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UniProtKB - P19652 (A1AG2_HUMAN)

Protein

Alpha-1-acid glycoprotein 2

Gene

ORM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as transport protein in the blood stream. Binds various hydrophobic ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability. Appears to function in modulating the activity of the immune system during the acute-phase reaction.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAcute phase, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-114608 Platelet degranulation
R-HSA-6798695 Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alpha-1-acid glycoprotein 2
Short name:
AGP 2
Alternative name(s):
Orosomucoid-2
Short name:
OMD 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ORM2
Synonyms:AGP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000228278.3

Human Gene Nomenclature Database

More...HGNCi		HGNC:8499 ORM2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		138610 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P19652

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		5005

Open Targets

More...OpenTargetsi		ENSG00000228278

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA32818

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL5958

Drug and drug target database

More...DrugBanki		DB00477 Chlorpromazine
DB00497 Oxycodone
DB01041 Thalidomide

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ORM2

Domain mapping of disease mutations (DMDM)

More...DMDMi		231458

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Add BLAST18
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001786119 – 201Alpha-1-acid glycoprotein 2Add BLAST183

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei19Pyrrolidone carboxylic acid1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi23 ↔ 165
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi33N-linked (GlcNAc...) (complex) asparagine8 Publications1
Glycosylationi56N-linked (GlcNAc...) asparagine4 Publications1
Glycosylationi72N-linked (GlcNAc...) asparagine3 Publications1
Disulfide bondi90 ↔ 183
Glycosylationi93N-linked (GlcNAc...) asparagine5 Publications1
GlycosylationiCAR_000171103N-linked (GlcNAc...) asparagine3 Publications1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated. N-glycan heterogeneity at Asn-33: Hex5HexNAc4 (minor), Hex6HexNAc5 (major) and dHex1Hex6HexNAc5 (minor).8 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		P19652

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P19652

PeptideAtlas

More...PeptideAtlasi		P19652

PRoteomics IDEntifications database

More...PRIDEi		P19652

ProteomicsDB human proteome resource

More...ProteomicsDBi		53685

2D gel databases

DOSAC-COBS 2D-PAGE database

More...DOSAC-COBS-2DPAGEi		P19652

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...SWISS-2DPAGEi		P19652

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		14

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P19652

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P19652

UniCarbKB; an annotated and curated database of glycan structures

More...UniCarbKBi		P19652

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed by the liver and secreted in plasma.

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Synthesis is controlled by glucocorticoids, interleukin-1 and interleukin-6, It increases 5- to 50-fold upon inflammation.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000228278 Expressed in 86 organ(s), highest expression level in right lobe of liver

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P19652 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA046438
HPA047725
HPA057726

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		111047, 5 interactors

Protein interaction database and analysis system

More...IntActi		P19652, 3 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000394936

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1201
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		P19652

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P19652

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P19652

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains a beta-barrel that binds various ligands in its interior.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IWZI Eukaryota
ENOG4111C49 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000012130

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000125170

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG000035

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P19652

KEGG Orthology (KO)

More...KOi		K17308

Identification of Orthologs from Complete Genome Data

More...OMAi		QSPECAN

Database of Orthologous Groups

More...OrthoDBi		EOG091G0NAQ

Database for complete collections of gene phylogenies

More...PhylomeDBi		P19652

TreeFam database of animal gene trees

More...TreeFami		TF343791

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.40.128.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001500 A1A_glycop
IPR012674 Calycin
IPR000566 Lipocln_cytosolic_FA-bd_dom

The PANTHER Classification System

More...PANTHERi		PTHR11967 PTHR11967, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00061 Lipocalin, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF036899 AGP, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00708 A1AGLPROTEIN

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50814 SSF50814, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P19652-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALSWVLTVL SLLPLLEAQI PLCANLVPVP ITNATLDRIT GKWFYIASAF 
        60         70         80         90        100
RNEEYNKSVQ EIQATFFYFT PNKTEDTIFL REYQTRQNQC FYNSSYLNVQ 
       110        120        130        140        150
RENGTVSRYE GGREHVAHLL FLRDTKTLMF GSYLDDEKNW GLSFYADKPE 
       160        170        180        190        200
TTKEQLGEFY EALDCLCIPR SDVMYTDWKK DKCEPLEKQH EKERKQEEGE 

