSITE-ProRule annotationAdd BLAST		31
Zinc fingerⁱ	421 – 452	Matrin-type 2PROSITE-ProRule annotationAdd BLAST		32

GO - Molecular functionⁱ

RNA binding
Source: SGD
Inferred from direct assayⁱ
- 8065365
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

mRNA 5'-splice site recognition
Source: GO_Central
Inferred from mutant phenotypeⁱ
- 2147224
mRNA splicing, via spliceosome
Source: SGD
Inferred from direct assayⁱ
- 8969185

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	mRNA processing, mRNA splicing
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-29456-MONOMER

BioCycⁱ

YEAST:G3O-29456-MONOMER

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Pre-mRNA-splicing factor PRP9
Gene namesⁱ	Name:PRP9 Ordered Locus Names:YDL030W ORF Names:D2773
Organismⁱ	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifierⁱ	559292 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae
Proteomesⁱ	UP000002311 Componentⁱ: Chromosome IV

Organism-specific databases

Saccharomyces Genome Database More...SGDⁱ	S000002188 PRP9

SGDⁱ

S000002188 PRP9

Keywords - Cellular componentⁱ

Nucleus, Spliceosome

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000174321	1 – 530	Pre-mRNA-splicing factor PRP9Add BLAST		530

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P19736
PaxDbⁱ	P19736
PRIDEⁱ	P19736

Interactionⁱ

Subunit structureⁱ

Belongs to the CWC complex (or CEF1-associated complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome composed of the U2, U5 and U6 snRNAs and at least BUD13, BUD31, BRR2, CDC40, CEF1, CLF1, CUS1, CWC2, CWC15, CWC21, CWC22, CWC23, CWC24, CWC25, CWC27, ECM2, HSH155, IST3, ISY1, LEA1, MSL1, NTC20, PRP8, PRP9, PRP11, PRP19, PRP21, PRP22, PRP45, PRP46, SLU7, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, SNT309, SNU114, SPP2, SYF1, SYF2, RSE1 and YJU2.1 Publication

Protein-protein interaction databases

BioGridⁱ	32026, 502 interactors
ComplexPortalⁱ	CPX-1648 SF3A complex CPX-1651 PRP19-associated complex CPX-26 U2 snRNP
Database of interacting proteins More...DIPⁱ	DIP-651N
IntActⁱ	P19736, 23 interactors
Molecular INTeraction database More...MINTⁱ	P19736
STRINGⁱ	4932.YDL030W

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	3 – 27	Combined sources	25
Helixⁱ	30 – 40	Combined sources	11
Helixⁱ	51 – 56	Combined sources	6
Beta strandⁱ	58 – 61	Combined sources	4
Helixⁱ	69 – 96	Combined sources	28
Helixⁱ	113 – 122	Combined sources	10
Helixⁱ	137 – 143	Combined sources	7
Beta strandⁱ	149 – 154	Combined sources	6
Helixⁱ	159 – 161	Combined sources	3
Helixⁱ	166 – 168	Combined sources	3
Turnⁱ	172 – 178	Combined sources	7
Helixⁱ	183 – 193	Combined sources	11
Helixⁱ	200 – 208	Combined sources	9
Helixⁱ	209 – 211	Combined sources	3
Beta strandⁱ	212 – 214	Combined sources	3
Helixⁱ	215 – 218	Combined sources	4
Helixⁱ	227 – 247	Combined sources	21
Helixⁱ	253 – 266	Combined sources	14
Helixⁱ	268 – 270	Combined sources	3
Turnⁱ	276 – 278	Combined sources	3
Turnⁱ	283 – 286	Combined sources	4
Beta strandⁱ	289 – 291	Combined sources	3
Helixⁱ	292 – 296	Combined sources	5
Beta strandⁱ	299 – 301	Combined sources	3
Helixⁱ	302 – 310	Combined sources	9
Helixⁱ	312 – 327	Combined sources	16
Helixⁱ	329 – 343	Combined sources	15
Helixⁱ	347 – 361	Combined sources	15

Show more details

3D structure databases

ProteinModelPortalⁱ	P19736
SMRⁱ	P19736
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the SF3A3 family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	280 – 310	Matrin-type 1PROSITE-ProRule annotationAdd BLAST		31
Zinc fingerⁱ	421 – 452	Matrin-type 2PROSITE-ProRule annotationAdd BLAST		32

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063402
HOGENOMⁱ	HOG000160935
InParanoidⁱ	P19736
KEGG Orthology (KO) More...KOⁱ	K12827
OMAⁱ	EICGNYV
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C4TX9

Family and domain databases

InterProⁱ	View protein in InterPro IPR024598 DUF3449 IPR000690 Matrin/U1-C_Znf_C2H2 IPR003604 Matrin/U1-like-C_Znf_C2H2 IPR031590 PRP9_N IPR031776 SF3A3 IPR031774 SF3A3_dom IPR022755 Znf_C2H2_jaz IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
PANTHERⁱ	PTHR12786:SF2 PTHR12786:SF2, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF11931 DUF3449, 1 hit PF16958 PRP9_N, 1 hit PF16837 SF3A3, 1 hit PF12171 zf-C2H2_jaz, 1 hit
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 2 hits SM00451 ZnF_U1, 2 hits
SUPFAMⁱ	SSF57667 SSF57667, 1 hit
PROSITEⁱ	View protein in PROSITE PS50171 ZF_MATRIN, 2 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

