PMA2

Functionⁱ

The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H⁺-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.

Miscellaneous

There are two plasma membrane ATPases in yeast. This is the minor isoform.

Catalytic activityⁱ

ATP + H₂O + H⁺(In) = ADP + phosphate + H⁺(Out).

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	407	4-aspartylphosphate intermediateBy similarity	1
Metal bindingⁱ	663	MagnesiumBy similarity	1
Metal bindingⁱ	667	MagnesiumBy similarity	1

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW
proton-exporting ATPase activity, phosphorylative mechanism
Source: SGD
Inferred from direct assayⁱ
- 8396147

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

proton export across plasma membrane Source: InterPro
proton transmembrane transport
Source: SGD
Inferred from direct assayⁱ
- 8396147
regulation of intracellular pH
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of pH
Source: SGD
Inferred from expression patternⁱ
- 8929277

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Translocase
Biological process	Hydrogen ion transport, Ion transport, Transport
Ligand	ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-33950-MONOMER

BioCycⁱ

YEAST:G3O-33950-MONOMER

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Plasma membrane ATPase 2 (EC:7.1.2.1) Alternative name(s): Proton pump 2
Gene namesⁱ	Name:PMA2 Ordered Locus Names:YPL036W
Organismⁱ	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifierⁱ	559292 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae
Proteomesⁱ	UP000002311 Componentⁱ: Chromosome XVI

Organism-specific databases

Saccharomyces Genome Database More...SGDⁱ	S000005957 PMA2

SGDⁱ

S000005957 PMA2

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 144	CytoplasmicSequence analysisAdd BLAST	144
Transmembraneⁱ	145 – 165	Helical; Name=1Sequence analysisAdd BLAST	21
Topological domainⁱ	166 – 169	ExtracellularSequence analysis	4
Transmembraneⁱ	170 – 189	Helical; Name=2Sequence analysisAdd BLAST	20
Topological domainⁱ	190 – 320	CytoplasmicSequence analysisAdd BLAST	131
Transmembraneⁱ	321 – 342	Helical; Name=3Sequence analysisAdd BLAST	22
Topological domainⁱ	343 – 353	ExtracellularSequence analysisAdd BLAST	11
Transmembraneⁱ	354 – 376	Helical; Name=4Sequence analysisAdd BLAST	23
Topological domainⁱ	377 – 748	CytoplasmicSequence analysisAdd BLAST	372
Transmembraneⁱ	749 – 767	Helical; Name=5Sequence analysisAdd BLAST	19
Topological domainⁱ	768 – 783	ExtracellularSequence analysisAdd BLAST	16
Transmembraneⁱ	784 – 803	Helical; Name=6Sequence analysisAdd BLAST	20
Topological domainⁱ	804 – 853	CytoplasmicSequence analysisAdd BLAST	50
Transmembraneⁱ	854 – 874	Helical; Name=7Sequence analysisAdd BLAST	21
Topological domainⁱ	875 – 886	ExtracellularSequence analysisAdd BLAST	12
Transmembraneⁱ	887 – 903	Helical; Name=8Sequence analysisAdd BLAST	17
Topological domainⁱ	904 – 947	CytoplasmicSequence analysisAdd BLAST	44

Keywords - Cellular componentⁱ

Cell membrane, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000046272	1 – 947	Plasma membrane ATPase 2Add BLAST		947

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P19657
PaxDbⁱ	P19657
PRIDEⁱ	P19657

PTM databases

iPTMnetⁱ	P19657

iPTMnetⁱ

P19657

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	36143, 374 interactors
Database of interacting proteins More...DIPⁱ	DIP-4036N
IntActⁱ	P19657, 4 interactors
Molecular INTeraction database More...MINTⁱ	P19657
STRINGⁱ	4932.YPL036W

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P19657
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	33 – 47	Poly-SerAdd BLAST		15
Compositional biasⁱ	62 – 91	Asp/Glu-rich (acidic)Add BLAST		30

Sequence similaritiesⁱ

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144699
HOGENOMⁱ	HOG000160005
InParanoidⁱ	P19657
KEGG Orthology (KO) More...KOⁱ	K01535
OMAⁱ	HPGDGIY
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C0HLD

