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Protein

Glutathione S-transferase Mu 3

Gene

Gstm3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

GO - Biological processi

  • cellular response to drug Source: MGI
  • cellular response to organic cyclic compound Source: MGI
  • response to bacterium Source: MGI

Keywordsi

Molecular functionTransferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase Mu 3 (EC:2.5.1.18)
Alternative name(s):
GST class-mu 3
Glutathione S-transferase GT9.3
Gene namesi
Name:Gstm3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:106026 Gstm3

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001858282 – 218Glutathione S-transferase Mu 3Add BLAST217

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki50Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki69Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiP19639
PaxDbiP19639
PeptideAtlasiP19639
PRIDEiP19639

PTM databases

iPTMnetiP19639
PhosphoSitePlusiP19639

Expressioni

Gene expression databases

BgeeiENSMUSG00000004038 Expressed in 141 organ(s), highest expression level in colon
CleanExiMM_GSTM3
GenevisibleiP19639 MM

Interactioni

Subunit structurei

Homodimer.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000004136

Structurei

3D structure databases

ProteinModelPortaliP19639
SMRiP19639
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 88GST N-terminalAdd BLAST87
Domaini90 – 208GST C-terminalAdd BLAST119

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni7 – 8Glutathione bindingBy similarity2
Regioni46 – 50Glutathione bindingBy similarity5
Regioni59 – 60Glutathione bindingBy similarity2
Regioni72 – 73Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Mu family.Curated

Phylogenomic databases

eggNOGiENOG410IN5J Eukaryota
ENOG4110YU0 LUCA
GeneTreeiENSGT00550000074559
HOGENOMiHOG000115735
HOVERGENiHBG106842
InParanoidiP19639
KOiK00799
OMAiMILAYWD
OrthoDBiEOG091G0K2E
PhylomeDBiP19639
TreeFamiTF353040

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR040079 Glutathione_S-Trfase
IPR004045 Glutathione_S-Trfase_N
IPR004046 GST_C
IPR003081 GST_mu
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF00043 GST_C, 1 hit
PF02798 GST_N, 1 hit
PRINTSiPR01267 GSTRNSFRASEM
SFLDiSFLDS00019 Glutathione_Transferase_(cytos, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19639-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPMTLGYWNT RGLTHSIRLL LEYTDSSYEE KRYVMGDAPN FDRSQWLSEK
60 70 80 90 100
FNLGLDFPNL PYLIDGSHKV TQSNAILRYL GRKHNLCGET EEERIRVDTL
110 120 130 140 150
ENQVMDTRIQ LMIVCCSPDF EKQKPEFLKA IPEKMKLYSE FLGKRPWFAG
160 170 180 190 200
DKVTYVDFLA YDILDQYRMF EPKCLDAFPN LRDFLARFEG LKKISAYMKS
210
SRFLPRPVFT KIAQWGTD
Length:218
Mass (Da):25,702
Last modified:January 23, 2007 - v2
Checksum:iF4989897BE817868
GO

Sequence cautioni

The sequence AAA37748 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC044927 mRNA Translation: AAH44927.1
J03953 mRNA Translation: AAA37748.1 Different initiation.
CCDSiCCDS17744.1
PIRiB28946
E37520
RefSeqiNP_034489.1, NM_010359.2
UniGeneiMm.440885

Genome annotation databases

EnsembliENSMUST00000004136; ENSMUSP00000004136; ENSMUSG00000004038
GeneIDi14864
KEGGimmu:14864
UCSCiuc008qxv.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC044927 mRNA Translation: AAH44927.1
J03953 mRNA Translation: AAA37748.1 Different initiation.
CCDSiCCDS17744.1
PIRiB28946
E37520
RefSeqiNP_034489.1, NM_010359.2
UniGeneiMm.440885

3D structure databases

ProteinModelPortaliP19639
SMRiP19639
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000004136

PTM databases

iPTMnetiP19639
PhosphoSitePlusiP19639

Proteomic databases

MaxQBiP19639
PaxDbiP19639
PeptideAtlasiP19639
PRIDEiP19639

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000004136; ENSMUSP00000004136; ENSMUSG00000004038
GeneIDi14864
KEGGimmu:14864
UCSCiuc008qxv.2 mouse

Organism-specific databases

CTDi2947
MGIiMGI:106026 Gstm3

Phylogenomic databases

eggNOGiENOG410IN5J Eukaryota
ENOG4110YU0 LUCA
GeneTreeiENSGT00550000074559
HOGENOMiHOG000115735
HOVERGENiHBG106842
InParanoidiP19639
KOiK00799
OMAiMILAYWD
OrthoDBiEOG091G0K2E
PhylomeDBiP19639
TreeFamiTF353040

Miscellaneous databases

PROiPR:P19639
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000004038 Expressed in 141 organ(s), highest expression level in colon
CleanExiMM_GSTM3
GenevisibleiP19639 MM

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR040079 Glutathione_S-Trfase
IPR004045 Glutathione_S-Trfase_N
IPR004046 GST_C
IPR003081 GST_mu
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF00043 GST_C, 1 hit
PF02798 GST_N, 1 hit
PRINTSiPR01267 GSTRNSFRASEM
SFLDiSFLDS00019 Glutathione_Transferase_(cytos, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGSTM3_MOUSE
AccessioniPrimary (citable) accession number: P19639
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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