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UniProtKB - P19652 (A1AG2_HUMAN)
Protein
Alpha-1-acid glycoprotein 2
Gene
ORM2
Organism
Homo sapiens (Human)
Status
Functioni
Functions as transport protein in the blood stream. Binds various hydrophobic ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability. Appears to function in modulating the activity of the immune system during the acute-phase reaction.
1 PublicationGO - Biological processi
- acute-phase response Source: ProtInc
- positive regulation of interleukin-1 beta production Source: UniProtKB
- positive regulation of interleukin-1 production Source: UniProtKB
- positive regulation of tumor necrosis factor production Source: UniProtKB
- regulation of immune system process Source: InterPro
Keywordsi
Biological process | Acute phase, Transport |
Enzyme and pathway databases
PathwayCommonsi | P19652 |
Reactomei | R-HSA-114608, Platelet degranulation R-HSA-6798695, Neutrophil degranulation |
SignaLinki | P19652 |
Names & Taxonomyi
Protein namesi | Recommended name: Alpha-1-acid glycoprotein 2Short name: AGP 2 Alternative name(s): Orosomucoid-2 Short name: OMD 2 |
Gene namesi | Name:ORM2 Synonyms:AGP2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:8499, ORM2 |
MIMi | 138610, gene |
neXtProti | NX_P19652 |
VEuPathDBi | HostDB:ENSG00000228278 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- blood microparticle Source: UniProtKB
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
- extracellular space Source: UniProtKB
Lysosome
- azurophil granule lumen Source: Reactome
Other locations
- collagen-containing extracellular matrix Source: BHF-UCL
- platelet alpha granule lumen Source: Reactome
- specific granule lumen Source: Reactome
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 5005 |
OpenTargetsi | ENSG00000228278 |
PharmGKBi | PA32818 |
Miscellaneous databases
Pharosi | P19652, Tbio |
Chemistry databases
ChEMBLi | CHEMBL5958 |
DrugBanki | DB12001, Abemaciclib DB11703, Acalabrutinib DB00404, Alprazolam DB00278, Argatroban DB06216, Asenapine DB01072, Atazanavir DB00289, Atomoxetine DB01086, Benzocaine DB00608, Chloroquine DB00477, Chlorpromazine DB00907, Cocaine DB00280, Disopyramide DB00476, Duloxetine DB12466, Favipiravir DB00813, Fentanyl DB00950, Fexofenadine DB01195, Flecainide DB00986, Glycopyrronium DB01611, Hydroxychloroquine DB09053, Ibrutinib DB09262, Imidafenacin DB00458, Imipramine DB00808, Indapamide DB00332, Ipratropium DB01029, Irbesartan DB11757, Istradefylline DB00598, Labetalol DB00281, Lidocaine DB08932, Macitentan DB01203, Nadolol DB11828, Neratinib DB01115, Nifedipine DB00497, Oxycodone DB14582, Patisiran DB00960, Pindolol DB00409, Remoxipride DB01045, Rifampicin DB14840, Ripretinib DB00938, Salmeterol DB11689, Selumetinib DB01591, Solifenacin DB00421, Spironolactone DB00857, Terbinafine DB01041, Thalidomide DB00512, Vancomycin DB11641, Vinflunine DB01593, Zinc DB14487, Zinc acetate DB14533, Zinc chloride DB14548, Zinc sulfate, unspecified form |
Genetic variation databases
BioMutai | ORM2 |
DMDMi | 231458 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Add BLAST | 18 | |
ChainiPRO_0000017861 | 19 – 201 | Alpha-1-acid glycoprotein 2Add BLAST | 183 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 19 | Pyrrolidone carboxylic acid1 Publication | 1 | |
Disulfide bondi | 23 ↔ 165 | |||
Glycosylationi | 33 | N-linked (GlcNAc...) (complex) asparagine8 Publications | 1 | |