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd02076 P-type_ATPase_H, 1 hit
Gene3Dⁱ	3.40.1110.10, 1 hit 3.40.50.1000, 1 hit
InterProⁱ	View protein in InterPro IPR004014 ATPase_P-typ_cation-transptr_N IPR023299 ATPase_P-typ_cyto_dom_N IPR018303 ATPase_P-typ_P_site IPR023298 ATPase_P-typ_TM_dom_sf IPR008250 ATPase_P-typ_transduc_dom_A_sf IPR036412 HAD-like_sf IPR023214 HAD_sf IPR006534 P-type_ATPase_IIIA IPR001757 P_typ_ATPase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00690 Cation_ATPase_N, 1 hit
PRINTSⁱ	PR00120 HATPASE
SMARTⁱ	View protein in SMART SM00831 Cation_ATPase_N, 1 hit
SUPFAMⁱ	SSF56784 SSF56784, 1 hit SSF81653 SSF81653, 1 hit SSF81665 SSF81665, 1 hit
TIGRFAMsⁱ	TIGR01647 ATPase-IIIA_H, 1 hit TIGR01494 ATPase_P-type, 3 hits
PROSITEⁱ	View protein in PROSITE PS00154 ATPASE_E1_E2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P19657-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSSTEAKQYK EKPSKEYLHA SDGDDPANNS AASSSSSSST STSASSSAAA 
        60         70         80         90        100
VPRKAAAASA ADDSDSDEDI DQLIDELQSN YGEGDESGEE EVRTDGVHAG 
       110        120        130        140        150
QRVVPEKDLS TDPAYGLTSD EVARRRKKYG LNQMAEENES LIVKFLMFFV 
       160        170        180        190        200
GPIQFVMEAA AILAAGLSDW VDVGVICALL LLNASVGFIQ EFQAGSIVDE 
       210        220        230        240        250
LKKTLANTAT VIRDGQLIEI PANEVVPGEI LQLESGTIAP ADGRIVTEDC 
       260        270        280        290        300
FLQIDQSAIT GESLAAEKHY GDEVFSSSTV KTGEAFMVVT ATGDNTFVGR 
       310        320        330        340        350
AAALVGQASG VEGHFTEVLN GIGIILLVLV IATLLLVWTA CFYRTVGIVS 
       360        370        380        390        400
ILRYTLGITI IGVPVGLPAV VTTTMAVGAA YLAKKQAIVQ KLSAIESLAG 
       410        420        430        440        450
VEILCSDKTG TLTKNKLSLH EPYTVEGVSP DDLMLTACLA ASRKKKGLDA 
       460        470        480        490        500
IDKAFLKSLI EYPKAKDALT KYKVLEFHPF DPVSKKVTAV VESPEGERIV 
       510        520        530        540        550
CVKGAPLFVL KTVEEDHPIP EDVHENYENK VAELASRGFR ALGVARKRGE 
       560        570        580        590        600
GHWEILGVMP CMDPPRDDTA QTINEARNLG LRIKMLTGDA VGIAKETCRQ 
       610        620        630        640        650
LGLGTNIYNA ERLGLGGGGD MPGSELADFV ENADGFAEVF PQHKYRVVEI 
       660        670        680        690        700
LQNRGYLVAM TGDGVNDAPS LKKADTGIAV EGATDAARSA ADIVFLAPGL 
       710        720        730        740        750
SAIIDALKTS RQIFHRMYSY VVYRIALSLH LEIFLGLWIA ILNNSLDINL 
       760        770        780        790        800
IVFIAIFADV ATLTIAYDNA PYAPEPVKWN LPRLWGMSII LGIVLAIGSW 
       810        820        830        840        850
ITLTTMFLPN GGIIQNFGAM NGVMFLQISL TENWLIFVTR AAGPFWSSIP 
       860        870        880        890        900
SWQLAGAVFA VDIIATMFTL FGWWSENWTD IVSVVRVWIW SIGIFCVLGG 
       910        920        930        940 
FYYIMSTSQA FDRLMNGKSL KEKKSTRSVE DFMAAMQRVS TQHEKSS

Length:947

Mass (Da):102,172

Last modified:October 1, 1996 - v3

Checksum:ⁱ24CF0D3EAFD1E9D5

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	944	E → D in AAA83387 (PubMed:2904437).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J04421 Genomic DNA Translation: AAA83387.1 U44030 Genomic DNA Translation: AAB68184.1 BK006949 Genomic DNA Translation: DAA11394.1
PIRⁱ	S62039 PXBY2P
NCBI Reference Sequences More...RefSeqⁱ	NP_015289.1, NM_001183850.1

