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Protein

Sodium/hydrogen exchanger 1

Gene

SLC9A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.3 Publications

Miscellaneous

Inhibited by amiloride and 5-amino-substituted derivatives and activated in a cooperative fashion by intracellular H+. In quiescent cells upon growth factor stimulation, the apparent affinity for internal H+ is increased, resulting in a persistent rise in cytoplasmic pH.

Caution

The region between transmembrane regions M4 and M5 and between M6 and M7 (also termed intracellular loops IL2 and IL4, respectively) seem to be localized at least in part in the membrane. The hydrophobic region H10 is proposed to be located within the membrane.Curated
Although PubMed:12809501 report that TESC-binding results in a decrease in activity, studies with rat SLC9A1 show that TESC-binding results in the maturation and accumulation of SLC9A1 at the cell surface.Curated
Although PubMed:12809501 report that CHP1 and TESC bind to SLC9A1 at different sites, studies with rat SLC9A1 show that they bind at the same C-terminal site.Curated

pH dependencei

Fully active at acidic pHs, the antiporter is virtually turned off at neutral pH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei161Channel pore-liningCurated1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalmodulin-binding
Biological processAntiport, Ion transport, Sodium transport, Transport
LigandSodium

Enzyme and pathway databases

ReactomeiR-HSA-2160916 Hyaluronan uptake and degradation
R-HSA-425986 Sodium/Proton exchangers
SignaLinkiP19634
SIGNORiP19634

Protein family/group databases

TCDBi2.A.36.1.13 the monovalent cation:proton antiporter-1 (cpa1) family

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/hydrogen exchanger 1
Alternative name(s):
APNH
Na(+)/H(+) antiporter, amiloride-sensitive
Na(+)/H(+) exchanger 1
Short name:
NHE-1
Solute carrier family 9 member 1
Gene namesi
Name:SLC9A1
Synonyms:APNH1, NHE1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000090020.10
HGNCiHGNC:11071 SLC9A1
MIMi107310 gene
neXtProtiNX_P19634

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12CytoplasmicSequence analysisAdd BLAST12
Transmembranei13 – 33Helical; Name=M1Sequence analysisAdd BLAST21
Topological domaini34 – 105ExtracellularSequence analysisAdd BLAST72
Transmembranei106 – 127Helical; Name=M2Sequence analysisAdd BLAST22
Topological domaini128 – 129CytoplasmicSequence analysis2
Transmembranei130 – 149Helical; Name=M3Sequence analysisAdd BLAST20
Topological domaini150 – 154ExtracellularSequence analysis5
Transmembranei155 – 174Helical; Name=M4Sequence analysisAdd BLAST20
Topological domaini175 – 191CytoplasmicSequence analysisAdd BLAST17
Transmembranei192 – 211Helical; Name=M5Sequence analysisAdd BLAST20
Topological domaini212 – 227ExtracellularSequence analysisAdd BLAST16
Transmembranei228 – 247Helical; Name=M6Sequence analysisAdd BLAST20
Topological domaini248 – 256CytoplasmicSequence analysis9
Transmembranei257 – 276Helical; Name=M7Sequence analysisAdd BLAST20
Topological domaini277 – 294ExtracellularSequence analysisAdd BLAST18
Transmembranei295 – 315Helical; Name=M8Sequence analysisAdd BLAST21
Topological domaini316 – 338CytoplasmicSequence analysisAdd BLAST23
Transmembranei339 – 358Helical; Name=M9Sequence analysisAdd BLAST20
Topological domaini359 – 381ExtracellularSequence analysisAdd BLAST23
Intramembranei382 – 402Name=H10By similarityAdd BLAST21
Topological domaini403 – 410ExtracellularSequence analysis8
Transmembranei411 – 430Helical; Name=M10Sequence analysisAdd BLAST20
Topological domaini431 – 448CytoplasmicSequence analysisAdd BLAST18
Transmembranei449 – 470Helical; Name=M11Sequence analysisAdd BLAST22
Topological domaini471 – 479ExtracellularSequence analysis9
Transmembranei480 – 499Helical; Name=M12Sequence analysisAdd BLAST20
Topological domaini500 – 815CytoplasmicSequence analysisAdd BLAST316