Glycosylationi | 56 | N-linked (GlcNAc...) asparagine4 Publications | 1 | |
Glycosylationi | 72 | N-linked (GlcNAc...) asparagine3 Publications | 1 | |
Disulfide bondi | 90 ↔ 183 | |||
Glycosylationi | 93 | N-linked (GlcNAc...) asparagine5 Publications | 1 | |
GlycosylationiCAR_000171 | 103 | N-linked (GlcNAc...) asparagine3 Publications | 1 |
Post-translational modificationi
N-glycosylated. N-glycan heterogeneity at Asn-33: Hex5HexNAc4 (minor), Hex6HexNAc5 (major) and dHex1Hex6HexNAc5 (minor).8 Publications
Keywords - PTMi
Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acidProteomic databases
jPOSTi | P19652 |
MassIVEi | P19652 |
MaxQBi | P19652 |
PaxDbi | P19652 |
PeptideAtlasi | P19652 |
PRIDEi | P19652 |
ProteomicsDBi | 53685 |
2D gel databases
DOSAC-COBS-2DPAGEi | P19652 |
SWISS-2DPAGEi | P19652 |
PTM databases
GlyConnecti | 14, 74 N-Linked glycans (6 sites) |
GlyGeni | P19652, 7 sites, 99 N-linked glycans (7 sites) |
iPTMneti | P19652 |
PhosphoSitePlusi | P19652 |
Expressioni
Tissue specificityi
Expressed by the liver and secreted in plasma.
Inductioni
Synthesis is controlled by glucocorticoids, interleukin-1 and interleukin-6, It increases 5- to 50-fold upon inflammation.
Gene expression databases
Bgeei | ENSG00000228278, Expressed in right lobe of liver and 108 other tissues |
Genevisiblei | P19652, HS |
Organism-specific databases
HPAi | ENSG00000228278, Tissue enriched (liver) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 111047, 20 interactors |
IntActi | P19652, 5 interactors |
STRINGi | 9606.ENSP00000394936 |
Miscellaneous databases
RNActi | P19652, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P19652 |
SMRi | P19652 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P19652 |
Family & Domainsi
Domaini
Contains a beta-barrel that binds various ligands in its interior.1 Publication
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S0Q2, Eukaryota |
GeneTreei | ENSGT00390000012130 |
HOGENOMi | CLU_117688_0_0_1 |
InParanoidi | P19652 |
OMAi | CAPLIPV |
OrthoDBi | 1257041at2759 |
PhylomeDBi | P19652 |
TreeFami | TF343791 |
Family and domain databases
Gene3Di | 2.40.128.20, 1 hit |
InterProi | View protein in InterPro IPR001500, A1A_glycop IPR012674, Calycin IPR000566, Lipocln_cytosolic_FA-bd_dom |
Pfami | View protein in Pfam PF00061, Lipocalin, 1 hit |
PIRSFi | PIRSF036899, AGP, 1 hit |
PRINTSi | PR00708, A1AGLPROTEIN |
SUPFAMi | SSF50814, SSF50814, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P19652-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALSWVLTVL SLLPLLEAQI PLCANLVPVP ITNATLDRIT GKWFYIASAF
60 70 80 90 100
RNEEYNKSVQ EIQATFFYFT PNKTEDTIFL REYQTRQNQC FYNSSYLNVQ
110 120 130 140 150
RENGTVSRYE GGREHVAHLL FLRDTKTLMF GSYLDDEKNW GLSFYADKPE
160 170 180 190 200
TTKEQLGEFY EALDCLCIPR SDVMYTDWKK DKCEPLEKQH EKERKQEEGE
S
Sequence cautioni
The sequence CAA29873 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAA29874 differs from that shown. Reason: Erroneous gene model prediction.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 32 | T → I in CAG33211 (Ref. 4) Curated | 1 | |
Sequence conflicti | 102 | E → D in BAG35159 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 125 | T → I in BAG35159 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 162 | A → V in BAG35159 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 189 | Q → H in BAG35159 (PubMed:14702039).Curated | 1 |
Polymorphismi
Many different variants of ORM2 are known.
