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Protein

Serum amyloid A protein

Gene

SAA1

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Major acute phase reactant. Apolipoprotein of the HDL complex.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAcute phase

Names & Taxonomyi

Protein namesi
Recommended name:
Serum amyloid A protein
Short name:
SAA
Cleaved into the following chain:
Alternative name(s):
Amyloid fibril protein AA
Gene namesi
Name:SAA1
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 21

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Amyloid, HDL, Secreted

Pathology & Biotechi

Involvement in diseasei

Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 181 PublicationAdd BLAST18
ChainiPRO_000003157019 – 129Serum amyloid A proteinAdd BLAST111
ChainiPRO_000003157119 – 111Amyloid protein AAdd BLAST93
PropeptideiPRO_0000031572112 – 129Often cleaved during amyloidogenesisAdd BLAST18

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19Pyrrolidone carboxylic acidBy similarity1

Post-translational modificationi

This protein is the precursor of amyloid protein A, which is formed by the removal of residues from the C-terminal end.

Keywords - PTMi

Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP19708
PRIDEiP19708

Expressioni

Tissue specificityi

Expressed by the liver; secreted in plasma.

Inductioni

Upon cytokine stimulation.

Gene expression databases

BgeeiENSCAFG00000015205

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000013464

Structurei

3D structure databases

SMRiP19708
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SAA family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXU4 Eukaryota
ENOG410YSBK LUCA
GeneTreeiENSGT00390000004737
HOGENOMiHOG000126881
HOVERGENiHBG016327
InParanoidiP19708
KOiK17310
OMAiRIFASSH
OrthoDBiEOG091G17YH
TreeFamiTF332544

Family and domain databases

InterProiView protein in InterPro
IPR000096 Serum_amyloid_A
PfamiView protein in Pfam
PF00277 SAA, 1 hit
PIRSFiPIRSF002472 Serum_amyloid_A, 1 hit
PRINTSiPR00306 SERUMAMYLOID
SMARTiView protein in SMART
SM00197 SAA, 1 hit
PROSITEiView protein in PROSITE
PS00992 SAA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19708-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLFPGLLFC SLVLGVSGQW YSFVSEAAQG AWDMWRAYSD MREANYKNSD
60 70 80 90 100
KYFHARGNYD AAQRGPGGAW AAKVISDARE NSQRITDLLR FGDSGHGAED
110 120
SKADQAANEW GRSGKDPNHF RPAGLPDKY
Length:129
Mass (Da):14,339
Last modified:June 1, 1994 - v2
Checksum:i91B21ACBA1F998C9
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti25S → G. 1
Natural varianti35W → L. 1
Natural varianti88 – 90LLR → RLK. 3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59171 mRNA Translation: AAA62762.1
M59172 mRNA Translation: AAA62763.1
M59173 mRNA Translation: AAA62764.1
M59174 mRNA Translation: AAA62765.1
M59175 mRNA Translation: AAA51457.1
PIRiA38645 YLDGA
B38645
C38645
D38645
E38645
RefSeqiNP_001003050.1, NM_001003050.1
NP_001300801.1, NM_001313872.1
XP_005633787.1, XM_005633730.2
UniGeneiCfa.27722
Cfa.47865

Genome annotation databases

EnsembliENSCAFT00000014555; ENSCAFP00000013464; ENSCAFG00000015205
GeneIDi403585
751814
KEGGicfa:403585
cfa:751814

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSAA_CANLF
AccessioniPrimary (citable) accession number: P19708
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: June 1, 1994
Last modified: May 23, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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