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Involvement in diseasei

Lichtenstein-Knorr syndrome (LIKNS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive neurologic disorder characterized by progressive cerebellar ataxia and severe progressive sensorineural hearing loss.
See also OMIM:616291
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_073439305G → R in LIKNS; causes reduced expression of the mutant protein; hypoglycosylated; does not localize properly at the plasma membrane; small residual activity. 1 PublicationCorresponds to variant dbSNP:rs786204831EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi155F → C: Almost complete loss of activity. 1 Publication1
Mutagenesisi156L → C: Almost complete loss of activity. 1 Publication1
Mutagenesisi157Q → C: Reduces activity. 1 Publication1
Mutagenesisi158S → C: Almost complete loss of activity. 1 Publication1
Mutagenesisi159D → C: Almost complete loss of activity. 1 Publication1
Mutagenesisi160V → C: Reduces activity. 1 Publication1
Mutagenesisi161F → C: Reduces activity. 1 Publication1
Mutagenesisi162F → C: Almost complete loss of activity. 1 Publication1
Mutagenesisi163L → C: Reduces activity. 1 Publication1
Mutagenesisi164F → C: Almost complete loss of activity. 1 Publication1
Mutagenesisi165L → C: Reduces activity. 1 Publication1
Mutagenesisi166L → C: Reduces activity. 1 Publication1
Mutagenesisi167P → A: Reduces activity. 2 Publications1
Mutagenesisi167P → C or G: Almost complete loss of activity. Reduces membrane localization. 2 Publications1
Mutagenesisi168P → A or C: Almost complete loss of activity. 2 Publications1
Mutagenesisi168P → G: Reduces activity. 2 Publications1
Mutagenesisi169I → C: Reduces activity. 1 Publication1
Mutagenesisi170I → C: Reduces activity. 1 Publication1
Mutagenesisi171L → C: Reduces activity. 1 Publication1
Mutagenesisi172D → C: Almost complete loss of activity. 1 Publication1
Mutagenesisi173A → C: Reduces activity. 1 Publication1
Mutagenesisi174G → C: Reduces activity. 1 Publication1
Mutagenesisi175Y → C: Almost complete loss of activity. 1 Publication1
Mutagenesisi176F → C: Almost complete loss of activity. 1 Publication1
Mutagenesisi177L → C: Reduces activity. 1 Publication1
Mutagenesisi178P → A: No effect. 1
Mutagenesisi180R → C: Reduces activity. 1 Publication1
Mutagenesisi181Q → C: Reduces activity. 1 Publication1
Mutagenesisi518I → Q: Reduces interaction with CHP1 and the exchange activity; when associated with Q-522. 1 Publication1
Mutagenesisi522I → Q: Reduces interaction with CHP1 and the exchange activity; when associated with Q-518. 1 Publication1
Mutagenesisi526 – 531FLDHLL → QQDHQQ: Inhibits interaction with CHP1 and the exchange activity. CHPI does not localize at the cell membrane. 1 Publication6
Mutagenesisi526 – 531FLDHLL → RRDHRR: Inhibits interaction with CHP1 and the exchange activity. CHPI does not localize at the cell membrane. 1 Publication6
Mutagenesisi526F → Q: Reduces interaction with CHP1 and the exchange activity; when associated with Q-527. 1 Publication1
Mutagenesisi527L → Q: Reduces interaction with CHP1 and the exchange activity; when associated with Q-526. 1 Publication1
Mutagenesisi530L → Q: Reduces interaction with CHP1 and the exchange activity; when associated with Q-531. 1 Publication1
Mutagenesisi531L → Q: Reduces interaction with CHP1 and the exchange activity; when associated with Q-530. 1 Publication1
Mutagenesisi534I → D or K: Strongly reduced interaction with CHP2. 1 Publication1
Mutagenesisi537I → K: Strongly reduced interaction with CHP2. 1 Publication1

Keywords - Diseasei

Deafness, Disease mutation, Neurodegeneration

Organism-specific databases

DisGeNETi6548
MalaCardsiSLC9A1
MIMi616291 phenotype
OpenTargetsiENSG00000090020
PharmGKBiPA35928

Chemistry databases

ChEMBLiCHEMBL2781
DrugBankiDB00594 Amiloride
DB02624 Homoserine Lactone

Polymorphism and mutation databases

BioMutaiSLC9A1
DMDMi127809

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000523471 – 815Sodium/hydrogen exchanger 1Add BLAST815

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi42O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi56O-linked (GalNAc...) serineSequence analysis1
Glycosylationi61O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi62O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi68O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi75N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei599PhosphoserineCombined sources1
Modified residuei602PhosphoserineCombined sources1
Modified residuei603PhosphothreonineBy similarity1
Modified residuei605PhosphoserineCombined sources1
Modified residuei693PhosphoserineCombined sources1
Modified residuei697PhosphoserineCombined sources1
Modified residuei703PhosphoserineCombined sources1
Modified residuei723PhosphoserineCombined sources1
Modified residuei726PhosphoserineCombined sources1
Modified residuei729PhosphoserineCombined sources1
Modified residuei785PhosphoserineCombined sources1
Modified residuei787PhosphoserineBy similarity1
Modified residuei796PhosphoserineBy similarity1