P19736-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MNLLETRRSL LEEMEIIENA IAERIQRNPE LYYHYIQESS KVFPDTKLPR 
        60         70         80         90        100
SSLIAENKIY KFKKVKRKRK QIILQQHEIN IFLRDYQEKQ QTFNKINRPE 
       110        120        130        140        150
ETQEDDKDLP NFERKLQQLE KELKNEDENF ELDINSKKDK YALFSSSSDP 
       160        170        180        190        200
SRRTNILSDR ARDLDLNEIF TRDEQYGEYM ELEQFHSLWL NVIKRGDCSL 
       210        220        230        240        250
LQFLDILELF LDDEKYLLTP PMDRKNDRYM AFLLKLSKYV ETFFFKSYAL 
       260        270        280        290        300
LDAAAVENLI KSDFEHSYCR GSLRSEAKGI YCPFCSRWFK TSSVFESHLV 
       310        320        330        340        350
GKIHKKNESK RRNFVYSEYK LHRYLKYLND EFSRTRSFVE RKLAFTANER 
       360        370        380        390        400
MAEMDILTQK YEAPAYDSTE KEGAEQVDGE QRDGQLQEEH LSGKSFDMPL 
       410        420        430        440        450
GPDGLPMPYW LYKLHGLDRE YRCEICSNKV YNGRRTFERH FNEERHIYHL 
       460        470        480        490        500
RCLGIEPSSV FKGITKIKEA QELWKNMQGQ SQLTSIAAVP PKPNPSQLKV 
       510        520        530
PTELELEEED EEGNVMSKKV YDELKKQGLV

Length:530

Mass (Da):63,029

Last modified:February 1, 1991 - v1

Checksum:ⁱ9020885E620488F3

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X53466 Genomic DNA Translation: CAA37560.1 Z71781 Genomic DNA Translation: CAA96459.1 Z74078 Genomic DNA Translation: CAA98589.1 BK006938 Genomic DNA Translation: DAA11822.1
PIRⁱ	S12320
NCBI Reference Sequences More...RefSeqⁱ	NP_010254.1, NM_001180089.1

Genome annotation databases

EnsemblFungiⁱ	YDL030W; YDL030W; YDL030W
GeneIDⁱ	851531
KEGGⁱ	sce:YDL030W

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P19736	Prp9p		YEASC		530	UniRef100_P19736

Protein	Similar proteins		Species	Score	Length	Source
P19736	Prp9p		YEASC		530	UniRef90_P19736
Pre-mRNA splicing factor PRP9		YEAS1		530
Prp9p		SACCK		530
Prp9p		YEASV		530
YDL030Wp-like protein		YEAS6		530
+8

Protein	Similar proteins		Species	Score	Length	Source
P19736	Prp9p		YEASC		530	UniRef50_P19736
K7_Prp9p		YEASK		530
Prp9p		YEASL		530
Prp9p		YEASO		530
Pre-mRNA splicing factor PRP9		YEAS1		530
+9

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X53466 Genomic DNA Translation: CAA37560.1 Z71781 Genomic DNA Translation: CAA96459.1 Z74078 Genomic DNA Translation: CAA98589.1 BK006938 Genomic DNA Translation: DAA11822.1
PIRⁱ	S12320
RefSeqⁱ	NP_010254.1, NM_001180089.1

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4DGW	X-ray	3.11	A	1-389	[»]
	5NRL	electron microscopy	7.20	T	1-530	[»]
	5ZWM	electron microscopy	3.40	u	1-530	[»]
	5ZWO	electron microscopy	3.90	u	1-530	[»]
	6G90	electron microscopy	4.00	T	1-530	[»]
ProteinModelPortalⁱ	P19736
SMRⁱ	P19736
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	32026, 502 interactors
ComplexPortalⁱ	CPX-1648 SF3A complex CPX-1651 PRP19-associated complex CPX-26 U2 snRNP
DIPⁱ	DIP-651N
IntActⁱ	P19736, 23 interactors
MINTⁱ	P19736
STRINGⁱ	4932.YDL030W

Proteomic databases

MaxQBⁱ	P19736
PaxDbⁱ	P19736
PRIDEⁱ	P19736

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblFungiⁱ	YDL030W; YDL030W; YDL030W
GeneIDⁱ	851531
KEGGⁱ	sce:YDL030W

Organism-specific databases

SGDⁱ	S000002188 PRP9

Phylogenomic databases

GeneTreeⁱ	ENSGT00530000063402
HOGENOMⁱ	HOG000160935
InParanoidⁱ	P19736
KOⁱ	K12827
OMAⁱ	EICGNYV
OrthoDBⁱ	EOG092C4TX9

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-29456-MONOMER

BioCycⁱ

YEAST:G3O-29456-MONOMER

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P19736

PROⁱ

PR:P19736

Family and domain databases

InterProⁱ	View protein in InterPro IPR024598 DUF3449 IPR000690 Matrin/U1-C_Znf_C2H2 IPR003604 Matrin/U1-like-C_Znf_C2H2 IPR031590 PRP9_N IPR031776 SF3A3 IPR031774 SF3A3_dom IPR022755 Znf_C2H2_jaz IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
PANTHERⁱ	PTHR12786:SF2 PTHR12786:SF2, 1 hit
Pfamⁱ	View protein in Pfam PF11931 DUF3449, 1 hit PF16958 PRP9_N, 1 hit PF16837 SF3A3, 1 hit PF12171 zf-C2H2_jaz, 1 hit
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 2 hits SM00451 ZnF_U1, 2 hits
SUPFAMⁱ	SSF57667 SSF57667, 1 hit
PROSITEⁱ	View protein in PROSITE PS50171 ZF_MATRIN, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PRP9_YEAST
Accessionⁱ	P19736Primary (citable) accession number: P19736 Secondary accession number(s): D6VRW2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
	Last sequence update:	February 1, 1991
	Last modified:	November 7, 2018
	This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
Yeast chromosome IV
Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

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UniProtKB - P19736 (PRP9_YEAST)

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Pre-mRNA-splicing factor PRP9

PRP9

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