S
Length:201
Mass (Da):23,603
Last modified:April 1, 1993 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i49167ABCC22933B9
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA29873 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAA29874 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti32T → I in CAG33211 (Ref. 4) Curated1
Sequence conflicti102E → D in BAG35159 (PubMed:14702039).Curated1
Sequence conflicti125T → I in BAG35159 (PubMed:14702039).Curated1
Sequence conflicti162A → V in BAG35159 (PubMed:14702039).Curated1
Sequence conflicti189Q → H in BAG35159 (PubMed:14702039).Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Many different variants of ORM2 are known.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01466738R → Q. Corresponds to variant dbSNP:rs147969317Ensembl.1
Natural variantiVAR_05017299V → A. Corresponds to variant dbSNP:rs2636889Ensembl.1
Natural variantiVAR_050173141G → R. Corresponds to variant dbSNP:rs12685968Ensembl.1
Natural variantiVAR_050174167C → R. Corresponds to variant dbSNP:rs1126777Ensembl.1
Natural variantiVAR_050175174M → V. Corresponds to variant dbSNP:rs2636890Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X06675 Genomic DNA Translation: CAA29874.1 Sequence problems.
X05780 Genomic DNA No translation available.
X06674
, X06676, X06677, X06678, X06679, X06680 Genomic DNA Translation: CAA29873.2 Sequence problems.
X05784 Genomic DNA No translation available.
M21540 Genomic DNA Translation: AAA51549.1
AK312226 mRNA Translation: BAG35159.1
CR456930 mRNA Translation: CAG33211.1
AL356796 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87417.1
BC015964 mRNA Translation: AAH15964.1
BC056239 mRNA Translation: AAH56239.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS6804.1

Protein sequence database of the Protein Information Resource

More...PIRi		JT0326 OMHU2

NCBI Reference Sequences

More...RefSeqi		NP_000599.1, NM_000608.2

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.719954

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000431067; ENSP00000394936; ENSG00000228278

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5005

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5005

UCSC genome browser

More...UCSCi		uc004bil.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06675 Genomic DNA Translation: CAA29874.1 Sequence problems.
X05780 Genomic DNA No translation available.
X06674
, X06676, X06677, X06678, X06679, X06680 Genomic DNA Translation: CAA29873.2 Sequence problems.
X05784 Genomic DNA No translation available.
M21540 Genomic DNA Translation: AAA51549.1
AK312226 mRNA Translation: BAG35159.1
CR456930 mRNA Translation: CAG33211.1
AL356796 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87417.1
BC015964 mRNA Translation: AAH15964.1
BC056239 mRNA Translation: AAH56239.1
CCDSiCCDS6804.1
PIRiJT0326 OMHU2
RefSeqiNP_000599.1, NM_000608.2
UniGeneiHs.719954

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3APUX-ray2.10A/B19-201[»]
3APVX-ray2.15A/B19-201[»]
3APWX-ray2.20A/B19-201[»]
3APXX-ray2.20A19-201[»]
ProteinModelPortaliP19652
SMRiP19652
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111047, 5 interactors
IntActiP19652, 3 interactors
STRINGi9606.ENSP00000394936

Chemistry databases

ChEMBLiCHEMBL5958
DrugBankiDB00477 Chlorpromazine
DB00497 Oxycodone
DB01041 Thalidomide

PTM databases

GlyConnecti14
iPTMnetiP19652
PhosphoSitePlusiP19652
UniCarbKBiP19652

Polymorphism and mutation databases

BioMutaiORM2
DMDMi231458

2D gel databases

DOSAC-COBS-2DPAGEiP19652
SWISS-2DPAGEiP19652

Proteomic databases

MaxQBiP19652
PaxDbiP19652
PeptideAtlasiP19652
PRIDEiP19652
ProteomicsDBi53685

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		5005
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000431067; ENSP00000394936; ENSG00000228278
GeneIDi5005
KEGGihsa:5005
UCSCiuc004bil.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5005
DisGeNETi5005
EuPathDBiHostDB:ENSG00000228278.3

GeneCards: human genes, protein and diseases

More...GeneCardsi		ORM2
HGNCiHGNC:8499 ORM2
HPAiHPA046438
HPA047725
HPA057726
MIMi138610 gene
neXtProtiNX_P19652
OpenTargetsiENSG00000228278
PharmGKBiPA32818

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IWZI Eukaryota
ENOG4111C49 LUCA
GeneTreeiENSGT00390000012130
HOGENOMiHOG000125170
HOVERGENiHBG000035
InParanoidiP19652
KOiK17308
OMAiQSPECAN
OrthoDBiEOG091G0NAQ
PhylomeDBiP19652
TreeFamiTF343791

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

EvolutionaryTraceiP19652

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5005

Protein Ontology

More...PROi		PR:P19652

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000228278 Expressed in 86 organ(s), highest expression level in right lobe of liver
GenevisibleiP19652 HS

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR001500 A1A_glycop
IPR012674 Calycin
IPR000566 Lipocln_cytosolic_FA-bd_dom
PANTHERiPTHR11967 PTHR11967, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PIRSFiPIRSF036899 AGP, 1 hit
PRINTSiPR00708 A1AGLPROTEIN
SUPFAMiSSF50814 SSF50814, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA1AG2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P19652
Secondary accession number(s): B2R5L2
, Q16571, Q5T538, Q6IB74
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: April 1, 1993
Last modified: November 7, 2018
This is version 184 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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