Post-translational modificationi

O-glycosylated.1 Publication
Ubiquitinated, leading to its degradation by the proteasome. Ubiquitination is reduced by CHP1 (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei370Not glycosylated1

Keywords - PTMi

Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP19634
MaxQBiP19634
PaxDbiP19634
PeptideAtlasiP19634
PRIDEiP19634
ProteomicsDBi53683
53684 [P19634-2]

PTM databases

GlyConnecti1755
iPTMnetiP19634
PhosphoSitePlusiP19634

Expressioni

Tissue specificityi

Kidney and intestine.

Gene expression databases

BgeeiENSG00000090020 Expressed in 213 organ(s), highest expression level in saliva-secreting gland
CleanExiHS_SLC9A1
ExpressionAtlasiP19634 baseline and differential
GenevisibleiP19634 HS

Organism-specific databases

HPAiCAB022371
HPA048532
HPA052891

Interactioni

Subunit structurei

Oligomer (By similarity). Interacts with calmodulin and TESC. Interacts (via the juxtamembrane region of the cytoplasmic C-terminal domain) with CHP1; the interaction occurs at the plasma membrane in a calcium-dependent manner. Interacts with CHP2; the interaction occurs in a calcium-dependent manner.By similarity10 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112438, 48 interactors
IntActiP19634, 13 interactors
MINTiP19634
STRINGi9606.ENSP00000263980

Chemistry databases

BindingDBiP19634

Structurei

Secondary structure

1815
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP19634
SMRiP19634
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP19634

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni516 – 539Interaction with CHP2Add BLAST24

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1966 Eukaryota
COG0025 LUCA
GeneTreeiENSGT00760000119074
HOGENOMiHOG000247044
HOVERGENiHBG052615
InParanoidiP19634
KOiK05742
OMAiERSTHDL
OrthoDBiEOG091G02Q0
PhylomeDBiP19634
TreeFamiTF317212

Family and domain databases

InterProiView protein in InterPro
IPR006153 Cation/H_exchanger
IPR018422 Cation/H_exchanger_CPA1
IPR001970 Na/H_exchanger_1
IPR004709 NaH_exchanger
IPR032103 NHE_CaM-bd
PANTHERiPTHR10110 PTHR10110, 1 hit
PTHR10110:SF59 PTHR10110:SF59, 1 hit
PfamiView protein in Pfam
PF00999 Na_H_Exchanger, 1 hit
PF16644 NEXCaM_BD, 1 hit
PRINTSiPR01084 NAHEXCHNGR
PR01085 NAHEXCHNGR1
TIGRFAMsiTIGR00840 b_cpa1, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P19634-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVLRSGICGL SPHRIFPSLL VVVALVGLLP VLRSHGLQLS PTASTIRSSE
60 70 80 90 100
PPRERSIGDV TTAPPEVTPE SRPVNHSVTD HGMKPRKAFP VLGIDYTHVR
110 120 130 140 150
TPFEISLWIL LACLMKIGFH VIPTISSIVP ESCLLIVVGL LVGGLIKGVG
160 170 180 190 200
ETPPFLQSDV FFLFLLPPII LDAGYFLPLR QFTENLGTIL IFAVVGTLWN
210 220 230 240 250
AFFLGGLMYA VCLVGGEQIN NIGLLDNLLF GSIISAVDPV AVLAVFEEIH
260 270 280 290 300
INELLHILVF GESLLNDAVT VVLYHLFEEF ANYEHVGIVD IFLGFLSFFV
310 320 330 340 350
VALGGVLVGV VYGVIAAFTS RFTSHIRVIE PLFVFLYSYM AYLSAELFHL
360 370 380 390 400
SGIMALIASG VVMRPYVEAN ISHKSHTTIK YFLKMWSSVS ETLIFIFLGV
410 420 430 440 450
STVAGSHHWN WTFVISTLLF CLIARVLGVL GLTWFINKFR IVKLTPKDQF
460 470 480 490 500
IIAYGGLRGA IAFSLGYLLD KKHFPMCDLF LTAIITVIFF TVFVQGMTIR
510 520 530 540 550
PLVDLLAVKK KQETKRSINE EIHTQFLDHL LTGIEDICGH YGHHHWKDKL
560 570 580 590 600
NRFNKKYVKK CLIAGERSKE PQLIAFYHKM EMKQAIELVE SGGMGKIPSA
610 620 630 640 650
VSTVSMQNIH PKSLPSERIL PALSKDKEEE IRKILRNNLQ KTRQRLRSYN
660 670 680 690 700
RHTLVADPYE EAWNQMLLRR QKARQLEQKI NNYLTVPAHK LDSPTMSRAR
710 720 730 740 750
IGSDPLAYEP KEDLPVITID PASPQSPESV DLVNEELKGK VLGLSRDPAK
760 770 780 790 800
VAEEDEDDDG GIMMRSKETS SPGTDDVFTP APSDSPSSQR IQRCLSDPGP
810
HPEPGEGEPF FPKGQ
Length:815
Mass (Da):90,763
Last modified:November 1, 1991 - v2
Checksum:i02EC748C79DF6526
GO
Isoform 2 (identifier: P19634-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     496-554: GMTIRPLVDL...HWKDKLNRFN → VLGQGRAGPC...FWASVSSIVK
     555-815: Missing.