Genome annotation databases

EnsemblFungiⁱ	YPL036W; YPL036W; YPL036W
GeneIDⁱ	856071
KEGGⁱ	sce:YPL036W

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P19657	Plasma membrane ATPase		YEASC		947	UniRef100_P19657

Protein	Similar proteins		Species	Score	Length	Source
P19657	Plasma membrane ATPase		YEASC		947	UniRef90_P19657
Plasma membrane ATPase		YEASB		947
Plasma membrane ATPase		YEAS1		947
Plasma membrane ATPase		Saccharomyces sp. 'boulardii'		947
Plasma membrane ATPase (Fragment)		YEAS6		632
+9

Protein	Similar proteins		Species	Score	Length	Source
P19657	Plasma membrane ATPase		YEASC		947	UniRef50_P19657
Plasma membrane ATPase		YEAS2		947
Plasma membrane ATPase		YEAS7		947
Plasma membrane ATPase		SACCK		947
Plasma membrane ATPase		YEASB		947
+116

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J04421 Genomic DNA Translation: AAA83387.1 U44030 Genomic DNA Translation: AAB68184.1 BK006949 Genomic DNA Translation: DAA11394.1
PIRⁱ	S62039 PXBY2P
RefSeqⁱ	NP_015289.1, NM_001183850.1

3D structure databases

ProteinModelPortalⁱ	P19657
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	36143, 374 interactors
DIPⁱ	DIP-4036N
IntActⁱ	P19657, 4 interactors
MINTⁱ	P19657
STRINGⁱ	4932.YPL036W

PTM databases

iPTMnetⁱ	P19657

iPTMnetⁱ

P19657

Proteomic databases

MaxQBⁱ	P19657
PaxDbⁱ	P19657
PRIDEⁱ	P19657

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblFungiⁱ	YPL036W; YPL036W; YPL036W
GeneIDⁱ	856071
KEGGⁱ	sce:YPL036W

Organism-specific databases

SGDⁱ	S000005957 PMA2

Phylogenomic databases

GeneTreeⁱ	ENSGT00910000144699
HOGENOMⁱ	HOG000160005
InParanoidⁱ	P19657
KOⁱ	K01535
OMAⁱ	HPGDGIY
OrthoDBⁱ	EOG092C0HLD

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-33950-MONOMER

BioCycⁱ

YEAST:G3O-33950-MONOMER

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P19657

PROⁱ

PR:P19657

Family and domain databases

CDDⁱ	cd02076 P-type_ATPase_H, 1 hit
Gene3Dⁱ	3.40.1110.10, 1 hit 3.40.50.1000, 1 hit
InterProⁱ	View protein in InterPro IPR004014 ATPase_P-typ_cation-transptr_N IPR023299 ATPase_P-typ_cyto_dom_N IPR018303 ATPase_P-typ_P_site IPR023298 ATPase_P-typ_TM_dom_sf IPR008250 ATPase_P-typ_transduc_dom_A_sf IPR036412 HAD-like_sf IPR023214 HAD_sf IPR006534 P-type_ATPase_IIIA IPR001757 P_typ_ATPase
Pfamⁱ	View protein in Pfam PF00690 Cation_ATPase_N, 1 hit
PRINTSⁱ	PR00120 HATPASE
SMARTⁱ	View protein in SMART SM00831 Cation_ATPase_N, 1 hit
SUPFAMⁱ	SSF56784 SSF56784, 1 hit SSF81653 SSF81653, 1 hit SSF81665 SSF81665, 1 hit
TIGRFAMsⁱ	TIGR01647 ATPase-IIIA_H, 1 hit TIGR01494 ATPase_P-type, 3 hits
PROSITEⁱ	View protein in PROSITE PS00154 ATPASE_E1_E2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PMA2_YEAST
Accessionⁱ	P19657Primary (citable) accession number: P19657 Secondary accession number(s): D6W3X8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
	Last sequence update:	October 1, 1996
	Last modified:	November 7, 2018
	This is version 177 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Yeast chromosome XVI
Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names
Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P19657 (PMA2_YEAST)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Plasma membrane ATPase 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