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_014667 | 38 | R → Q. Corresponds to variant dbSNP:rs147969317Ensembl. | 1 | |
Natural variantiVAR_050172 | 99 | V → A. Corresponds to variant dbSNP:rs2636889Ensembl. | 1 | |
Natural variantiVAR_050173 | 141 | G → R. Corresponds to variant dbSNP:rs12685968Ensembl. | 1 | |
Natural variantiVAR_050174 | 167 | C → R. Corresponds to variant dbSNP:rs1126777Ensembl. | 1 | |
Natural variantiVAR_050175 | 174 | M → V. Corresponds to variant dbSNP:rs2636890Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X06675 Genomic DNA Translation: CAA29874.1 Sequence problems. X05780 Genomic DNA No translation available. X06674 , X06676, X06677, X06678, X06679, X06680 Genomic DNA Translation: CAA29873.2 Sequence problems. X05784 Genomic DNA No translation available. M21540 Genomic DNA Translation: AAA51549.1 AK312226 mRNA Translation: BAG35159.1 CR456930 mRNA Translation: CAG33211.1 AL356796 Genomic DNA No translation available. CH471090 Genomic DNA Translation: EAW87417.1 BC015964 mRNA Translation: AAH15964.1 BC056239 mRNA Translation: AAH56239.1 |
CCDSi | CCDS6804.1 |
PIRi | JT0326, OMHU2 |
RefSeqi | NP_000599.1, NM_000608.2 |
Genome annotation databases
Ensembli | ENST00000431067.4; ENSP00000394936.2; ENSG00000228278.5 |
GeneIDi | 5005 |
KEGGi | hsa:5005 |
MANE-Selecti | ENST00000431067.4; ENSP00000394936.2; NM_000608.4; NP_000599.1 |
UCSCi | uc004bil.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X06675 Genomic DNA Translation: CAA29874.1 Sequence problems. X05780 Genomic DNA No translation available. X06674 , X06676, X06677, X06678, X06679, X06680 Genomic DNA Translation: CAA29873.2 Sequence problems. X05784 Genomic DNA No translation available. M21540 Genomic DNA Translation: AAA51549.1 AK312226 mRNA Translation: BAG35159.1 CR456930 mRNA Translation: CAG33211.1 AL356796 Genomic DNA No translation available. CH471090 Genomic DNA Translation: EAW87417.1 BC015964 mRNA Translation: AAH15964.1 BC056239 mRNA Translation: AAH56239.1 |
CCDSi | CCDS6804.1 |
PIRi | JT0326, OMHU2 |
RefSeqi | NP_000599.1, NM_000608.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3APU | X-ray | 2.10 | A/B | 19-201 | [»] | |
3APV | X-ray | 2.15 | A/B | 19-201 | [»] | |
3APW | X-ray | 2.20 | A/B | 19-201 | [»] | |
3APX | X-ray | 2.20 | A | 19-201 | [»] | |
7OUB | X-ray | 1.82 | B | 19-190 | [»] | |
AlphaFoldDBi | P19652 | |||||
SMRi | P19652 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111047, 20 interactors |
IntActi | P19652, 5 interactors |
STRINGi | 9606.ENSP00000394936 |
Chemistry databases
ChEMBLi | CHEMBL5958 |
DrugBanki | DB12001, Abemaciclib DB11703, Acalabrutinib DB00404, Alprazolam DB00278, Argatroban DB06216, Asenapine DB01072, Atazanavir DB00289, Atomoxetine DB01086, Benzocaine DB00608, Chloroquine DB00477, Chlorpromazine DB00907, Cocaine DB00280, Disopyramide DB00476, Duloxetine DB12466, Favipiravir DB00813, Fentanyl DB00950, Fexofenadine DB01195, Flecainide DB00986, Glycopyrronium DB01611, Hydroxychloroquine DB09053, Ibrutinib DB09262, Imidafenacin DB00458, Imipramine DB00808, Indapamide DB00332, Ipratropium DB01029, Irbesartan