Note: No experimental confirmation available.
Show »
Length:555
Mass (Da):61,013
Checksum:i961A4B1AEDEA68A5
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1ALD5B1ALD5_HUMAN
Sodium/hydrogen exchanger 1
SLC9A1
135Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_073439305G → R in LIKNS; causes reduced expression of the mutant protein; hypoglycosylated; does not localize properly at the plasma membrane; small residual activity. 1 PublicationCorresponds to variant dbSNP:rs786204831EnsemblClinVar.1
Natural variantiVAR_050231682N → K. Corresponds to variant dbSNP:rs35703140Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_022101496 – 554GMTIR…LNRFN → VLGQGRAGPCLGDPHRLFPW KERKACDLKCDSSPSSTTNL LCDLGRATPPFWASVSSIVK in isoform 2. 1 PublicationAdd BLAST59
Alternative sequenceiVSP_022102555 – 815Missing in isoform 2. 1 PublicationAdd BLAST261

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81768 mRNA Translation: AAB59460.1 Sequence problems.
S68616 mRNA Translation: AAC60606.1
AF141350 mRNA Translation: AAF21350.1
AF141351 mRNA Translation: AAF21351.1
AF141352 mRNA Translation: AAF21352.1
AF141353 mRNA Translation: AAF21353.1
AF141354 mRNA Translation: AAF21354.1
AF141355 mRNA Translation: AAF21355.1
AF141356 mRNA Translation: AAF21356.1
AF141357 mRNA Translation: AAF21357.1
AF141358 mRNA Translation: AAF21358.1
AF141359 mRNA Translation: AAF21359.1
AF146430 mRNA Translation: AAF25592.1
AF146431 mRNA Translation: AAF25593.1
AF146432 mRNA Translation: AAF25594.1
AF146433 mRNA Translation: AAF25595.1
AF146434 mRNA Translation: AAF25596.1
AF146435 mRNA Translation: AAF25597.1
AF146436 mRNA Translation: AAF25598.1
AF146437 mRNA Translation: AAF25599.1
AF146438 mRNA Translation: AAF25600.1
AF146439 mRNA Translation: AAF25601.1
AL590640 Genomic DNA No translation available.
AL137860 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07773.1
CH471059 Genomic DNA Translation: EAX07774.1
BC012121 mRNA Translation: AAH12121.1
CCDSiCCDS295.1 [P19634-1]
PIRiI57487
RefSeqiNP_003038.2, NM_003047.4 [P19634-1]
UniGeneiHs.469116

Genome annotation databases

EnsembliENST00000263980; ENSP00000263980; ENSG00000090020 [P19634-1]
ENST00000374086; ENSP00000363199; ENSG00000090020 [P19634-2]
GeneIDi6548
KEGGihsa:6548
UCSCiuc001bnm.5 human [P19634-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81768 mRNA Translation: AAB59460.1 Sequence problems.
S68616 mRNA Translation: AAC60606.1
AF141350 mRNA Translation: AAF21350.1
AF141351 mRNA Translation: AAF21351.1
AF141352 mRNA Translation: AAF21352.1
AF141353 mRNA Translation: AAF21353.1
AF141354 mRNA Translation: AAF21354.1
AF141355 mRNA Translation: AAF21355.1
AF141356 mRNA Translation: AAF21356.1
AF141357 mRNA Translation: AAF21357.1
AF141358 mRNA Translation: AAF21358.1
AF141359 mRNA Translation: AAF21359.1
AF146430 mRNA Translation: AAF25592.1
AF146431 mRNA Translation: AAF25593.1
AF146432 mRNA Translation: AAF25594.1
AF146433 mRNA Translation: AAF25595.1
AF146434 mRNA Translation: AAF25596.1
AF146435 mRNA Translation: AAF25597.1
AF146436 mRNA Translation: AAF25598.1
AF146437 mRNA Translation: AAF25599.1
AF146438 mRNA Translation: AAF25600.1
AF146439 mRNA Translation: AAF25601.1
AL590640 Genomic DNA No translation available.
AL137860 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07773.1
CH471059 Genomic DNA Translation: EAX07774.1
BC012121 mRNA Translation: AAH12121.1
CCDSiCCDS295.1 [P19634-1]
PIRiI57487
RefSeqiNP_003038.2, NM_003047.4 [P19634-1]
UniGeneiHs.469116

