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Protein

Guanylate cyclase soluble subunit alpha-1

Gene

Gucy1a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.

Catalytic activityi

GTP = 3',5'-cyclic GMP + diphosphate.By similarity

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Has also activity with Mn2+ (in vitro).By similarity

Enzyme regulationi

Activated by nitric oxide in the presence of magnesium or manganese ions.By similarity

GO - Molecular functioni

  • GTP binding Source: RGD
  • guanylate cyclase activity Source: RGD
  • heme binding Source: InterPro
  • ion binding Source: RGD
  • protein heterodimerization activity Source: RGD

GO - Biological processi

  • cGMP biosynthetic process Source: RGD
  • nitric oxide mediated signal transduction Source: RGD
  • response to herbicide Source: RGD
  • response to organic cyclic compound Source: RGD

Keywordsi

Molecular functionLyase
Biological processcGMP biosynthesis
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi4.6.1.2 5301

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate cyclase soluble subunit alpha-1 (EC:4.6.1.2By similarity)
Short name:
GCS-alpha-1
Alternative name(s):
Guanylate cyclase soluble subunit alpha-3
Short name:
GCS-alpha-3
Soluble guanylate cyclase large subunit
Gene namesi
Name:Gucy1a1
Synonyms:Guc1a1, Gucy1a3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi68436 Gucy1a3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi1288

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000741121 – 690Guanylate cyclase soluble subunit alpha-1Add BLAST690

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei266PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP19686
PRIDEiP19686

PTM databases

iPTMnetiP19686

Interactioni

Subunit structurei

The active enzyme is formed by a heterodimer of an alpha and a beta subunit. Heterodimer with GUCY1B1.By similarity

GO - Molecular functioni

  • protein heterodimerization activity Source: RGD

Protein-protein interaction databases

IntActiP19686, 2 interactors
STRINGi10116.ENSRNOP00000017190

Structurei

3D structure databases

ProteinModelPortaliP19686
SMRiP19686
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini480 – 607Guanylate cyclasePROSITE-ProRule annotationAdd BLAST128

Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4171 Eukaryota
COG2114 LUCA
HOVERGENiHBG106603
InParanoidiP19686

Family and domain databases

Gene3Di3.30.70.1230, 1 hit
3.90.1520.10, 1 hit
InterProiView protein in InterPro
IPR001054 A/G_cyclase
IPR018297 A/G_cyclase_CS
IPR038158 H-NOX_domain_sf
IPR011645 HNOB_dom_associated
IPR024096 NO_sig/Golgi_transp_ligand-bd
IPR029787 Nucleotide_cyclase
PfamiView protein in Pfam
PF00211 Guanylate_cyc, 1 hit
PF07701 HNOBA, 1 hit
SMARTiView protein in SMART
SM00044 CYCc, 1 hit
SUPFAMiSSF111126 SSF111126, 1 hit
SSF55073 SSF55073, 1 hit
PROSITEiView protein in PROSITE
PS00452 GUANYLATE_CYCLASE_1, 1 hit
PS50125 GUANYLATE_CYCLASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

P19686-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFCRKFKDLK ITGECPFSLL APGQVPTEPI EEVAGVSESC QATLPTCQEF
60 70 80 90 100
AENAEGSHPQ RKTSRNRVYL HTLAESIGKL IFPEFERLNL ALQRTLAKHK
110 120 130 140 150
IKENRNSSEK EDLERIIAEE AIAAGVPVEV LKDSLGEELF KICYEEDEHI
160 170 180 190 200
LGVVGGTLKD FLNSFSTLLK QSSHCQEAER RGRLEDASIL CLDKDQDFLN
210 220 230 240 250
VYYFFPKRTT ALLLPGIIKA AARILYESHV EVSLMPPCFR SECTEFVNQP
260 270 280 290 300
YLLYSVHVKS TKPSLSPGKP QSSLVIPTSL FCKTFPFHFM LDRDLAILQL
310 320 330 340 350
GNGIRRLVNK RDFQGKPNFE EFFEILTPKI NQTFSGIMTM LNMQFVIRVR
360 370 380 390 400
RWDNLVKKSS RVMDLKGQMI YIVESSAILF LGSPCVDRLE DFTGRGLYLS
410 420 430 440 450
DIPIHNALRD VVLIGEQARA QDGLKKRLGK LKATLEHAHQ ALEEEKKKTV
460 470 480 490 500
DLLCSIFPSE VAQQLWQGQI VQAKKFNEVT MLFSDIVGFT AICSQCSPLQ
510 520 530 540 550
VITMLNALYT RFDQQCGELD VYKVETIGDA YCVAGGLHRE SDTHAVQIAL
560 570 580 590 600
MALKMMELSN EVMSPHGEPI KMRIGLHSGS VFAGVVGVKM PRYCLFGNNV
610 620 630 640 650
TLANKFESCS VPRKINVSPT TYRLLKDCPG FVFTPRSREE LPPNFPSDIP
660 670 680 690
GICHFLDAYQ HQGPNSKPWF QQKDAEDGNA NFLGKASGVD
Length:690
Mass (Da):77,567
Last modified:February 1, 1991 - v1
Checksum:iE4819B2CA4F86401
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57405 mRNA Translation: AAA41206.1
U60835 mRNA Translation: AAB17953.1
PIRiA38297 OYRTA1
UniGeneiRn.1974

Genome annotation databases

UCSCiRGD:68436 rat

Similar proteinsi

Entry informationi

Entry nameiGCYA1_RAT
AccessioniPrimary (citable) accession number: P19686
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: July 18, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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