DB11757, Istradefylline DB00598, Labetalol DB00281, Lidocaine DB08932, Macitentan DB01203, Nadolol DB11828, Neratinib DB01115, Nifedipine DB00497, Oxycodone DB14582, Patisiran DB00960, Pindolol DB00409, Remoxipride DB01045, Rifampicin DB14840, Ripretinib DB00938, Salmeterol DB11689, Selumetinib DB01591, Solifenacin DB00421, Spironolactone DB00857, Terbinafine DB01041, Thalidomide DB00512, Vancomycin DB11641, Vinflunine DB01593, Zinc DB14487, Zinc acetate DB14533, Zinc chloride DB14548, Zinc sulfate, unspecified form |
PTM databases
GlyConnecti | 14, 74 N-Linked glycans (6 sites) |
GlyGeni | P19652, 7 sites, 99 N-linked glycans (7 sites) |
iPTMneti | P19652 |
PhosphoSitePlusi | P19652 |
Genetic variation databases
BioMutai | ORM2 |
DMDMi | 231458 |
2D gel databases
DOSAC-COBS-2DPAGEi | P19652 |
SWISS-2DPAGEi | P19652 |
Proteomic databases
jPOSTi | P19652 |
MassIVEi | P19652 |
MaxQBi | P19652 |
PaxDbi | P19652 |
PeptideAtlasi | P19652 |
PRIDEi | P19652 |
ProteomicsDBi | 53685 |
Protocols and materials databases
Antibodypediai | 29909, 255 antibodies from 28 providers |
DNASUi | 5005 |
Genome annotation databases
Ensembli | ENST00000431067.4; ENSP00000394936.2; ENSG00000228278.5 |
GeneIDi | 5005 |
KEGGi | hsa:5005 |
MANE-Selecti | ENST00000431067.4; ENSP00000394936.2; NM_000608.4; NP_000599.1 |
UCSCi | uc004bil.4, human |
Organism-specific databases
CTDi | 5005 |
DisGeNETi | 5005 |
GeneCardsi | ORM2 |
HGNCi | HGNC:8499, ORM2 |
HPAi | ENSG00000228278, Tissue enriched (liver) |
MIMi | 138610, gene |
neXtProti | NX_P19652 |
OpenTargetsi | ENSG00000228278 |
PharmGKBi | PA32818 |
VEuPathDBi | HostDB:ENSG00000228278 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S0Q2, Eukaryota |
GeneTreei | ENSGT00390000012130 |
HOGENOMi | CLU_117688_0_0_1 |
InParanoidi | P19652 |
OMAi | CAPLIPV |
OrthoDBi | 1257041at2759 |
PhylomeDBi | P19652 |
TreeFami | TF343791 |
Enzyme and pathway databases
PathwayCommonsi | P19652 |
Reactomei | R-HSA-114608, Platelet degranulation R-HSA-6798695, Neutrophil degranulation |
SignaLinki | P19652 |
Miscellaneous databases
BioGRID-ORCSi | 5005, 11 hits in 1023 CRISPR screens |
ChiTaRSi | ORM2, human |
EvolutionaryTracei | P19652 |
GenomeRNAii | 5005 |
Pharosi | P19652, Tbio |
PROi | PR:P19652 |
RNActi | P19652, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000228278, Expressed in right lobe of liver and 108 other tissues |
Genevisiblei | P19652, HS |
Family and domain databases
Gene3Di | 2.40.128.20, 1 hit |
InterProi | View protein in InterPro IPR001500, A1A_glycop IPR012674, Calycin IPR000566, Lipocln_cytosolic_FA-bd_dom |
Pfami | View protein in Pfam PF00061, Lipocalin, 1 hit |
PIRSFi | PIRSF036899, AGP, 1 hit |
PRINTSi | PR00708, A1AGLPROTEIN |
SUPFAMi | SSF50814, SSF50814, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A1AG2_HUMAN | |
Accessioni | P19652Primary (citable) accession number: P19652 Secondary accession number(s): B2R5L2 Q6IB74 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1991 |
Last sequence update: | April 1, 1993 | |
Last modified: | May 25, 2022 | |
This is version 202 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families