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Y4ENMR-A155-180[»]
2BECX-ray2.70B503-545[»]
2E30NMR-B503-545[»]
2HTGNMR-A250-274[»]
2KBVNMR-A447-472[»]
2L0ENMR-A226-250[»]
2MDFNMR-A226-274[»]
2YGGX-ray2.23A622-689[»]
ProteinModelPortaliP19634
SMRiP19634
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112438, 48 interactors
IntActiP19634, 13 interactors
MINTiP19634
STRINGi9606.ENSP00000263980

Chemistry databases

BindingDBiP19634
ChEMBLiCHEMBL2781
DrugBankiDB00594 Amiloride
DB02624 Homoserine Lactone

Protein family/group databases

TCDBi2.A.36.1.13 the monovalent cation:proton antiporter-1 (cpa1) family

PTM databases

GlyConnecti1755
iPTMnetiP19634
PhosphoSitePlusiP19634

Polymorphism and mutation databases

BioMutaiSLC9A1
DMDMi127809

Proteomic databases

EPDiP19634
MaxQBiP19634
PaxDbiP19634
PeptideAtlasiP19634
PRIDEiP19634
ProteomicsDBi53683
53684 [P19634-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263980; ENSP00000263980; ENSG00000090020 [P19634-1]
ENST00000374086; ENSP00000363199; ENSG00000090020 [P19634-2]
GeneIDi6548
KEGGihsa:6548
UCSCiuc001bnm.5 human [P19634-1]

Organism-specific databases

CTDi6548
DisGeNETi6548
EuPathDBiHostDB:ENSG00000090020.10
GeneCardsiSLC9A1
HGNCiHGNC:11071 SLC9A1
HPAiCAB022371
HPA048532
HPA052891
MalaCardsiSLC9A1
MIMi107310 gene
616291 phenotype
neXtProtiNX_P19634
OpenTargetsiENSG00000090020
PharmGKBiPA35928
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1966 Eukaryota
COG0025 LUCA
GeneTreeiENSGT00760000119074
HOGENOMiHOG000247044
HOVERGENiHBG052615
InParanoidiP19634
KOiK05742
OMAiERSTHDL
OrthoDBiEOG091G02Q0
PhylomeDBiP19634
TreeFamiTF317212

Enzyme and pathway databases

ReactomeiR-HSA-2160916 Hyaluronan uptake and degradation
R-HSA-425986 Sodium/Proton exchangers
SignaLinkiP19634
SIGNORiP19634

Miscellaneous databases

ChiTaRSiSLC9A1 human
EvolutionaryTraceiP19634
GeneWikiiSodium%E2%80%93hydrogen_antiporter_1
GenomeRNAii6548
PROiPR:P19634
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000090020 Expressed in 213 organ(s), highest expression level in saliva-secreting gland
CleanExiHS_SLC9A1
ExpressionAtlasiP19634 baseline and differential
GenevisibleiP19634 HS

Family and domain databases

InterProiView protein in InterPro
IPR006153 Cation/H_exchanger
IPR018422 Cation/H_exchanger_CPA1
IPR001970 Na/H_exchanger_1
IPR004709 NaH_exchanger
IPR032103 NHE_CaM-bd
PANTHERiPTHR10110 PTHR10110, 1 hit
PTHR10110:SF59 PTHR10110:SF59, 1 hit
PfamiView protein in Pfam
PF00999 Na_H_Exchanger, 1 hit
PF16644 NEXCaM_BD, 1 hit
PRINTSiPR01084 NAHEXCHNGR
PR01085 NAHEXCHNGR1
TIGRFAMsiTIGR00840 b_cpa1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSL9A1_HUMAN
AccessioniPrimary (citable) accession number: P19634
Secondary accession number(s): B1ALD6, D3DPL4, Q96EM2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: November 1, 1991
Last modified: October 10, 2018
This is version 203 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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